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Cutaneous Mature T-Cell and NK-Cell Neoplasm

MedGen UID:
317556
•Concept ID:
C1707552
•
Neoplastic Process

Definition

A group of neoplasms composed of T-lymphocytes with a mature (peripheral/post-thymic) immunophenotypic profile and/or NK-cells affecting the skin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCutaneous Mature T-Cell and NK-Cell Neoplasm

Professional guidelines

PubMed

NK/T-cell lymphoma, nasal type, γδ T-cell lymphoma, and CD8-positive epidermotropic T-cell lymphoma-clinical and histopathologic features, differential diagnosis, and treatment.
Geller S, Myskowski PL, Pulitzer M
Semin Cutan Med Surg 2018 Mar;37(1):30-38. doi: 10.12788/j.sder.2018.020. PMID: 29719018Free PMC Article
Treatment algorithms for mature T-cell and natural killer-cell neoplasms.
Tse E, Kwong YL
Future Oncol 2011 Sep;7(9):1101-12. doi: 10.2217/fon.11.84. PMID: 21919697
Guidelines for the management of mature T-cell and NK-cell neoplasms (excluding cutaneous T-cell lymphoma).
Dearden CE, Johnson R, Pettengell R, Devereux S, Cwynarski K, Whittaker S, McMillan A; British Committee for Standards in Haematology
Br J Haematol 2011 May;153(4):451-85. Epub 2011 Apr 11 doi: 10.1111/j.1365-2141.2011.08651.x. PMID: 21480860

Recent clinical studies

Etiology

Update on T-Cell Lymphoma Epidemiology.
Chen JJ, Tokumori FC, Del Guzzo C, Kim J, Ruan J
Curr Hematol Malig Rep 2024 Jun;19(3):93-103. Epub 2024 Mar 7 doi: 10.1007/s11899-024-00727-w. PMID: 38451372
Transplantation.
Zain J
Cancer Treat Res 2019;176:269-287. doi: 10.1007/978-3-319-99716-2_13. PMID: 30596223
Nationwide Statistical Analysis of Lymphoid Malignancies in Korea.
Lee H, Park HJ, Park EH, Ju HY, Oh CM, Kong HJ, Jung KW, Park BK, Lee E, Eom HS, Won YJ
Cancer Res Treat 2018 Jan;50(1):222-238. Epub 2017 Mar 30 doi: 10.4143/crt.2017.093. PMID: 28361523Free PMC Article
Mature T- and NK-cell non-Hodgkin lymphoma in children and young adolescents.
Pillai V, Tallarico M, Bishop MR, Lim MS
Br J Haematol 2016 May;173(4):573-81. Epub 2016 Mar 15 doi: 10.1111/bjh.14044. PMID: 26992145
Classification and treatment of rare and aggressive types of peripheral T-cell/natural killer-cell lymphomas of the skin.
Rezania D, Sokol L, Cualing HD
Cancer Control 2007 Apr;14(2):112-23. doi: 10.1177/107327480701400204. PMID: 17387296

Diagnosis

Update on T-Cell Lymphoma Epidemiology.
Chen JJ, Tokumori FC, Del Guzzo C, Kim J, Ruan J
Curr Hematol Malig Rep 2024 Jun;19(3):93-103. Epub 2024 Mar 7 doi: 10.1007/s11899-024-00727-w. PMID: 38451372
Mature (non-anaplastic, non-cutaneous) T-/NK-cell lymphomas in children, adolescents and young adults: state of the science.
Flower A, Xavier AC, Cairo MS
Br J Haematol 2019 May;185(3):418-435. Epub 2019 Feb 1 doi: 10.1111/bjh.15767. PMID: 30706450
Transplantation.
Zain J
Cancer Treat Res 2019;176:269-287. doi: 10.1007/978-3-319-99716-2_13. PMID: 30596223
Mature T- and NK-cell non-Hodgkin lymphoma in children and young adolescents.
Pillai V, Tallarico M, Bishop MR, Lim MS
Br J Haematol 2016 May;173(4):573-81. Epub 2016 Mar 15 doi: 10.1111/bjh.14044. PMID: 26992145
Classification and treatment of rare and aggressive types of peripheral T-cell/natural killer-cell lymphomas of the skin.
Rezania D, Sokol L, Cualing HD
Cancer Control 2007 Apr;14(2):112-23. doi: 10.1177/107327480701400204. PMID: 17387296

Therapy

Treating relapsed/refractory mature T- and NK-cell neoplasms with tislelizumab: a multicenter open-label phase 2 study.
Bachy E, Savage KJ, Huang H, Kwong YL, Gritti G, Zhang Q, Liberati AM, Cao J, Yang H, Hao S, Hu J, Zhou K, Petrini M, Russo F, Zhang H, Sang W, Ji J, Ferreri AJM, Damaj GL, Liu H, Zhang W, Ke X, Ghiggi C, Huang S, Li X, Yao H, Paik J, Novotny W, Zhou W, Zhu H, Zinzani PL
Blood Adv 2023 Aug 22;7(16):4435-4447. doi: 10.1182/bloodadvances.2022009575. PMID: 37276067Free PMC Article
Mature (non-anaplastic, non-cutaneous) T-/NK-cell lymphomas in children, adolescents and young adults: state of the science.
Flower A, Xavier AC, Cairo MS
Br J Haematol 2019 May;185(3):418-435. Epub 2019 Feb 1 doi: 10.1111/bjh.15767. PMID: 30706450
Transplantation.
Zain J
Cancer Treat Res 2019;176:269-287. doi: 10.1007/978-3-319-99716-2_13. PMID: 30596223
Mature T- and NK-cell non-Hodgkin lymphoma in children and young adolescents.
Pillai V, Tallarico M, Bishop MR, Lim MS
Br J Haematol 2016 May;173(4):573-81. Epub 2016 Mar 15 doi: 10.1111/bjh.14044. PMID: 26992145
Classification and treatment of rare and aggressive types of peripheral T-cell/natural killer-cell lymphomas of the skin.
Rezania D, Sokol L, Cualing HD
Cancer Control 2007 Apr;14(2):112-23. doi: 10.1177/107327480701400204. PMID: 17387296

Prognosis

Update on T-Cell Lymphoma Epidemiology.
Chen JJ, Tokumori FC, Del Guzzo C, Kim J, Ruan J
Curr Hematol Malig Rep 2024 Jun;19(3):93-103. Epub 2024 Mar 7 doi: 10.1007/s11899-024-00727-w. PMID: 38451372
Mature (non-anaplastic, non-cutaneous) T-/NK-cell lymphomas in children, adolescents and young adults: state of the science.
Flower A, Xavier AC, Cairo MS
Br J Haematol 2019 May;185(3):418-435. Epub 2019 Feb 1 doi: 10.1111/bjh.15767. PMID: 30706450
The 2017 WHO update on mature T- and natural killer (NK) cell neoplasms.
Matutes E
Int J Lab Hematol 2018 May;40 Suppl 1:97-103. doi: 10.1111/ijlh.12817. PMID: 29741263
Nationwide Statistical Analysis of Lymphoid Malignancies in Korea.
Lee H, Park HJ, Park EH, Ju HY, Oh CM, Kong HJ, Jung KW, Park BK, Lee E, Eom HS, Won YJ
Cancer Res Treat 2018 Jan;50(1):222-238. Epub 2017 Mar 30 doi: 10.4143/crt.2017.093. PMID: 28361523Free PMC Article
Treatment algorithms for mature T-cell and natural killer-cell neoplasms.
Tse E, Kwong YL
Future Oncol 2011 Sep;7(9):1101-12. doi: 10.2217/fon.11.84. PMID: 21919697

Clinical prediction guides

Epidemiology of mature T/NK-cell lymphomas in Germany - A representative cross-sectional study based on SHI claims data.
Assaf C, Dobos G, Zech IM, Doess A, May M, Jadasz J
J Dtsch Dermatol Ges 2023 Nov;21(11):1320-1327. Epub 2023 Oct 16 doi: 10.1111/ddg.15187. PMID: 37845021
Treating relapsed/refractory mature T- and NK-cell neoplasms with tislelizumab: a multicenter open-label phase 2 study.
Bachy E, Savage KJ, Huang H, Kwong YL, Gritti G, Zhang Q, Liberati AM, Cao J, Yang H, Hao S, Hu J, Zhou K, Petrini M, Russo F, Zhang H, Sang W, Ji J, Ferreri AJM, Damaj GL, Liu H, Zhang W, Ke X, Ghiggi C, Huang S, Li X, Yao H, Paik J, Novotny W, Zhou W, Zhu H, Zinzani PL
Blood Adv 2023 Aug 22;7(16):4435-4447. doi: 10.1182/bloodadvances.2022009575. PMID: 37276067Free PMC Article
Nationwide Statistical Analysis of Lymphoid Malignancies in Korea.
Lee H, Park HJ, Park EH, Ju HY, Oh CM, Kong HJ, Jung KW, Park BK, Lee E, Eom HS, Won YJ
Cancer Res Treat 2018 Jan;50(1):222-238. Epub 2017 Mar 30 doi: 10.4143/crt.2017.093. PMID: 28361523Free PMC Article
Guidelines for the management of mature T-cell and NK-cell neoplasms (excluding cutaneous T-cell lymphoma).
Dearden CE, Johnson R, Pettengell R, Devereux S, Cwynarski K, Whittaker S, McMillan A; British Committee for Standards in Haematology
Br J Haematol 2011 May;153(4):451-85. Epub 2011 Apr 11 doi: 10.1111/j.1365-2141.2011.08651.x. PMID: 21480860
Expression of the plasmacytoid dendritic cell marker BDCA-2 supports a spectrum of maturation among CD4+ CD56+ hematodermic neoplasms.
Jaye DL, Geigerman CM, Herling M, Eastburn K, Waller EK, Jones D
Mod Pathol 2006 Dec;19(12):1555-62. Epub 2006 Sep 22 doi: 10.1038/modpathol.3800679. PMID: 16998465

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