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Hematologic disorder

MedGen UID:
5483
Concept ID:
C0018939
Disease or Syndrome
Synonyms: Hematologic disease; Hematologic disorders; Rare hematologic disease
SNOMED CT: Disease of blood AND/OR blood forming organ (34093004); Disorder of hematopoietic system (34093004); Hematopoietic system syndrome (34093004); Hematologic disease (34093004); Blood dyscrasia (34093004); Blood disorder (34093004); Hemopoietic disorder (34093004); Hemopoietic disease (34093004); Disease of blood AND/OR blood-forming organ (191124002); Diseases of blood and blood-forming organs (191124002)
 
Monarch Initiative: MONDO:0005570
Orphanet: ORPHA97992

Definition

A neoplastic or non-neoplastic disorder that affects the production and proliferation of the hematopoietic cells including lymphoid cells, the synthesis of hemoglobin, and/or the mechanisms of coagulation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHematologic disorder

Professional guidelines

PubMed

Pierson SK, Lim MS, Srkalovic G, Brandstadter JD, Sarmiento Bustamante M, Shyamsundar S, Mango N, Lavery C, Austin B, Alapat D, Lechowicz MJ, Bagg A, Li H, Casper C, van Rhee F, Fajgenbaum DC
Blood Adv 2023 Nov 14;7(21):6652-6664. doi: 10.1182/bloodadvances.2023010745. PMID: 37656441Free PMC Article
Ciftciler R, Haznedaroglu IC
Eur Rev Med Pharmacol Sci 2021 Dec;25(24):7787-7798. doi: 10.26355/eurrev_202112_27625. PMID: 34982440
Rosenbaum E, Marks D, Raza S
Hematol Oncol 2018 Feb;36(1):3-14. Epub 2017 Apr 10 doi: 10.1002/hon.2417. PMID: 28397326

Recent clinical studies

Etiology

Abramson M, Shaikh A
Adv Kidney Dis Health 2024 Jul;31(4):326-333. doi: 10.1053/j.akdh.2024.03.003. PMID: 39084758
Metzeler KH, Herold T, Rothenberg-Thurley M, Amler S, Sauerland MC, Görlich D, Schneider S, Konstandin NP, Dufour A, Bräundl K, Ksienzyk B, Zellmeier E, Hartmann L, Greif PA, Fiegl M, Subklewe M, Bohlander SK, Krug U, Faldum A, Berdel WE, Wörmann B, Büchner T, Hiddemann W, Braess J, Spiekermann K; AMLCG Study Group
Blood 2016 Aug 4;128(5):686-98. Epub 2016 Jun 10 doi: 10.1182/blood-2016-01-693879. PMID: 27288520
Bridoux F, Leung N, Hutchison CA, Touchard G, Sethi S, Fermand JP, Picken MM, Herrera GA, Kastritis E, Merlini G, Roussel M, Fervenza FC, Dispenzieri A, Kyle RA, Nasr SH; International Kidney and Monoclonal Gammopathy Research Group
Kidney Int 2015 Apr;87(4):698-711. Epub 2015 Jan 21 doi: 10.1038/ki.2014.408. PMID: 25607108
Raheja D, Specht C, Simmons Z
Muscle Nerve 2015 Jan;51(1):1-13. Epub 2014 Nov 22 doi: 10.1002/mus.24471. PMID: 25288371
Leung N, Bridoux F, Hutchison CA, Nasr SH, Cockwell P, Fermand JP, Dispenzieri A, Song KW, Kyle RA; International Kidney and Monoclonal Gammopathy Research Group
Blood 2012 Nov 22;120(22):4292-5. Epub 2012 Oct 9 doi: 10.1182/blood-2012-07-445304. PMID: 23047823

Diagnosis

Abramson M, Shaikh A
Adv Kidney Dis Health 2024 Jul;31(4):326-333. doi: 10.1053/j.akdh.2024.03.003. PMID: 39084758
Bridoux F, Leung N, Hutchison CA, Touchard G, Sethi S, Fermand JP, Picken MM, Herrera GA, Kastritis E, Merlini G, Roussel M, Fervenza FC, Dispenzieri A, Kyle RA, Nasr SH; International Kidney and Monoclonal Gammopathy Research Group
Kidney Int 2015 Apr;87(4):698-711. Epub 2015 Jan 21 doi: 10.1038/ki.2014.408. PMID: 25607108
Raheja D, Specht C, Simmons Z
Muscle Nerve 2015 Jan;51(1):1-13. Epub 2014 Nov 22 doi: 10.1002/mus.24471. PMID: 25288371
Kistangari G, McCrae KR
Hematol Oncol Clin North Am 2013 Jun;27(3):495-520. doi: 10.1016/j.hoc.2013.03.001. PMID: 23714309Free PMC Article
Leung N, Bridoux F, Hutchison CA, Nasr SH, Cockwell P, Fermand JP, Dispenzieri A, Song KW, Kyle RA; International Kidney and Monoclonal Gammopathy Research Group
Blood 2012 Nov 22;120(22):4292-5. Epub 2012 Oct 9 doi: 10.1182/blood-2012-07-445304. PMID: 23047823

Therapy

Ciftciler R, Haznedaroglu IC
Eur Rev Med Pharmacol Sci 2021 Dec;25(24):7787-7798. doi: 10.26355/eurrev_202112_27625. PMID: 34982440
Roboz GJ, DiNardo CD, Stein EM, de Botton S, Mims AS, Prince GT, Altman JK, Arellano ML, Donnellan W, Erba HP, Mannis GN, Pollyea DA, Stein AS, Uy GL, Watts JM, Fathi AT, Kantarjian HM, Tallman MS, Choe S, Dai D, Fan B, Wang H, Zhang V, Yen KE, Kapsalis SM, Hickman D, Liu H, Agresta SV, Wu B, Attar EC, Stone RM
Blood 2020 Feb 13;135(7):463-471. doi: 10.1182/blood.2019002140. PMID: 31841594Free PMC Article
Metzeler KH, Herold T, Rothenberg-Thurley M, Amler S, Sauerland MC, Görlich D, Schneider S, Konstandin NP, Dufour A, Bräundl K, Ksienzyk B, Zellmeier E, Hartmann L, Greif PA, Fiegl M, Subklewe M, Bohlander SK, Krug U, Faldum A, Berdel WE, Wörmann B, Büchner T, Hiddemann W, Braess J, Spiekermann K; AMLCG Study Group
Blood 2016 Aug 4;128(5):686-98. Epub 2016 Jun 10 doi: 10.1182/blood-2016-01-693879. PMID: 27288520
Leung N, Bridoux F, Hutchison CA, Nasr SH, Cockwell P, Fermand JP, Dispenzieri A, Song KW, Kyle RA; International Kidney and Monoclonal Gammopathy Research Group
Blood 2012 Nov 22;120(22):4292-5. Epub 2012 Oct 9 doi: 10.1182/blood-2012-07-445304. PMID: 23047823
Scaradavou A
Blood Rev 2002 Mar;16(1):73-6. doi: 10.1054/blre.2001.0188. PMID: 11914001

Prognosis

Abu-Ismail L, Taha MJJ, Abuawwad MT, Al-Bustanji Y, Al-Shami K, Nashwan A, Yassin M
Hemoglobin 2023 May;47(3):122-129. Epub 2023 Jul 31 doi: 10.1080/03630269.2023.2236546. PMID: 37519257
Simioni C, Martelli AM, Zauli G, Melloni E, Neri LM
Cells 2019 Feb 21;8(2) doi: 10.3390/cells8020190. PMID: 30795552Free PMC Article
Metzeler KH, Herold T, Rothenberg-Thurley M, Amler S, Sauerland MC, Görlich D, Schneider S, Konstandin NP, Dufour A, Bräundl K, Ksienzyk B, Zellmeier E, Hartmann L, Greif PA, Fiegl M, Subklewe M, Bohlander SK, Krug U, Faldum A, Berdel WE, Wörmann B, Büchner T, Hiddemann W, Braess J, Spiekermann K; AMLCG Study Group
Blood 2016 Aug 4;128(5):686-98. Epub 2016 Jun 10 doi: 10.1182/blood-2016-01-693879. PMID: 27288520
Swiecicki PL, Hegerova LT, Gertz MA
Blood 2013 Aug 15;122(7):1114-21. Epub 2013 Jun 11 doi: 10.1182/blood-2013-02-474437. PMID: 23757733
Scaradavou A
Blood Rev 2002 Mar;16(1):73-6. doi: 10.1054/blre.2001.0188. PMID: 11914001

Clinical prediction guides

Kim JS, Jang JH, Jo DY, Ahn SY, Yoon SS, Lee JH, Kim SH, Choi CW, Shin HJ, Kim MK, Lee JH, Mun YC, Kong JH, Hyun B, Nam H, Kim E, Kwak MJ, Won YK, Lee JW
J Korean Med Sci 2023 Oct 23;38(41):e328. doi: 10.3346/jkms.2023.38.e328. PMID: 37873628Free PMC Article
Pierson SK, Lim MS, Srkalovic G, Brandstadter JD, Sarmiento Bustamante M, Shyamsundar S, Mango N, Lavery C, Austin B, Alapat D, Lechowicz MJ, Bagg A, Li H, Casper C, van Rhee F, Fajgenbaum DC
Blood Adv 2023 Nov 14;7(21):6652-6664. doi: 10.1182/bloodadvances.2023010745. PMID: 37656441Free PMC Article
Abu-Ismail L, Taha MJJ, Abuawwad MT, Al-Bustanji Y, Al-Shami K, Nashwan A, Yassin M
Hemoglobin 2023 May;47(3):122-129. Epub 2023 Jul 31 doi: 10.1080/03630269.2023.2236546. PMID: 37519257
Peacock-Young B, Macrae FL, Newton DJ, Hill A, Ariëns RAS
Haematologica 2018 Jan;103(1):9-17. Epub 2017 Dec 15 doi: 10.3324/haematol.2017.177618. PMID: 29246924
Metzeler KH, Herold T, Rothenberg-Thurley M, Amler S, Sauerland MC, Görlich D, Schneider S, Konstandin NP, Dufour A, Bräundl K, Ksienzyk B, Zellmeier E, Hartmann L, Greif PA, Fiegl M, Subklewe M, Bohlander SK, Krug U, Faldum A, Berdel WE, Wörmann B, Büchner T, Hiddemann W, Braess J, Spiekermann K; AMLCG Study Group
Blood 2016 Aug 4;128(5):686-98. Epub 2016 Jun 10 doi: 10.1182/blood-2016-01-693879. PMID: 27288520

Recent systematic reviews

Belachew A, Tewabe T
Syst Rev 2020 Feb 12;9(1):31. doi: 10.1186/s13643-020-01289-7. PMID: 32051034Free PMC Article
Hartman EAR, van Royen-Kerkhof A, Jacobs JWG, Welsing PMJ, Fritsch-Stork RDE
Autoimmun Rev 2018 Mar;17(3):316-322. Epub 2018 Jan 31 doi: 10.1016/j.autrev.2018.01.007. PMID: 29366725
Zuo KJ, Fung E, Tredget EE, Lin AN
J Plast Reconstr Aesthet Surg 2015 Mar;68(3):295-303. Epub 2014 Dec 29 doi: 10.1016/j.bjps.2014.12.036. PMID: 25589459
Martí-Carvajal AJ, Peña-Martí GE, Comunián-Carrasco G
Cochrane Database Syst Rev 2009 Oct 7;2009(4):CD007722. doi: 10.1002/14651858.CD007722.pub2. PMID: 19821437Free PMC Article

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