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Uterine carcinosarcoma

MedGen UID:
83678
Concept ID:
C0280630
Neoplastic Process
Synonyms: Carcinosarcoma of the Uterus; carcinosarcoma of the uterus; Carcinosarcoma of uterus; Malignant Mixed Mesodermal (Mullerian) Tumor of the Uterus; malignant mixed mesodermal (Mullerian) tumor of the uterus; malignant mixed mesodermal (Mullerian) tumour of the uterus; Malignant Mixed Mesodermal (Müllerian) Tumor of the Uterus; malignant mixed mesodermal (Müllerian) tumor of the uterus; malignant mixed mesodermal (Müllerian) tumour of the uterus; Malignant mixed Mullerian tumor of uterus; mixed mullerian sarcoma of uterus; Uterine Carcinosarcoma; uterine carcinosarcoma; uterine carcinosarcoma/uterine malignant mixed mullerian tumor; uterine carcinosarcoma/uterine malignant mixed mullerian tumour; Uterine Malignant Mixed Mesodermal (Mullerian) Tumor; uterine malignant mixed mesodermal (Mullerian) tumor; uterine malignant mixed mesodermal (Mullerian) tumour; Uterine Malignant Mixed Mesodermal (Müllerian) Tumor; uterine malignant mixed mesodermal (Müllerian) tumor; uterine malignant mixed mesodermal (Müllerian) tumour; uterus carcinosarcoma
SNOMED CT: Uterine carcinosarcoma (702369008); Carcinosarcoma of uterus (702369008); Malignant mixed Mullerian tumor of uterus (702369008)
 
Monarch Initiative: MONDO:0006485

Definition

A usually aggressive malignant neoplasm arising from the uterine corpus and less often the cervix. It is characterized by the presence of two components: a malignant epithelial component and a sarcomatous component. In the uterine corpus the epithelial component is usually glandular whereas in the cervix is usually non-glandular. Carcinosarcoma of the cervix, although it is aggressive, it may have a better prognosis compared to the uterine corpus carcinosarcoma. [from NCI]

Professional guidelines

PubMed

Crane E
Curr Treat Options Oncol 2022 Nov;23(11):1590-1600. Epub 2022 Oct 7 doi: 10.1007/s11864-022-01014-7. PMID: 36205807
Denschlag D, Ulrich UA
Oncol Res Treat 2018;41(11):675-679. Epub 2018 Oct 13 doi: 10.1159/000494335. PMID: 30317231
Menczer J
Curr Treat Options Oncol 2015 Nov;16(11):53. doi: 10.1007/s11864-015-0370-4. PMID: 26374341

Recent clinical studies

Etiology

Nishikawa T, Hasegawa K, Matsumoto K, Mori M, Hirashima Y, Takehara K, Ariyoshi K, Kato T, Yagishita S, Hamada A, Kawasaki M, Kawashima S, Tomatsuri S, Nagasaka Y, Yoshida H, Machida R, Hirakawa A, Nakamura K, Yonemori K
J Clin Oncol 2023 May 20;41(15):2789-2799. Epub 2023 Mar 28 doi: 10.1200/JCO.22.02558. PMID: 36977309Free PMC Article
Matsuzaki S, Klar M, Matsuzaki S, Roman LD, Sood AK, Matsuo K
Gynecol Oncol 2021 Feb;160(2):586-601. Epub 2020 Nov 9 doi: 10.1016/j.ygyno.2020.10.043. PMID: 33183764
Gómez-Raposo C, Merino Salvador M, Aguayo Zamora C, Casado Saenz E
Cancer Chemother Pharmacol 2020 Mar;85(3):477-486. Epub 2020 Jan 16 doi: 10.1007/s00280-019-04027-6. PMID: 31950214
Denschlag D, Ulrich UA
Oncol Res Treat 2018;41(11):675-679. Epub 2018 Oct 13 doi: 10.1159/000494335. PMID: 30317231
Singh R
J Cancer Res Ther 2014 Jul-Sep;10(3):461-8. doi: 10.4103/0973-1482.138197. PMID: 25313723

Diagnosis

Pezzicoli G, Moscaritolo F, Silvestris E, Silvestris F, Cormio G, Porta C, D'Oronzo S
Crit Rev Oncol Hematol 2021 Jul;163:103369. Epub 2021 May 27 doi: 10.1016/j.critrevonc.2021.103369. PMID: 34051304
Matsuzaki S, Klar M, Matsuzaki S, Roman LD, Sood AK, Matsuo K
Gynecol Oncol 2021 Feb;160(2):586-601. Epub 2020 Nov 9 doi: 10.1016/j.ygyno.2020.10.043. PMID: 33183764
Sagebiel TL, Bhosale PR, Patnana M, Faria SC, Devine CE
Semin Ultrasound CT MR 2019 Aug;40(4):295-301. Epub 2019 Mar 9 doi: 10.1053/j.sult.2019.03.004. PMID: 31375170
Denschlag D, Ulrich UA
Oncol Res Treat 2018;41(11):675-679. Epub 2018 Oct 13 doi: 10.1159/000494335. PMID: 30317231
Arend R, Doneza JA, Wright JD
Curr Opin Oncol 2011 Sep;23(5):531-6. doi: 10.1097/CCO.0b013e328349a45b. PMID: 21743326

Therapy

Nishikawa T, Hasegawa K, Matsumoto K, Mori M, Hirashima Y, Takehara K, Ariyoshi K, Kato T, Yagishita S, Hamada A, Kawasaki M, Kawashima S, Tomatsuri S, Nagasaka Y, Yoshida H, Machida R, Hirakawa A, Nakamura K, Yonemori K
J Clin Oncol 2023 May 20;41(15):2789-2799. Epub 2023 Mar 28 doi: 10.1200/JCO.22.02558. PMID: 36977309Free PMC Article
Powell MA, Filiaci VL, Hensley ML, Huang HQ, Moore KN, Tewari KS, Copeland LJ, Secord AA, Mutch DG, Santin A, Warshal DP, Spirtos NM, DiSilvestro PA, Ioffe OB, Miller DS
J Clin Oncol 2022 Mar 20;40(9):968-977. Epub 2022 Jan 10 doi: 10.1200/JCO.21.02050. PMID: 35007153Free PMC Article
Matsuzaki S, Klar M, Matsuzaki S, Roman LD, Sood AK, Matsuo K
Gynecol Oncol 2021 Feb;160(2):586-601. Epub 2020 Nov 9 doi: 10.1016/j.ygyno.2020.10.043. PMID: 33183764
Arend R, Doneza JA, Wright JD
Curr Opin Oncol 2011 Sep;23(5):531-6. doi: 10.1097/CCO.0b013e328349a45b. PMID: 21743326
El-Nashar SA, Mariani A
Clin Obstet Gynecol 2011 Jun;54(2):292-304. doi: 10.1097/GRF.0b013e31821ac635. PMID: 21508698

Prognosis

Pezzicoli G, Moscaritolo F, Silvestris E, Silvestris F, Cormio G, Porta C, D'Oronzo S
Crit Rev Oncol Hematol 2021 Jul;163:103369. Epub 2021 May 27 doi: 10.1016/j.critrevonc.2021.103369. PMID: 34051304
Matsuzaki S, Klar M, Matsuzaki S, Roman LD, Sood AK, Matsuo K
Gynecol Oncol 2021 Feb;160(2):586-601. Epub 2020 Nov 9 doi: 10.1016/j.ygyno.2020.10.043. PMID: 33183764
Sagebiel TL, Bhosale PR, Patnana M, Faria SC, Devine CE
Semin Ultrasound CT MR 2019 Aug;40(4):295-301. Epub 2019 Mar 9 doi: 10.1053/j.sult.2019.03.004. PMID: 31375170
Ganjoo KN
Curr Probl Cancer 2019 Aug;43(4):283-288. Epub 2019 Jun 14 doi: 10.1016/j.currproblcancer.2019.06.001. PMID: 31235185
Arend R, Doneza JA, Wright JD
Curr Opin Oncol 2011 Sep;23(5):531-6. doi: 10.1097/CCO.0b013e328349a45b. PMID: 21743326

Clinical prediction guides

Zhao S, Li Y, Xu J, Shen L
Neurol Res 2024 Mar;46(3):227-242. Epub 2024 Jan 22 doi: 10.1080/01616412.2023.2287340. PMID: 38007705
Nishikawa T, Hasegawa K, Matsumoto K, Mori M, Hirashima Y, Takehara K, Ariyoshi K, Kato T, Yagishita S, Hamada A, Kawasaki M, Kawashima S, Tomatsuri S, Nagasaka Y, Yoshida H, Machida R, Hirakawa A, Nakamura K, Yonemori K
J Clin Oncol 2023 May 20;41(15):2789-2799. Epub 2023 Mar 28 doi: 10.1200/JCO.22.02558. PMID: 36977309Free PMC Article
Guo M, Wang SM
Cells 2022 Dec 1;11(23) doi: 10.3390/cells11233877. PMID: 36497135Free PMC Article
Burla L, Kalaitzopoulos DR, Mrozek A, Eberhard M, Samartzis N
Fertil Steril 2022 Feb;117(2):461-462. Epub 2022 Jan 2 doi: 10.1016/j.fertnstert.2021.11.016. PMID: 34986982
Zhao F, Xu Y, Zhang H, Ren Y
Gynecol Obstet Invest 2019;84(3):277-282. Epub 2018 Nov 30 doi: 10.1159/000481885. PMID: 30504724

Recent systematic reviews

Raffone A, Travaglino A, Raimondo D, Maletta M, De Vivo V, Visiello U, Casadio P, Seracchioli R, Zullo F, Insabato L, Mollo A
Int J Gynaecol Obstet 2022 Sep;158(3):520-527. Epub 2021 Dec 11 doi: 10.1002/ijgo.14033. PMID: 34797919Free PMC Article
Travaglino A, Raffone A, Raimondo D, Arciuolo D, Angelico G, Valente M, Scaglione G, D'alessandris N, Casadio P, Inzani F, Mollo A, Santoro A, Seracchioli R, Franco Zannoni G
Int J Gynaecol Obstet 2022 Jul;158(1):13-20. Epub 2021 Oct 11 doi: 10.1002/ijgo.13937. PMID: 34536971Free PMC Article
Vitale SG, Laganà AS, Capriglione S, Angioli R, La Rosa VL, Lopez S, Valenti G, Sapia F, Sarpietro G, Butticè S, Tuscano C, Fanale D, Tropea A, Rossetti D
Int J Mol Sci 2017 May 20;18(5) doi: 10.3390/ijms18051100. PMID: 28531111Free PMC Article
Galaal K, van der Heijden E, Godfrey K, Naik R, Kucukmetin A, Bryant A, Das N, Lopes AD
Cochrane Database Syst Rev 2013 Feb 28;2013(2):CD006812. doi: 10.1002/14651858.CD006812.pub3. PMID: 23450572Free PMC Article
Galaal K, Godfrey K, Naik R, Kucukmetin A, Bryant A
Cochrane Database Syst Rev 2011 Jan 19;(1):CD006812. doi: 10.1002/14651858.CD006812.pub2. PMID: 21249682Free PMC Article

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