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Recurrent Aggressive NK-Cell Leukemia

MedGen UID:
1680914
•Concept ID:
C4763796
•
Neoplastic Process
Synonym: Recurrent Aggressive NK-Cell Leukemia/Lymphoma

Definition

The reemergence of aggressive NK-cell leukemia after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Aggressive NK-Cell Leukemia

Professional guidelines

PubMed

Diagnosis, prevention and treatment of central nervous system involvement in peripheral t-cell lymphomas.
Zing N, Fischer T, Federico M, Chiattone C, Ferreri AJM
Crit Rev Oncol Hematol 2021 Nov;167:103496. Epub 2021 Oct 12 doi: 10.1016/j.critrevonc.2021.103496. PMID: 34653598
Latest Advances in the Diagnosis and Treatment of Large Granular Lymphocytic Leukemia.
Moignet A, Lamy T
Am Soc Clin Oncol Educ Book 2018 May 23;38:616-625. doi: 10.1200/EDBK_200689. PMID: 30231346
Diagnosis and management of natural killer-cell malignancies.
Ishida F, Kwong YL
Expert Rev Hematol 2010 Oct;3(5):593-602. doi: 10.1586/ehm.10.51. PMID: 21083476

Recent clinical studies

Etiology

Allogeneic hematopoietic stem cell transplantation for NK/T-cell lymphoma: an international collaborative analysis.
Berning P, Schmitz N, Ngoya M, Finel H, Boumendil A, Wang F, Huang XJ, Hermine O, Philippe L, Couronné L, Jaccard A, Liu D, Wu D, Reinhardt HC, Chalandon Y, Wagner-Drouet E, Kwon M, Zhang X, Carpenter B, Yakoub-Agha I, Wulf G, López-Jiménez J, Sanz J, Labussière-Wallet H, Shimoni A, Dreger P, Sureda A, Kim WS, Glass B
Leukemia 2023 Jul;37(7):1511-1520. Epub 2023 May 8 doi: 10.1038/s41375-023-01924-x. PMID: 37157017Free PMC Article
Genomic landscape of TCRαβ and TCRγδ T-large granular lymphocyte leukemia.
Cheon H, Xing JC, Moosic KB, Ung J, Chan VW, Chung DS, Toro MF, Elghawy O, Wang JS, Hamele CE, Hardison RC, Olson TL, Tan SF, Feith DJ, Ratan A, Loughran TP
Blood 2022 May 19;139(20):3058-3072. doi: 10.1182/blood.2021013164. PMID: 35015834Free PMC Article
Mature T-cell leukemias: Molecular and Clinical Aspects.
Bailey NG, Elenitoba-Johnson KS
Curr Hematol Malig Rep 2015 Dec;10(4):421-8. doi: 10.1007/s11899-015-0288-8. PMID: 26433891
Diagnosis and management of natural killer-cell malignancies.
Ishida F, Kwong YL
Expert Rev Hematol 2010 Oct;3(5):593-602. doi: 10.1586/ehm.10.51. PMID: 21083476
Natural killer cell neoplasms.
Liang X, Graham DK
Cancer 2008 Apr 1;112(7):1425-36. doi: 10.1002/cncr.23316. PMID: 18286525

Diagnosis

Allogeneic hematopoietic stem cell transplantation for NK/T-cell lymphoma: an international collaborative analysis.
Berning P, Schmitz N, Ngoya M, Finel H, Boumendil A, Wang F, Huang XJ, Hermine O, Philippe L, Couronné L, Jaccard A, Liu D, Wu D, Reinhardt HC, Chalandon Y, Wagner-Drouet E, Kwon M, Zhang X, Carpenter B, Yakoub-Agha I, Wulf G, López-Jiménez J, Sanz J, Labussière-Wallet H, Shimoni A, Dreger P, Sureda A, Kim WS, Glass B
Leukemia 2023 Jul;37(7):1511-1520. Epub 2023 May 8 doi: 10.1038/s41375-023-01924-x. PMID: 37157017Free PMC Article
Diagnosis, prevention and treatment of central nervous system involvement in peripheral t-cell lymphomas.
Zing N, Fischer T, Federico M, Chiattone C, Ferreri AJM
Crit Rev Oncol Hematol 2021 Nov;167:103496. Epub 2021 Oct 12 doi: 10.1016/j.critrevonc.2021.103496. PMID: 34653598
Aggressive mature natural killer cell neoplasms: from epidemiology to diagnosis.
Lima M
Orphanet J Rare Dis 2013 Jul 1;8:95. doi: 10.1186/1750-1172-8-95. PMID: 23816348Free PMC Article
T-cell and natural killer-cell large granular lymphocyte leukemia neoplasias.
Watters RJ, Liu X, Loughran TP Jr
Leuk Lymphoma 2011 Dec;52(12):2217-25. Epub 2011 Jul 13 doi: 10.3109/10428194.2011.593276. PMID: 21749307Free PMC Article
Natural killer cell neoplasms.
Liang X, Graham DK
Cancer 2008 Apr 1;112(7):1425-36. doi: 10.1002/cncr.23316. PMID: 18286525

Therapy

A phase 2 biomarker-driven study of ruxolitinib demonstrates effectiveness of JAK/STAT targeting in T-cell lymphomas.
Moskowitz AJ, Ghione P, Jacobsen E, Ruan J, Schatz JH, Noor S, Myskowski P, Vardhana S, Ganesan N, Hancock H, Davey T, Perez L, Ryu S, Santarosa A, Dowd J, Obadi O, Pomerantz L, Yi N, Sohail S, Galasso N, Neuman R, Liotta B, Blouin W, Baik J, Geyer MB, Noy A, Straus D, Kumar P, Dogan A, Hollmann T, Drill E, Rademaker J, Schoder H, Inghirami G, Weinstock DM, Horwitz SM
Blood 2021 Dec 30;138(26):2828-2837. doi: 10.1182/blood.2021013379. PMID: 34653242Free PMC Article
The Advent of CAR T-Cell Therapy for Lymphoproliferative Neoplasms: Integrating Research Into Clinical Practice.
Cerrano M, Ruella M, Perales MA, Vitale C, Faraci DG, Giaccone L, Coscia M, Maloy M, Sanchez-Escamilla M, Elsabah H, Fadul A, Maffini E, Pittari G, Bruno B
Front Immunol 2020;11:888. Epub 2020 May 12 doi: 10.3389/fimmu.2020.00888. PMID: 32477359Free PMC Article
Lymphoproliferative tumors involving the lacrimal drainage system: a major review.
Singh S, Ali MJ
Orbit 2020 Aug;39(4):276-284. Epub 2019 Jul 3 doi: 10.1080/01676830.2019.1634104. PMID: 31267826
Pathogenesis and treatment of leukemia: an Asian perspective.
Kwong YL
Expert Opin Ther Targets 2012 Mar;16 Suppl 1:S37-43. Epub 2012 Feb 7 doi: 10.1517/14728222.2011.621418. PMID: 22313234
Diagnosis and management of natural killer-cell malignancies.
Ishida F, Kwong YL
Expert Rev Hematol 2010 Oct;3(5):593-602. doi: 10.1586/ehm.10.51. PMID: 21083476

Prognosis

Allogeneic hematopoietic stem cell transplantation for NK/T-cell lymphoma: an international collaborative analysis.
Berning P, Schmitz N, Ngoya M, Finel H, Boumendil A, Wang F, Huang XJ, Hermine O, Philippe L, Couronné L, Jaccard A, Liu D, Wu D, Reinhardt HC, Chalandon Y, Wagner-Drouet E, Kwon M, Zhang X, Carpenter B, Yakoub-Agha I, Wulf G, López-Jiménez J, Sanz J, Labussière-Wallet H, Shimoni A, Dreger P, Sureda A, Kim WS, Glass B
Leukemia 2023 Jul;37(7):1511-1520. Epub 2023 May 8 doi: 10.1038/s41375-023-01924-x. PMID: 37157017Free PMC Article
Large granular lymphocyte leukemia: An indolent clonal proliferative disease associated with an array of various immunologic disorders.
Drillet G, Pastoret C, Moignet A, Lamy T, Marchand T
Rev Med Interne 2023 Jun;44(6):295-306. Epub 2023 Apr 21 doi: 10.1016/j.revmed.2023.03.014. PMID: 37087371
Lymphoproliferative tumors involving the lacrimal drainage system: a major review.
Singh S, Ali MJ
Orbit 2020 Aug;39(4):276-284. Epub 2019 Jul 3 doi: 10.1080/01676830.2019.1634104. PMID: 31267826
Mature T-cell leukemias: Molecular and Clinical Aspects.
Bailey NG, Elenitoba-Johnson KS
Curr Hematol Malig Rep 2015 Dec;10(4):421-8. doi: 10.1007/s11899-015-0288-8. PMID: 26433891
Diagnosis and management of natural killer-cell malignancies.
Ishida F, Kwong YL
Expert Rev Hematol 2010 Oct;3(5):593-602. doi: 10.1586/ehm.10.51. PMID: 21083476

Clinical prediction guides

Key candidate genes and pathways in T lymphoblastic leukemia/lymphoma identified by bioinformatics and serological analyses.
Ren Y, Liang H, Huang Y, Miao Y, Li R, Qiang J, Wu L, Qi J, Li Y, Xia Y, Huang L, Wang S, Kong X, Zhou Y, Zhang Q, Zhu G
Front Immunol 2024;15:1341255. Epub 2024 Feb 23 doi: 10.3389/fimmu.2024.1341255. PMID: 38464517Free PMC Article
Cytogenetics in the management of mature T-cell and NK-cell neoplasms: Guidelines from the Groupe Francophone de Cytogénétique Hématologique (GFCH).
Gaillard JB, Chapiro E, Daudignon A, Nadal N, Penther D, Chauzeix J, Nguyen-Khac F, Veronese L, Lefebvre C
Curr Res Transl Med 2023 Oct-Dec;71(4):103428. Epub 2023 Oct 31 doi: 10.1016/j.retram.2023.103428. PMID: 38016421
Allogeneic hematopoietic stem cell transplantation for NK/T-cell lymphoma: an international collaborative analysis.
Berning P, Schmitz N, Ngoya M, Finel H, Boumendil A, Wang F, Huang XJ, Hermine O, Philippe L, Couronné L, Jaccard A, Liu D, Wu D, Reinhardt HC, Chalandon Y, Wagner-Drouet E, Kwon M, Zhang X, Carpenter B, Yakoub-Agha I, Wulf G, López-Jiménez J, Sanz J, Labussière-Wallet H, Shimoni A, Dreger P, Sureda A, Kim WS, Glass B
Leukemia 2023 Jul;37(7):1511-1520. Epub 2023 May 8 doi: 10.1038/s41375-023-01924-x. PMID: 37157017Free PMC Article
Genomic landscape of TCRαβ and TCRγδ T-large granular lymphocyte leukemia.
Cheon H, Xing JC, Moosic KB, Ung J, Chan VW, Chung DS, Toro MF, Elghawy O, Wang JS, Hamele CE, Hardison RC, Olson TL, Tan SF, Feith DJ, Ratan A, Loughran TP
Blood 2022 May 19;139(20):3058-3072. doi: 10.1182/blood.2021013164. PMID: 35015834Free PMC Article
Recurrent anti-GBM disease with T-cell large granular lymphocytic leukemia: A case report.
Zhang M, Guan N, Zhu P, Chen T, Liu S, Hao C, Xue J
Medicine (Baltimore) 2019 Aug;98(31):e16649. doi: 10.1097/MD.0000000000016649. PMID: 31374037Free PMC Article

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