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Advanced Vulvar Carcinoma

MedGen UID:
1748137
•Concept ID:
C5418795
•
Neoplastic Process

Definition

Vulvar carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Vulvar Carcinoma

Professional guidelines

PubMed

Radiation therapy for vulvar cancer: consensus technical guidelines of the GINECOR working group of the Spanish Society of Radiation Oncology. Part 2: radiotherapy recommendations.
Cordoba Largo S, Rodriguez Rodriguez I, Rodriguez Villalba S, Najjari Jamal D, Anchuelo Latorre J, Celada Alvarez F, Garcia Cabezas S, de la Fuente Alonso C, Couselo Paniagua L, Martinez Montesinos I, Villafranca Iturre E, Belinchon Olmeda B, Farga Albiol D, Navarrete Solano PA, Sanchez Belda M; GINECOR (Spanish gynaecological tumors group of SEOR)
Clin Transl Oncol 2023 Jul;25(7):2169-2182. Epub 2023 Mar 24 doi: 10.1007/s12094-023-03101-z. PMID: 36961728
Locally advanced vulvar carcinoma diagnosed during cervical cancer screening.
Chiva L, Gonzalez-Rodriguez M, Tendobi C
Int J Gynecol Cancer 2022 Nov 7;32(11):1492. doi: 10.1136/ijgc-2022-003917. PMID: 36343970
Consensus Recommendations for Radiation Therapy Contouring and Treatment of Vulvar Carcinoma.
Gaffney DK, King B, Viswanathan AN, Barkati M, Beriwal S, Eifel P, Erickson B, Fyles A, Goulart J, Harkenrider M, Jhingran A, Klopp A, Koh WJ, Lim K, Petersen I, Portelance L, Small W Jr, Stewart A, Wiebe E, Wolfson A, Yashar C, Bosch W
Int J Radiat Oncol Biol Phys 2016 Jul 15;95(4):1191-200. Epub 2016 Feb 21 doi: 10.1016/j.ijrobp.2016.02.043. PMID: 27130794Free PMC Article

Recent clinical studies

Etiology

Primary chemoradiation versus neoadjuvant chemotherapy followed by surgery as treatment strategy for locally advanced vulvar carcinoma (VULCANize2).
Amant F, van Velzen AF, Reyners A, Zijlmans H, Schaake EE, Nooij L
Int J Gynecol Cancer 2024 Oct 7;34(10):1639-1642. doi: 10.1136/ijgc-2024-005493. PMID: 38719277
Neoadjuvant chemotherapy followed by radical surgery in locally advanced vulvar carcinoma: a single-institution experience.
Adorni M, Bazzurini L, Lissoni AA, Vecchione F, Negri S, Grassi T, Buda A, Landoni F
Tumori 2022 Oct;108(5):495-501. Epub 2021 Jul 21 doi: 10.1177/03008916211027627. PMID: 34289750
Outcome of Radiation Therapy for Locally Advanced Vulvar Carcinoma: Analysis of Inguinal Lymph Node.
Mukai Y, Koike I, Matsunaga T, Yokota NR, Kaizu H, Takano S, Sugiura M, Ito E, Miyagi E, Hata M
In Vivo 2020 Jan-Feb;34(1):307-313. doi: 10.21873/invivo.11775. PMID: 31882493Free PMC Article
Clinical analysis of neoadjuvant chemotherapy in patients with advanced vulvar cancer: A STROBE-compliant article.
Niu Y, Yin R, Wang D, Li Q, Gao X, Huang M
Medicine (Baltimore) 2018 Aug;97(34):e11786. doi: 10.1097/MD.0000000000011786. PMID: 30142764Free PMC Article
Penile carcinoma: lessons learned from vulvar carcinoma.
Longpre MJ, Lange PH, Kwon JS, Black PC
J Urol 2013 Jan;189(1):17-24. Epub 2012 Nov 16 doi: 10.1016/j.juro.2012.08.082. PMID: 23158472

Diagnosis

Locally advanced vulvar carcinoma diagnosed during cervical cancer screening.
Chiva L, Gonzalez-Rodriguez M, Tendobi C
Int J Gynecol Cancer 2022 Nov 7;32(11):1492. doi: 10.1136/ijgc-2022-003917. PMID: 36343970
Neoadjuvant chemotherapy followed by radical surgery in locally advanced vulvar carcinoma: a single-institution experience.
Adorni M, Bazzurini L, Lissoni AA, Vecchione F, Negri S, Grassi T, Buda A, Landoni F
Tumori 2022 Oct;108(5):495-501. Epub 2021 Jul 21 doi: 10.1177/03008916211027627. PMID: 34289750
Consensus Recommendations for Radiation Therapy Contouring and Treatment of Vulvar Carcinoma.
Gaffney DK, King B, Viswanathan AN, Barkati M, Beriwal S, Eifel P, Erickson B, Fyles A, Goulart J, Harkenrider M, Jhingran A, Klopp A, Koh WJ, Lim K, Petersen I, Portelance L, Small W Jr, Stewart A, Wiebe E, Wolfson A, Yashar C, Bosch W
Int J Radiat Oncol Biol Phys 2016 Jul 15;95(4):1191-200. Epub 2016 Feb 21 doi: 10.1016/j.ijrobp.2016.02.043. PMID: 27130794Free PMC Article
Penile carcinoma: lessons learned from vulvar carcinoma.
Longpre MJ, Lange PH, Kwon JS, Black PC
J Urol 2013 Jan;189(1):17-24. Epub 2012 Nov 16 doi: 10.1016/j.juro.2012.08.082. PMID: 23158472
Primary vulvar nocardiosis.
Gallo A, Bettoni G, Trezzi G, Lalinga V, Frigerio L
Obstet Gynecol 2006 Sep;108(3 Pt 2):728-30. doi: 10.1097/01.AOG.0000188068.10174.90. PMID: 17018480

Therapy

Neoadjuvant chemotherapy followed by radical surgery in locally advanced vulvar carcinoma: a single-institution experience.
Adorni M, Bazzurini L, Lissoni AA, Vecchione F, Negri S, Grassi T, Buda A, Landoni F
Tumori 2022 Oct;108(5):495-501. Epub 2021 Jul 21 doi: 10.1177/03008916211027627. PMID: 34289750
Primary vulvar nocardiosis.
Gallo A, Bettoni G, Trezzi G, Lalinga V, Frigerio L
Obstet Gynecol 2006 Sep;108(3 Pt 2):728-30. doi: 10.1097/01.AOG.0000188068.10174.90. PMID: 17018480
Advanced vulvar carcinoma: is it worth operating? A perioperative management protocol for radical and reconstructive surgery.
Fanfani F, Garganese G, Fagotti A, Lorusso D, Gagliardi ML, Rossi M, Salgarello M, Scambia G
Gynecol Oncol 2006 Nov;103(2):467-72. Epub 2006 May 2 doi: 10.1016/j.ygyno.2006.03.022. PMID: 16647747
Primary radiation, cisplatin, and 5-fluorouracil for advanced squamous carcinoma of the vulva.
Cunningham MJ, Goyer RP, Gibbons SK, Kredentser DC, Malfetano JH, Keys H
Gynecol Oncol 1997 Aug;66(2):258-61. doi: 10.1006/gyno.1997.4758. PMID: 9264573
Prolonged continuous infusion cisplatin and 5-fluorouracil with radiation for locally advanced carcinoma of the vulva.
Eifel PJ, Morris M, Burke TW, Levenback C, Gershenson DM
Gynecol Oncol 1995 Oct;59(1):51-6. doi: 10.1006/gyno.1995.1267. PMID: 7557615

Prognosis

Locally advanced squamous cell carcinoma of the vulva: A challenging question for gynecologic oncologists.
Gadducci A, Aletti GD
Gynecol Oncol 2020 Jul;158(1):208-217. Epub 2020 May 25 doi: 10.1016/j.ygyno.2020.05.021. PMID: 32460996
Outcome of Radiation Therapy for Locally Advanced Vulvar Carcinoma: Analysis of Inguinal Lymph Node.
Mukai Y, Koike I, Matsunaga T, Yokota NR, Kaizu H, Takano S, Sugiura M, Ito E, Miyagi E, Hata M
In Vivo 2020 Jan-Feb;34(1):307-313. doi: 10.21873/invivo.11775. PMID: 31882493Free PMC Article
Clinical analysis of neoadjuvant chemotherapy in patients with advanced vulvar cancer: A STROBE-compliant article.
Niu Y, Yin R, Wang D, Li Q, Gao X, Huang M
Medicine (Baltimore) 2018 Aug;97(34):e11786. doi: 10.1097/MD.0000000000011786. PMID: 30142764Free PMC Article
Advanced vulvar carcinoma: is it worth operating? A perioperative management protocol for radical and reconstructive surgery.
Fanfani F, Garganese G, Fagotti A, Lorusso D, Gagliardi ML, Rossi M, Salgarello M, Scambia G
Gynecol Oncol 2006 Nov;103(2):467-72. Epub 2006 May 2 doi: 10.1016/j.ygyno.2006.03.022. PMID: 16647747
Primary radiation, cisplatin, and 5-fluorouracil for advanced squamous carcinoma of the vulva.
Cunningham MJ, Goyer RP, Gibbons SK, Kredentser DC, Malfetano JH, Keys H
Gynecol Oncol 1997 Aug;66(2):258-61. doi: 10.1006/gyno.1997.4758. PMID: 9264573

Clinical prediction guides

A modified triple incision technique for women with locally advanced vulvar cancer: a description of the technique and outcomes.
Li J, Zhou H, Wang LJ, Lu XM, Rao QX, Lu HW, Lin ZQ
Eur J Obstet Gynecol Reprod Biol 2012 Oct;164(2):185-90. Epub 2012 Jun 26 doi: 10.1016/j.ejogrb.2012.05.035. PMID: 22739654
Preoperative intensity-modulated radiotherapy and chemotherapy for locally advanced vulvar carcinoma.
Beriwal S, Coon D, Heron DE, Kelley JL, Edwards RP, Sukumvanich P, Zorn KK, Krivak TC
Gynecol Oncol 2008 May;109(2):291-5. doi: 10.1016/j.ygyno.2007.10.026. PMID: 18455637
Chemoradiation as primary or adjuvant treatment for locally advanced carcinoma of the vulva.
Han SC, Kim DH, Higgins SA, Carcangiu ML, Kacinski BM
Int J Radiat Oncol Biol Phys 2000 Jul 15;47(5):1235-44. doi: 10.1016/s0360-3016(00)00569-1. PMID: 10889377
Combined preoperative chemoradiotherapy followed by radical surgery in locally advanced vulvar carcinoma. A pilot study.
Lupi G, Raspagliesi F, Zucali R, Fontanelli R, Paladini D, Kenda R, di Re F
Cancer 1996 Apr 15;77(8):1472-8. doi: 10.1002/(SICI)1097-0142(19960415)77:8<1472::AID-CNCR8>3.0.CO;2-E. PMID: 8608531
Cisplatin (P), bleomycin (B), and methotrexate (M) preoperative chemotherapy in locally advanced vulvar carcinoma.
Benedetti-Panici P, Greggi S, Scambia G, Salerno G, Mancuso S
Gynecol Oncol 1993 Jul;50(1):49-53. doi: 10.1006/gyno.1993.1163. PMID: 7688709

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