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Ovary leiomyosarcoma

MedGen UID:
233275
•Concept ID:
C1335163
•
Neoplastic Process
Synonyms: Leiomyosarcoma of Ovary; leiomyosarcoma of ovary; Leiomyosarcoma of the Ovary; leiomyosarcoma of the ovary; Ovarian Leiomyosarcoma; ovarian leiomyosarcoma; ovary leiomyosarcoma
 
Monarch Initiative: MONDO:0003355

Definition

An aggressive malignant smooth muscle neoplasm, arising from the ovary. It is characterized by a proliferation of neoplastic spindle cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvary leiomyosarcoma

Professional guidelines

PubMed

Therapeutic Management of Rare Primary Ovarian Neoplasms: Carcinosarcoma, Leiomyosarcoma, Melanoma and Carcinoid.
Kozłowski M, Nowak K, Kordek A, Cymbaluk-Płoska A
Int J Environ Res Public Health 2021 Jul 23;18(15) doi: 10.3390/ijerph18157819. PMID: 34360112Free PMC Article
Vulvar sarcomas: Short guideline for histopathological recognition and clinical management. Part 1.
Chokoeva AA, Tchernev G, Cardoso JC, Patterson JW, Dechev I, Valkanov S, Zanardelli M, Lotti T, Wollina U
Int J Immunopathol Pharmacol 2015 Jun;28(2):168-77. Epub 2015 Mar 26 doi: 10.1177/0394632015576029. PMID: 25816394
Diagnosis and treatment of sarcoma of the uterus. A review.
Tropé CG, Abeler VM, Kristensen GB
Acta Oncol 2012 Jul;51(6):694-705. doi: 10.3109/0284186X.2012.689111. PMID: 22793037

Recent clinical studies

Etiology

Hormone receptor status and the role of oophorectomy in uterine leiomyosarcoma.
Hinchcliff E, Rumpf J, Ratan R, Fleming ND, Jazaeri A, Fellman B, Meyer L, Soliman P
Gynecol Oncol 2022 Dec;167(3):490-495. Epub 2022 Oct 19 doi: 10.1016/j.ygyno.2022.09.024. PMID: 36270831
(68)Ga-FAPI-PET/CT in patients with various gynecological malignancies.
Dendl K, Koerber SA, Finck R, Mokoala KMG, Staudinger F, Schillings L, Heger U, Röhrich M, Kratochwil C, Sathekge M, Jäger D, Debus J, Haberkorn U, Giesel FL
Eur J Nucl Med Mol Imaging 2021 Nov;48(12):4089-4100. Epub 2021 May 29 doi: 10.1007/s00259-021-05378-0. PMID: 34050777Free PMC Article
Inflammatory Myofibroblastic Tumor in Female Genital Tract.
Shukla PS, Mittal K
Arch Pathol Lab Med 2019 Jan;143(1):122-129. Epub 2018 Jul 2 doi: 10.5858/arpa.2017-0575-RA. PMID: 29965784
Diagnosis and treatment of sarcoma of the uterus. A review.
Tropé CG, Abeler VM, Kristensen GB
Acta Oncol 2012 Jul;51(6):694-705. doi: 10.3109/0284186X.2012.689111. PMID: 22793037
p16 expression in the female genital tract and its value in diagnosis.
O'Neill CJ, McCluggage WG
Adv Anat Pathol 2006 Jan;13(1):8-15. doi: 10.1097/01.pap.0000201828.92719.f3. PMID: 16462152

Diagnosis

(68)Ga-FAPI-PET/CT in patients with various gynecological malignancies.
Dendl K, Koerber SA, Finck R, Mokoala KMG, Staudinger F, Schillings L, Heger U, Röhrich M, Kratochwil C, Sathekge M, Jäger D, Debus J, Haberkorn U, Giesel FL
Eur J Nucl Med Mol Imaging 2021 Nov;48(12):4089-4100. Epub 2021 May 29 doi: 10.1007/s00259-021-05378-0. PMID: 34050777Free PMC Article
Gynecological Sarcomas: Molecular Characteristics, Behavior, and Histology-Driven Therapy.
Libertini M, Hallin M, Thway K, Noujaim J, Benson C, van der Graaf W, Jones RL
Int J Surg Pathol 2021 Feb;29(1):4-20. Epub 2020 Sep 10 doi: 10.1177/1066896920958120. PMID: 32909482
Gynecologic cancer in pregnancy.
Korenaga TK, Tewari KS
Gynecol Oncol 2020 Jun;157(3):799-809. Epub 2020 Apr 5 doi: 10.1016/j.ygyno.2020.03.015. PMID: 32268951Free PMC Article
Inflammatory Myofibroblastic Tumor in Female Genital Tract.
Shukla PS, Mittal K
Arch Pathol Lab Med 2019 Jan;143(1):122-129. Epub 2018 Jul 2 doi: 10.5858/arpa.2017-0575-RA. PMID: 29965784
Diagnosis and treatment of sarcoma of the uterus. A review.
Tropé CG, Abeler VM, Kristensen GB
Acta Oncol 2012 Jul;51(6):694-705. doi: 10.3109/0284186X.2012.689111. PMID: 22793037

Therapy

Ovarian and uterine leiomyosarcoma: which one is the primary?
Shafiee MN, Kah Teik C, Md Zain RR, Kampan N
Horm Mol Biol Clin Investig 2019 Aug 9;41(2) doi: 10.1515/hmbci-2019-0037. PMID: 31398145
Cancer risk and PCOS.
Dumesic DA, Lobo RA
Steroids 2013 Aug;78(8):782-5. Epub 2013 Apr 24 doi: 10.1016/j.steroids.2013.04.004. PMID: 23624028
Ultrasonic therapy for gynecologic tumors.
Yu T, Zhou S, Zhang J
J Minim Invasive Gynecol 2008 Nov-Dec;15(6):667-72. Epub 2008 Sep 6 doi: 10.1016/j.jmig.2008.07.018. PMID: 18774758
Pregnancy following recurrent angiosarcoma of the ovary--a case report and review of literature.
Jha S, Chan KK, Poole CJ, Rollason TP
Gynecol Oncol 2005 Jun;97(3):935-7. Epub 2005 Apr 15 doi: 10.1016/j.ygyno.2005.02.027. PMID: 15943995
Management of uterine leiomyosarcoma in Australia.
Gard GB, Mulvany NJ, Quinn MA
Aust N Z J Obstet Gynaecol 1999 Feb;39(1):93-8. doi: 10.1111/j.1479-828x.1999.tb03453.x. PMID: 10099759

Prognosis

Primary leiomyosarcoma of ovary: A rare malignancy as an incidental finding.
Raychaudhuri S, Sidam D, Jain M, Chawla R, Pujani M, Wadhwa R
Indian J Pathol Microbiol 2022 Oct-Dec;65(4):938-941. doi: 10.4103/ijpm.ijpm_99_21. PMID: 36308213
Gynecological Sarcomas: Molecular Characteristics, Behavior, and Histology-Driven Therapy.
Libertini M, Hallin M, Thway K, Noujaim J, Benson C, van der Graaf W, Jones RL
Int J Surg Pathol 2021 Feb;29(1):4-20. Epub 2020 Sep 10 doi: 10.1177/1066896920958120. PMID: 32909482
Gynecologic cancer in pregnancy.
Korenaga TK, Tewari KS
Gynecol Oncol 2020 Jun;157(3):799-809. Epub 2020 Apr 5 doi: 10.1016/j.ygyno.2020.03.015. PMID: 32268951Free PMC Article
Smooth Muscle Tumors of the Female Genital Tract.
Devereaux KA, Schoolmeester JK
Surg Pathol Clin 2019 Jun;12(2):397-455. doi: 10.1016/j.path.2019.02.004. PMID: 31097110
Gynecological sarcomas.
DiSaia PJ, Pecorelli S
Semin Surg Oncol 1994 Sep-Oct;10(5):369-73. doi: 10.1002/ssu.2980100510. PMID: 7997731

Clinical prediction guides

Hormone receptor status and the role of oophorectomy in uterine leiomyosarcoma.
Hinchcliff E, Rumpf J, Ratan R, Fleming ND, Jazaeri A, Fellman B, Meyer L, Soliman P
Gynecol Oncol 2022 Dec;167(3):490-495. Epub 2022 Oct 19 doi: 10.1016/j.ygyno.2022.09.024. PMID: 36270831
The Potential Prognostic and Therapeutic Implications of Prolactin Receptor and Growth Hormone-releasing Hormone Receptor Expression in Uterine Leiomyosarcomas.
Jones TE, La HS, Upadhyay-Baskota S, Bhargava R, Jones MW
Int J Gynecol Pathol 2022 Nov 1;41(6):566-572. Epub 2021 Dec 3 doi: 10.1097/PGP.0000000000000844. PMID: 34856572
(68)Ga-FAPI-PET/CT in patients with various gynecological malignancies.
Dendl K, Koerber SA, Finck R, Mokoala KMG, Staudinger F, Schillings L, Heger U, Röhrich M, Kratochwil C, Sathekge M, Jäger D, Debus J, Haberkorn U, Giesel FL
Eur J Nucl Med Mol Imaging 2021 Nov;48(12):4089-4100. Epub 2021 May 29 doi: 10.1007/s00259-021-05378-0. PMID: 34050777Free PMC Article
Gynecological Sarcomas: Molecular Characteristics, Behavior, and Histology-Driven Therapy.
Libertini M, Hallin M, Thway K, Noujaim J, Benson C, van der Graaf W, Jones RL
Int J Surg Pathol 2021 Feb;29(1):4-20. Epub 2020 Sep 10 doi: 10.1177/1066896920958120. PMID: 32909482
FIGO stage, histology, histologic grade, age and race as prognostic factors in determining survival for cancers of the female gynecological system: an analysis of 1973-87 SEER cases of cancers of the endometrium, cervix, ovary, vulva, and vagina.
Kosary CL
Semin Surg Oncol 1994 Jan-Feb;10(1):31-46. doi: 10.1002/ssu.2980100107. PMID: 8115784

Recent systematic reviews

Primary leiomyosarcoma of the ovary: a report of three cases and a systematic review of literature.
Yuksel D, Cakir C, Kilic C, Karalok A, Kimyon G, Çöteli S, Boyraz G, Tekin ÖM, Turan T
J Gynecol Obstet Hum Reprod 2021 Jun;50(6):101825. Epub 2020 Jun 1 doi: 10.1016/j.jogoh.2020.101825. PMID: 32497729

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