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Central nervous system melanocytic neoplasm

MedGen UID:
232333
•Concept ID:
C1332887
•
Neoplastic Process
Synonyms: Central Nervous System Melanocytic Neoplasm; central nervous system melanocytic neoplasm; Central Nervous System Melanocytic Neoplasms; central nervous system melanocytic neoplasms; Central Nervous System Melanocytic Tumor; central nervous system melanocytic tumor; central nervous system melanocytic tumour; central nervous system primary melanocytic lesion; CNS Melanocytic Neoplasm; CNS melanocytic neoplasm; CNS Melanocytic Tumor; CNS melanocytic tumor; CNS melanocytic tumour; Melanocytic Neoplasm of Central Nervous System; melanocytic neoplasm of central nervous system; Melanocytic Neoplasm of CNS; melanocytic neoplasm of CNS; Melanocytic Neoplasm of the Central Nervous System; melanocytic neoplasm of the central nervous system; Melanocytic Neoplasm of the CNS; melanocytic neoplasm of the CNS; Melanocytic Tumor of Central Nervous System; melanocytic tumor of central nervous system; Melanocytic Tumor of CNS; melanocytic tumor of CNS; Melanocytic Tumor of the Central Nervous System; melanocytic tumor of the central nervous system; Melanocytic Tumor of the CNS; melanocytic tumor of the CNS; melanocytic tumour of central nervous system; melanocytic tumour of CNS; melanocytic tumour of the central nervous system; melanocytic tumour of the CNS; primary melanocytic lesion of meninges; primary melanocytic lesions of the CNS
 
Monarch Initiative: MONDO:0003222

Definition

A primary tumor of the central nervous system that arises from leptomeningeal melanocytes. It may present as a diffuse proliferative leptomeningeal process (often as a component of the neurocutaneous melanosis complex) or as a distinct mass lesion. [from NCI]

Professional guidelines

PubMed

Care of Congenital Melanocytic Nevi in Newborns and Infants: Review and Management Recommendations.
Jahnke MN, O'Haver J, Gupta D, Hawryluk EB, Finelt N, Kruse L, Jen M, Horii KA, Frieden IJ, Price H, Coughlin CC
Pediatrics 2021 Dec 1;148(6) doi: 10.1542/peds.2021-051536. PMID: 34845496
Clinical Follow-Up of Patients with Neurocutaneous Melanosis in a Tertiary Center; Proposed Modification in Diagnostic Criteria.
Habibi Z, Ebrahimi H, Meybodi KT, Yaghmaei B, Nejat F
World Neurosurg 2021 Feb;146:e1063-e1070. Epub 2020 Nov 24 doi: 10.1016/j.wneu.2020.11.091. PMID: 33246180
Primary sellar melanocytoma: pathological, clinical and treatment review.
Albano L, Losa M, Barzaghi LR, Spatola G, Panni P, Terreni MR, Mortini P
J Endocrinol Invest 2020 May;43(5):575-585. Epub 2019 Dec 3 doi: 10.1007/s40618-019-01158-8. PMID: 31797309

Recent clinical studies

Etiology

Melanocytic lesions of the central nervous system: a case series.
Varela-Poblete J, Vidal-Tellez A, Cruz-Quiroga JP, Montoya-Salvadores F, Medina-Escobar J
Arq Neuropsiquiatr 2022 Feb;80(2):153-160. doi: 10.1590/0004-282X-ANP-2021-0082. PMID: 35352754Free PMC Article
SOX10: 20 years of phenotypic plurality and current understanding of its developmental function.
Pingault V, Zerad L, Bertani-Torres W, Bondurand N
J Med Genet 2022 Feb;59(2):105-114. Epub 2021 Oct 19 doi: 10.1136/jmedgenet-2021-108105. PMID: 34667088Free PMC Article
Care of Congenital Melanocytic Nevi in Newborns and Infants: Review and Management Recommendations.
Jahnke MN, O'Haver J, Gupta D, Hawryluk EB, Finelt N, Kruse L, Jen M, Horii KA, Frieden IJ, Price H, Coughlin CC
Pediatrics 2021 Dec 1;148(6) doi: 10.1542/peds.2021-051536. PMID: 34845496
Melanoma in congenital melanocytic naevi.
Kinsler VA, O'Hare P, Bulstrode N, Calonje JE, Chong WK, Hargrave D, Jacques T, Lomas D, Sebire NJ, Slater O
Br J Dermatol 2017 May;176(5):1131-1143. Epub 2017 Apr 4 doi: 10.1111/bjd.15301. PMID: 28078671Free PMC Article
Neurocutaneous melanosis.
Islam MP
Handb Clin Neurol 2015;132:111-7. doi: 10.1016/B978-0-444-62702-5.00007-X. PMID: 26564074

Diagnosis

Dural and Leptomeningeal Diseases: Anatomy, Causes, and Neuroimaging Findings.
Kurokawa R, Kurokawa M, Isshiki S, Harada T, Nakaya M, Baba A, Naganawa S, Kim J, Bapuraj J, Srinivasan A, Abe O, Moritani T
Radiographics 2023 Aug;43(9):e230039. doi: 10.1148/rg.230039. PMID: 37535461
SOX10: 20 years of phenotypic plurality and current understanding of its developmental function.
Pingault V, Zerad L, Bertani-Torres W, Bondurand N
J Med Genet 2022 Feb;59(2):105-114. Epub 2021 Oct 19 doi: 10.1136/jmedgenet-2021-108105. PMID: 34667088Free PMC Article
Care of Congenital Melanocytic Nevi in Newborns and Infants: Review and Management Recommendations.
Jahnke MN, O'Haver J, Gupta D, Hawryluk EB, Finelt N, Kruse L, Jen M, Horii KA, Frieden IJ, Price H, Coughlin CC
Pediatrics 2021 Dec 1;148(6) doi: 10.1542/peds.2021-051536. PMID: 34845496
Primary sellar melanocytoma.
Claus M, Van Der Linden M, Van Dorpe J, Lapauw B, T'Sjoen G
Pituitary 2021 Dec;24(6):970-977. Epub 2021 Sep 13 doi: 10.1007/s11102-021-01186-9. PMID: 34518998
Neurocutaneous melanosis.
Islam MP
Handb Clin Neurol 2015;132:111-7. doi: 10.1016/B978-0-444-62702-5.00007-X. PMID: 26564074

Therapy

MC1R Functions, Expression, and Implications for Targeted Therapy.
Guida S, Guida G, Goding CR
J Invest Dermatol 2022 Feb;142(2):293-302.e1. Epub 2021 Aug 4 doi: 10.1016/j.jid.2021.06.018. PMID: 34362555
Neuroendocrine factors: The missing link in non‑melanoma skin cancer (Review).
Lupu M, Caruntu A, Caruntu C, Papagheorghe LML, Ilie MA, Voiculescu V, Boda D, Constantin C, Tanase C, Sifaki M, Drakoulis N, Mamoulakis C, Tzanakakis G, Neagu M, Spandidos DA, Izotov BN, Tsatsakis AM
Oncol Rep 2017 Sep;38(3):1327-1340. Epub 2017 Jul 13 doi: 10.3892/or.2017.5817. PMID: 28713981Free PMC Article
Congenital Glioblastoma multiforme and eruptive disseminated Spitz nevi.
Mandel VD, Persechino F, Berardi A, Ponti G, Ciardo S, Rossi C, Pellacani G, Farnetani F
Ital J Pediatr 2016 May 14;42(1):47. doi: 10.1186/s13052-016-0260-9. PMID: 27180150Free PMC Article
Dermal melanocytosis and associated disorders.
Franceschini D, Dinulos JG
Curr Opin Pediatr 2015 Aug;27(4):480-5. doi: 10.1097/MOP.0000000000000247. PMID: 26087431
Neurotrophic effects of ACTH/MSH neuropeptides.
de Wied D
Acta Neurobiol Exp (Wars) 1990;50(4-5):353-66. PMID: 1966658

Prognosis

Melanoma on congenital melanocytic nevi.
Alos L, Carrasco A, Teixidó C, Szumera-Ciećkiewicz A, Vicente A, Massi D, Carrera C
Pathol Res Pract 2024 Apr;256:155262. Epub 2024 Mar 11 doi: 10.1016/j.prp.2024.155262. PMID: 38518732
Melanocytic lesions of the central nervous system: a case series.
Varela-Poblete J, Vidal-Tellez A, Cruz-Quiroga JP, Montoya-Salvadores F, Medina-Escobar J
Arq Neuropsiquiatr 2022 Feb;80(2):153-160. doi: 10.1590/0004-282X-ANP-2021-0082. PMID: 35352754Free PMC Article
Neurocutaneous melanosis.
Islam MP
Handb Clin Neurol 2015;132:111-7. doi: 10.1016/B978-0-444-62702-5.00007-X. PMID: 26564074
Primary leptomeningeal melanoma.
Xie ZY, Hsieh KL, Tsang YM, Cheung WK, Hsieh CH
J Clin Neurosci 2014 Jun;21(6):1051-2. Epub 2013 Oct 23 doi: 10.1016/j.jocn.2013.08.018. PMID: 24331626
Neurocutaneous melanosis.
Burstein F, Seier H, Hudgins PA, Zapiach L
J Craniofac Surg 2005 Sep;16(5):874-6. doi: 10.1097/01.scs.0000181050.06696.4d. PMID: 16192875

Clinical prediction guides

Congenital melanocytic nevus syndrome: An association between congenital melanocytic nevi and neurological abnormalities.
Ruth J
Semin Pediatr Neurol 2024 Oct;51:101153. Epub 2024 Sep 13 doi: 10.1016/j.spen.2024.101153. PMID: 39389659
SOX10: 20 years of phenotypic plurality and current understanding of its developmental function.
Pingault V, Zerad L, Bertani-Torres W, Bondurand N
J Med Genet 2022 Feb;59(2):105-114. Epub 2021 Oct 19 doi: 10.1136/jmedgenet-2021-108105. PMID: 34667088Free PMC Article
Imaging and Clinical Features of Neurocutaneous Melanosis in the Pediatric Population.
Mormina E, Granata F, Vinci SL, Coglitore A, Caragliano AA, Tessitore A, Longo M, Visalli C
Curr Med Imaging 2021;17(12):1391-1402. doi: 10.2174/1573405617666210527091109. PMID: 34047260
Neuroendocrine factors: The missing link in non‑melanoma skin cancer (Review).
Lupu M, Caruntu A, Caruntu C, Papagheorghe LML, Ilie MA, Voiculescu V, Boda D, Constantin C, Tanase C, Sifaki M, Drakoulis N, Mamoulakis C, Tzanakakis G, Neagu M, Spandidos DA, Izotov BN, Tsatsakis AM
Oncol Rep 2017 Sep;38(3):1327-1340. Epub 2017 Jul 13 doi: 10.3892/or.2017.5817. PMID: 28713981Free PMC Article
Congenital melanocytic nevus: two clinicopathological forms.
Magaña M, Sánchez-Romero E, Magaña P, Beck-Magaña A, Magaña-Lozano M
Am J Dermatopathol 2015 Jan;37(1):31-7. doi: 10.1097/DAD.0000000000000183. PMID: 25140664

Recent systematic reviews

A state-of-the-art systematic review of cancer in hidradenitis suppurativa.
Abu Rached N, Rüth J, Gambichler T, Ocker L, Bechara FG
Ann Med 2024 Dec;56(1):2382372. Epub 2024 Jul 24 doi: 10.1080/07853890.2024.2382372. PMID: 39046819Free PMC Article
Neurological signs, symptoms and MRI abnormalities in patients with congenital melanocytic naevi and evaluation of routine MRI-screening: systematic review and meta-analysis.
Fledderus AC, Widdershoven AL, Lapid O, Breugem CC, Pasmans SGMA, van der Horst CMAM, Engelen MM, Spuls PI
Orphanet J Rare Dis 2022 Mar 2;17(1):95. doi: 10.1186/s13023-022-02234-8. PMID: 35236387Free PMC Article
Epilepsy in isolated parenchymal neurocutaneous melanosis: A systematic review.
Pellino G, Gencarelli J, Bertelli S, Russo A, Fiumana E, Faggioli R
Epilepsy Behav 2020 Jun;107:107061. Epub 2020 Apr 6 doi: 10.1016/j.yebeh.2020.107061. PMID: 32272368

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