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Melanocytic neoplasm

MedGen UID:
224910
•Concept ID:
C1302746
•
Neoplastic Process
Synonyms: Melanocytic Neoplasm; melanocytic neoplasm; melanomas and nevi
SNOMED CT: Melanocytic neoplasm (399956005)
 
Monarch Initiative: MONDO:0021143

Definition

A benign or malignant, primary or metastatic neoplasm affecting the melanocytes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMelanocytic neoplasm

Professional guidelines

PubMed

Management and treatment of mucosal melanoma of the genital tract.
Vaccari S, Barisani A, Dika E, Fanti PA, DE Iaco P, Gurioli C, Tosti G
G Ital Dermatol Venereol 2017 Jun;152(3):270-273. Epub 2017 Jan 24 doi: 10.23736/S0392-0488.17.05573-0. PMID: 28121085
Surgical and histologic pitfalls in the management of lentigo maligna melanoma.
Situm M, Buljan M
G Ital Dermatol Venereol 2012 Feb;147(1):21-7. PMID: 22370566
Lentigo maligna : prognosis and treatment options.
Stevenson O, Ahmed I
Am J Clin Dermatol 2005;6(3):151-64. doi: 10.2165/00128071-200506030-00002. PMID: 15943492

Recent clinical studies

Etiology

Morphologic Diversity of Merkel Cell Carcinoma.
Ogawa T, Donizy P, Wu CL, Cornejo KM, Ryś J, Hoang MP
Am J Dermatopathol 2020 Sep;42(9):629-640. doi: 10.1097/DAD.0000000000001548. PMID: 32833736
Spitz Nevus and Other Spitzoid Tumors in Children -Part 1: Clinical, Histopathologic, and Immunohistochemical Features.
Sainz-Gaspar L, Sánchez-Bernal J, Noguera-Morel L, Hernández-Martín A, Colmenero I, Torrelo A
Actas Dermosifiliogr (Engl Ed) 2020 Jan 2;111(1):7-19. Epub 2019 Nov 28 doi: 10.1016/j.ad.2019.02.011. PMID: 31787210
Black and Brown Oro-facial Mucocutaneous Neoplasms.
Natarajan E
Head Neck Pathol 2019 Mar;13(1):56-70. Epub 2019 Jan 29 doi: 10.1007/s12105-019-01008-2. PMID: 30693458Free PMC Article
C-kit expression of melanocytic neoplasm and association with clinicopathological parameters and anatomic locations in Chinese people.
Lin YC, Chang YM, Ho JY, Lin HC, Tsai YM, Chiang CP, Wang WM, Gao HW
Am J Dermatopathol 2013 Jul;35(5):569-75. doi: 10.1097/DAD.0b013e318279566a. PMID: 23221472
Ancient melanocytic nevus.
Kerl H, Soyer HP, Cerroni L, Wolf IH, Ackerman AB
Semin Diagn Pathol 1998 Aug;15(3):210-5. PMID: 9711671

Diagnosis

Primary sellar melanocytoma.
Claus M, Van Der Linden M, Van Dorpe J, Lapauw B, T'Sjoen G
Pituitary 2021 Dec;24(6):970-977. Epub 2021 Sep 13 doi: 10.1007/s11102-021-01186-9. PMID: 34518998
Morphologic Diversity of Merkel Cell Carcinoma.
Ogawa T, Donizy P, Wu CL, Cornejo KM, Ryś J, Hoang MP
Am J Dermatopathol 2020 Sep;42(9):629-640. doi: 10.1097/DAD.0000000000001548. PMID: 32833736
Black and Brown Oro-facial Mucocutaneous Neoplasms.
Natarajan E
Head Neck Pathol 2019 Mar;13(1):56-70. Epub 2019 Jan 29 doi: 10.1007/s12105-019-01008-2. PMID: 30693458Free PMC Article
Proteomic Mass Spectrometry Imaging for Skin Cancer Diagnosis.
Lazova R, Seeley EH
Dermatol Clin 2017 Oct;35(4):513-519. Epub 2017 Jul 11 doi: 10.1016/j.det.2017.06.012. PMID: 28886807
Ancient melanocytic nevus.
Kerl H, Soyer HP, Cerroni L, Wolf IH, Ackerman AB
Semin Diagn Pathol 1998 Aug;15(3):210-5. PMID: 9711671

Therapy

Incorporation of dermoscopy improves inter-observer agreement among dermatopathologists in histologic assessment of melanocytic neoplasms.
Shi K, Compres E, Walton KE, Mohan LS, Zhang B, Panah E, Quan VL, Garfield EM, Khan AU, Kim D, Yazdan P, Robinson JK, Gerami P
Arch Dermatol Res 2021 Mar;313(2):101-108. Epub 2020 Apr 27 doi: 10.1007/s00403-020-02079-w. PMID: 32338293
Appearance of cutaneous melanoma and subcutaneous metastases in metastatic gastric carcinoma undergoing chemotherapy with oral 5-fluorouracil prodrug.
De Giorgi V, Scarfì F, Trane L, Silvestri F, Maida P, Gori A, Covarelli P
Anticancer Drugs 2019 Nov;30(10):1055-1057. doi: 10.1097/CAD.0000000000000828. PMID: 31609761
Epithelioid and fusiform blue nevus of chronically sun-damaged skin, an entity distinct from the epithelioid blue nevus of the Carney complex.
Yazdan P, Haghighat Z, Guitart J, Gerami P
Am J Surg Pathol 2013 Jan;37(1):81-8. doi: 10.1097/PAS.0b013e3182608fa5. PMID: 22892599
Update in molecular diagnostics in melanocytic neoplasms.
Cooper C, Sorrell J, Gerami P
Adv Anat Pathol 2012 Nov;19(6):410-6. doi: 10.1097/PAP.0b013e318271a5cb. PMID: 23060066
Lentigo maligna : prognosis and treatment options.
Stevenson O, Ahmed I
Am J Clin Dermatol 2005;6(3):151-64. doi: 10.2165/00128071-200506030-00002. PMID: 15943492

Prognosis

Integrative histopathological and immunophenotypical characterisation of the inflammatory microenvironment in spitzoid melanocytic neoplasms.
Hillen LM, Vandyck HLD, Leunissen DJG, de Greef BTA, Bosisio FM, Zur Hausen A, van den Oord J, Winnepenninckx V
Histopathology 2021 Mar;78(4):607-626. Epub 2020 Nov 19 doi: 10.1111/his.14259. PMID: 32970867Free PMC Article
Morphologic Diversity of Merkel Cell Carcinoma.
Ogawa T, Donizy P, Wu CL, Cornejo KM, Ryś J, Hoang MP
Am J Dermatopathol 2020 Sep;42(9):629-640. doi: 10.1097/DAD.0000000000001548. PMID: 32833736
Proteomic Mass Spectrometry Imaging for Skin Cancer Diagnosis.
Lazova R, Seeley EH
Dermatol Clin 2017 Oct;35(4):513-519. Epub 2017 Jul 11 doi: 10.1016/j.det.2017.06.012. PMID: 28886807
Lentigo maligna : prognosis and treatment options.
Stevenson O, Ahmed I
Am J Clin Dermatol 2005;6(3):151-64. doi: 10.2165/00128071-200506030-00002. PMID: 15943492
Ancient melanocytic nevus.
Kerl H, Soyer HP, Cerroni L, Wolf IH, Ackerman AB
Semin Diagn Pathol 1998 Aug;15(3):210-5. PMID: 9711671

Clinical prediction guides

Beyond typical histology of BAP1-inactivated melanocytoma.
Donati M, Kazakov DV
Pathol Res Pract 2024 Jul;259:155162. Epub 2024 Jan 24 doi: 10.1016/j.prp.2024.155162. PMID: 38326181
Morphologic Diversity of Merkel Cell Carcinoma.
Ogawa T, Donizy P, Wu CL, Cornejo KM, Ryś J, Hoang MP
Am J Dermatopathol 2020 Sep;42(9):629-640. doi: 10.1097/DAD.0000000000001548. PMID: 32833736
Proteomic Mass Spectrometry Imaging for Skin Cancer Diagnosis.
Lazova R, Seeley EH
Dermatol Clin 2017 Oct;35(4):513-519. Epub 2017 Jul 11 doi: 10.1016/j.det.2017.06.012. PMID: 28886807
C-kit expression of melanocytic neoplasm and association with clinicopathological parameters and anatomic locations in Chinese people.
Lin YC, Chang YM, Ho JY, Lin HC, Tsai YM, Chiang CP, Wang WM, Gao HW
Am J Dermatopathol 2013 Jul;35(5):569-75. doi: 10.1097/DAD.0b013e318279566a. PMID: 23221472
Spitz naevus: diagnostic problems and their management implications.
Dahlstrom JE, Scolyer RA, Thompson JF, Jain S
Pathology 2004 Oct;36(5):452-7. doi: 10.1080/00313020412331285318. PMID: 15370115

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