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Metastatic Uterine Corpus Carcinosarcoma

MedGen UID:
1767026
•Concept ID:
C5418885
•
Neoplastic Process

Definition

Uterine corpus carcinosarcoma that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Uterine Corpus Carcinosarcoma

Recent clinical studies

Etiology

Role of Nucleolin in Endometrial Precancerous Hyperplasia and Carcinogenesis: Ex Vivo and In Silico Study.
Barzilova VD, Drury J, Rogers B, Thomas E, Ahmed F, Bradfield A, Al-Lamee H, Hapangama DK
Int J Mol Sci 2022 Jun 2;23(11) doi: 10.3390/ijms23116228. PMID: 35682908Free PMC Article
Phase 2 study of anastrozole in rare cohorts of patients with estrogen receptor/progesterone receptor positive leiomyosarcomas and carcinosarcomas of the uterine corpus: The PARAGON trial (ANZGOG 0903).
Edmondson RJ, O'Connell RL, Banerjee S, Mileshkin L, Sykes P, Beale P, Fisher A, Bonaventura A, Millan D, Nottley S, Benson C, Hamilton A, Sjoquist K, Alexander L, Kelly C, Carty K, Divers L, Bradshaw N, Friedlander M; PARAGON investigators
Gynecol Oncol 2021 Dec;163(3):524-530. Epub 2021 Oct 5 doi: 10.1016/j.ygyno.2021.09.010. PMID: 34625284
Is vascular and lymphatic space invasion a main prognostic factor in uterine neoplasms with a sarcomatous component? A retrospective study of prognostic factors of 60 patients stratified by stages.
Rovirosa A, Ascaso C, Ordi J, Abellana R, Arenas M, Lejarcegui JA, Pahisa J, Puig-Tintoré LM, Mellado B, Armenteros B, Iglesias X, Biete A
Int J Radiat Oncol Biol Phys 2002 Apr 1;52(5):1320-9. doi: 10.1016/s0360-3016(01)02808-5. PMID: 11955745
Cervical carcinosarcoma occurring after subtotal hysterectomy, a case report.
Farley JH, Taylor RR
Gynecol Oncol 1997 Dec;67(3):322-4. doi: 10.1006/gyno.1997.4872. PMID: 9441782
Intramural carcinomas of the uterine corpus: a clinicopathological study.
Kuwashima Y, Kurosumi M, Kasamatsu T, Shiromizu K, Kishi K
In Vivo 1997 May-Jun;11(3):253-60. PMID: 9239520

Diagnosis

Role of Nucleolin in Endometrial Precancerous Hyperplasia and Carcinogenesis: Ex Vivo and In Silico Study.
Barzilova VD, Drury J, Rogers B, Thomas E, Ahmed F, Bradfield A, Al-Lamee H, Hapangama DK
Int J Mol Sci 2022 Jun 2;23(11) doi: 10.3390/ijms23116228. PMID: 35682908Free PMC Article
Primary osteosarcoma of the uterine cervix: A case report.
Tsuji K, Watanabe Y, Tokunaga H, Shimada M, Watanabe M, Yaegashi N
J Obstet Gynaecol Res 2017 Nov;43(11):1781-1783. Epub 2017 Aug 17 doi: 10.1111/jog.13443. PMID: 28815813
Primary carcinosarcoma of the vagina.
Shibata R, Umezawa A, Takehara K, Aoki D, Nozawa S, Hata J
Pathol Int 2003 Feb;53(2):106-10. doi: 10.1046/j.1440-1827.2003.01442.x. PMID: 12588439
Is vascular and lymphatic space invasion a main prognostic factor in uterine neoplasms with a sarcomatous component? A retrospective study of prognostic factors of 60 patients stratified by stages.
Rovirosa A, Ascaso C, Ordi J, Abellana R, Arenas M, Lejarcegui JA, Pahisa J, Puig-Tintoré LM, Mellado B, Armenteros B, Iglesias X, Biete A
Int J Radiat Oncol Biol Phys 2002 Apr 1;52(5):1320-9. doi: 10.1016/s0360-3016(01)02808-5. PMID: 11955745
Intramural carcinomas of the uterine corpus: a clinicopathological study.
Kuwashima Y, Kurosumi M, Kasamatsu T, Shiromizu K, Kishi K
In Vivo 1997 May-Jun;11(3):253-60. PMID: 9239520

Therapy

Phase 2 study of anastrozole in rare cohorts of patients with estrogen receptor/progesterone receptor positive leiomyosarcomas and carcinosarcomas of the uterine corpus: The PARAGON trial (ANZGOG 0903).
Edmondson RJ, O'Connell RL, Banerjee S, Mileshkin L, Sykes P, Beale P, Fisher A, Bonaventura A, Millan D, Nottley S, Benson C, Hamilton A, Sjoquist K, Alexander L, Kelly C, Carty K, Divers L, Bradshaw N, Friedlander M; PARAGON investigators
Gynecol Oncol 2021 Dec;163(3):524-530. Epub 2021 Oct 5 doi: 10.1016/j.ygyno.2021.09.010. PMID: 34625284
Postradiation carcinosarcoma of the corpus uteri--a case report.
Zwierzchowska A, Panek G, Gajewska M
Eur J Gynaecol Oncol 2015;36(6):746-9. PMID: 26775366

Prognosis

Mesonephric-like Carcinosarcoma of the Uterine Corpus: Clinicopathological, Molecular and Prognostic Characteristics in Comparison With Uterine Mesonephric-like Adenocarcinoma and Conventional Endometrial Carcinosarcoma.
Park S, Park E, Kim HS
Cancer Genomics Proteomics 2022 Nov-Dec;19(6):747-760. doi: 10.21873/cgp.20357. PMID: 36316041Free PMC Article
Role of Nucleolin in Endometrial Precancerous Hyperplasia and Carcinogenesis: Ex Vivo and In Silico Study.
Barzilova VD, Drury J, Rogers B, Thomas E, Ahmed F, Bradfield A, Al-Lamee H, Hapangama DK
Int J Mol Sci 2022 Jun 2;23(11) doi: 10.3390/ijms23116228. PMID: 35682908Free PMC Article
Primary carcinosarcoma of the vagina.
Shibata R, Umezawa A, Takehara K, Aoki D, Nozawa S, Hata J
Pathol Int 2003 Feb;53(2):106-10. doi: 10.1046/j.1440-1827.2003.01442.x. PMID: 12588439
Is vascular and lymphatic space invasion a main prognostic factor in uterine neoplasms with a sarcomatous component? A retrospective study of prognostic factors of 60 patients stratified by stages.
Rovirosa A, Ascaso C, Ordi J, Abellana R, Arenas M, Lejarcegui JA, Pahisa J, Puig-Tintoré LM, Mellado B, Armenteros B, Iglesias X, Biete A
Int J Radiat Oncol Biol Phys 2002 Apr 1;52(5):1320-9. doi: 10.1016/s0360-3016(01)02808-5. PMID: 11955745
Cervical carcinosarcoma occurring after subtotal hysterectomy, a case report.
Farley JH, Taylor RR
Gynecol Oncol 1997 Dec;67(3):322-4. doi: 10.1006/gyno.1997.4872. PMID: 9441782

Clinical prediction guides

Role of Nucleolin in Endometrial Precancerous Hyperplasia and Carcinogenesis: Ex Vivo and In Silico Study.
Barzilova VD, Drury J, Rogers B, Thomas E, Ahmed F, Bradfield A, Al-Lamee H, Hapangama DK
Int J Mol Sci 2022 Jun 2;23(11) doi: 10.3390/ijms23116228. PMID: 35682908Free PMC Article
Intramural carcinomas of the uterine corpus: a clinicopathological study.
Kuwashima Y, Kurosumi M, Kasamatsu T, Shiromizu K, Kishi K
In Vivo 1997 May-Jun;11(3):253-60. PMID: 9239520

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