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Platinum-Resistant Lung Small Cell Carcinoma

MedGen UID:
1679488
•Concept ID:
C4764254
•
Neoplastic Process

Definition

Lung small cell carcinoma that is resistant to platinum therapy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPlatinum-Resistant Lung Small Cell Carcinoma

Professional guidelines

PubMed

Lurbinectedin for the treatment of small cell lung cancer.
Li L, Zou C, Dong S, Wu ZX, Ashby CR Jr, Chen ZS, Qiu C
Drugs Today (Barc) 2021 Jun;57(6):377-385. doi: 10.1358/dot.2021.57.6.3294559. PMID: 34151904
FDA Approval Summary: Lurbinectedin for the Treatment of Metastatic Small Cell Lung Cancer.
Singh S, Jaigirdar AA, Mulkey F, Cheng J, Hamed SS, Li Y, Liu J, Zhao H, Goheer A, Helms WS, Wang X, Agarwal R, Pragani R, Korsah K, Tang S, Leighton J, Rahman A, Beaver JA, Pazdur R, Theoret MR, Singh H
Clin Cancer Res 2021 May 1;27(9):2378-2382. Epub 2020 Dec 7 doi: 10.1158/1078-0432.CCR-20-3901. PMID: 33288660Free PMC Article
Lonidamine: efficacy and safety in clinical trials for the treatment of solid tumors.
Di Cosimo S, Ferretti G, Papaldo P, Carlini P, Fabi A, Cognetti F
Drugs Today (Barc) 2003 Mar;39(3):157-74. doi: 10.1358/dot.2003.39.3.799451. PMID: 12730701

Recent clinical studies

Etiology

Second-line treatment outcomes after first-line chemotherapy plus immunotherapy in Extensive-Stage small cell lung cancer (ES-SCLC) patients: A large French multicenter study.
Pons-Tostivint E, Ezzedine R, Goronflot T, Crequit P, Chatellier T, Raimbourg J, Bennouna J, Giroux Leprieur E, Porte M
Lung Cancer 2024 Aug;194:107887. Epub 2024 Jul 8 doi: 10.1016/j.lungcan.2024.107887. PMID: 38991282
Berzosertib Plus Topotecan vs Topotecan Alone in Patients With Relapsed Small Cell Lung Cancer: A Randomized Clinical Trial.
Takahashi N, Hao Z, Villaruz LC, Zhang J, Ruiz J, Petty WJ, Mamdani H, Riess JW, Nieva J, Pachecho JM, Fuld AD, Shum E, Chauhan A, Nichols S, Shimellis H, McGlone J, Sciuto L, Pinkiert D, Graham C, Shelat M, Kattappuram R, Abel M, Schroeder B, Upadhyay D, Krishnamurthy M, Sharma AK, Kumar R, Malin J, Schultz CW, Goyal S, Redon CE, Pommier Y, Aladjem MI, Gore SD, Steinberg SM, Vilimas R, Desai P, Thomas A
JAMA Oncol 2023 Dec 1;9(12):1669-1677. doi: 10.1001/jamaoncol.2023.4025. PMID: 37824137Free PMC Article
FOLFIRI in advanced platinum-resistant/refractory small-cell lung cancer: a retrospective study.
Roussel-Simonin C, Gougis P, Lassoued D, Vozy A, Veyri M, Morardet L, Wassermann J, Foka Tichoue H, Jaffrelot L, Hassani L, Perrier A, Bergeret S, Taillade L, Spano JP, Campedel L, Abbar B
Acta Oncol 2023 Jun;62(6):579-586. Epub 2023 Jun 5 doi: 10.1080/0284186X.2023.2216339. PMID: 37276270
Second-line docetaxel for patients with platinum-refractory advanced non-small cell lung cancer and interstitial pneumonia.
Watanabe N, Niho S, Kirita K, Umemura S, Matsumoto S, Yoh K, Ohmatsu H, Goto K
Cancer Chemother Pharmacol 2015 Jul;76(1):69-74. Epub 2015 May 15 doi: 10.1007/s00280-015-2775-y. PMID: 25976217
Randomized phase III trial of docetaxel versus vinorelbine or ifosfamide in patients with advanced non-small-cell lung cancer previously treated with platinum-containing chemotherapy regimens. The TAX 320 Non-Small Cell Lung Cancer Study Group.
Fossella FV, DeVore R, Kerr RN, Crawford J, Natale RR, Dunphy F, Kalman L, Miller V, Lee JS, Moore M, Gandara D, Karp D, Vokes E, Kris M, Kim Y, Gamza F, Hammershaimb L
J Clin Oncol 2000 Jun;18(12):2354-62. doi: 10.1200/JCO.2000.18.12.2354. PMID: 10856094

Diagnosis

Berzosertib Plus Topotecan vs Topotecan Alone in Patients With Relapsed Small Cell Lung Cancer: A Randomized Clinical Trial.
Takahashi N, Hao Z, Villaruz LC, Zhang J, Ruiz J, Petty WJ, Mamdani H, Riess JW, Nieva J, Pachecho JM, Fuld AD, Shum E, Chauhan A, Nichols S, Shimellis H, McGlone J, Sciuto L, Pinkiert D, Graham C, Shelat M, Kattappuram R, Abel M, Schroeder B, Upadhyay D, Krishnamurthy M, Sharma AK, Kumar R, Malin J, Schultz CW, Goyal S, Redon CE, Pommier Y, Aladjem MI, Gore SD, Steinberg SM, Vilimas R, Desai P, Thomas A
JAMA Oncol 2023 Dec 1;9(12):1669-1677. doi: 10.1001/jamaoncol.2023.4025. PMID: 37824137Free PMC Article
Lurbinectedin for the treatment of small cell lung cancer.
Li L, Zou C, Dong S, Wu ZX, Ashby CR Jr, Chen ZS, Qiu C
Drugs Today (Barc) 2021 Jun;57(6):377-385. doi: 10.1358/dot.2021.57.6.3294559. PMID: 34151904
A Phase II Trial of Prexasertib (LY2606368) in Patients With Extensive-Stage Small-Cell Lung Cancer.
Byers LA, Navarro A, Schaefer E, Johnson M, Özgüroğlu M, Han JY, Bondarenko I, Cicin I, Dragnev KH, Abel A, Wang X, McNeely S, Hynes S, Lin AB, Forster M
Clin Lung Cancer 2021 Nov;22(6):531-540. Epub 2021 Apr 24 doi: 10.1016/j.cllc.2021.04.005. PMID: 34034991
Bevacizumab: a review of its use in advanced cancer.
Keating GM
Drugs 2014 Oct;74(16):1891-1925. doi: 10.1007/s40265-014-0302-9. PMID: 25315029
Clinical perspectives on platinum resistance.
Giaccone G
Drugs 2000;59 Suppl 4:9-17; discussion 37-8. doi: 10.2165/00003495-200059004-00002. PMID: 10864226

Therapy

Phase 1a dose escalation study of ivonescimab (AK112/SMT112), an anti-PD-1/VEGF-A bispecific antibody, in patients with advanced solid tumors.
Frentzas S, Austria Mislang AR, Lemech C, Nagrial A, Underhill C, Wang W, Wang ZM, Li B, Xia Y, Coward JIG
J Immunother Cancer 2024 Apr 19;12(4) doi: 10.1136/jitc-2023-008037. PMID: 38642937Free PMC Article
Berzosertib Plus Topotecan vs Topotecan Alone in Patients With Relapsed Small Cell Lung Cancer: A Randomized Clinical Trial.
Takahashi N, Hao Z, Villaruz LC, Zhang J, Ruiz J, Petty WJ, Mamdani H, Riess JW, Nieva J, Pachecho JM, Fuld AD, Shum E, Chauhan A, Nichols S, Shimellis H, McGlone J, Sciuto L, Pinkiert D, Graham C, Shelat M, Kattappuram R, Abel M, Schroeder B, Upadhyay D, Krishnamurthy M, Sharma AK, Kumar R, Malin J, Schultz CW, Goyal S, Redon CE, Pommier Y, Aladjem MI, Gore SD, Steinberg SM, Vilimas R, Desai P, Thomas A
JAMA Oncol 2023 Dec 1;9(12):1669-1677. doi: 10.1001/jamaoncol.2023.4025. PMID: 37824137Free PMC Article
FOLFIRI in advanced platinum-resistant/refractory small-cell lung cancer: a retrospective study.
Roussel-Simonin C, Gougis P, Lassoued D, Vozy A, Veyri M, Morardet L, Wassermann J, Foka Tichoue H, Jaffrelot L, Hassani L, Perrier A, Bergeret S, Taillade L, Spano JP, Campedel L, Abbar B
Acta Oncol 2023 Jun;62(6):579-586. Epub 2023 Jun 5 doi: 10.1080/0284186X.2023.2216339. PMID: 37276270
First-in-Human Study of PF-06647020 (Cofetuzumab Pelidotin), an Antibody-Drug Conjugate Targeting Protein Tyrosine Kinase 7, in Advanced Solid Tumors.
Maitland ML, Sachdev JC, Sharma MR, Moreno V, Boni V, Kummar S, Stringer-Reasor E, Lakhani N, Moreau AR, Xuan D, Li R, Powell EL, Jackson-Fisher A, Bowers M, Alekar S, Xin X, Tolcher AW, Calvo E
Clin Cancer Res 2021 Aug 15;27(16):4511-4520. Epub 2021 Jun 3 doi: 10.1158/1078-0432.CCR-20-3757. PMID: 34083232Free PMC Article
Randomized phase III trial of docetaxel versus vinorelbine or ifosfamide in patients with advanced non-small-cell lung cancer previously treated with platinum-containing chemotherapy regimens. The TAX 320 Non-Small Cell Lung Cancer Study Group.
Fossella FV, DeVore R, Kerr RN, Crawford J, Natale RR, Dunphy F, Kalman L, Miller V, Lee JS, Moore M, Gandara D, Karp D, Vokes E, Kris M, Kim Y, Gamza F, Hammershaimb L
J Clin Oncol 2000 Jun;18(12):2354-62. doi: 10.1200/JCO.2000.18.12.2354. PMID: 10856094

Prognosis

Berzosertib Plus Topotecan vs Topotecan Alone in Patients With Relapsed Small Cell Lung Cancer: A Randomized Clinical Trial.
Takahashi N, Hao Z, Villaruz LC, Zhang J, Ruiz J, Petty WJ, Mamdani H, Riess JW, Nieva J, Pachecho JM, Fuld AD, Shum E, Chauhan A, Nichols S, Shimellis H, McGlone J, Sciuto L, Pinkiert D, Graham C, Shelat M, Kattappuram R, Abel M, Schroeder B, Upadhyay D, Krishnamurthy M, Sharma AK, Kumar R, Malin J, Schultz CW, Goyal S, Redon CE, Pommier Y, Aladjem MI, Gore SD, Steinberg SM, Vilimas R, Desai P, Thomas A
JAMA Oncol 2023 Dec 1;9(12):1669-1677. doi: 10.1001/jamaoncol.2023.4025. PMID: 37824137Free PMC Article
FOLFIRI in advanced platinum-resistant/refractory small-cell lung cancer: a retrospective study.
Roussel-Simonin C, Gougis P, Lassoued D, Vozy A, Veyri M, Morardet L, Wassermann J, Foka Tichoue H, Jaffrelot L, Hassani L, Perrier A, Bergeret S, Taillade L, Spano JP, Campedel L, Abbar B
Acta Oncol 2023 Jun;62(6):579-586. Epub 2023 Jun 5 doi: 10.1080/0284186X.2023.2216339. PMID: 37276270
First-in-Human Study of PF-06647020 (Cofetuzumab Pelidotin), an Antibody-Drug Conjugate Targeting Protein Tyrosine Kinase 7, in Advanced Solid Tumors.
Maitland ML, Sachdev JC, Sharma MR, Moreno V, Boni V, Kummar S, Stringer-Reasor E, Lakhani N, Moreau AR, Xuan D, Li R, Powell EL, Jackson-Fisher A, Bowers M, Alekar S, Xin X, Tolcher AW, Calvo E
Clin Cancer Res 2021 Aug 15;27(16):4511-4520. Epub 2021 Jun 3 doi: 10.1158/1078-0432.CCR-20-3757. PMID: 34083232Free PMC Article
Erlotinib or gefitinib for the treatment of relapsed platinum pretreated non-small cell lung cancer and ovarian cancer: a systematic review.
Murphy M, Stordal B
Drug Resist Updat 2011 Jun;14(3):177-90. Epub 2011 Mar 24 doi: 10.1016/j.drup.2011.02.004. PMID: 21435938
Clinical perspectives on platinum resistance.
Giaccone G
Drugs 2000;59 Suppl 4:9-17; discussion 37-8. doi: 10.2165/00003495-200059004-00002. PMID: 10864226

Clinical prediction guides

Phase 1a dose escalation study of ivonescimab (AK112/SMT112), an anti-PD-1/VEGF-A bispecific antibody, in patients with advanced solid tumors.
Frentzas S, Austria Mislang AR, Lemech C, Nagrial A, Underhill C, Wang W, Wang ZM, Li B, Xia Y, Coward JIG
J Immunother Cancer 2024 Apr 19;12(4) doi: 10.1136/jitc-2023-008037. PMID: 38642937Free PMC Article
FOLFIRI in advanced platinum-resistant/refractory small-cell lung cancer: a retrospective study.
Roussel-Simonin C, Gougis P, Lassoued D, Vozy A, Veyri M, Morardet L, Wassermann J, Foka Tichoue H, Jaffrelot L, Hassani L, Perrier A, Bergeret S, Taillade L, Spano JP, Campedel L, Abbar B
Acta Oncol 2023 Jun;62(6):579-586. Epub 2023 Jun 5 doi: 10.1080/0284186X.2023.2216339. PMID: 37276270
First-in-Human Study of PF-06647020 (Cofetuzumab Pelidotin), an Antibody-Drug Conjugate Targeting Protein Tyrosine Kinase 7, in Advanced Solid Tumors.
Maitland ML, Sachdev JC, Sharma MR, Moreno V, Boni V, Kummar S, Stringer-Reasor E, Lakhani N, Moreau AR, Xuan D, Li R, Powell EL, Jackson-Fisher A, Bowers M, Alekar S, Xin X, Tolcher AW, Calvo E
Clin Cancer Res 2021 Aug 15;27(16):4511-4520. Epub 2021 Jun 3 doi: 10.1158/1078-0432.CCR-20-3757. PMID: 34083232Free PMC Article
Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress.
Thomas A, Takahashi N, Rajapakse VN, Zhang X, Sun Y, Ceribelli M, Wilson KM, Zhang Y, Beck E, Sciuto L, Nichols S, Elenbaas B, Puc J, Dahmen H, Zimmermann A, Varonin J, Schultz CW, Kim S, Shimellis H, Desai P, Klumpp-Thomas C, Chen L, Travers J, McKnight C, Michael S, Itkin Z, Lee S, Yuno A, Lee MJ, Redon CE, Kindrick JD, Peer CJ, Wei JS, Aladjem MI, Figg WD, Steinberg SM, Trepel JB, Zenke FT, Pommier Y, Khan J, Thomas CJ
Cancer Cell 2021 Apr 12;39(4):566-579.e7. doi: 10.1016/j.ccell.2021.02.014. PMID: 33848478Free PMC Article
Clinical perspectives on platinum resistance.
Giaccone G
Drugs 2000;59 Suppl 4:9-17; discussion 37-8. doi: 10.2165/00003495-200059004-00002. PMID: 10864226

Recent systematic reviews

Erlotinib or gefitinib for the treatment of relapsed platinum pretreated non-small cell lung cancer and ovarian cancer: a systematic review.
Murphy M, Stordal B
Drug Resist Updat 2011 Jun;14(3):177-90. Epub 2011 Mar 24 doi: 10.1016/j.drup.2011.02.004. PMID: 21435938
Second line treatments in advanced platinum-resistant non small cell lung cancer. A critical review of literature.
Tassinari D, Carloni F, Santelmo C, Tamburini E, Lazzari Agli L, Tombesi P, Sartori S
Rev Recent Clin Trials 2009 Jan;4(1):27-33. doi: 10.2174/157488709787047549. PMID: 19149760

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