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Recurrent Acute Lymphoblastic Leukemia

MedGen UID:
1632670
•Concept ID:
C1504525
•
Neoplastic Process

Definition

The reemergence of acute lymphoblastic leukemia after a period of remission. [from NCI]

Professional guidelines

PubMed

Management of Recurrent Acute Lymphoblastic Leukemia With T-Cell Engagement: CAR T, BiTEs, and Beyond.
Park J
J Natl Compr Canc Netw 2019 Nov;17(11.5):1448-1450. doi: 10.6004/jnccn.2019.5030. PMID: 31766014
Strategies for the treatment of recurrent acute lymphoblastic leukemia in adults.
Bassan R, Lerede T, Barbui T
Haematologica 1996 Jan-Feb;81(1):20-36. PMID: 8900848
Treatment of acute lymphoblastic leukemia in relapse: efficacy of a four-drug reinduction regimen.
Poplack DG, Reaman GH, Wesley R
Cancer Treat Rep 1981;65 Suppl 4:93-6. PMID: 6955015

Recent clinical studies

Etiology

Myeloablative hematopoietic cell transplantation for acute lymphoblastic leukemia: analysis of graft sources and long-term outcome.
Tomblyn MB, Arora M, Baker KS, Blazar BR, Brunstein CG, Burns LJ, DeFor TE, Dusenbery KE, Kaufman DS, Kersey JH, MacMillan ML, McGlave PB, Miller JS, Orchard PJ, Slungaard A, Tomblyn MR, Vercellotti GM, Verneris MR, Wagner JE, Weisdorf DJ
J Clin Oncol 2009 Aug 1;27(22):3634-41. Epub 2009 Jul 6 doi: 10.1200/JCO.2008.20.2960. PMID: 19581540Free PMC Article
Recurrent acute lymphoblastic leukemia presenting in the lacrimal gland.
Cardone S, Yen MT, Chévez-Barrios P, Foroozan R, Yen KG
Ophthalmic Plast Reconstr Surg 2006 Jan-Feb;22(1):56-7. doi: 10.1097/01.iop.0000192644.97365.51. PMID: 16418669
Acute lymphoblastic leukemia in a patient with Greig cephalopolysyndactyly and interstitial deletion of chromosome 7 del(7)(p11.2 p14) involving the GLI3 and ZNFN1A1 genes.
Mendoza-Londono R, Kashork CD, Shaffer LG, Krance R, Plon SE
Genes Chromosomes Cancer 2005 Jan;42(1):82-6. doi: 10.1002/gcc.20100. PMID: 15390181
Autologous versus unrelated donor allogeneic marrow transplantation for acute lymphoblastic leukemia.
Weisdorf DJ, Billett AL, Hannan P, Ritz J, Sallan SE, Steinbuch M, Ramsay NK
Blood 1997 Oct 15;90(8):2962-8. PMID: 9376576
Strategies for the treatment of recurrent acute lymphoblastic leukemia in adults.
Bassan R, Lerede T, Barbui T
Haematologica 1996 Jan-Feb;81(1):20-36. PMID: 8900848

Diagnosis

Myeloablative hematopoietic cell transplantation for acute lymphoblastic leukemia: analysis of graft sources and long-term outcome.
Tomblyn MB, Arora M, Baker KS, Blazar BR, Brunstein CG, Burns LJ, DeFor TE, Dusenbery KE, Kaufman DS, Kersey JH, MacMillan ML, McGlave PB, Miller JS, Orchard PJ, Slungaard A, Tomblyn MR, Vercellotti GM, Verneris MR, Wagner JE, Weisdorf DJ
J Clin Oncol 2009 Aug 1;27(22):3634-41. Epub 2009 Jul 6 doi: 10.1200/JCO.2008.20.2960. PMID: 19581540Free PMC Article
Recurrent acute lymphoblastic leukemia presenting in the lacrimal gland.
Cardone S, Yen MT, Chévez-Barrios P, Foroozan R, Yen KG
Ophthalmic Plast Reconstr Surg 2006 Jan-Feb;22(1):56-7. doi: 10.1097/01.iop.0000192644.97365.51. PMID: 16418669
Imaging findings of recurrent acute lymphoblastic leukemia in children and young adults, with emphasis on MRI.
Porter RP, Kaste SC
Pediatr Radiol 2004 May;34(5):400-8. Epub 2004 Feb 25 doi: 10.1007/s00247-003-1137-9. PMID: 14985880
Response of recurrent acute lymphoblastic leukemia to glucocorticoids: serial studies of receptor content, in vivo cytokinetic changes and clinical responses.
Pui CH, Costlow ME, Dahl GV, Rivera G, Murphy SB
Leuk Res 1983;7(6):747-53. doi: 10.1016/0145-2126(83)90068-1. PMID: 6582341
Daunorubicin, vincristine, and prednisone for remission induction in patients with acute lymphoblastic leukemia in relapse.
Pavlovsky S, Muriel FS, Eppinger-Helft M, Bustelo P, Garay G, Giuntoli JM, Kvicala R, Divito J, Picón A
Cancer Treat Rep 1983 May;67(5):425-7. PMID: 6573958

Therapy

Myeloablative hematopoietic cell transplantation for acute lymphoblastic leukemia: analysis of graft sources and long-term outcome.
Tomblyn MB, Arora M, Baker KS, Blazar BR, Brunstein CG, Burns LJ, DeFor TE, Dusenbery KE, Kaufman DS, Kersey JH, MacMillan ML, McGlave PB, Miller JS, Orchard PJ, Slungaard A, Tomblyn MR, Vercellotti GM, Verneris MR, Wagner JE, Weisdorf DJ
J Clin Oncol 2009 Aug 1;27(22):3634-41. Epub 2009 Jul 6 doi: 10.1200/JCO.2008.20.2960. PMID: 19581540Free PMC Article
Recurrent acute lymphoblastic leukemia presenting in the lacrimal gland.
Cardone S, Yen MT, Chévez-Barrios P, Foroozan R, Yen KG
Ophthalmic Plast Reconstr Surg 2006 Jan-Feb;22(1):56-7. doi: 10.1097/01.iop.0000192644.97365.51. PMID: 16418669
Strategies for the treatment of recurrent acute lymphoblastic leukemia in adults.
Bassan R, Lerede T, Barbui T
Haematologica 1996 Jan-Feb;81(1):20-36. PMID: 8900848
Response of recurrent acute lymphoblastic leukemia to glucocorticoids: serial studies of receptor content, in vivo cytokinetic changes and clinical responses.
Pui CH, Costlow ME, Dahl GV, Rivera G, Murphy SB
Leuk Res 1983;7(6):747-53. doi: 10.1016/0145-2126(83)90068-1. PMID: 6582341
Vindesine, prednisone, and daunomycin in acute lymphoblastic leukemia in relapse.
Garay G, Milone J, Dibar E, Pavlovsky S, Kvicala R, Sackmann Muriel F, Montres Varela D, Eppinger-Helft M
Cancer Chemother Pharmacol 1983;10(3):224-6. doi: 10.1007/BF00255770. PMID: 6345018

Prognosis

Myeloablative hematopoietic cell transplantation for acute lymphoblastic leukemia: analysis of graft sources and long-term outcome.
Tomblyn MB, Arora M, Baker KS, Blazar BR, Brunstein CG, Burns LJ, DeFor TE, Dusenbery KE, Kaufman DS, Kersey JH, MacMillan ML, McGlave PB, Miller JS, Orchard PJ, Slungaard A, Tomblyn MR, Vercellotti GM, Verneris MR, Wagner JE, Weisdorf DJ
J Clin Oncol 2009 Aug 1;27(22):3634-41. Epub 2009 Jul 6 doi: 10.1200/JCO.2008.20.2960. PMID: 19581540Free PMC Article
Recurrent acute lymphoblastic leukemia presenting in the lacrimal gland.
Cardone S, Yen MT, Chévez-Barrios P, Foroozan R, Yen KG
Ophthalmic Plast Reconstr Surg 2006 Jan-Feb;22(1):56-7. doi: 10.1097/01.iop.0000192644.97365.51. PMID: 16418669
Strategies for the treatment of recurrent acute lymphoblastic leukemia in adults.
Bassan R, Lerede T, Barbui T
Haematologica 1996 Jan-Feb;81(1):20-36. PMID: 8900848
Response of recurrent acute lymphoblastic leukemia to glucocorticoids: serial studies of receptor content, in vivo cytokinetic changes and clinical responses.
Pui CH, Costlow ME, Dahl GV, Rivera G, Murphy SB
Leuk Res 1983;7(6):747-53. doi: 10.1016/0145-2126(83)90068-1. PMID: 6582341
Vindesine, prednisone, and daunomycin in acute lymphoblastic leukemia in relapse.
Garay G, Milone J, Dibar E, Pavlovsky S, Kvicala R, Sackmann Muriel F, Montres Varela D, Eppinger-Helft M
Cancer Chemother Pharmacol 1983;10(3):224-6. doi: 10.1007/BF00255770. PMID: 6345018

Clinical prediction guides

Asparaginase pharmacokinetics after intensive polyethylene glycol-conjugated L-asparaginase therapy for children with relapsed acute lymphoblastic leukemia.
Hawkins DS, Park JR, Thomson BG, Felgenhauer JL, Holcenberg JS, Panosyan EH, Avramis VI
Clin Cancer Res 2004 Aug 15;10(16):5335-41. doi: 10.1158/1078-0432.CCR-04-0222. PMID: 15328169
Combination therapy with methotrexate, vincristine, polyethylene-glycol conjugated-asparaginase, and prednisone in the treatment of patients with refractory or recurrent acute lymphoblastic leukemia.
Aguayo A, Cortes J, Thomas D, Pierce S, Keating M, Kantarjian H
Cancer 1999 Oct 1;86(7):1203-9. doi: 10.1002/(sici)1097-0142(19991001)86:7<1203::aid-cncr15>3.0.co;2-3. PMID: 10506705
Autologous bone marrow transplantation after a long first remission for children with recurrent acute lymphoblastic leukemia.
Billett AL, Kornmehl E, Tarbell NJ, Weinstein HJ, Gelber RD, Ritz J, Sallan SE
Blood 1993 Mar 15;81(6):1651-7. PMID: 8453110
Response of recurrent acute lymphoblastic leukemia to glucocorticoids: serial studies of receptor content, in vivo cytokinetic changes and clinical responses.
Pui CH, Costlow ME, Dahl GV, Rivera G, Murphy SB
Leuk Res 1983;7(6):747-53. doi: 10.1016/0145-2126(83)90068-1. PMID: 6582341
Daunorubicin, vincristine, and prednisone for remission induction in patients with acute lymphoblastic leukemia in relapse.
Pavlovsky S, Muriel FS, Eppinger-Helft M, Bustelo P, Garay G, Giuntoli JM, Kvicala R, Divito J, Picón A
Cancer Treat Rep 1983 May;67(5):425-7. PMID: 6573958

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