U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Conjunctival Junctional Nevus

MedGen UID:
1761774
•Concept ID:
C5420767
•
Neoplastic Process

Definition

A junctional nevus that arises from the conjunctiva. It occurs almost exclusively in the juxtalimbal bulbar conjunctiva. It is characterized by an intraepithelial proliferation of type A nevus cells and/ or type B nevus cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVConjunctival Junctional Nevus

Recent clinical studies

Etiology

Clinical and immunohistopathological study of conjunctival melanocytic lesions in pediatric and adolescent patients. A case series.
Bogdănici CM, Costea CF, Dumitrescu GF, Sava A, Ciobanu Apostol DG, Scripcariu DV, Nicoară SD, Tănase DM, Andriescu EC, Cărăuleanu A, Danciu M, Sălăvăstru SC, Schmitzer S, Cucu AI, Niagu IA
Rom J Morphol Embryol 2021 Oct-Dec;62(4):907-915. doi: 10.47162/RJME.62.4.03. PMID: 35673810Free PMC Article
Survey of 138 Conjunctival Tumors in the Dominican Republic.
Pellerano F, Gil G, Rosario A, Mañon N, Vargas T, Vizcaíno G
Ophthalmic Epidemiol 2020 Aug;27(4):278-282. Epub 2020 Feb 17 doi: 10.1080/09286586.2020.1730912. PMID: 32066308
Inflammatory juvenile compound conjunctival nevi. A clinicopathological study and literature review.
Costea CF, Turliuc MD, Dimitriu G, Bogdănici CM, MoŢoc A, Chihaia MA, Dancă C, Cucu A, Cărăuleanu A, Dumitrescu N, Indrei L, Turliuc Ş
Rom J Morphol Embryol 2017;58(3):739-747. PMID: 29250649
Clinicopathological characteristics and surgical outcomes of divided nevus of the eyelids: a decade's experience on 73 cases.
Jia R, Zhu H, Lin M, Li Z, Sun Y, Luo M, Fan X
Ann Plast Surg 2012 Feb;68(2):166-70. doi: 10.1097/SAP.0b013e3182119155. PMID: 21629103
Clinicopathologic characteristics of premalignant and malignant melanocytic lesions of the conjunctiva.
Jakobiec FA, Folberg R, Iwamoto T
Ophthalmology 1989 Feb;96(2):147-66. doi: 10.1016/s0161-6420(89)32920-4. PMID: 2649838

Diagnosis

Clinical and immunohistopathological study of conjunctival melanocytic lesions in pediatric and adolescent patients. A case series.
Bogdănici CM, Costea CF, Dumitrescu GF, Sava A, Ciobanu Apostol DG, Scripcariu DV, Nicoară SD, Tănase DM, Andriescu EC, Cărăuleanu A, Danciu M, Sălăvăstru SC, Schmitzer S, Cucu AI, Niagu IA
Rom J Morphol Embryol 2021 Oct-Dec;62(4):907-915. doi: 10.47162/RJME.62.4.03. PMID: 35673810Free PMC Article
Survey of 138 Conjunctival Tumors in the Dominican Republic.
Pellerano F, Gil G, Rosario A, Mañon N, Vargas T, Vizcaíno G
Ophthalmic Epidemiol 2020 Aug;27(4):278-282. Epub 2020 Feb 17 doi: 10.1080/09286586.2020.1730912. PMID: 32066308
Clinicopathological characteristics and surgical outcomes of divided nevus of the eyelids: a decade's experience on 73 cases.
Jia R, Zhu H, Lin M, Li Z, Sun Y, Luo M, Fan X
Ann Plast Surg 2012 Feb;68(2):166-70. doi: 10.1097/SAP.0b013e3182119155. PMID: 21629103
Bilateral conjunctival melanocytic nevi of simultaneous onset simulating conjunctivitis in a child.
Jakobiec FA, Sandhu H, Bhat P, Colby K
Cornea 2010 Aug;29(8):937-40. doi: 10.1097/ICO.0b013e3181c84480. PMID: 20508514
Benign conjunctival melanocytic lesions. Clinicopathologic features.
Folberg R, Jakobiec FA, Bernardino VB, Iwamoto T
Ophthalmology 1989 Apr;96(4):436-61. doi: 10.1016/s0161-6420(89)32878-8. PMID: 2657539

Therapy

Clinicopathological characteristics and surgical outcomes of divided nevus of the eyelids: a decade's experience on 73 cases.
Jia R, Zhu H, Lin M, Li Z, Sun Y, Luo M, Fan X
Ann Plast Surg 2012 Feb;68(2):166-70. doi: 10.1097/SAP.0b013e3182119155. PMID: 21629103

Prognosis

Survey of 138 Conjunctival Tumors in the Dominican Republic.
Pellerano F, Gil G, Rosario A, Mañon N, Vargas T, Vizcaíno G
Ophthalmic Epidemiol 2020 Aug;27(4):278-282. Epub 2020 Feb 17 doi: 10.1080/09286586.2020.1730912. PMID: 32066308
Clinicopathological characteristics and surgical outcomes of divided nevus of the eyelids: a decade's experience on 73 cases.
Jia R, Zhu H, Lin M, Li Z, Sun Y, Luo M, Fan X
Ann Plast Surg 2012 Feb;68(2):166-70. doi: 10.1097/SAP.0b013e3182119155. PMID: 21629103
Conjunctival nevi: clinical features and natural course in 410 consecutive patients.
Shields CL, Fasiuddin AF, Mashayekhi A, Shields JA
Arch Ophthalmol 2004 Feb;122(2):167-75. doi: 10.1001/archopht.122.2.167. PMID: 14769591
Pigmented conjunctival and scleral lesions.
Liesegang TJ
Mayo Clin Proc 1994 Feb;69(2):151-61. doi: 10.1016/s0025-6196(12)61042-8. PMID: 8309267
Conjunctival melanocytic lesions. Natural history.
Henkind P, Benjamin JV
Trans Ophthalmol Soc U K (1962) 1977 Sep;97(3):373-7. PMID: 273993

Clinical prediction guides

Superficial Wnt-Activated Melanocytic Nevi/Melanocytomas With a Junctional Component: A Case Series.
Ng S, Hall KC, Busam KJ, Lezcano C, Moy AP, Pulitzer M, Sriharan A, Yan S, Linos K
Am J Dermatopathol 2024 Oct 1;46(10):648-652. Epub 2024 Aug 14 doi: 10.1097/DAD.0000000000002804. PMID: 39141718
Clinical and immunohistopathological study of conjunctival melanocytic lesions in pediatric and adolescent patients. A case series.
Bogdănici CM, Costea CF, Dumitrescu GF, Sava A, Ciobanu Apostol DG, Scripcariu DV, Nicoară SD, Tănase DM, Andriescu EC, Cărăuleanu A, Danciu M, Sălăvăstru SC, Schmitzer S, Cucu AI, Niagu IA
Rom J Morphol Embryol 2021 Oct-Dec;62(4):907-915. doi: 10.47162/RJME.62.4.03. PMID: 35673810Free PMC Article
Caruncular late-onset junctional nevus: apropos of an anatomo-clinical observation.
Boruga O, Bălăşoiu AT, Giuri S, Munteanu M, Stanca HT, Iovănescu G, Preda MA
Rom J Morphol Embryol 2017;58(4):1461-1464. PMID: 29556641
Conjunctival nevi: clinical features and natural course in 410 consecutive patients.
Shields CL, Fasiuddin AF, Mashayekhi A, Shields JA
Arch Ophthalmol 2004 Feb;122(2):167-75. doi: 10.1001/archopht.122.2.167. PMID: 14769591
Conjunctival naevi in Denmark 1960-1980. A 21-year follow-up study.
Gerner N, Nørregaard JC, Jensen OA, Prause JU
Acta Ophthalmol Scand 1996 Aug;74(4):334-7. doi: 10.1111/j.1600-0420.1996.tb00703.x. PMID: 8883545

Supplemental Content

Table of contents

    Practice guidelines

    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...