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Compound Nevus

MedGen UID:
78058
•Concept ID:
C0259781
•
Neoplastic Process
Synonyms: Compound nevus; Compound nevus of skin; Compound Nevus of Skin; Compound Nevus of the Skin; Dermal and epidermal nevus
SNOMED CT: Compound nevus of skin (254805008); Compound nevus (49409001); Dermal and epidermal nevus (49409001)

Definition

A nevus composed of neoplastic melanocytes that infiltrate both the epidermis and the dermis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCompound Nevus

Professional guidelines

PubMed

Features, management, and outcomes of pediatric scalp melanomas.
Mologousis MA, Moustafa D, Hawryluk EB
Pediatr Dermatol 2024 Mar-Apr;41(2):266-269. Epub 2023 Dec 21 doi: 10.1111/pde.15507. PMID: 38128580
Differential diagnosis of pediatric tumors of the nasal cavity and paranasal sinuses: a 45-year multi-institutional review.
Holsinger FC, Hafemeister AC, Hicks MJ, Sulek M, Huh WW, Friedman EM
Ear Nose Throat J 2010 Nov;89(11):534-40. PMID: 21086277
Blue nevus: classical types and new related entities. A differential diagnostic review.
González-Cámpora R, Galera-Davidson H, Vázquez-Ramírez FJ, Díaz-Cano S
Pathol Res Pract 1994 Jun;190(6):627-35. doi: 10.1016/S0344-0338(11)80402-4. PMID: 7984522

Recent clinical studies

Etiology

Benign Skin Neoplasms among the Histopathological Specimens of Skin Neoplasm in a Teaching Hospital: A Descriptive Cross-sectional Study.
Thapa S, Ghosh A, Ghartimagar D, Regmi S
JNMA J Nepal Med Assoc 2021 Nov 15;59(243):1106-1110. doi: 10.31729/jnma.6086. PMID: 35199769Free PMC Article
Pediatric conjunctival melanoma arising from a compound nevus.
Liu KC, Mruthyunjaya P, Proia AD, Vora GK
J AAPOS 2017 Oct;21(5):416-418. Epub 2017 Aug 30 doi: 10.1016/j.jaapos.2017.04.014. PMID: 28860029
Cryopreserved Ultra-Thick Human Amniotic Membrane for Conjunctival Surface Reconstruction After Excision of Conjunctival Tumors.
Tanaka TS, Demirci H
Cornea 2016 Apr;35(4):445-50. doi: 10.1097/ICO.0000000000000737. PMID: 26807897
Neurocutaneous melanosis in children with giant congenital melanocytic nevi.
Bekiesinska-Figatowska M, Szczygielski O, Boczar M, Madzik J, Klepacka T, Michalak E, Romaniuk-Doroszewska A, Uliasz M, Peczkowski P, Sawicka E
Clin Imaging 2014 Mar-Apr;38(2):79-84. Epub 2013 Oct 16 doi: 10.1016/j.clinimag.2013.10.001. PMID: 24239041
Clinicopathologic characteristics of premalignant and malignant melanocytic lesions of the conjunctiva.
Jakobiec FA, Folberg R, Iwamoto T
Ophthalmology 1989 Feb;96(2):147-66. doi: 10.1016/s0161-6420(89)32920-4. PMID: 2649838

Diagnosis

Features, management, and outcomes of pediatric scalp melanomas.
Mologousis MA, Moustafa D, Hawryluk EB
Pediatr Dermatol 2024 Mar-Apr;41(2):266-269. Epub 2023 Dec 21 doi: 10.1111/pde.15507. PMID: 38128580
Compound Nevus of the External Auditory Canal Mimicking Pyogenic Granuloma.
Reddy Y M, Singh SK, Jennifer B
Otol Neurotol 2022 Jan 1;43(1):e137-e139. doi: 10.1097/MAO.0000000000003367. PMID: 34711776
Oral compound nevus: an unusual presentation.
Pulivarthi S, Ramlal G, Divya Shree P
Indian J Dermatol Venereol Leprol 2020 May-Jun;86(3):284-285. doi: 10.4103/ijdvl.IJDVL_676_18. PMID: 30860168
Inflammatory juvenile compound nevi: A melanoma is not all that it appears to be.
García de Oteyza G, Betancourt J, Benedetti Sandner M, Vázquez-Romo KA, Hernández-Ayuso I, Ramos-Betancourt N
Arch Soc Esp Oftalmol (Engl Ed) 2019 Feb;94(2):90-94. Epub 2018 Aug 8 doi: 10.1016/j.oftal.2018.06.022. PMID: 30098823
Pseudomelanoma after laser therapy.
Hwang K, Lee WJ, Lee SI
Ann Plast Surg 2002 May;48(5):562-4. doi: 10.1097/00000637-200205000-00021. PMID: 11981202

Therapy

Personalized and targeted mutational analysis of multiple second primary melanomas under kinase inhibitors.
Donati M, Zelano G, Coppola R, Cinelli E, Verri M, Persichetti P, Perrella E, Devirgiliis V, Calvieri S, Crescenzi A, Panasiti V
Ital J Dermatol Venerol 2021 Oct;156(5):593-598. Epub 2019 Dec 4 doi: 10.23736/S2784-8671.19.06516-7. PMID: 31804055
Staged Mosaic Punching Excision of a Kissing Nevus on the Eyelid.
Cho HJ, Lee W, Jeon MK, Park JO, Yang EJ
Aesthetic Plast Surg 2019 Jun;43(3):652-657. Epub 2019 Apr 1 doi: 10.1007/s00266-019-01362-0. PMID: 30937473
Hyperpigmented scar due to minocycline therapy.
Patterson JW, Wilson B, Wick MR, Heath C
Cutis 2004 Nov;74(5):293-8. PMID: 15605966
Pseudomelanoma after laser therapy.
Hwang K, Lee WJ, Lee SI
Ann Plast Surg 2002 May;48(5):562-4. doi: 10.1097/00000637-200205000-00021. PMID: 11981202
A technical consideration in the serial excision of a nevus.
Altchek ED
Plast Reconstr Surg 1980 Dec;66(6):849-50. doi: 10.1097/00006534-198012000-00008. PMID: 7443850

Prognosis

Neurocutaneous melanosis in children with giant congenital melanocytic nevi.
Bekiesinska-Figatowska M, Szczygielski O, Boczar M, Madzik J, Klepacka T, Michalak E, Romaniuk-Doroszewska A, Uliasz M, Peczkowski P, Sawicka E
Clin Imaging 2014 Mar-Apr;38(2):79-84. Epub 2013 Oct 16 doi: 10.1016/j.clinimag.2013.10.001. PMID: 24239041
Pigmented nevus of the external auditory canal.
Lee FP
Otolaryngol Head Neck Surg 2006 Jul;135(1):124-8. doi: 10.1016/j.otohns.2005.11.027. PMID: 16815196
A giant melanocytic nevus treated with combined use of normal mode ruby laser and Q-switched alexandrite laser.
Kono T, Ercocen AR, Kikuchi Y, Isago T, Honda T, Nozaki M
J Dermatol 2003 Jul;30(7):538-42. doi: 10.1111/j.1346-8138.2003.tb00429.x. PMID: 12928544
Pigmented conjunctival and scleral lesions.
Liesegang TJ
Mayo Clin Proc 1994 Feb;69(2):151-61. doi: 10.1016/s0025-6196(12)61042-8. PMID: 8309267
Systematized progradient multiple combined melanocytic and blue nevus.
Pock L, Trnka J, Vosmík F, Záruba F
Am J Dermatopathol 1991 Jun;13(3):282-7. doi: 10.1097/00000372-199106000-00011. PMID: 1867359

Clinical prediction guides

Targetoid haemosiderotic nevus: four cases and a literature review.
Zhang LW, Li Y, Wang WJ, Fu LX, Nie J, Lu YH, Chen T, Xu RH
Eur J Dermatol 2023 Jun 1;33(3):255-259. doi: 10.1684/ejd.2023.4481. PMID: 37594332
Attempting to Solve the Pigmented Epithelioid Melanocytoma (PEM) Conundrum: PRKAR1A Inactivation Can Occur in Different Genetic Backgrounds (Common, Blue, and Spitz Subgroups) With Variation in Their Clinicopathologic Characteristics.
de la Fouchardiere A, Tirode F, Castillo C, Buisson A, Boivin F, Macagno N, Pissaloux D
Am J Surg Pathol 2022 Aug 1;46(8):1106-1115. Epub 2022 Mar 22 doi: 10.1097/PAS.0000000000001888. PMID: 35319526
Personalized and targeted mutational analysis of multiple second primary melanomas under kinase inhibitors.
Donati M, Zelano G, Coppola R, Cinelli E, Verri M, Persichetti P, Perrella E, Devirgiliis V, Calvieri S, Crescenzi A, Panasiti V
Ital J Dermatol Venerol 2021 Oct;156(5):593-598. Epub 2019 Dec 4 doi: 10.23736/S2784-8671.19.06516-7. PMID: 31804055
A giant melanocytic nevus treated with combined use of normal mode ruby laser and Q-switched alexandrite laser.
Kono T, Ercocen AR, Kikuchi Y, Isago T, Honda T, Nozaki M
J Dermatol 2003 Jul;30(7):538-42. doi: 10.1111/j.1346-8138.2003.tb00429.x. PMID: 12928544
Problems in the interpretation of apparent "radial growth phase" malignant melanomas that metastasize.
Abramova L, Slingluff CL Jr, Patterson JW
J Cutan Pathol 2002 Aug;29(7):407-14. doi: 10.1034/j.1600-0560.2002.290704.x. PMID: 12139635

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