U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Congenital Melanocytic Nevus

MedGen UID:
272090
•Concept ID:
C1318558
•
Neoplastic Process
Synonyms: Congenital dermal melanocytic nevus; Congenital melanocytic nevus; Congenital melanocytic nevus of skin; Congenital Melanocytic Nevus of Skin; Congenital Melanocytic Nevus of the Skin; Congenital Nevus of Skin; Congenital Nevus of the Skin; Congenital pigmented melanocytic nevus; Congenital pigmented melanocytic nevus of skin; Congenital pigmented nevus; Congenital pigmented nevus of skin; Congenital Pigmented Nevus of Skin; Congenital Pigmented Nevus of the Skin; Congenital Pigmented Skin Nevus; Congenital Skin Nevus
SNOMED CT: Congenital pigmented melanocytic nevus (398696001); Congenital pigmented melanocytic nevus of skin (398943008); Congenital melanocytic nevus (400151006); Congenital melanocytic nevus (398696001); Congenital pigmented nevus (398696001); Congenital dermal melanocytic nevus (398943008); Congenital melanocytic nevus of skin (398943008); Congenital pigmented nevus of skin (398943008)

Definition

A melanocytic nevus that is present at birth. It may present as a small macular, papular, or plaque-like lesion or as a large brown to black hairy skin lesion. [from NCI]

Professional guidelines

PubMed

Comparison of three different surgical approaches for the treatment of large/giant congenital melanocytic nevus.
Cheng X, Wang W, He Y, Bao W, Jia C, Dai T
J Cosmet Dermatol 2022 Oct;21(10):4609-4616. Epub 2022 Jul 19 doi: 10.1111/jocd.15219. PMID: 35810351
Treatment of maxillofacial congenital melanocytic nevus with percutaneous radiofrequency thermal ablation: A case series study.
Wang X, Chen W, Xie H, Jiang T, Weng C, Zhang Z, Lin X, Gao Y
Dermatol Ther 2021 Mar;34(2):e14876. Epub 2021 Feb 21 doi: 10.1111/dth.14876. PMID: 33583124
Laser treatment of congenital melanocytic nevi: a review of the literature.
Bray FN, Shah V, Nouri K
Lasers Med Sci 2016 Jan;31(1):197-204. Epub 2015 Nov 12 doi: 10.1007/s10103-015-1833-3. PMID: 26563957

Recent clinical studies

Etiology

Newborn Skin: Part II. Birthmarks.
Snyder KAM, Voelckers AD
Am Fam Physician 2024 Mar;109(3):217-221. PMID: 38574211
Germline genomic findings in children and young adults with melanocytic tumors.
Nagel MB, Perrino MR, Nuccio R, Blake AK, Harrison L, Nichols KE, Pappo AS
Pediatr Blood Cancer 2023 Jul;70(7):e30361. Epub 2023 Apr 19 doi: 10.1002/pbc.30361. PMID: 37073685
Topical therapy for regression and melanoma prevention of congenital giant nevi.
Choi YS, Erlich TH, von Franque M, Rachmin I, Flesher JL, Schiferle EB, Zhang Y, Pereira da Silva M, Jiang A, Dobry AS, Su M, Germana S, Lacher S, Freund O, Feder E, Cortez JL, Ryu S, Babila Propp T, Samuels YL, Zakka LR, Azin M, Burd CE, Sharpless NE, Liu XS, Meyer C, Austen WG Jr, Bojovic B, Cetrulo CL Jr, Mihm MC, Hoon DS, Demehri S, Hawryluk EB, Fisher DE
Cell 2022 Jun 9;185(12):2071-2085.e12. Epub 2022 May 12 doi: 10.1016/j.cell.2022.04.025. PMID: 35561684Free PMC Article
Imaging of pediatric cutaneous melanoma.
Kaste SC
Pediatr Radiol 2019 Oct;49(11):1476-1487. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04374-9. PMID: 31620848Free PMC Article
Patterns of distribution of giant congenital melanocytic nevi (GCMN): The 6B rule.
Martins da Silva VP, Marghoob A, Pigem R, Carrera C, Aguilera P, Puig-Butillé JA, Puig S, Malvehy J
J Am Acad Dermatol 2017 Apr;76(4):689-694. doi: 10.1016/j.jaad.2016.05.042. PMID: 28325390

Diagnosis

Newborn Skin: Part II. Birthmarks.
Snyder KAM, Voelckers AD
Am Fam Physician 2024 Mar;109(3):217-221. PMID: 38574211
Germline genomic findings in children and young adults with melanocytic tumors.
Nagel MB, Perrino MR, Nuccio R, Blake AK, Harrison L, Nichols KE, Pappo AS
Pediatr Blood Cancer 2023 Jul;70(7):e30361. Epub 2023 Apr 19 doi: 10.1002/pbc.30361. PMID: 37073685
Pigmented Lesions in Children: Update on Clinical, Histopathologic and Ancillary Testing.
Bartenstein Reusch D, Hawryluk EB
Dermatol Clin 2022 Jan;40(1):25-36. Epub 2021 Oct 22 doi: 10.1016/j.det.2021.09.003. PMID: 34799033
Imaging of pediatric cutaneous melanoma.
Kaste SC
Pediatr Radiol 2019 Oct;49(11):1476-1487. Epub 2019 Oct 16 doi: 10.1007/s00247-019-04374-9. PMID: 31620848Free PMC Article
Neurocutaneous melanosis: clinical features of large congenital melanocytic nevi in patients with manifest central nervous system melanosis.
DeDavid M, Orlow SJ, Provost N, Marghoob AA, Rao BK, Wasti Q, Huang CL, Kopf AW, Bart RS
J Am Acad Dermatol 1996 Oct;35(4):529-38. doi: 10.1016/s0190-9622(96)90674-x. PMID: 8859278

Therapy

Psychosocial Experiences in Children With Congenital Melanocytic Nevus on the Face and Their Parents Throughout the Tissue Expansion Treatment.
Zhang C, Wu L, Zhao S, Wang Q, Li T, Wang J
J Craniofac Surg 2022 May 1;33(3):754-758. Epub 2021 Sep 17 doi: 10.1097/SCS.0000000000008151. PMID: 34538792
CO(2) laser treatment of a kissing nevus of the penis: an alternative solution for a rare condition.
Correia B, Duarte AF, Haneke E, Correia O
J Dermatolog Treat 2021 Feb;32(1):120-123. Epub 2019 Jun 26 doi: 10.1080/09546634.2019.1629384. PMID: 31173504
Cutaneous skeletal hypophosphatemia syndrome (CSHS) is a multilineage somatic mosaic RASopathy.
Lim YH, Ovejero D, Derrick KM; Yale Center for Mendelian Genomics, Collins MT, Choate KA
J Am Acad Dermatol 2016 Aug;75(2):420-7. doi: 10.1016/j.jaad.2015.11.012. PMID: 27444071Free PMC Article
Pediatric melanoma, moles, and sun safety.
Hawryluk EB, Liang MG
Pediatr Clin North Am 2014 Apr;61(2):279-91. Epub 2014 Jan 28 doi: 10.1016/j.pcl.2013.11.004. PMID: 24636646
Ondansetron treatment in a child presenting with chronic intractable pruritus.
Frigon C, Desparmet J
Pain Res Manag 2006 Winter;11(4):245-7. doi: 10.1155/2006/873870. PMID: 17149457Free PMC Article

Prognosis

The W-Plasty Serial Excision Method for Treating Medium Congenital Melanocytic Nevi: A Retrospective Analytical Study.
Luo XY, Hu Y, Yang WJ, Song XZ, Peng JZ
Dermatol Surg 2024 Oct 1;50(10):908-912. Epub 2024 May 28 doi: 10.1097/DSS.0000000000004245. PMID: 38809166
Evolutionary processes of melanomas from giant congenital melanocytic nevi.
Lim Y, Shin HT, Choi Y, Lee DY
Pigment Cell Melanoma Res 2020 Mar;33(2):318-325. Epub 2019 Oct 20 doi: 10.1111/pcmr.12829. PMID: 31584755
Age related changes in brain MR appearance in the course of neurocutaneous melanosis.
Bekiesińska-Figatowska M, Sawicka E, Żak K, Szczygielski O
Eur J Radiol 2016 Aug;85(8):1427-31. Epub 2016 May 24 doi: 10.1016/j.ejrad.2016.05.014. PMID: 27423683
Treatment of congenital melanocytic nevi using the combined (normal-mode plus Q-switched) ruby laser in Asians: clinical response in relation to histological type.
Kono T, Erçöçen AR, Nozaki M
Ann Plast Surg 2005 May;54(5):494-501. doi: 10.1097/01.sap.0000154866.01964.8c. PMID: 15838210
Neurocutaneous melanosis: clinical features of large congenital melanocytic nevi in patients with manifest central nervous system melanosis.
DeDavid M, Orlow SJ, Provost N, Marghoob AA, Rao BK, Wasti Q, Huang CL, Kopf AW, Bart RS
J Am Acad Dermatol 1996 Oct;35(4):529-38. doi: 10.1016/s0190-9622(96)90674-x. PMID: 8859278

Clinical prediction guides

The W-Plasty Serial Excision Method for Treating Medium Congenital Melanocytic Nevi: A Retrospective Analytical Study.
Luo XY, Hu Y, Yang WJ, Song XZ, Peng JZ
Dermatol Surg 2024 Oct 1;50(10):908-912. Epub 2024 May 28 doi: 10.1097/DSS.0000000000004245. PMID: 38809166
Newborn Skin: Part II. Birthmarks.
Snyder KAM, Voelckers AD
Am Fam Physician 2024 Mar;109(3):217-221. PMID: 38574211
Evolutionary processes of melanomas from giant congenital melanocytic nevi.
Lim Y, Shin HT, Choi Y, Lee DY
Pigment Cell Melanoma Res 2020 Mar;33(2):318-325. Epub 2019 Oct 20 doi: 10.1111/pcmr.12829. PMID: 31584755
Patterns of distribution of giant congenital melanocytic nevi (GCMN): The 6B rule.
Martins da Silva VP, Marghoob A, Pigem R, Carrera C, Aguilera P, Puig-Butillé JA, Puig S, Malvehy J
J Am Acad Dermatol 2017 Apr;76(4):689-694. doi: 10.1016/j.jaad.2016.05.042. PMID: 28325390
Giant congenital melanocytic nevi.
Arneja JS, Gosain AK
Plast Reconstr Surg 2007 Aug;120(2):26e-40e. doi: 10.1097/01.prs.0000267583.63342.0a. PMID: 17632335

Recent systematic reviews

Treatments of palpebral congenital melanocytic nevus: a systematic review.
Camargo CP, Saliba M, Saad EA, Milan M, Caldera JM
Acta Cir Bras 2023;38:e384823. Epub 2023 Dec 1 doi: 10.1590/acb384823. PMID: 38055392Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...