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Recurrent Vulvar Carcinoma

MedGen UID:
78877
•Concept ID:
C0278734
•
Neoplastic Process
Synonyms: Recurrent Cancer of the Vulva; Recurrent Cancer of Vulva; Recurrent Vulva Cancer; Recurrent Vulvar Cancer; Relapsed Cancer of the Vulva; Relapsed Cancer of Vulva; Relapsed Vulva Cancer; Relapsed Vulvar Cancer

Definition

The reemergence of vulvar carcinoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Vulvar Carcinoma

Professional guidelines

PubMed

Electrochemotherapy as an Alternative Treatment Option to Pelvic Exenteration for Recurrent Vulvar Cancer of the Perineum Region.
Vivod G, Kovacevic N, Čemažar M, Serša G, Jesenko T, Bošnjak M, Kranjc Brezar S, Merlo S
Technol Cancer Res Treat 2022 Jan-Dec;21:15330338221116489. doi: 10.1177/15330338221116489. PMID: 35899313Free PMC Article
The role of brachytherapy (interventional radiotherapy) for primary and/or recurrent vulvar cancer: a Gemelli Vul.Can multidisciplinary team systematic review.
Lancellotta V, Macchia G, Garganese G, Fionda B, Fragomeni SM, D'Aviero A, Casà C, Gui B, Gentileschi S, Corrado G, Inzani F, Rovirosa A, Morganti AG, Gambacorta MA, Tagliaferri L
Clin Transl Oncol 2021 Aug;23(8):1611-1619. Epub 2021 Mar 1 doi: 10.1007/s12094-021-02557-1. PMID: 33650029
Radiation therapy and conservation surgery for primary and recurrent carcinoma of the vulva: report of 40 patients and a review of the literature.
Pao WM, Perez CA, Kuske RR, Sommers GM, Camel HM, Galakatos AE
Int J Radiat Oncol Biol Phys 1988 Jun;14(6):1123-32. doi: 10.1016/0360-3016(88)90388-4. PMID: 3290167

Recent clinical studies

Etiology

The role of brachytherapy (interventional radiotherapy) for primary and/or recurrent vulvar cancer: a Gemelli Vul.Can multidisciplinary team systematic review.
Lancellotta V, Macchia G, Garganese G, Fionda B, Fragomeni SM, D'Aviero A, Casà C, Gui B, Gentileschi S, Corrado G, Inzani F, Rovirosa A, Morganti AG, Gambacorta MA, Tagliaferri L
Clin Transl Oncol 2021 Aug;23(8):1611-1619. Epub 2021 Mar 1 doi: 10.1007/s12094-021-02557-1. PMID: 33650029
Definitive radiotherapy for recurrent vulvar carcinoma after primary surgery: a two-institutional Italian experience.
Laliscia C, Gadducci A, Fabrini MG, Barcellini A, Parietti E, Pasqualetti F, Morganti R, Mazzotti V, Cafaro I, Paiar F
Tumori 2019 Jun;105(3):225-230. Epub 2019 Feb 21 doi: 10.1177/0300891618811279. PMID: 30791828
Pembrolizumab in Recurrent Squamous Cell Carcinoma of the Vulva: Case Report and Review of the Literature.
Shields LBE, Gordinier ME
Gynecol Obstet Invest 2019;84(1):94-98. Epub 2018 Jul 17 doi: 10.1159/000491090. PMID: 30016784
Brachytherapy as part of the conservative treatment for primary and recurrent vulvar carcinoma.
Castelnau-Marchand P, Escande A, Mazeron R, Bentivegna E, Cavalcanti A, Gouy S, Baratiny C, Maroun P, Morice P, Haie-Meder C, Chargari C
Brachytherapy 2017 May-Jun;16(3):518-525. Epub 2017 Mar 3 doi: 10.1016/j.brachy.2017.01.005. PMID: 28262516
Radiotherapy as Definitive Treatment of Patients with Primary Vulvar Carcinoma Unfit for Surgery and with Recurrent Vulvar Carcinoma After Primary Radical Surgery: Results of a Retrospective Single-center Study.
Laliscia C, Gadducci A, Montrone S, Tana R, Morganti R, Fabrini MG
Anticancer Res 2016 Jan;36(1):387-91. PMID: 26722070

Diagnosis

A Case of Recurrent Vulvar Carcinoma With Cardiac Metastasis: Case Report and Review of the Literature.
Linder R, Lauterbach R, Reiss A
Int J Gynecol Pathol 2020 Jul;39(4):400-403. doi: 10.1097/PGP.0000000000000624. PMID: 31433376

Therapy

The role of brachytherapy (interventional radiotherapy) for primary and/or recurrent vulvar cancer: a Gemelli Vul.Can multidisciplinary team systematic review.
Lancellotta V, Macchia G, Garganese G, Fionda B, Fragomeni SM, D'Aviero A, Casà C, Gui B, Gentileschi S, Corrado G, Inzani F, Rovirosa A, Morganti AG, Gambacorta MA, Tagliaferri L
Clin Transl Oncol 2021 Aug;23(8):1611-1619. Epub 2021 Mar 1 doi: 10.1007/s12094-021-02557-1. PMID: 33650029
Pembrolizumab in Recurrent Squamous Cell Carcinoma of the Vulva: Case Report and Review of the Literature.
Shields LBE, Gordinier ME
Gynecol Obstet Invest 2019;84(1):94-98. Epub 2018 Jul 17 doi: 10.1159/000491090. PMID: 30016784
Recurrent Vulvar Carcinoma in a Skin Graft: A Case Reiort and Review of the Literature.
Clark JM, Hopkins MP, Krol E, Chase D, Sparks D
Conn Med 2017 Mar;81(3):165-167. PMID: 29772163
Brachytherapy as part of the conservative treatment for primary and recurrent vulvar carcinoma.
Castelnau-Marchand P, Escande A, Mazeron R, Bentivegna E, Cavalcanti A, Gouy S, Baratiny C, Maroun P, Morice P, Haie-Meder C, Chargari C
Brachytherapy 2017 May-Jun;16(3):518-525. Epub 2017 Mar 3 doi: 10.1016/j.brachy.2017.01.005. PMID: 28262516
Cisplatin and vinorelbine chemotherapy in recurrent vulvar carcinoma.
Cormio G, Loizzi V, Gissi F, Serrati G, Panzarino M, Carriero C, Selvaggi L
Oncology 2009;77(5):281-4. Epub 2009 Nov 16 doi: 10.1159/000259259. PMID: 19923866

Prognosis

A Case of Recurrent Vulvar Carcinoma With Cardiac Metastasis: Case Report and Review of the Literature.
Linder R, Lauterbach R, Reiss A
Int J Gynecol Pathol 2020 Jul;39(4):400-403. doi: 10.1097/PGP.0000000000000624. PMID: 31433376
Definitive radiotherapy for recurrent vulvar carcinoma after primary surgery: a two-institutional Italian experience.
Laliscia C, Gadducci A, Fabrini MG, Barcellini A, Parietti E, Pasqualetti F, Morganti R, Mazzotti V, Cafaro I, Paiar F
Tumori 2019 Jun;105(3):225-230. Epub 2019 Feb 21 doi: 10.1177/0300891618811279. PMID: 30791828
Pembrolizumab in Recurrent Squamous Cell Carcinoma of the Vulva: Case Report and Review of the Literature.
Shields LBE, Gordinier ME
Gynecol Obstet Invest 2019;84(1):94-98. Epub 2018 Jul 17 doi: 10.1159/000491090. PMID: 30016784
Brachytherapy as part of the conservative treatment for primary and recurrent vulvar carcinoma.
Castelnau-Marchand P, Escande A, Mazeron R, Bentivegna E, Cavalcanti A, Gouy S, Baratiny C, Maroun P, Morice P, Haie-Meder C, Chargari C
Brachytherapy 2017 May-Jun;16(3):518-525. Epub 2017 Mar 3 doi: 10.1016/j.brachy.2017.01.005. PMID: 28262516
Radiation therapy and conservation surgery for primary and recurrent carcinoma of the vulva: report of 40 patients and a review of the literature.
Pao WM, Perez CA, Kuske RR, Sommers GM, Camel HM, Galakatos AE
Int J Radiat Oncol Biol Phys 1988 Jun;14(6):1123-32. doi: 10.1016/0360-3016(88)90388-4. PMID: 3290167

Clinical prediction guides

Electrochemotherapy as an Alternative Treatment Option to Pelvic Exenteration for Recurrent Vulvar Cancer of the Perineum Region.
Vivod G, Kovacevic N, Čemažar M, Serša G, Jesenko T, Bošnjak M, Kranjc Brezar S, Merlo S
Technol Cancer Res Treat 2022 Jan-Dec;21:15330338221116489. doi: 10.1177/15330338221116489. PMID: 35899313Free PMC Article
Definitive radiotherapy for recurrent vulvar carcinoma after primary surgery: a two-institutional Italian experience.
Laliscia C, Gadducci A, Fabrini MG, Barcellini A, Parietti E, Pasqualetti F, Morganti R, Mazzotti V, Cafaro I, Paiar F
Tumori 2019 Jun;105(3):225-230. Epub 2019 Feb 21 doi: 10.1177/0300891618811279. PMID: 30791828
Reconstructive plastic surgery in the treatment of vulvar carcinomas.
Weikel W, Schmidt M, Steiner E, Knapstein PG, Koelbl H
Eur J Obstet Gynecol Reprod Biol 2008 Jan;136(1):102-9. Epub 2006 Nov 22 doi: 10.1016/j.ejogrb.2006.08.026. PMID: 17118519
Concurrent preoperative chemotherapy with 5-fluorouracil and mitomycin C and radiotherapy (FUMIR) followed by limited surgery in locally advanced and recurrent vulvar carcinoma.
Landoni F, Maneo A, Zanetta G, Colombo A, Nava S, Placa F, Tancini G, Mangioni C
Gynecol Oncol 1996 Jun;61(3):321-7. doi: 10.1006/gyno.1996.0150. PMID: 8641609
Prospective phase I/II studies of definitive irradiation and chemotherapy for advanced gynecologic malignancies.
Grigsby PW, Graham MV, Perez CA, Galakatos AE, Camel HM, Kao MS
Am J Clin Oncol 1996 Feb;19(1):1-6. doi: 10.1097/00000421-199602000-00001. PMID: 8554027

Recent systematic reviews

The role of brachytherapy (interventional radiotherapy) for primary and/or recurrent vulvar cancer: a Gemelli Vul.Can multidisciplinary team systematic review.
Lancellotta V, Macchia G, Garganese G, Fionda B, Fragomeni SM, D'Aviero A, Casà C, Gui B, Gentileschi S, Corrado G, Inzani F, Rovirosa A, Morganti AG, Gambacorta MA, Tagliaferri L
Clin Transl Oncol 2021 Aug;23(8):1611-1619. Epub 2021 Mar 1 doi: 10.1007/s12094-021-02557-1. PMID: 33650029

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