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Leptomeningeal melanoma

MedGen UID:
272793
•Concept ID:
C1334386
•
Neoplastic Process
Synonyms: Leptomeningeal Melanoma; leptomeningeal melanoma; leptomeninx melanoma; leptomeninx melanoma (disease); malignant melanoma of meninges; melanoma (disease) of leptomeninx; Melanoma of Leptomeninges; melanoma of leptomeninges; Melanoma of the Leptomeninges; melanoma of the leptomeninges; Meningeal Melanoma; Meningeal melanoma; meningeal melanoma
SNOMED CT: Meningeal melanoma (726420002)
 
Monarch Initiative: MONDO:0003761

Definition

A melanoma that arises from leptomeningeal melanocytes. [from NCI]

Professional guidelines

PubMed

Advances in Diagnosis and Treatment for Leptomeningeal Disease in Melanoma.
Piña Y, Yadugiri S, Yeboa DN, Ferguson SD, Forsyth PA, Oliva ICG
Curr Oncol Rep 2022 Jan;24(1):43-54. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01162-3. PMID: 35059999
Malignant Melanoma: Skin Cancer-Diagnosis, Prevention, and Treatment.
Ahmed B, Qadir MI, Ghafoor S
Crit Rev Eukaryot Gene Expr 2020;30(4):291-297. doi: 10.1615/CritRevEukaryotGeneExpr.2020028454. PMID: 32894659
Advances in Management of Brain and Leptomeningeal Metastases.
Venur VA, Chukwueke UN, Lee EQ
Curr Neurol Neurosci Rep 2020 Jun 6;20(7):26. doi: 10.1007/s11910-020-01039-1. PMID: 32506161

Recent clinical studies

Etiology

Neurocutaneous Melanocytosis and Leptomeningeal Melanoma.
Mitre V, Heym K, Clark GD, Venkatramani R
J Pediatr Hematol Oncol 2021 Mar 1;43(2):e195-e197. doi: 10.1097/MPH.0000000000001680. PMID: 31764519
Malignant transformation of neurocutaneous melanosis (NCM) following immunosuppression.
Schaff LR, Marghoob A, Rosenblum MK, Meyer R, Khakoo Y
Pediatr Dermatol 2019 Jul;36(4):497-500. Epub 2019 Mar 13 doi: 10.1111/pde.13804. PMID: 30868657Free PMC Article
Primary leptomeningeal melanoma.
Xie ZY, Hsieh KL, Tsang YM, Cheung WK, Hsieh CH
J Clin Neurosci 2014 Jun;21(6):1051-2. Epub 2013 Oct 23 doi: 10.1016/j.jocn.2013.08.018. PMID: 24331626
Congenital melanocytic naevi.
Kovalyshyn I, Braun R, Marghoob A
Australas J Dermatol 2009 Nov;50(4):231-40; quiz 241-2. doi: 10.1111/j.1440-0960.2009.00553_1.x. PMID: 19916964
Melanoma in children and adolescents.
Wu SJ, Lambert DR
Pediatr Dermatol 1997 Mar-Apr;14(2):87-92. doi: 10.1111/j.1525-1470.1997.tb00211.x. PMID: 9144691

Diagnosis

Primary leptomeningeal melanoma: the prognostic significance of its genetic signature and embryological origin.
Buckland A, Green C, Kho LK, Prentice D
BMJ Case Rep 2021 May 24;14(5) doi: 10.1136/bcr-2020-239496. PMID: 34031065Free PMC Article
Managing leptomeningeal melanoma metastases in the era of immune and targeted therapy.
Smalley KS, Fedorenko IV, Kenchappa RS, Sahebjam S, Forsyth PA
Int J Cancer 2016 Sep 15;139(6):1195-201. Epub 2016 Apr 30 doi: 10.1002/ijc.30147. PMID: 27084046Free PMC Article
Primary leptomeningeal melanoma mimicking meningitis: a case report and literature review.
Hsieh YY, Yang ST, Li WH, Hu CJ, Wang LS
J Clin Oncol 2015 Apr 20;33(12):e57-61. Epub 2014 Mar 17 doi: 10.1200/JCO.2013.50.0264. PMID: 24637995
Primary leptomeningeal melanoma.
Xie ZY, Hsieh KL, Tsang YM, Cheung WK, Hsieh CH
J Clin Neurosci 2014 Jun;21(6):1051-2. Epub 2013 Oct 23 doi: 10.1016/j.jocn.2013.08.018. PMID: 24331626
Neurocutaneous melanosis: definition and review of the literature.
Kadonaga JN, Frieden IJ
J Am Acad Dermatol 1991 May;24(5 Pt 1):747-55. doi: 10.1016/0190-9622(91)70115-i. PMID: 1869648

Therapy

Durable complete remission of leptomeningeal melanoma by intrathecal methotrexate maintained with systemic ipilimumab.
Dietrich C, Salzmann M, Steinbrecher A, Herbst R, Hassel JC
Immunotherapy 2021 Sep;13(13):1079-1083. Epub 2021 Jul 14 doi: 10.2217/imt-2021-0031. PMID: 34259028
Neurocutaneous Melanocytosis and Leptomeningeal Melanoma.
Mitre V, Heym K, Clark GD, Venkatramani R
J Pediatr Hematol Oncol 2021 Mar 1;43(2):e195-e197. doi: 10.1097/MPH.0000000000001680. PMID: 31764519
Malignant transformation of neurocutaneous melanosis (NCM) following immunosuppression.
Schaff LR, Marghoob A, Rosenblum MK, Meyer R, Khakoo Y
Pediatr Dermatol 2019 Jul;36(4):497-500. Epub 2019 Mar 13 doi: 10.1111/pde.13804. PMID: 30868657Free PMC Article
Inflammatory demyelinating polyneuropathy versus leptomeningeal disease following Ipilimumab.
Cafuir L, Lawson D, Desai N, Kesner V, Voloschin A
J Immunother Cancer 2018 Jan 30;6(1):11. doi: 10.1186/s40425-018-0318-x. PMID: 29382383Free PMC Article
Managing leptomeningeal melanoma metastases in the era of immune and targeted therapy.
Smalley KS, Fedorenko IV, Kenchappa RS, Sahebjam S, Forsyth PA
Int J Cancer 2016 Sep 15;139(6):1195-201. Epub 2016 Apr 30 doi: 10.1002/ijc.30147. PMID: 27084046Free PMC Article

Prognosis

Primary leptomeningeal melanoma: the prognostic significance of its genetic signature and embryological origin.
Buckland A, Green C, Kho LK, Prentice D
BMJ Case Rep 2021 May 24;14(5) doi: 10.1136/bcr-2020-239496. PMID: 34031065Free PMC Article
Neurocutaneous Melanocytosis and Leptomeningeal Melanoma.
Mitre V, Heym K, Clark GD, Venkatramani R
J Pediatr Hematol Oncol 2021 Mar 1;43(2):e195-e197. doi: 10.1097/MPH.0000000000001680. PMID: 31764519
Managing leptomeningeal melanoma metastases in the era of immune and targeted therapy.
Smalley KS, Fedorenko IV, Kenchappa RS, Sahebjam S, Forsyth PA
Int J Cancer 2016 Sep 15;139(6):1195-201. Epub 2016 Apr 30 doi: 10.1002/ijc.30147. PMID: 27084046Free PMC Article
Primary leptomeningeal melanoma.
Xie ZY, Hsieh KL, Tsang YM, Cheung WK, Hsieh CH
J Clin Neurosci 2014 Jun;21(6):1051-2. Epub 2013 Oct 23 doi: 10.1016/j.jocn.2013.08.018. PMID: 24331626
Primary leptomeningeal melanoma.
Schneider F, Putzier M
Spine (Phila Pa 1976) 2002 Dec 15;27(24):E545-7. doi: 10.1097/00007632-200212150-00026. PMID: 12486366

Clinical prediction guides

Durable complete remission of leptomeningeal melanoma by intrathecal methotrexate maintained with systemic ipilimumab.
Dietrich C, Salzmann M, Steinbrecher A, Herbst R, Hassel JC
Immunotherapy 2021 Sep;13(13):1079-1083. Epub 2021 Jul 14 doi: 10.2217/imt-2021-0031. PMID: 34259028
Genomic analysis reveals low tumor mutation burden which may be associated with GNAQ/11 alteration in a series of primary leptomeningeal melanomas.
Fortin Ensign S, Bollin K, Millis SZ, Hinds BR, Kosty M, Uchiyama C
Pigment Cell Melanoma Res 2020 May;33(3):458-465. Epub 2019 Dec 18 doi: 10.1111/pcmr.12839. PMID: 31663661
Intrathecal cytotoxic T-cell immunotherapy for metastatic leptomeningeal melanoma.
Clemons-Miller AR, Chatta GS, Hutchins L, Angtuaco EJ, Ravaggi A, Santin AD, Cannon MJ
Clin Cancer Res 2001 Mar;7(3 Suppl):917s-924s. PMID: 11300492

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