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Female reproductive organ cancer

MedGen UID:
195944
•Concept ID:
C0699889
•
Neoplastic Process
Synonym: Malignant Female Reproductive System Neoplasm
 
Monarch Initiative: MONDO:0001416

Definition

A primary or metastatic malignant neoplasm involving the female reproductive system. Representative examples include endometrial carcinoma, cervical carcinoma, ovarian carcinoma, uterine corpus leiomyosarcoma, adenosarcoma, malignant mixed mesodermal (mullerian) tumor, and gestational choriocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFemale reproductive organ cancer

Professional guidelines

PubMed

Diagnosis and management of uterine fibroids: current trends and future strategies.
Ahmad A, Kumar M, Bhoi NR, Badruddeen, Akhtar J, Khan MI, Ajmal M, Ahmad M
J Basic Clin Physiol Pharmacol 2023 May 1;34(3):291-310. Epub 2023 Mar 30 doi: 10.1515/jbcpp-2022-0219. PMID: 36989026
Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society Clinical Practice Guideline.
Hembree WC, Cohen-Kettenis PT, Gooren L, Hannema SE, Meyer WJ, Murad MH, Rosenthal SM, Safer JD, Tangpricha V, T'Sjoen GG
J Clin Endocrinol Metab 2017 Nov 1;102(11):3869-3903. doi: 10.1210/jc.2017-01658. PMID: 28945902
Consensus Recommendations for Radiation Therapy Contouring and Treatment of Vulvar Carcinoma.
Gaffney DK, King B, Viswanathan AN, Barkati M, Beriwal S, Eifel P, Erickson B, Fyles A, Goulart J, Harkenrider M, Jhingran A, Klopp A, Koh WJ, Lim K, Petersen I, Portelance L, Small W Jr, Stewart A, Wiebe E, Wolfson A, Yashar C, Bosch W
Int J Radiat Oncol Biol Phys 2016 Jul 15;95(4):1191-200. Epub 2016 Feb 21 doi: 10.1016/j.ijrobp.2016.02.043. PMID: 27130794Free PMC Article

Curated

UK NICE Guideline NG12, Suspected cancer: recognition and referral, 2023

Suggested Reading

PubMed

Cancer Genetics Risk Assessment and Counseling (PDQ®): Health Professional Version.
PDQ Cancer Genetics Editorial Board
2002 PMID: 26389258
Genetics of Breast and Gynecologic Cancers (PDQ®): Health Professional Version.
PDQ Cancer Genetics Editorial Board
2002 PMID: 26389210

Recent clinical studies

Etiology

Mitochondrial Dysfunction in PCOS: Insights into Reproductive Organ Pathophysiology.
Siemers KM, Klein AK, Baack ML
Int J Mol Sci 2023 Aug 23;24(17) doi: 10.3390/ijms241713123. PMID: 37685928Free PMC Article
FIGO staging of endometrial cancer: 2023.
Berek JS, Matias-Guiu X, Creutzberg C, Fotopoulou C, Gaffney D, Kehoe S, Lindemann K, Mutch D, Concin N; Endometrial Cancer Staging Subcommittee, FIGO Women's Cancer Committee
J Gynecol Oncol 2023 Sep;34(5):e85. Epub 2023 Aug 8 doi: 10.3802/jgo.2023.34.e85. PMID: 37593813Free PMC Article
Cancer of the corpus uteri: 2021 update.
Koskas M, Amant F, Mirza MR, Creutzberg CL
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):45-60. doi: 10.1002/ijgo.13866. PMID: 34669196Free PMC Article
The Role of the Cervicovaginal Microbiome on the Genesis and as a Biomarker of Premalignant Cervical Intraepithelial Neoplasia and Invasive Cervical Cancer.
Curty G, de Carvalho PS, Soares MA
Int J Mol Sci 2019 Dec 28;21(1) doi: 10.3390/ijms21010222. PMID: 31905652Free PMC Article
The Microbiome and Genitourinary Cancer: A Collaborative Review.
Markowski MC, Boorjian SA, Burton JP, Hahn NM, Ingersoll MA, Maleki Vareki S, Pal SK, Sfanos KS
Eur Urol 2019 Apr;75(4):637-646. Epub 2019 Jan 15 doi: 10.1016/j.eururo.2018.12.043. PMID: 30655087Free PMC Article

Diagnosis

Minimally invasive approaches for the early detection of endometrial cancer.
Shen Y, Yang W, Liu J, Zhang Y
Mol Cancer 2023 Mar 17;22(1):53. doi: 10.1186/s12943-023-01757-3. PMID: 36932368Free PMC Article
Endocrine disorders and fertility and pregnancy: An update.
Bendarska-Czerwińska A, Zmarzły N, Morawiec E, Panfil A, Bryś K, Czarniecka J, Ostenda A, Dziobek K, Sagan D, Boroń D, Michalski P, Pallazo-Michalska V, Grabarek BO
Front Endocrinol (Lausanne) 2022;13:970439. Epub 2023 Jan 17 doi: 10.3389/fendo.2022.970439. PMID: 36733805Free PMC Article
Role of m6A modification in female infertility and reproductive system diseases.
Chen J, Fang Y, Xu Y, Sun H
Int J Biol Sci 2022;18(9):3592-3604. Epub 2022 May 16 doi: 10.7150/ijbs.69771. PMID: 35813486Free PMC Article
The Role of Microbiota in the Immunopathogenesis of Endometrial Cancer.
Sobstyl M, Brecht P, Sobstyl A, Mertowska P, Grywalska E
Int J Mol Sci 2022 May 20;23(10) doi: 10.3390/ijms23105756. PMID: 35628566Free PMC Article
Endometrial Cancer: Genetic, Metabolic Characteristics, Therapeutic Strategies and Nanomedicine.
Cai Y, Wang B, Xu W, Liu K, Gao Y, Guo C, Chen J, Kamal MA, Yuan C
Curr Med Chem 2021;28(42):8755-8781. doi: 10.2174/0929867328666210705144456. PMID: 34225603

Therapy

ECOG-ACRIN Guideline for Contouring and Treatment of Early Stage Anal Cancer Using IMRT/IGRT.
Damico N, Meyer J, Das P, Murphy J, Miller E, Koontz B, Hall W, McBride M, Pereira G, Catalano P, Chakravarthy AB, O'Dwyer PJ, Dorth J
Pract Radiat Oncol 2022 Jul-Aug;12(4):335-347. doi: 10.1016/j.prro.2022.01.015. PMID: 35717050
The microbiome and gynaecological cancer development, prevention and therapy.
Łaniewski P, Ilhan ZE, Herbst-Kralovetz MM
Nat Rev Urol 2020 Apr;17(4):232-250. Epub 2020 Feb 18 doi: 10.1038/s41585-020-0286-z. PMID: 32071434Free PMC Article
Preservation of fertility in patients with cancer (Review).
Del-Pozo-Lérida S, Salvador C, Martínez-Soler F, Tortosa A, Perucho M, Giménez-Bonafé P
Oncol Rep 2019 May;41(5):2607-2614. Epub 2019 Mar 14 doi: 10.3892/or.2019.7063. PMID: 30896846
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group report.
Jagasia MH, Greinix HT, Arora M, Williams KM, Wolff D, Cowen EW, Palmer J, Weisdorf D, Treister NS, Cheng GS, Kerr H, Stratton P, Duarte RF, McDonald GB, Inamoto Y, Vigorito A, Arai S, Datiles MB, Jacobsohn D, Heller T, Kitko CL, Mitchell SA, Martin PJ, Shulman H, Wu RS, Cutler CS, Vogelsang GB, Lee SJ, Pavletic SZ, Flowers ME
Biol Blood Marrow Transplant 2015 Mar;21(3):389-401.e1. Epub 2014 Dec 18 doi: 10.1016/j.bbmt.2014.12.001. PMID: 25529383Free PMC Article
Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials.
Early Breast Cancer Trialists' Collaborative Group (EBCTCG)
Lancet 2005 May 14-20;365(9472):1687-717. doi: 10.1016/S0140-6736(05)66544-0. PMID: 15894097

Prognosis

Revolutionizing the female reproductive system research using microfluidic chip platform.
Yan J, Wu T, Zhang J, Gao Y, Wu JM, Wang S
J Nanobiotechnology 2023 Dec 19;21(1):490. doi: 10.1186/s12951-023-02258-7. PMID: 38111049Free PMC Article
New Strategies for Endometrial Cancer Detection and Management.
Paleari L
Int J Mol Sci 2023 Mar 30;24(7) doi: 10.3390/ijms24076462. PMID: 37047434Free PMC Article
Endometrial cancer prevention in high-risk women.
Njoku K, Abiola J, Russell J, Crosbie EJ
Best Pract Res Clin Obstet Gynaecol 2020 May;65:66-78. Epub 2019 Dec 20 doi: 10.1016/j.bpobgyn.2019.12.005. PMID: 32107136
The Microbiome and Genitourinary Cancer: A Collaborative Review.
Markowski MC, Boorjian SA, Burton JP, Hahn NM, Ingersoll MA, Maleki Vareki S, Pal SK, Sfanos KS
Eur Urol 2019 Apr;75(4):637-646. Epub 2019 Jan 15 doi: 10.1016/j.eururo.2018.12.043. PMID: 30655087Free PMC Article
Endometrial cancer.
Sorosky JI
Obstet Gynecol 2008 Feb;111(2 Pt 1):436-47. doi: 10.1097/AOG.0b013e318162f690. PMID: 18238985

Clinical prediction guides

Genital tract microbiota composition profiles and use of prebiotics and probiotics in gynaecological cancer prevention: review of the current evidence, the European Society of Gynaecological Oncology prevention committee statement.
Mitra A, Gultekin M, Burney Ellis L, Bizzarri N, Bowden S, Taumberger N, Bracic T, Vieira-Baptista P, Sehouli J, Kyrgiou M
Lancet Microbe 2024 Mar;5(3):e291-e300. Epub 2023 Dec 20 doi: 10.1016/S2666-5247(23)00257-4. PMID: 38141634
Reducing Ovarian Cancer Mortality Through Early Detection: Approaches Using Circulating Biomarkers.
Trinidad CV, Tetlow AL, Bantis LE, Godwin AK
Cancer Prev Res (Phila) 2020 Mar;13(3):241-252. doi: 10.1158/1940-6207.CAPR-19-0184. PMID: 32132118Free PMC Article
Mitochondrial dynamics regulating chemoresistance in gynecological cancers.
Kong B, Tsuyoshi H, Orisaka M, Shieh DB, Yoshida Y, Tsang BK
Ann N Y Acad Sci 2015 Sep;1350:1-16. doi: 10.1111/nyas.12883. PMID: 26375862
PELVIS Syndrome.
Girard C, Bigorre M, Guillot B, Bessis D
Arch Dermatol 2006 Jul;142(7):884-8. doi: 10.1001/archderm.142.7.884. PMID: 16847205
Screening for endometrial cancer.
Robertson G
Med J Aust 2003 Jun 16;178(12):657-9. doi: 10.5694/j.1326-5377.2003.tb05400.x. PMID: 12797861

Recent systematic reviews

Live birth rate after female fertility preservation for cancer or haematopoietic stem cell transplantation: a systematic review and meta-analysis of the three main techniques; embryo, oocyte and ovarian tissue cryopreservation.
Fraison E, Huberlant S, Labrune E, Cavalieri M, Montagut M, Brugnon F, Courbiere B
Hum Reprod 2023 Mar 1;38(3):489-502. doi: 10.1093/humrep/deac249. PMID: 36421038Free PMC Article
Molecular Insights in Uterine Leiomyosarcoma: A Systematic Review.
Sparić R, Andjić M, Babović I, Nejković L, Mitrović M, Štulić J, Pupovac M, Tinelli A
Int J Mol Sci 2022 Aug 27;23(17) doi: 10.3390/ijms23179728. PMID: 36077127Free PMC Article
Endometrial hyperplasia as a risk factor of endometrial cancer.
Nees LK, Heublein S, Steinmacher S, Juhasz-Böss I, Brucker S, Tempfer CB, Wallwiener M
Arch Gynecol Obstet 2022 Aug;306(2):407-421. Epub 2022 Jan 10 doi: 10.1007/s00404-021-06380-5. PMID: 35001185Free PMC Article
Integrating HPV vaccination programs with enhanced cervical cancer screening and treatment, a systematic review.
Wirtz C, Mohamed Y, Engel D, Sidibe A, Holloway M, Bloem P, Kumar S, Brotherton J, Reis V, Morgan C
Vaccine 2022 Mar 31;40 Suppl 1:A116-A123. Epub 2021 Dec 1 doi: 10.1016/j.vaccine.2021.11.013. PMID: 34863615
Hormone Therapy and Other Treatments for Symptoms of Menopause.
Hill DA, Crider M, Hill SR
Am Fam Physician 2016 Dec 1;94(11):884-889. PMID: 27929271

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    Curated

    • NICE, 2023
      UK NICE Guideline NG12, Suspected cancer: recognition and referral, 2023

    Consumer resources

    Reviews

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