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HHV8-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

MedGen UID:
1615300
•Concept ID:
C4527554
•
Neoplastic Process
Synonyms: HHV8-Positive Diffuse Large B-Cell Lymphoma, NOS; HHV8-Positive DLBCL, NOS; Human Herpesvirus 8-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified; KSHV/HHV8-Positive Diffuse Large B-Cell Lymphoma

Definition

A large B-cell lymphoma characterized by the presence of a diffuse proliferation of large, atypical HHV8-positive neoplastic lymphocytes. It usually arises in association with HHV8-positive multicentric Castleman disease. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHHV8-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

Recent clinical studies

Etiology

Demographic characteristics and prognosis of HHV8-positive diffuse large B-cell lymphoma, not otherwise specified: Insights from a population-based study with a 10-year follow-up.
Wang F, Du Z
Medicine (Baltimore) 2023 Dec 15;102(50):e36464. doi: 10.1097/MD.0000000000036464. PMID: 38115350Free PMC Article
KSHV/HHV8-positive large B-cell lymphomas and associated diseases: a heterogeneous group of lymphoproliferative processes with significant clinicopathological overlap.
Vega F, Miranda RN, Medeiros LJ
Mod Pathol 2020 Jan;33(1):18-28. Epub 2019 Sep 16 doi: 10.1038/s41379-019-0365-y. PMID: 31527708

Diagnosis

Demographic characteristics and prognosis of HHV8-positive diffuse large B-cell lymphoma, not otherwise specified: Insights from a population-based study with a 10-year follow-up.
Wang F, Du Z
Medicine (Baltimore) 2023 Dec 15;102(50):e36464. doi: 10.1097/MD.0000000000036464. PMID: 38115350Free PMC Article
Diffuse large B-cell lymphoma variants: an update.
Sukswai N, Lyapichev K, Khoury JD, Medeiros LJ
Pathology 2020 Jan;52(1):53-67. Epub 2019 Nov 15 doi: 10.1016/j.pathol.2019.08.013. PMID: 31735345
KSHV/HHV8-positive large B-cell lymphomas and associated diseases: a heterogeneous group of lymphoproliferative processes with significant clinicopathological overlap.
Vega F, Miranda RN, Medeiros LJ
Mod Pathol 2020 Jan;33(1):18-28. Epub 2019 Sep 16 doi: 10.1038/s41379-019-0365-y. PMID: 31527708

Prognosis

Demographic characteristics and prognosis of HHV8-positive diffuse large B-cell lymphoma, not otherwise specified: Insights from a population-based study with a 10-year follow-up.
Wang F, Du Z
Medicine (Baltimore) 2023 Dec 15;102(50):e36464. doi: 10.1097/MD.0000000000036464. PMID: 38115350Free PMC Article

Clinical prediction guides

Demographic characteristics and prognosis of HHV8-positive diffuse large B-cell lymphoma, not otherwise specified: Insights from a population-based study with a 10-year follow-up.
Wang F, Du Z
Medicine (Baltimore) 2023 Dec 15;102(50):e36464. doi: 10.1097/MD.0000000000036464. PMID: 38115350Free PMC Article

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