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Refractory Endometrial Undifferentiated Carcinoma

MedGen UID:
1718245
•Concept ID:
C5237069
•
Neoplastic Process

Definition

Endometrial undifferentiated carcinoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Endometrial Undifferentiated Carcinoma

Professional guidelines

PubMed

Lenvatinib dose, efficacy, and safety in the treatment of multiple malignancies.
Motzer RJ, Taylor MH, Evans TRJ, Okusaka T, Glen H, Lubiniecki GM, Dutcus C, Smith AD, Okpara CE, Hussein Z, Hayato S, Tamai T, Makker V
Expert Rev Anticancer Ther 2022 Apr;22(4):383-400. Epub 2022 Apr 7 doi: 10.1080/14737140.2022.2039123. PMID: 35260027Free PMC Article
Tumor Mutational Burden Guides Therapy in a Treatment Refractory POLE-Mutant Uterine Carcinosarcoma.
Bhangoo MS, Boasberg P, Mehta P, Elvin JA, Ali SM, Wu W, Klempner SJ
Oncologist 2018 May;23(5):518-523. Epub 2018 Jan 31 doi: 10.1634/theoncologist.2017-0342. PMID: 29386312Free PMC Article
GnRH antagonists in the treatment of gynecological and breast cancers.
Emons G, Gründker C, Günthert AR, Westphalen S, Kavanagh J, Verschraegen C
Endocr Relat Cancer 2003 Jun;10(2):291-9. doi: 10.1677/erc.0.0100291. PMID: 12790790

Recent clinical studies

Etiology

A phase 2 study of dasatinib in recurrent clear cell carcinoma of the ovary, fallopian tube, peritoneum or endometrium: NRG oncology/gynecologic oncology group study 0283.
O'Cearbhaill RE, Miller A, Soslow RA, Lankes HA, DeLair D, Segura S, Chavan S, Zamarin D, DeBernardo R, Moore K, Moroney J, Shahin M, Thaker PH, Wahner-Hendrickson AE, Aghajanian C
Gynecol Oncol 2023 Sep;176:16-24. Epub 2023 Jul 5 doi: 10.1016/j.ygyno.2023.06.021. PMID: 37418832Free PMC Article
A Risk-scoring Model for Predicting Post-recurrence Survival in Patients With Endometrial Carcinoma.
Kolehmainen A, Pasanen A, Koivisto-Korander R, Bützow R, Loukovaara M
Clin Oncol (R Coll Radiol) 2023 Jul;35(7):472-477. Epub 2023 May 6 doi: 10.1016/j.clon.2023.05.001. PMID: 37173220
SWI/SNF-deficiency defines highly aggressive undifferentiated endometrial carcinoma.
Tessier-Cloutier B, Coatham M, Carey M, Nelson GS, Hamilton S, Lum A, Soslow RA, Stewart CJ, Postovit LM, Köbel M, Lee CH
J Pathol Clin Res 2021 Mar;7(2):144-153. Epub 2020 Oct 30 doi: 10.1002/cjp2.188. PMID: 33125840Free PMC Article
Efficacy of combination chemotherapy using irinotecan and nedaplatin for patients with recurrent and refractory endometrial carcinomas: preliminary analysis and literature review.
Miyamoto M, Takano M, Kuwahara M, Soyama H, Kato K, Matuura H, Sakamoto T, Takasaki K, Aoyama T, Yoshikawa T, Furuya K
Cancer Chemother Pharmacol 2018 Jan;81(1):111-117. Epub 2017 Nov 9 doi: 10.1007/s00280-017-3454-y. PMID: 29124328
Circadian chemotherapy for gynecological and genitourinary cancers.
Kobayashi M, Wood PA, Hrushesky WJ
Chronobiol Int 2002 Jan;19(1):237-51. doi: 10.1081/cbi-120002600. PMID: 11962679

Diagnosis

A Risk-scoring Model for Predicting Post-recurrence Survival in Patients With Endometrial Carcinoma.
Kolehmainen A, Pasanen A, Koivisto-Korander R, Bützow R, Loukovaara M
Clin Oncol (R Coll Radiol) 2023 Jul;35(7):472-477. Epub 2023 May 6 doi: 10.1016/j.clon.2023.05.001. PMID: 37173220
SWI/SNF-deficiency defines highly aggressive undifferentiated endometrial carcinoma.
Tessier-Cloutier B, Coatham M, Carey M, Nelson GS, Hamilton S, Lum A, Soslow RA, Stewart CJ, Postovit LM, Köbel M, Lee CH
J Pathol Clin Res 2021 Mar;7(2):144-153. Epub 2020 Oct 30 doi: 10.1002/cjp2.188. PMID: 33125840Free PMC Article
Uterine serous carcinoma: Reassessing effectiveness of platinum-based adjuvant therapy.
Tortorella L, Langstraat CL, Weaver AL, McGree ME, Bakkum-Gamez JN, Dowdy SC, Cliby WA, Keeney GL, Sherman ME, Weroha SJ, Mariani A, Podratz KC
Gynecol Oncol 2018 May;149(2):291-296. Epub 2018 Mar 14 doi: 10.1016/j.ygyno.2018.02.022. PMID: 29550183
Treatment outcomes of paclitaxel for refractory or recurrent epithelial ovarian cancer patients in Thailand.
Pitakkarnkul S, Tangjitgamol S, Srijaipracharoen S, Manusirivithaya S, Pataradool K, Prutthiphongsit W, Khunnarong J, Thavaramara T
Asian Pac J Cancer Prev 2013;14(4):2421-7. doi: 10.7314/apjcp.2013.14.4.2421. PMID: 23725151
Endometrial neoplasia: prognostic significance of ploidy status.
Evans MP, Podratz KC
Clin Obstet Gynecol 1996 Sep;39(3):696-706. doi: 10.1097/00003081-199609000-00017. PMID: 8862893

Therapy

Recent updates in the therapeutic uses of Pembrolizumab: a brief narrative review.
Silva V, Matos C
Clin Transl Oncol 2024 Oct;26(10):2431-2443. Epub 2024 Apr 24 doi: 10.1007/s12094-024-03491-8. PMID: 38658461
A phase 2 study of dasatinib in recurrent clear cell carcinoma of the ovary, fallopian tube, peritoneum or endometrium: NRG oncology/gynecologic oncology group study 0283.
O'Cearbhaill RE, Miller A, Soslow RA, Lankes HA, DeLair D, Segura S, Chavan S, Zamarin D, DeBernardo R, Moore K, Moroney J, Shahin M, Thaker PH, Wahner-Hendrickson AE, Aghajanian C
Gynecol Oncol 2023 Sep;176:16-24. Epub 2023 Jul 5 doi: 10.1016/j.ygyno.2023.06.021. PMID: 37418832Free PMC Article
Lenvatinib dose, efficacy, and safety in the treatment of multiple malignancies.
Motzer RJ, Taylor MH, Evans TRJ, Okusaka T, Glen H, Lubiniecki GM, Dutcus C, Smith AD, Okpara CE, Hussein Z, Hayato S, Tamai T, Makker V
Expert Rev Anticancer Ther 2022 Apr;22(4):383-400. Epub 2022 Apr 7 doi: 10.1080/14737140.2022.2039123. PMID: 35260027Free PMC Article
Effect of Capivasertib in Patients With an AKT1 E17K-Mutated Tumor: NCI-MATCH Subprotocol EAY131-Y Nonrandomized Trial.
Kalinsky K, Hong F, McCourt CK, Sachdev JC, Mitchell EP, Zwiebel JA, Doyle LA, McShane LM, Li S, Gray RJ, Rubinstein LV, Patton D, Williams PM, Hamilton SR, Conley BA, O'Dwyer PJ, Harris LN, Arteaga CL, Chen AP, Flaherty KT
JAMA Oncol 2021 Feb 1;7(2):271-278. doi: 10.1001/jamaoncol.2020.6741. PMID: 33377972Free PMC Article
The Association and Significance of p53 in Gynecologic Cancers: The Potential of Targeted Therapy.
Nakamura M, Obata T, Daikoku T, Fujiwara H
Int J Mol Sci 2019 Nov 4;20(21) doi: 10.3390/ijms20215482. PMID: 31689961Free PMC Article

Prognosis

A phase 2 study of dasatinib in recurrent clear cell carcinoma of the ovary, fallopian tube, peritoneum or endometrium: NRG oncology/gynecologic oncology group study 0283.
O'Cearbhaill RE, Miller A, Soslow RA, Lankes HA, DeLair D, Segura S, Chavan S, Zamarin D, DeBernardo R, Moore K, Moroney J, Shahin M, Thaker PH, Wahner-Hendrickson AE, Aghajanian C
Gynecol Oncol 2023 Sep;176:16-24. Epub 2023 Jul 5 doi: 10.1016/j.ygyno.2023.06.021. PMID: 37418832Free PMC Article
A Risk-scoring Model for Predicting Post-recurrence Survival in Patients With Endometrial Carcinoma.
Kolehmainen A, Pasanen A, Koivisto-Korander R, Bützow R, Loukovaara M
Clin Oncol (R Coll Radiol) 2023 Jul;35(7):472-477. Epub 2023 May 6 doi: 10.1016/j.clon.2023.05.001. PMID: 37173220
DKK1 is a predictive biomarker for response to DKN-01: Results of a phase 2 basket study in women with recurrent endometrial carcinoma.
Arend R, Dholakia J, Castro C, Matulonis U, Hamilton E, Jackson CG, LyBarger K, Goodman HM, Duska LR, Mahdi H, ElNaggar AC, Kagey MH, Liu A, Piper D, Barroilhet LM, Bradley W, Sachdev J, Sirard CA, O'Malley DM, Birrer M
Gynecol Oncol 2023 May;172:82-91. Epub 2023 Mar 29 doi: 10.1016/j.ygyno.2023.03.013. PMID: 37001446
Immunosuppressive tumor microenvironment in uterine serous carcinoma via CCL7 signal with myeloid-derived suppressor cells.
Mise Y, Hamanishi J, Daikoku T, Takamatsu S, Miyamoto T, Taki M, Yamanoi K, Yamaguchi K, Ukita M, Horikawa N, Abiko K, Murakami R, Furutake Y, Hosoe Y, Terakawa J, Kagabu M, Sugai T, Osakabe M, Fujiwara H, Matsumura N, Mandai M, Baba T
Carcinogenesis 2022 Aug 30;43(7):647-658. doi: 10.1093/carcin/bgac032. PMID: 35353883
The Association and Significance of p53 in Gynecologic Cancers: The Potential of Targeted Therapy.
Nakamura M, Obata T, Daikoku T, Fujiwara H
Int J Mol Sci 2019 Nov 4;20(21) doi: 10.3390/ijms20215482. PMID: 31689961Free PMC Article

Clinical prediction guides

A phase 2 study of dasatinib in recurrent clear cell carcinoma of the ovary, fallopian tube, peritoneum or endometrium: NRG oncology/gynecologic oncology group study 0283.
O'Cearbhaill RE, Miller A, Soslow RA, Lankes HA, DeLair D, Segura S, Chavan S, Zamarin D, DeBernardo R, Moore K, Moroney J, Shahin M, Thaker PH, Wahner-Hendrickson AE, Aghajanian C
Gynecol Oncol 2023 Sep;176:16-24. Epub 2023 Jul 5 doi: 10.1016/j.ygyno.2023.06.021. PMID: 37418832Free PMC Article
A Risk-scoring Model for Predicting Post-recurrence Survival in Patients With Endometrial Carcinoma.
Kolehmainen A, Pasanen A, Koivisto-Korander R, Bützow R, Loukovaara M
Clin Oncol (R Coll Radiol) 2023 Jul;35(7):472-477. Epub 2023 May 6 doi: 10.1016/j.clon.2023.05.001. PMID: 37173220
DKK1 is a predictive biomarker for response to DKN-01: Results of a phase 2 basket study in women with recurrent endometrial carcinoma.
Arend R, Dholakia J, Castro C, Matulonis U, Hamilton E, Jackson CG, LyBarger K, Goodman HM, Duska LR, Mahdi H, ElNaggar AC, Kagey MH, Liu A, Piper D, Barroilhet LM, Bradley W, Sachdev J, Sirard CA, O'Malley DM, Birrer M
Gynecol Oncol 2023 May;172:82-91. Epub 2023 Mar 29 doi: 10.1016/j.ygyno.2023.03.013. PMID: 37001446
Immunosuppressive tumor microenvironment in uterine serous carcinoma via CCL7 signal with myeloid-derived suppressor cells.
Mise Y, Hamanishi J, Daikoku T, Takamatsu S, Miyamoto T, Taki M, Yamanoi K, Yamaguchi K, Ukita M, Horikawa N, Abiko K, Murakami R, Furutake Y, Hosoe Y, Terakawa J, Kagabu M, Sugai T, Osakabe M, Fujiwara H, Matsumura N, Mandai M, Baba T
Carcinogenesis 2022 Aug 30;43(7):647-658. doi: 10.1093/carcin/bgac032. PMID: 35353883
The Association and Significance of p53 in Gynecologic Cancers: The Potential of Targeted Therapy.
Nakamura M, Obata T, Daikoku T, Fujiwara H
Int J Mol Sci 2019 Nov 4;20(21) doi: 10.3390/ijms20215482. PMID: 31689961Free PMC Article

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