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Glioma

MedGen UID:
9030
Concept ID:
C0017638
Neoplastic Process
Synonyms: Glial Cell Tumor; Glial Cell Tumors; Gliomas; Tumor, Glial Cell; Tumors, Glial Cell
SNOMED CT: Glioma (393564001); Glioma (115240006)
 
Related genes: SUFU, GPR161, PTCH2, ELP1, TP53, IDH1, ERBB2, CTNNB1, BRCA2
 
HPO: HP:0009733
Monarch Initiative: MONDO:0021042
Orphanet: ORPHA182067

Definition

The presence of a glioma, which is a neoplasm of the central nervous system originating from a glial cell (astrocytes or oligodendrocytes). [from HPO]

Term Hierarchy

Follow this link to review classifications for Glioma in Orphanet.

Conditions with this feature

Hamartoma of hypothalamus
MedGen UID:
137970
Concept ID:
C0342418
Finding
Pallister-Hall-like syndrome (PHLS) is a pleiotropic autosomal recessive disorder characterized by phenotypic variability. Patients exhibit postaxial polydactyly as well as hypothalamic hamartoma, cardiac and skeletal anomalies, and craniofacial dysmorphisms. Hirschsprung disease has also been observed (Rubino et al., 2018; Le et al., 2020). Pallister-Hall syndrome (146510) is an autosomal dominant disorder with features overlapping those of PHLS, caused by mutation in the GLI3 gene (165240).
Microcephaly, normal intelligence and immunodeficiency
MedGen UID:
140771
Concept ID:
C0398791
Disease or Syndrome
Nijmegen breakage syndrome (NBS) is characterized by progressive microcephaly, early growth deficiency that improves with age, recurrent respiratory infections, an increased risk for malignancy (primarily lymphoma), and premature ovarian failure in females. Developmental milestones are attained at the usual time during the first year; however, borderline delays in development and hyperactivity may be observed in early childhood. Intellectual abilities tend to decline over time. Recurrent pneumonia and bronchitis may result in respiratory failure and early death. Other reported malignancies include solid tumors (e.g., medulloblastoma, glioma, rhabdomyosarcoma).
Li-Fraumeni syndrome 2
MedGen UID:
1849727
Concept ID:
C5882668
Disease or Syndrome
Li-Fraumeni syndrome is a rare disorder that greatly increases the risk of developing several types of cancer, particularly in children and young adults.\n\nThe cancers most often associated with Li-Fraumeni syndrome include breast cancer, a form of bone cancer called osteosarcoma, and cancers of soft tissues (such as muscle) called soft tissue sarcomas. Other cancers commonly seen in this syndrome include brain tumors, cancers of blood-forming tissues (leukemias), and a cancer called adrenocortical carcinoma that affects the outer layer of the adrenal glands (small hormone-producing glands on top of each kidney). Several other types of cancer also occur more frequently in people with Li-Fraumeni syndrome.\n\nA very similar condition called Li-Fraumeni-like syndrome shares many of the features of classic Li-Fraumeni syndrome. Both conditions significantly increase the chances of developing multiple cancers beginning in childhood; however, the pattern of specific cancers seen in affected family members is different.

Professional guidelines

PubMed

van den Bent MJ, Geurts M, French PJ, Smits M, Capper D, Bromberg JEC, Chang SM
Lancet 2023 Oct 28;402(10412):1564-1579. Epub 2023 Sep 19 doi: 10.1016/S0140-6736(23)01054-1. PMID: 37738997
Czarnywojtek A, Borowska M, Dyrka K, Van Gool S, Sawicka-Gutaj N, Moskal J, Kościński J, Graczyk P, Hałas T, Lewandowska AM, Czepczyński R, Ruchała M
Pharmacology 2023;108(5):423-431. Epub 2023 Jul 17 doi: 10.1159/000531319. PMID: 37459849
Xu S, Tang L, Li X, Fan F, Liu Z
Cancer Lett 2020 Apr 28;476:1-12. Epub 2020 Feb 7 doi: 10.1016/j.canlet.2020.02.002. PMID: 32044356

Curated

Febbo PG, Ladanyi M, Aldape KD, De Marzo AM, Hammond ME, Hayes DF, Iafrate AJ, Kelley RK, Marcucci G, Ogino S, Pao W, Sgroi DC, Birkeland ML
J Natl Compr Canc Netw 2011 Nov;9 Suppl 5:S1-32; quiz S33. doi: 10.6004/jnccn.2011.0137. PMID: 22138009

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Central Nervous System Cancers, 2023

UK NICE Guideline NG99, Brain tumours (primary) and brain metastases in over 16s, 2021

Recent clinical studies

Etiology

Luo J, Pan M, Mo K, Mao Y, Zou D
Semin Cancer Biol 2023 Jun;91:110-123. Epub 2023 Mar 11 doi: 10.1016/j.semcancer.2023.03.006. PMID: 36907387
Fan W, Wang D, Li G, Xu J, Ren C, Sun Z, Wang Z, Ma W, Zhao Z, Bao Z, Jiang T, Zhang Y
CNS Neurosci Ther 2022 Dec;28(12):2090-2103. Epub 2022 Aug 19 doi: 10.1111/cns.13944. PMID: 35985661Free PMC Article
Davis ME
Semin Oncol Nurs 2018 Dec;34(5):420-429. Epub 2018 Nov 2 doi: 10.1016/j.soncn.2018.10.001. PMID: 30392758
Cahill D, Turcan S
Semin Neurol 2018 Feb;38(1):5-10. Epub 2018 Mar 16 doi: 10.1055/s-0037-1620238. PMID: 29548046
Ostrom QT, Bauchet L, Davis FG, Deltour I, Fisher JL, Langer CE, Pekmezci M, Schwartzbaum JA, Turner MC, Walsh KM, Wrensch MR, Barnholtz-Sloan JS
Neuro Oncol 2014 Jul;16(7):896-913. doi: 10.1093/neuonc/nou087. PMID: 24842956Free PMC Article

Diagnosis

Wang LM, Englander ZK, Miller ML, Bruce JN
Adv Exp Med Biol 2023;1405:1-30. doi: 10.1007/978-3-031-23705-8_1. PMID: 37452933
Luo J, Pan M, Mo K, Mao Y, Zou D
Semin Cancer Biol 2023 Jun;91:110-123. Epub 2023 Mar 11 doi: 10.1016/j.semcancer.2023.03.006. PMID: 36907387
Tamai S, Ichinose T, Nakada M
Brain Tumor Pathol 2023 Apr;40(2):66-77. Epub 2023 Feb 17 doi: 10.1007/s10014-023-00452-x. PMID: 36800124
Gianno F, Giovannoni I, Cafferata B, Diomedi-Camassei F, Minasi S, Barresi S, Buttarelli FR, Alesi V, Cardoni A, Antonelli M, Puggioni C, Colafati GS, Carai A, Vinci M, Mastronuzzi A, Miele E, Alaggio R, Giangaspero F, Rossi S
Pathologica 2022 Dec;114(6):422-435. doi: 10.32074/1591-951X-830. PMID: 36534421Free PMC Article
Feng S, Liu Y
Adv Exp Med Biol 2021;1280:261-276. doi: 10.1007/978-3-030-51652-9_18. PMID: 33791988

Therapy

Mahmoudi K, Garvey KL, Bouras A, Cramer G, Stepp H, Jesu Raj JG, Bozec D, Busch TM, Hadjipanayis CG
J Neurooncol 2019 Feb;141(3):595-607. Epub 2019 Jan 18 doi: 10.1007/s11060-019-03103-4. PMID: 30659522Free PMC Article
Fahlbusch R, Samii A
Neurosurg Focus 2016 Mar;40(3):E3. doi: 10.3171/2015.12.FOCUS15631. PMID: 26926061
Lin NU, Lee EQ, Aoyama H, Barani IJ, Barboriak DP, Baumert BG, Bendszus M, Brown PD, Camidge DR, Chang SM, Dancey J, de Vries EG, Gaspar LE, Harris GJ, Hodi FS, Kalkanis SN, Linskey ME, Macdonald DR, Margolin K, Mehta MP, Schiff D, Soffietti R, Suh JH, van den Bent MJ, Vogelbaum MA, Wen PY; Response Assessment in Neuro-Oncology (RANO) group
Lancet Oncol 2015 Jun;16(6):e270-8. Epub 2015 May 27 doi: 10.1016/S1470-2045(15)70057-4. PMID: 26065612
Wen PY, Macdonald DR, Reardon DA, Cloughesy TF, Sorensen AG, Galanis E, Degroot J, Wick W, Gilbert MR, Lassman AB, Tsien C, Mikkelsen T, Wong ET, Chamberlain MC, Stupp R, Lamborn KR, Vogelbaum MA, van den Bent MJ, Chang SM
J Clin Oncol 2010 Apr 10;28(11):1963-72. Epub 2010 Mar 15 doi: 10.1200/JCO.2009.26.3541. PMID: 20231676
Ruiz J, Lesser GJ
Curr Treat Options Oncol 2009 Aug;10(3-4):231-42. Epub 2009 Apr 19 doi: 10.1007/s11864-009-0096-2. PMID: 19381819

Prognosis

Luo C, Xu S, Dai G, Xiao Z, Chen L, Liu Z
Biomed Pharmacother 2020 Jul;127:110193. Epub 2020 May 11 doi: 10.1016/j.biopha.2020.110193. PMID: 32407989
Appay R, Dehais C, Maurage CA, Alentorn A, Carpentier C, Colin C, Ducray F, Escande F, Idbaih A, Kamoun A, Marie Y, Mokhtari K, Tabouret E, Trabelsi N, Uro-Coste E, Delattre JY, Figarella-Branger D; POLA Network
Neuro Oncol 2019 Dec 17;21(12):1519-1528. doi: 10.1093/neuonc/noz124. PMID: 31832685Free PMC Article
Samudra N, Zacharias T, Plitt A, Lega B, Pan E
J Neurol Sci 2019 Sep 15;404:80-85. Epub 2019 Jul 19 doi: 10.1016/j.jns.2019.07.026. PMID: 31352293
Li H, Xi Z, Dai X, Wu W, Li Y, Liu Y, Zhang H
J Neurooncol 2017 Aug;134(1):145-156. Epub 2017 May 30 doi: 10.1007/s11060-017-2499-4. PMID: 28560663
Ostrom QT, Gittleman H, Stetson L, Virk SM, Barnholtz-Sloan JS
Cancer Treat Res 2015;163:1-14. doi: 10.1007/978-3-319-12048-5_1. PMID: 25468222

Clinical prediction guides

Li G, Wu F, Zeng F, Zhai Y, Feng Y, Chang Y, Wang D, Jiang T, Zhang W
CNS Neurosci Ther 2021 Feb;27(2):186-195. Epub 2020 Oct 16 doi: 10.1111/cns.13464. PMID: 33063446Free PMC Article
Erker C, Tamrazi B, Poussaint TY, Mueller S, Mata-Mbemba D, Franceschi E, Brandes AA, Rao A, Haworth KB, Wen PY, Goldman S, Vezina G, MacDonald TJ, Dunkel IJ, Morgan PS, Jaspan T, Prados MD, Warren KE
Lancet Oncol 2020 Jun;21(6):e317-e329. doi: 10.1016/S1470-2045(20)30173-X. PMID: 32502458
Fangusaro J, Witt O, Hernáiz Driever P, Bag AK, de Blank P, Kadom N, Kilburn L, Lober RM, Robison NJ, Fisher MJ, Packer RJ, Young Poussaint T, Papusha L, Avula S, Brandes AA, Bouffet E, Bowers D, Artemov A, Chintagumpala M, Zurakowski D, van den Bent M, Bison B, Yeom KW, Taal W, Warren KE
Lancet Oncol 2020 Jun;21(6):e305-e316. doi: 10.1016/S1470-2045(20)30064-4. PMID: 32502457
Norouzi M
Pharmacol Res 2020 Jun;156:104753. Epub 2020 Mar 21 doi: 10.1016/j.phrs.2020.104753. PMID: 32209363
Davis ME
Semin Oncol Nurs 2018 Dec;34(5):420-429. Epub 2018 Nov 2 doi: 10.1016/j.soncn.2018.10.001. PMID: 30392758

Recent systematic reviews

Agosti E, Zeppieri M, De Maria L, Tedeschi C, Fontanella MM, Panciani PP, Ius T
Int J Mol Sci 2023 Oct 10;24(20) doi: 10.3390/ijms242015037. PMID: 37894718Free PMC Article
Chen B, Yan Y, Wang H, Xu J
Aging Cell 2023 Jul;22(7):e13874. Epub 2023 May 26 doi: 10.1111/acel.13874. PMID: 37232505Free PMC Article
Koekkoek JAF, van der Meer PB, Pace A, Hertler C, Harrison R, Leeper HE, Forst DA, Jalali R, Oliver K, Philip J, Taphoorn MJB, Dirven L, Walbert T
Neuro Oncol 2023 Mar 14;25(3):447-456. doi: 10.1093/neuonc/noac216. PMID: 36271873Free PMC Article
Li Y, Liu Y, Liang Y, Wei R, Zhang W, Yao W, Luo S, Pang X, Wang Y, Jiang X, Lai S, Yang R
Eur Radiol 2022 Nov;32(11):8039-8051. Epub 2022 May 19 doi: 10.1007/s00330-022-08828-x. PMID: 35587827
Efferth T, Oesch F
Semin Cancer Biol 2022 May;80:39-57. Epub 2020 Feb 4 doi: 10.1016/j.semcancer.2020.01.015. PMID: 32027979

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Central Nervous System Cancers, 2023
    • NICE, 2021
      UK NICE Guideline NG99, Brain tumours (primary) and brain metastases in over 16s, 2021
    • NCCN, 2011
      NCCN Task Force report: Evaluating the clinical utility of tumor markers in oncology.

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