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AIDS-related primary central nervous system lymphoma

MedGen UID:
79263
•Concept ID:
C0281241
•
Neoplastic Process
Synonyms: AIDS Related Lymphoma of Primary Central Nervous System; AIDS related lymphoma of primary central nervous system; AIDS Related Lymphoma of the Primary Central Nervous System; AIDS related lymphoma of the primary central nervous system; AIDS Related Primary Central Nervous System Lymphoma; AIDS related primary central nervous system lymphoma; AIDS Related Primary CNS Lymphoma; AIDS related primary CNS lymphoma; AIDS-Related Lymphoma of Primary Central Nervous System; AIDS-related lymphoma of primary central nervous system; AIDS-Related Lymphoma of the Primary Central Nervous System; AIDS-related lymphoma of the primary central nervous system; AIDS-Related Primary Central Nervous System Lymphoma; AIDS-Related Primary CNS Lymphoma; AIDS-related primary CNS lymphoma
 
Monarch Initiative: MONDO:0006078

Definition

A lymphoma (non-Hodgkin or Hodgkin) arising from the central nervous system and occurring in HIV-positive patients. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAIDS-related primary central nervous system lymphoma

Professional guidelines

PubMed

Long-term survival in AIDS-related primary central nervous system lymphoma.
Gupta NK, Nolan A, Omuro A, Reid EG, Wang CC, Mannis G, Jaglal M, Chavez JC, Rubinstein PG, Griffin A, Abrams DI, Hwang J, Kaplan LD, Luce JA, Volberding P, Treseler PA, Rubenstein JL
Neuro Oncol 2017 Jan;19(1):99-108. Epub 2016 Aug 30 doi: 10.1093/neuonc/now155. PMID: 27576871Free PMC Article
Factors associated with survival among patients with AIDS-related primary central nervous system lymphoma.
Uldrick TS, Pipkin S, Scheer S, Hessol NA
AIDS 2014 Jan 28;28(3):397-405. doi: 10.1097/QAD.0000000000000030. PMID: 24076659Free PMC Article
Combined-modality therapy in the treatment of primary central nervous system lymphoma in AIDS.
Forsyth PA, Yahalom J, DeAngelis LM
Neurology 1994 Aug;44(8):1473-9. doi: 10.1212/wnl.44.8.1473. PMID: 8058152

Recent clinical studies

Etiology

Long-term survival in AIDS-related primary central nervous system lymphoma.
Gupta NK, Nolan A, Omuro A, Reid EG, Wang CC, Mannis G, Jaglal M, Chavez JC, Rubinstein PG, Griffin A, Abrams DI, Hwang J, Kaplan LD, Luce JA, Volberding P, Treseler PA, Rubenstein JL
Neuro Oncol 2017 Jan;19(1):99-108. Epub 2016 Aug 30 doi: 10.1093/neuonc/now155. PMID: 27576871Free PMC Article
AIDS-related primary central nervous system lymphoma: a Norwegian national survey 1989-2003.
Haldorsen IS, Kråkenes J, Goplen AK, Dunlop O, Mella O, Espeland A
BMC Cancer 2008 Aug 6;8:225. doi: 10.1186/1471-2407-8-225. PMID: 18684320Free PMC Article
Antiviral and immunomodulatory treatment for AIDS-related primary central nervous system lymphoma: AIDS Malignancies Consortium pilot study 019.
Aboulafia DM, Ratner L, Miles SA, Harrington WJ Jr; AIDS Associated Malignancies Clinical Trials Consortium
Clin Lymphoma Myeloma 2006 Mar;6(5):399-402. doi: 10.3816/clm.2006.n.017. PMID: 16640817
High-dose methotrexate-based chemotherapy followed by consolidating radiotherapy in non-AIDS-related primary central nervous system lymphoma: European Organization for Research and Treatment of Cancer Lymphoma Group Phase II Trial 20962.
Poortmans PM, Kluin-Nelemans HC, Haaxma-Reiche H, Van't Veer M, Hansen M, Soubeyran P, Taphoorn M, Thomas J, Van den Bent M, Fickers M, Van Imhoff G, Rozewicz C, Teodorovic I, van Glabbeke M; European Organization for Research and Treatment of Cancer Lymphoma Group
J Clin Oncol 2003 Dec 15;21(24):4483-8. Epub 2003 Nov 3 doi: 10.1200/JCO.2003.03.108. PMID: 14597741
Evaluation of cerebrospinal fluid EBV-DNA and IL-10 as markers for in vivo diagnosis of AIDS-related primary central nervous system lymphoma.
De Luca A, Antinori A, Cingolani A, Larocca LM, Linzalone A, Ammassari A, Scerrati M, Roselli R, Tamburrini E, Ortona L
Br J Haematol 1995 Aug;90(4):844-9. doi: 10.1111/j.1365-2141.1995.tb05205.x. PMID: 7669663

Diagnosis

Long-term remission of AIDS-related primary central nervous system lymphoma in a patient under antiretroviral therapy: a case report and review of the literature.
Gijs PJ, Clerc O
AIDS Res Ther 2021 Oct 19;18(1):76. doi: 10.1186/s12981-021-00403-6. PMID: 34666791Free PMC Article
Long-term survival in AIDS-related primary central nervous system lymphoma.
Gupta NK, Nolan A, Omuro A, Reid EG, Wang CC, Mannis G, Jaglal M, Chavez JC, Rubinstein PG, Griffin A, Abrams DI, Hwang J, Kaplan LD, Luce JA, Volberding P, Treseler PA, Rubenstein JL
Neuro Oncol 2017 Jan;19(1):99-108. Epub 2016 Aug 30 doi: 10.1093/neuonc/now155. PMID: 27576871Free PMC Article
AIDS-related primary central nervous system lymphoma: a Norwegian national survey 1989-2003.
Haldorsen IS, Kråkenes J, Goplen AK, Dunlop O, Mella O, Espeland A
BMC Cancer 2008 Aug 6;8:225. doi: 10.1186/1471-2407-8-225. PMID: 18684320Free PMC Article
AIDS-related primary central nervous system lymphoma.
Kasamon YL, Ambinder RF
Hematol Oncol Clin North Am 2005 Aug;19(4):665-87, vi-vii. doi: 10.1016/j.hoc.2005.05.004. PMID: 16083829
Acquired immunodeficiency syndrome-related lymphoma.
Roth EL
Semin Oncol Nurs 1998 Nov;14(4):284-92. doi: 10.1016/s0749-2081(98)80006-5. PMID: 9839341

Therapy

Long-term survival in AIDS-related primary central nervous system lymphoma.
Gupta NK, Nolan A, Omuro A, Reid EG, Wang CC, Mannis G, Jaglal M, Chavez JC, Rubinstein PG, Griffin A, Abrams DI, Hwang J, Kaplan LD, Luce JA, Volberding P, Treseler PA, Rubenstein JL
Neuro Oncol 2017 Jan;19(1):99-108. Epub 2016 Aug 30 doi: 10.1093/neuonc/now155. PMID: 27576871Free PMC Article
Antiviral and immunomodulatory treatment for AIDS-related primary central nervous system lymphoma: AIDS Malignancies Consortium pilot study 019.
Aboulafia DM, Ratner L, Miles SA, Harrington WJ Jr; AIDS Associated Malignancies Clinical Trials Consortium
Clin Lymphoma Myeloma 2006 Mar;6(5):399-402. doi: 10.3816/clm.2006.n.017. PMID: 16640817
High-dose methotrexate-based chemotherapy followed by consolidating radiotherapy in non-AIDS-related primary central nervous system lymphoma: European Organization for Research and Treatment of Cancer Lymphoma Group Phase II Trial 20962.
Poortmans PM, Kluin-Nelemans HC, Haaxma-Reiche H, Van't Veer M, Hansen M, Soubeyran P, Taphoorn M, Thomas J, Van den Bent M, Fickers M, Van Imhoff G, Rozewicz C, Teodorovic I, van Glabbeke M; European Organization for Research and Treatment of Cancer Lymphoma Group
J Clin Oncol 2003 Dec 15;21(24):4483-8. Epub 2003 Nov 3 doi: 10.1200/JCO.2003.03.108. PMID: 14597741
Treatment of AIDS-related primary central nervous system lymphoma with zidovudine, ganciclovir, and interleukin 2.
Raez L, Cabral L, Cai JP, Landy H, Sfakianakis G, Byrne GE Jr, Hurley J, Scerpella E, Jayaweera D, Harrington WJ Jr
AIDS Res Hum Retroviruses 1999 May 20;15(8):713-9. doi: 10.1089/088922299310809. PMID: 10357467
Acquired immunodeficiency syndrome-related lymphoma.
Roth EL
Semin Oncol Nurs 1998 Nov;14(4):284-92. doi: 10.1016/s0749-2081(98)80006-5. PMID: 9839341

Prognosis

Long-term remission of AIDS-related primary central nervous system lymphoma in a patient under antiretroviral therapy: a case report and review of the literature.
Gijs PJ, Clerc O
AIDS Res Ther 2021 Oct 19;18(1):76. doi: 10.1186/s12981-021-00403-6. PMID: 34666791Free PMC Article
Long-term survival in AIDS-related primary central nervous system lymphoma.
Gupta NK, Nolan A, Omuro A, Reid EG, Wang CC, Mannis G, Jaglal M, Chavez JC, Rubinstein PG, Griffin A, Abrams DI, Hwang J, Kaplan LD, Luce JA, Volberding P, Treseler PA, Rubenstein JL
Neuro Oncol 2017 Jan;19(1):99-108. Epub 2016 Aug 30 doi: 10.1093/neuonc/now155. PMID: 27576871Free PMC Article
Factors associated with survival among patients with AIDS-related primary central nervous system lymphoma.
Uldrick TS, Pipkin S, Scheer S, Hessol NA
AIDS 2014 Jan 28;28(3):397-405. doi: 10.1097/QAD.0000000000000030. PMID: 24076659Free PMC Article
AIDS-related primary central nervous system lymphoma: a Norwegian national survey 1989-2003.
Haldorsen IS, Kråkenes J, Goplen AK, Dunlop O, Mella O, Espeland A
BMC Cancer 2008 Aug 6;8:225. doi: 10.1186/1471-2407-8-225. PMID: 18684320Free PMC Article
Antiviral and immunomodulatory treatment for AIDS-related primary central nervous system lymphoma: AIDS Malignancies Consortium pilot study 019.
Aboulafia DM, Ratner L, Miles SA, Harrington WJ Jr; AIDS Associated Malignancies Clinical Trials Consortium
Clin Lymphoma Myeloma 2006 Mar;6(5):399-402. doi: 10.3816/clm.2006.n.017. PMID: 16640817

Clinical prediction guides

HHV-8/KSHV is not associated with AIDS-related primary central nervous system lymphoma.
Antinori A, Larocca LM, Fassone L, Cattani P, Capello D, Cingolani A, Saglio G, Fadda G, Gaidano G, Ortona L
Brain Pathol 1999 Apr;9(2):199-208. doi: 10.1111/j.1750-3639.1999.tb00218.x. PMID: 10219737Free PMC Article
Gamma Knife radiosurgery in AIDS-related primary central nervous system lymphoma.
Nicolato A, Gerosa MA, Foroni R, Piovan E, Zampieri PG, Pasoli A, Giri MG, Iuzzolino P, Ghimenton C, Luzzati R
Stereotact Funct Neurosurg 1995;64 Suppl 1:42-55. doi: 10.1159/000098763. PMID: 8584839

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