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EBV-Related Lymphoma

MedGen UID:
272582
•Concept ID:
C1333431
•
Neoplastic Process
Synonym: Lymphoma, EBV-associated

Definition

Lymphoma that is caused by Epstein-Barr virus infection. [from NCI]

Professional guidelines

PubMed

Current Treatment Options for Older Patients with Hodgkin Lymphoma.
Carter J, David KA, Kritharis A, Evens AM
Curr Treat Options Oncol 2020 Apr 23;21(5):42. doi: 10.1007/s11864-020-00745-9. PMID: 32328822
EBV-related lymphomas: new approaches to treatment.
Kanakry JA, Ambinder RF
Curr Treat Options Oncol 2013 Jun;14(2):224-36. doi: 10.1007/s11864-013-0231-y. PMID: 23549980Free PMC Article
Differential diagnosis of hemophagocytic syndrome: underlying disorders and selection of the most effective treatment.
Imashuku S
Int J Hematol 1997 Aug;66(2):135-51. doi: 10.1016/s0925-5710(97)00584-7. PMID: 9277044

Recent clinical studies

Etiology

CD56-Negative Extranodal Natural Killer/T-Cell Lymphoma: A Retrospective Study in 443 Patients Treated by Chemotherapy With or Without Asparaginase.
Yang J, Li P, Piao Y, Liu X, Wei L, Sang W, Zhang L, Wang L
Front Immunol 2022;13:829366. Epub 2022 Mar 17 doi: 10.3389/fimmu.2022.829366. PMID: 35371002Free PMC Article
The Broad Clinical Spectrum and Transplant Results of PNP Deficiency.
Schejter YD, Even-Or E, Shadur B, NaserEddin A, Stepensky P, Zaidman I
J Clin Immunol 2020 Jan;40(1):123-130. Epub 2019 Nov 9 doi: 10.1007/s10875-019-00698-1. PMID: 31707514
Intensified alemtuzumab-CHOP therapy for peripheral T-cell lymphoma.
Kluin-Nelemans HC, van Marwijk Kooy M, Lugtenburg PJ, van Putten WLJ, Luten M, Oudejans J, van Imhoff GW
Ann Oncol 2011 Jul;22(7):1595-1600. Epub 2011 Jan 6 doi: 10.1093/annonc/mdq635. PMID: 21212158
Neoplastic conditions in the context of HIV-1 infection.
Aoki Y, Tosato G
Curr HIV Res 2004 Oct;2(4):343-9. doi: 10.2174/1570162043351002. PMID: 15544455
Safety of allogeneic Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes for patients with refractory EBV-related lymphoma.
Sun Q, Burton R, Reddy V, Lucas KG
Br J Haematol 2002 Sep;118(3):799-808. doi: 10.1046/j.1365-2141.2002.03683.x. PMID: 12181048

Diagnosis

SLP76 Mutation Associated with Combined Immunodeficiency and EBV-Related Lymphoma.
Lev A, Asleh M, Levy S, Lee YN, Simon AJ, Stepensky P, Nalbandyan K, Nahum A, Ben-Harosh M, Yablonski D, Broides A, Somech R
J Clin Immunol 2023 Apr;43(3):625-635. Epub 2022 Dec 7 doi: 10.1007/s10875-022-01412-4. PMID: 36474126
CD56-Negative Extranodal Natural Killer/T-Cell Lymphoma: A Retrospective Study in 443 Patients Treated by Chemotherapy With or Without Asparaginase.
Yang J, Li P, Piao Y, Liu X, Wei L, Sang W, Zhang L, Wang L
Front Immunol 2022;13:829366. Epub 2022 Mar 17 doi: 10.3389/fimmu.2022.829366. PMID: 35371002Free PMC Article
Intensified alemtuzumab-CHOP therapy for peripheral T-cell lymphoma.
Kluin-Nelemans HC, van Marwijk Kooy M, Lugtenburg PJ, van Putten WLJ, Luten M, Oudejans J, van Imhoff GW
Ann Oncol 2011 Jul;22(7):1595-1600. Epub 2011 Jan 6 doi: 10.1093/annonc/mdq635. PMID: 21212158
Epstein-Barr viral load as a marker of lymphoma in AIDS patients.
Fan H, Kim SC, Chima CO, Israel BF, Lawless KM, Eagan PA, Elmore S, Moore DT, Schichman SA, Swinnen LJ, Gulley ML
J Med Virol 2005 Jan;75(1):59-69. doi: 10.1002/jmv.20238. PMID: 15543571
Diagnostic application of Epstein-Barr virus-encoded RNA in situ hybridisation.
Loughrey M, Trivett M, Lade S, Murray W, Turner H, Waring P
Pathology 2004 Aug;36(4):301-8. doi: 10.1080/0031302042000224584. PMID: 15370127

Therapy

CD56-Negative Extranodal Natural Killer/T-Cell Lymphoma: A Retrospective Study in 443 Patients Treated by Chemotherapy With or Without Asparaginase.
Yang J, Li P, Piao Y, Liu X, Wei L, Sang W, Zhang L, Wang L
Front Immunol 2022;13:829366. Epub 2022 Mar 17 doi: 10.3389/fimmu.2022.829366. PMID: 35371002Free PMC Article
A mutation in PIK3CD gene causing pediatric systemic lupus erythematosus: A case report.
Li GM, Liu HM, Guan WZ, Xu H, Wu BB, Feng JY, Sun L
Medicine (Baltimore) 2019 May;98(18):e15329. doi: 10.1097/MD.0000000000015329. PMID: 31045771Free PMC Article
Intensified alemtuzumab-CHOP therapy for peripheral T-cell lymphoma.
Kluin-Nelemans HC, van Marwijk Kooy M, Lugtenburg PJ, van Putten WLJ, Luten M, Oudejans J, van Imhoff GW
Ann Oncol 2011 Jul;22(7):1595-1600. Epub 2011 Jan 6 doi: 10.1093/annonc/mdq635. PMID: 21212158
Safety of allogeneic Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes for patients with refractory EBV-related lymphoma.
Sun Q, Burton R, Reddy V, Lucas KG
Br J Haematol 2002 Sep;118(3):799-808. doi: 10.1046/j.1365-2141.2002.03683.x. PMID: 12181048
Epstein-Barr virus-driven gene therapy for EBV-related lymphomas.
Franken M, Estabrooks A, Cavacini L, Sherburne B, Wang F, Scadden DT
Nat Med 1996 Dec;2(12):1379-82. doi: 10.1038/nm1296-1379. PMID: 8946840

Prognosis

CD56-Negative Extranodal Natural Killer/T-Cell Lymphoma: A Retrospective Study in 443 Patients Treated by Chemotherapy With or Without Asparaginase.
Yang J, Li P, Piao Y, Liu X, Wei L, Sang W, Zhang L, Wang L
Front Immunol 2022;13:829366. Epub 2022 Mar 17 doi: 10.3389/fimmu.2022.829366. PMID: 35371002Free PMC Article
The Challenge of Next Generation Sequencing in a Boy With Severe Mononucleosis and EBV-related Lymphoma.
Verzegnassi F, Valencic E, Kiren V, Giurici N, Bianco AM, Marcuzzi A, Vozzi D, Tommasini A, Faletra F
J Pediatr Hematol Oncol 2018 Jul;40(5):e323-e326. doi: 10.1097/MPH.0000000000001004. PMID: 29176466
Intensified alemtuzumab-CHOP therapy for peripheral T-cell lymphoma.
Kluin-Nelemans HC, van Marwijk Kooy M, Lugtenburg PJ, van Putten WLJ, Luten M, Oudejans J, van Imhoff GW
Ann Oncol 2011 Jul;22(7):1595-1600. Epub 2011 Jan 6 doi: 10.1093/annonc/mdq635. PMID: 21212158
Neoplastic conditions in the context of HIV-1 infection.
Aoki Y, Tosato G
Curr HIV Res 2004 Oct;2(4):343-9. doi: 10.2174/1570162043351002. PMID: 15544455
Safety of allogeneic Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes for patients with refractory EBV-related lymphoma.
Sun Q, Burton R, Reddy V, Lucas KG
Br J Haematol 2002 Sep;118(3):799-808. doi: 10.1046/j.1365-2141.2002.03683.x. PMID: 12181048

Clinical prediction guides

TNFα antagonist therapy does not increase the Epstein-Barr virus burden in patients with rheumatoid arthritis or ankylosing spondylitis.
Couderc M, Payet S, Henquell C, Dubost JJ, Soubrier M
Joint Bone Spine 2010 Oct;77(5):414-7. Epub 2010 Jun 9 doi: 10.1016/j.jbspin.2010.04.014. PMID: 20542718
Possible role for external environmental stimuli in nasopharyngeal NK/T-cell lymphomas in the northeast of China with EBV infection-related autophagic cell death: a pathoepidemiological analysis.
Wang J, Hasui K, Jia X, Matsuyama T, Eizuru Y
J Clin Exp Hematop 2009 Nov;49(2):97-108. doi: 10.3960/jslrt.49.97. PMID: 19907114
Safety of allogeneic Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes for patients with refractory EBV-related lymphoma.
Sun Q, Burton R, Reddy V, Lucas KG
Br J Haematol 2002 Sep;118(3):799-808. doi: 10.1046/j.1365-2141.2002.03683.x. PMID: 12181048
VZV fulminant necrotizing encephalitis with concomitant EBV-related lymphoma and CMV ventriculitis: report of an AIDS case.
Nebuloni M, Vago L, Boldorini R, Bonetto S, Costanzi G
J Neurovirol 1998 Aug;4(4):457-60. doi: 10.3109/13550289809114546. PMID: 9718139
High or low dose steroid therapy for acute renal transplant rejection after prophylactic OKT3 treatment: a prospective randomized study.
De Backer D, Abramowicz D, Goldman M, De Pauw L, Viseur P, Vanherweghem JL, Kinnaert P, Vereerstraeten P
Transpl Int 1992;5 Suppl 1:S437-9. doi: 10.1007/978-3-642-77423-2_127. PMID: 14621839

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