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Endometrial Mesonephric-Like Adenocarcinoma

MedGen UID:
1792050
•Concept ID:
C5555609
•
Neoplastic Process
Synonyms: Endometrial MLA; Uterine Corpus Mesonephric-Like Adenocarcinoma; Uterine Corpus MLA

Definition

An exceedingly rare adenocarcinoma that arises from the endometrium and displays mesonephric differentiation. Some tumors are thought to derive from mesonephric duct (Wolffian duct) remnants. Others may have a Mullerian duct lineage. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEndometrial Mesonephric-Like Adenocarcinoma

Professional guidelines

PubMed

Mesonephric-like adenocarcinoma of the female genital tract: possible role of KRAS-targeted treatment-detailed molecular analysis of a case series and review of the literature for targetable somatic KRAS-mutations.
Brambs CE, Horn LC, Hiller R, Krücken I, Braun C, Christmann C, Monecke A, Höhn AK
J Cancer Res Clin Oncol 2023 Nov;149(17):15727-15736. Epub 2023 Sep 5 doi: 10.1007/s00432-023-05306-9. PMID: 37668797Free PMC Article

Recent clinical studies

Etiology

Mesonephric-like adenocarcinomas of the uterine corpus: report of a case series and review of the literature indicating poor prognosis for this subtype of endometrial adenocarcinoma.
Horn LC, Höhn AK, Krücken I, Stiller M, Obeck U, Brambs CE
J Cancer Res Clin Oncol 2020 Apr;146(4):971-983. Epub 2020 Jan 11 doi: 10.1007/s00432-019-03123-7. PMID: 31927619
Coexistence of endometrial mesonephric-like adenocarcinoma and endometrioid carcinoma suggests a Müllerian duct lineage: a case report.
Yano M, Shintani D, Katoh T, Hamada M, Ito K, Kozawa E, Hasegawa K, Yasuda M
Diagn Pathol 2019 Jun 7;14(1):54. doi: 10.1186/s13000-019-0830-4. PMID: 31174566Free PMC Article

Diagnosis

Endometrial Mesonephric-like Adenocarcinoma Presenting as an Ocular Lesion: A Case Report.
Al Nabhani S, Doyle A, Kennedy S, McVey R, Crown J, Gibbons D
Int J Gynecol Pathol 2022 Mar 1;41(2):161-167. doi: 10.1097/PGP.0000000000000781. PMID: 33935158
Mesonephric-like adenocarcinomas of the uterine corpus: report of a case series and review of the literature indicating poor prognosis for this subtype of endometrial adenocarcinoma.
Horn LC, Höhn AK, Krücken I, Stiller M, Obeck U, Brambs CE
J Cancer Res Clin Oncol 2020 Apr;146(4):971-983. Epub 2020 Jan 11 doi: 10.1007/s00432-019-03123-7. PMID: 31927619
Coexistence of endometrial mesonephric-like adenocarcinoma and endometrioid carcinoma suggests a Müllerian duct lineage: a case report.
Yano M, Shintani D, Katoh T, Hamada M, Ito K, Kozawa E, Hasegawa K, Yasuda M
Diagn Pathol 2019 Jun 7;14(1):54. doi: 10.1186/s13000-019-0830-4. PMID: 31174566Free PMC Article

Therapy

Coexistence of endometrial mesonephric-like adenocarcinoma and endometrioid carcinoma suggests a Müllerian duct lineage: a case report.
Yano M, Shintani D, Katoh T, Hamada M, Ito K, Kozawa E, Hasegawa K, Yasuda M
Diagn Pathol 2019 Jun 7;14(1):54. doi: 10.1186/s13000-019-0830-4. PMID: 31174566Free PMC Article

Prognosis

Mesonephric-like adenocarcinomas of the uterine corpus: report of a case series and review of the literature indicating poor prognosis for this subtype of endometrial adenocarcinoma.
Horn LC, Höhn AK, Krücken I, Stiller M, Obeck U, Brambs CE
J Cancer Res Clin Oncol 2020 Apr;146(4):971-983. Epub 2020 Jan 11 doi: 10.1007/s00432-019-03123-7. PMID: 31927619

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