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Nevus of Female Genitalia

MedGen UID:
273581
•Concept ID:
C1518315
•
Neoplastic Process

Definition

A nevus that arises from the female genital organs. This category includes congenital nevus, acquired nevus, dysplastic nevus, blue nevus, and atypical melanocytic nevus of the genital type. [from NCI]

Recent clinical studies

Etiology

PRAME Immunohistochemistry for Distinguishing Vulvar and Vaginal Melanoma From Benign Melanocytic Nevi.
Martin SD, Martin KC, Gilks CB, Crawford RI, Hoang LN
Int J Gynecol Pathol 2024 Jul 1;43(4):389-396. Epub 2023 Dec 6 doi: 10.1097/PGP.0000000000001004. PMID: 38085951
Linear lesions in dermatology: a clinicoaetiopathological study.
Das A, Mohanty S, Gharami RC, Chowdhury SN, Kumar P, Das NK, Bandyopadhyay D
Clin Exp Dermatol 2021 Dec;46(8):1452-1461. Epub 2021 Jul 6 doi: 10.1111/ced.14753. PMID: 34022084
A rare case of nevus sebaceous of the bilateral labia minora: A case report and review of literature.
Wen Q, Zhao Z, Yang Y, Zhao F, Wang L, Cheng J, Wu J, Miao Y
Medicine (Baltimore) 2021 Mar 12;100(10):e25047. doi: 10.1097/MD.0000000000025047. PMID: 33725889Free PMC Article
Nonoverlapping Clinical and Mutational Patterns in Melanomas from the Female Genital Tract and Atypical Genital Nevi.
Yélamos O, Merkel EA, Sholl LM, Zhang B, Amin SM, Lee CY, Guitart GE, Yang J, Wenzel AT, Bunick CG, Yazdan P, Choi J, Gerami P
J Invest Dermatol 2016 Sep;136(9):1858-1865. Epub 2016 May 21 doi: 10.1016/j.jid.2016.05.094. PMID: 27220476Free PMC Article
Pigmented lesions of the vulva.
Venkatesan A
Dermatol Clin 2010 Oct;28(4):795-805. doi: 10.1016/j.det.2010.08.007. PMID: 20883921

Diagnosis

Linear lesions in dermatology: a clinicoaetiopathological study.
Das A, Mohanty S, Gharami RC, Chowdhury SN, Kumar P, Das NK, Bandyopadhyay D
Clin Exp Dermatol 2021 Dec;46(8):1452-1461. Epub 2021 Jul 6 doi: 10.1111/ced.14753. PMID: 34022084
Vulvar Neoplasms, Benign and Malignant.
Allbritton JI
Obstet Gynecol Clin North Am 2017 Sep;44(3):339-352. doi: 10.1016/j.ogc.2017.04.002. PMID: 28778635
Nonoverlapping Clinical and Mutational Patterns in Melanomas from the Female Genital Tract and Atypical Genital Nevi.
Yélamos O, Merkel EA, Sholl LM, Zhang B, Amin SM, Lee CY, Guitart GE, Yang J, Wenzel AT, Bunick CG, Yazdan P, Choi J, Gerami P
J Invest Dermatol 2016 Sep;136(9):1858-1865. Epub 2016 May 21 doi: 10.1016/j.jid.2016.05.094. PMID: 27220476Free PMC Article
Benign Tumors and Tumor-like Lesions of the Vulva.
Heller DS
Clin Obstet Gynecol 2015 Sep;58(3):526-35. doi: 10.1097/GRF.0000000000000133. PMID: 26125957
Pigmented lesions of the vulva.
Venkatesan A
Dermatol Clin 2010 Oct;28(4):795-805. doi: 10.1016/j.det.2010.08.007. PMID: 20883921

Therapy

Vulval and perianal inflammatory linear verrucous epidermal naevus.
Le K, Wong LC, Fischer G
Australas J Dermatol 2009 May;50(2):115-7. doi: 10.1111/j.1440-0960.2009.00518.x. PMID: 19397564
Birthmarks and transient skin lesions in newborns and their relationship to maternal factors: a preliminary report from northern Italy.
Boccardi D, Menni S, Ferraroni M, Stival G, Bernardo L, La Vecchia C, Decarli A
Dermatology 2007;215(1):53-8. doi: 10.1159/000102034. PMID: 17587840
High frequency of BRAFV600E mutation in acquired nevi and small congenital nevi, but low frequency of mutation in medium-sized congenital nevi.
Ichii-Nakato N, Takata M, Takayanagi S, Takashima S, Lin J, Murata H, Fujimoto A, Hatta N, Saida T
J Invest Dermatol 2006 Sep;126(9):2111-8. Epub 2006 May 11 doi: 10.1038/sj.jid.5700366. PMID: 16691193
Prevalence and anatomical distribution of naevi in young Queensland children.
Whiteman DC, Brown RM, Purdie DM, Hughes MC
Int J Cancer 2003 Oct 10;106(6):930-3. doi: 10.1002/ijc.11293. PMID: 12918072
Dysplastic nevi, cutaneous melanoma, and gynecologic disorders.
Frisch RE, Wyshak G, Albert LS, Sober AJ
Int J Dermatol 1992 May;31(5):331-5. doi: 10.1111/j.1365-4362.1992.tb03948.x. PMID: 1587661

Prognosis

Blue nevus-like melanoma of the uterine cervix. Case report and review of the literature.
Eniu DT, Staicu A, Şomcutian O, Buiga R, Albu C, Goidescu IG, Chiorean AR, Nistor-Ciurba CC
Rom J Morphol Embryol 2019;60(4):1317-1321. PMID: 32239111
Melanocytic Nevi of Special Sites.
Ahn CS, Guerra A, Sangüeza OP
Am J Dermatopathol 2016 Dec;38(12):867-881. doi: 10.1097/DAD.0000000000000568. PMID: 27870726
The spectrum of grossly visible pigmented lesions in the uterine cervix: a prospective study.
Tran TA, Niu G, Tomasello CA, Tran HV, Ross JS, Carlson JA
Int J Gynecol Pathol 2014 Jan;33(1):89-99. doi: 10.1097/PGP.0b013e31827c6343. PMID: 24300541
Pigmented epithelioid melanocytoma: favorable outcome after 5-year follow-up.
Mandal RV, Murali R, Lundquist KF, Ragsdale BD, Heenan P, McCarthy SW, Mihm MC Jr, Scolyer RA, Zembowicz A
Am J Surg Pathol 2009 Dec;33(12):1778-82. doi: 10.1097/PAS.0b013e3181b94f3c. PMID: 19773637
Melanocytic lesions of the genital area with attention given to atypical genital nevi.
Ribé A
J Cutan Pathol 2008 Nov;35 Suppl 2:24-7. doi: 10.1111/j.1600-0560.2008.01150.x. PMID: 18976416

Clinical prediction guides

Dermoscopy of pigmented lesions of the vulva: a retrospective morphological study.
Ferrari A, Zalaudek I, Argenziano G, Buccini P, De Simone P, Silipo V, Eibenschutz L, Mariani G, Covello R, Sperduti I, Mariani L, Catricalà C
Dermatology 2011;222(2):157-66. Epub 2011 Feb 9 doi: 10.1159/000323409. PMID: 21311169
Pigmented epithelioid melanocytoma: favorable outcome after 5-year follow-up.
Mandal RV, Murali R, Lundquist KF, Ragsdale BD, Heenan P, McCarthy SW, Mihm MC Jr, Scolyer RA, Zembowicz A
Am J Surg Pathol 2009 Dec;33(12):1778-82. doi: 10.1097/PAS.0b013e3181b94f3c. PMID: 19773637
Melanocytic lesions of the genital area with attention given to atypical genital nevi.
Ribé A
J Cutan Pathol 2008 Nov;35 Suppl 2:24-7. doi: 10.1111/j.1600-0560.2008.01150.x. PMID: 18976416
LEOPARD syndrome: what are café noir spots?
Rodríguez-Bujaldón A, Vazquez-Bayo C, Jimenez-Puya R, Galan-Gutierrez M, Moreno-Gimenez J, Rodriguez-Garcia A, Tercedor J, Velez-Garcia A
Pediatr Dermatol 2008 Jul-Aug;25(4):444-8. doi: 10.1111/j.1525-1470.2008.00734.x. PMID: 18789084
Vascular nevi in children.
Senthilkumar M, Thappa DM
Indian J Dermatol Venereol Leprol 2006 Jan-Feb;72(1):19-23. doi: 10.4103/0378-6323.19712. PMID: 16481704

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