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High Grade B-Cell Lymphoma with Blastoid Morphologic Features

MedGen UID:
234040
•Concept ID:
C1332568
•
Neoplastic Process
Synonyms: Blastoid HGBL; Diffuse Blastoid B-Cell Lymphoma; High-Grade B-Cell Lymphoma with Blastoid Morphologic Features

Definition

A high-grade B-cell lymphoma characterized by the presence of medium-size neoplastic lymphocytes with a scant amount of cytoplasm and inconspicuous nucleoli, resembling lymphoblasts. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHigh Grade B-Cell Lymphoma with Blastoid Morphologic Features

Recent clinical studies

Prognosis

Mantle cell lymphomas with concomitant MYC and CCND1 breakpoints are recurrently TdT positive and frequently show high-grade pathological and genetic features.
Aukema SM, Croci GA, Bens S, Oehl-Huber K, Wagener R, Ott G, Rosenwald A, Kluin PM, van den Berg E, Bosga-Bouwer AG, Hoogendoorn M, Hoster E, Bittmann I, Nagel I, Murga Penas EM, Kreuz M, Bausinger J, Belder W, Oschlies I, Dyer MJS, Jayne S, Siebert R, Klapper W
Virchows Arch 2021 Jul;479(1):133-145. Epub 2021 Feb 2 doi: 10.1007/s00428-021-03022-8. PMID: 33528622
Further Exploration of the Complexities of Large B-Cell Lymphomas With MYC Abnormalities and the Importance of a Blastoid Morphology.
Moore EM, Aggarwal N, Surti U, Swerdlow SH
Am J Surg Pathol 2017 Sep;41(9):1155-1166. doi: 10.1097/PAS.0000000000000818. PMID: 28614202
High-grade B cell lymphoma, unclassifiable, with blastoid features: an unusual morphological subgroup associated frequently with BCL2 and/or MYC gene rearrangements and a poor prognosis.
Kanagal-Shamanna R, Medeiros LJ, Lu G, Wang SA, Manning JT, Lin P, Penn GM, Young KH, You MJ, Vega F, Bassett R, Miranda RN
Histopathology 2012 Nov;61(5):945-54. Epub 2012 Jul 17 doi: 10.1111/j.1365-2559.2012.04301.x. PMID: 22804688
B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements are aggressive neoplasms with clinical and pathologic features distinct from Burkitt lymphoma and diffuse large B-cell lymphoma.
Snuderl M, Kolman OK, Chen YB, Hsu JJ, Ackerman AM, Dal Cin P, Ferry JA, Harris NL, Hasserjian RP, Zukerberg LR, Abramson JS, Hochberg EP, Lee H, Lee AI, Toomey CE, Sohani AR
Am J Surg Pathol 2010 Mar;34(3):327-40. doi: 10.1097/PAS.0b013e3181cd3aeb. PMID: 20118770Free PMC Article
Diffuse blastoid B-cell lymphoma: a histologically aggressive variant of t(14;18)-negative follicular lymphoma.
Chiu A, Frizzera G, Mathew S, Hyjek EM, Chadburn A, Tam W, Knowles DM, Orazi A
Mod Pathol 2009 Nov;22(11):1507-17. Epub 2009 Jul 24 doi: 10.1038/modpathol.2009.106. PMID: 19633642

Clinical prediction guides

Mantle cell lymphomas with concomitant MYC and CCND1 breakpoints are recurrently TdT positive and frequently show high-grade pathological and genetic features.
Aukema SM, Croci GA, Bens S, Oehl-Huber K, Wagener R, Ott G, Rosenwald A, Kluin PM, van den Berg E, Bosga-Bouwer AG, Hoogendoorn M, Hoster E, Bittmann I, Nagel I, Murga Penas EM, Kreuz M, Bausinger J, Belder W, Oschlies I, Dyer MJS, Jayne S, Siebert R, Klapper W
Virchows Arch 2021 Jul;479(1):133-145. Epub 2021 Feb 2 doi: 10.1007/s00428-021-03022-8. PMID: 33528622
Further Exploration of the Complexities of Large B-Cell Lymphomas With MYC Abnormalities and the Importance of a Blastoid Morphology.
Moore EM, Aggarwal N, Surti U, Swerdlow SH
Am J Surg Pathol 2017 Sep;41(9):1155-1166. doi: 10.1097/PAS.0000000000000818. PMID: 28614202
B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements are aggressive neoplasms with clinical and pathologic features distinct from Burkitt lymphoma and diffuse large B-cell lymphoma.
Snuderl M, Kolman OK, Chen YB, Hsu JJ, Ackerman AM, Dal Cin P, Ferry JA, Harris NL, Hasserjian RP, Zukerberg LR, Abramson JS, Hochberg EP, Lee H, Lee AI, Toomey CE, Sohani AR
Am J Surg Pathol 2010 Mar;34(3):327-40. doi: 10.1097/PAS.0b013e3181cd3aeb. PMID: 20118770Free PMC Article
Focal follicular features in tonsillar diffuse large B-cell lymphomas: follicular lymphoma with diffuse areas or follicular colonization.
Ree HJ, Kikuchi M, Lee SS, Ohshima K, Yang WI, Ko YH, Cho EY, Rhee JC
Hum Pathol 2002 Jul;33(7):732-40. doi: 10.1053/hupa.2002.125371. PMID: 12196925

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