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Chronic Adult T-Cell Leukemia/Lymphoma

MedGen UID:
272480
•Concept ID:
C1333032
•
Neoplastic Process
Synonym: Chronic Adult T-Cell Lymphoma/Leukemia

Definition

An adult T-cell leukemia/ lymphoma associated with skin lesions and mild lymphadenopathy. Neoplastic lymphocytes are not numerous in the peripheral blood. Hypercalcemia is absent. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic Adult T-Cell Leukemia/Lymphoma

Professional guidelines

PubMed

An update on the developments in the treatment of adult T-cell leukemia-lymphoma: current knowledge and future perspective.
Makiyama J, Ishitsuka K, Munakata W, Maruyama D, Nagai H
Jpn J Clin Oncol 2023 Dec 7;53(12):1104-1111. doi: 10.1093/jjco/hyad108. PMID: 37592900
Treatment of Adult T-Cell Leukemia/Lymphoma: Established Paradigms and Emerging Directions.
Stuver R, Horwitz SM, Epstein-Peterson ZD
Curr Treat Options Oncol 2023 Aug;24(8):948-964. Epub 2023 Jun 10 doi: 10.1007/s11864-023-01111-1. PMID: 37300656Free PMC Article
Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report.
Cook LB, Fuji S, Hermine O, Bazarbachi A, Ramos JC, Ratner L, Horwitz S, Fields P, Tanase A, Bumbea H, Cwynarski K, Taylor G, Waldmann TA, Bittencourt A, Marcais A, Suarez F, Sibon D, Phillips A, Lunning M, Farid R, Imaizumi Y, Choi I, Ishida T, Ishitsuka K, Fukushima T, Uchimaru K, Takaori-Kondo A, Tokura Y, Utsunomiya A, Matsuoka M, Tsukasaki K, Watanabe T
J Clin Oncol 2019 Mar 10;37(8):677-687. Epub 2019 Jan 18 doi: 10.1200/JCO.18.00501. PMID: 30657736Free PMC Article

Recent clinical studies

Etiology

An Index Case of Concomitant Tumoral and Ichthyosiform Mycosis Fungoides-Like Presentation of Chronic Adult T-cell Leukemia/Lymphoma Associated With Upregulation of TOX.
Nguyen GH, Wang JY, Hymes KB, Magro CM
Am J Dermatopathol 2017 Jan;39(1):28-32. doi: 10.1097/DAD.0000000000000537. PMID: 27759688

Diagnosis

Long-term clinical remission maintained after cessation of zidovudine and interferon-α therapy in chronic adult T-cell leukemia/lymphoma.
Cook LB, Rowan AG, Demontis MA, Sagawe S, Gillet NA, Melamed A, Greiller C, Witkover A, Bangham CRM, Taylor GP
Int J Hematol 2018 Mar;107(3):378-382. Epub 2017 Oct 31 doi: 10.1007/s12185-017-2361-7. PMID: 29090417
Adult T-cell leukemia/lymphoma triggered by adalimumab.
Bittencourt AL, Oliveira PD, Bittencourt VG, Carvalho EM, Farre L
J Clin Virol 2013 Oct;58(2):494-6. Epub 2013 Aug 1 doi: 10.1016/j.jcv.2013.07.011. PMID: 23911677
Phase 2 study of the efficacy and safety of the combination of arsenic trioxide, interferon alpha, and zidovudine in newly diagnosed chronic adult T-cell leukemia/lymphoma (ATL).
Kchour G, Tarhini M, Kooshyar MM, El Hajj H, Wattel E, Mahmoudi M, Hatoum H, Rahimi H, Maleki M, Rafatpanah H, Rezaee SA, Yazdi MT, Shirdel A, de Thé H, Hermine O, Farid R, Bazarbachi A
Blood 2009 Jun 25;113(26):6528-32. Epub 2009 May 1 doi: 10.1182/blood-2009-03-211821. PMID: 19411628
A lymphoproliferative disorder caused by human T-lymphotropic virus type I. Demonstration of a continuum between acute and chronic adult T-cell leukemia/lymphoma.
Ratner L, Griffith RC, Marselle L, Hoh M, Wong-Staal F, Saxinger C
Am J Med 1987 Nov;83(5):953-8. doi: 10.1016/0002-9343(87)90658-9. PMID: 2890302

Therapy

Long-term clinical remission maintained after cessation of zidovudine and interferon-α therapy in chronic adult T-cell leukemia/lymphoma.
Cook LB, Rowan AG, Demontis MA, Sagawe S, Gillet NA, Melamed A, Greiller C, Witkover A, Bangham CRM, Taylor GP
Int J Hematol 2018 Mar;107(3):378-382. Epub 2017 Oct 31 doi: 10.1007/s12185-017-2361-7. PMID: 29090417
An Index Case of Concomitant Tumoral and Ichthyosiform Mycosis Fungoides-Like Presentation of Chronic Adult T-cell Leukemia/Lymphoma Associated With Upregulation of TOX.
Nguyen GH, Wang JY, Hymes KB, Magro CM
Am J Dermatopathol 2017 Jan;39(1):28-32. doi: 10.1097/DAD.0000000000000537. PMID: 27759688
Adult T-cell leukemia/lymphoma triggered by adalimumab.
Bittencourt AL, Oliveira PD, Bittencourt VG, Carvalho EM, Farre L
J Clin Virol 2013 Oct;58(2):494-6. Epub 2013 Aug 1 doi: 10.1016/j.jcv.2013.07.011. PMID: 23911677
Phase 2 study of the efficacy and safety of the combination of arsenic trioxide, interferon alpha, and zidovudine in newly diagnosed chronic adult T-cell leukemia/lymphoma (ATL).
Kchour G, Tarhini M, Kooshyar MM, El Hajj H, Wattel E, Mahmoudi M, Hatoum H, Rahimi H, Maleki M, Rafatpanah H, Rezaee SA, Yazdi MT, Shirdel A, de Thé H, Hermine O, Farid R, Bazarbachi A
Blood 2009 Jun 25;113(26):6528-32. Epub 2009 May 1 doi: 10.1182/blood-2009-03-211821. PMID: 19411628

Prognosis

An Index Case of Concomitant Tumoral and Ichthyosiform Mycosis Fungoides-Like Presentation of Chronic Adult T-cell Leukemia/Lymphoma Associated With Upregulation of TOX.
Nguyen GH, Wang JY, Hymes KB, Magro CM
Am J Dermatopathol 2017 Jan;39(1):28-32. doi: 10.1097/DAD.0000000000000537. PMID: 27759688
Phase 2 study of the efficacy and safety of the combination of arsenic trioxide, interferon alpha, and zidovudine in newly diagnosed chronic adult T-cell leukemia/lymphoma (ATL).
Kchour G, Tarhini M, Kooshyar MM, El Hajj H, Wattel E, Mahmoudi M, Hatoum H, Rahimi H, Maleki M, Rafatpanah H, Rezaee SA, Yazdi MT, Shirdel A, de Thé H, Hermine O, Farid R, Bazarbachi A
Blood 2009 Jun 25;113(26):6528-32. Epub 2009 May 1 doi: 10.1182/blood-2009-03-211821. PMID: 19411628
Infections in patients with chronic adult T-cell leukemia/lymphoma: case report and review.
Rhew DC, Gaultier CR, Daar ES, Zakowski PC, Said J
Clin Infect Dis 1995 Oct;21(4):1014-6. doi: 10.1093/clinids/21.4.1014. PMID: 8645790

Clinical prediction guides

An Index Case of Concomitant Tumoral and Ichthyosiform Mycosis Fungoides-Like Presentation of Chronic Adult T-cell Leukemia/Lymphoma Associated With Upregulation of TOX.
Nguyen GH, Wang JY, Hymes KB, Magro CM
Am J Dermatopathol 2017 Jan;39(1):28-32. doi: 10.1097/DAD.0000000000000537. PMID: 27759688
Phase 2 study of the efficacy and safety of the combination of arsenic trioxide, interferon alpha, and zidovudine in newly diagnosed chronic adult T-cell leukemia/lymphoma (ATL).
Kchour G, Tarhini M, Kooshyar MM, El Hajj H, Wattel E, Mahmoudi M, Hatoum H, Rahimi H, Maleki M, Rafatpanah H, Rezaee SA, Yazdi MT, Shirdel A, de Thé H, Hermine O, Farid R, Bazarbachi A
Blood 2009 Jun 25;113(26):6528-32. Epub 2009 May 1 doi: 10.1182/blood-2009-03-211821. PMID: 19411628

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