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Desmoplastic nevus

MedGen UID:
91083
•Concept ID:
C0346098
•
Neoplastic Process
Synonyms: Desmoplastic Nevus; desmoplastic nevus
 
Monarch Initiative: MONDO:0044797

Definition

A benign melanocytic nevus characterized by the presence of desmoplastic stroma. [from NCI]

Professional guidelines

PubMed

PRAME is a useful marker for the differential diagnosis of melanocytic tumours and histological mimics.
Chen YP, Zhang WW, Qiu YT, Ke LF, Chen H, Chen G
Histopathology 2023 Jan;82(2):285-295. Epub 2022 Oct 13 doi: 10.1111/his.14814. PMID: 36200756
Desmoplastic melanoma on the nose: electrochemotherapy as an alternative treatment to local advanced disease.
Carrera C, Bennassar A, Ishioka P, Dalle S, Vilalta A, Fuertes I, Alos L, Thomas L, Puig S, Malvehy J
J Eur Acad Dermatol Venereol 2014 Apr;28(4):424-32. Epub 2013 Mar 18 doi: 10.1111/jdv.12115. PMID: 23506474
Melanoma: criteria for histological diagnosis and its reporting.
Metcalf JS
Semin Oncol 1996 Dec;23(6):688-92. PMID: 8970588

Recent clinical studies

Etiology

Desmoplastic nevus: An entity distinct from spitz nevus and blue nevus.
Sherrill AM, Crespo G, Prakash AV, Messina JL
Am J Dermatopathol 2011 Feb;33(1):35-9. doi: 10.1097/DAD.0b013e3181e5dfa0. PMID: 21124206
Epithelioid blue nevus: neoplasm Sui generis or variation on a theme?
Groben PA, Harvell JD, White WL
Am J Dermatopathol 2000 Dec;22(6):473-88. doi: 10.1097/00000372-200012000-00001. PMID: 11190438
Desmoplastic malignant melanoma on the buttock of an 18-year-old girl: differentiation from desmoplastic nevus.
Chan GS, Choy C, Ng WK, Chan KW
Am J Dermatopathol 1999 Apr;21(2):170-3. doi: 10.1097/00000372-199904000-00011. PMID: 10218679

Diagnosis

Desmoplastic nevus of chronically sun-damaged skin: an entity to be distinguished from desmoplastic melanoma.
Sidiropoulos M, Sholl LM, Obregon R, Guitart J, Gerami P
Am J Dermatopathol 2014 Aug;36(8):629-34. doi: 10.1097/DAD.0000000000000069. PMID: 25051041
Desmoplastic nevus: An entity distinct from spitz nevus and blue nevus.
Sherrill AM, Crespo G, Prakash AV, Messina JL
Am J Dermatopathol 2011 Feb;33(1):35-9. doi: 10.1097/DAD.0b013e3181e5dfa0. PMID: 21124206
Desmoplastic nevus: clinicopathologic keynotes.
Ferrara G, Brasiello M, Annese P, Francione S, Giorgio CM, Moscarella E, Zalaudek I, Argenziano G
Am J Dermatopathol 2009 Oct;31(7):718-22. doi: 10.1097/DAD.0b013e3181a9f0ee. PMID: 19684509
Desmoplastic (sclerotic) nevus: an underrecognized entity that resembles dermatofibroma and desmoplastic melanoma.
Harris GR, Shea CR, Horenstein MG, Reed JA, Burchette JL Jr, Prieto VG
Am J Surg Pathol 1999 Jul;23(7):786-94. doi: 10.1097/00000478-199907000-00006. PMID: 10403301
Desmoplastic nevus: a distinct histologic variant of mixed spindle cell and epithelioid cell nevus.
Barr RJ, Morales RV, Graham JH
Cancer 1980 Aug 1;46(3):557-64. doi: 10.1002/1097-0142(19800801)46:3<557::aid-cncr2820460323>3.0.co;2-l. PMID: 7397626

Therapy

Desmoplastic nevus of chronically sun-damaged skin: an entity to be distinguished from desmoplastic melanoma.
Sidiropoulos M, Sholl LM, Obregon R, Guitart J, Gerami P
Am J Dermatopathol 2014 Aug;36(8):629-34. doi: 10.1097/DAD.0000000000000069. PMID: 25051041

Prognosis

Gene expression signature as an ancillary method in the diagnosis of desmoplastic melanoma.
Clarke LE, Pimentel JD, Zalaznick H, Wang L, Busam KJ
Hum Pathol 2017 Dec;70:113-120. Epub 2017 Oct 24 doi: 10.1016/j.humpath.2017.10.005. PMID: 29079183
Desmoplastic nevus of chronically sun-damaged skin: an entity to be distinguished from desmoplastic melanoma.
Sidiropoulos M, Sholl LM, Obregon R, Guitart J, Gerami P
Am J Dermatopathol 2014 Aug;36(8):629-34. doi: 10.1097/DAD.0000000000000069. PMID: 25051041

Clinical prediction guides

Gene expression signature as an ancillary method in the diagnosis of desmoplastic melanoma.
Clarke LE, Pimentel JD, Zalaznick H, Wang L, Busam KJ
Hum Pathol 2017 Dec;70:113-120. Epub 2017 Oct 24 doi: 10.1016/j.humpath.2017.10.005. PMID: 29079183
Desmoplastic nevus of chronically sun-damaged skin: an entity to be distinguished from desmoplastic melanoma.
Sidiropoulos M, Sholl LM, Obregon R, Guitart J, Gerami P
Am J Dermatopathol 2014 Aug;36(8):629-34. doi: 10.1097/DAD.0000000000000069. PMID: 25051041
The anti-MAGE antibody B57 as a diagnostic marker in melanocytic lesions.
Kazakov DV, Kutzner H, Rütten A, Michal M, Requena L, Burg G, Dummer R, Kempf W
Am J Dermatopathol 2004 Apr;26(2):102-7. doi: 10.1097/00000372-200404000-00003. PMID: 15024190

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