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Meningeal Gliomatosis

MedGen UID:
233693
•Concept ID:
C1334695
•
Neoplastic Process
Synonyms: Gliomatosis of Meninges; Gliomatosis of the Meninges; Meninges Gliomatosis

Definition

Diffuse or multifocal infiltration of the meninges by malignant glioma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMeningeal Gliomatosis

Professional guidelines

PubMed

Treatment of meningeal gliomatosis.
Pradat PF, Hoang-Xuan K, Cornu P, Mokhtari K, Martin-Duverneuil N, Poisson M, Delattre JY
J Neurooncol 1999 Sep;44(2):163-8. doi: 10.1023/a:1006399804896. PMID: 10619500
Intrathecal 5-fluoro-2'-deoxyuridine (FdUrd) for the treatment of solid tumor neoplastic meningitis: an in vivo study.
Nakagawa H, Yamada M, Fukushima M, Ikenaka K
Cancer Chemother Pharmacol 1999;43(3):247-56. doi: 10.1007/s002800050891. PMID: 9923556

Recent clinical studies

Etiology

Primary and secondary leptomeningeal gliomatosis in dogs.
Rissi DR, Reyes VAA, Donovan TA, Church ME, Howerth EW, Klang A, Woolard KD, Miller AD
Vet Pathol 2024 Mar;61(2):171-178. Epub 2023 Aug 14 doi: 10.1177/03009858231193104. PMID: 37577961
Tumours and tumour-like lesions of the spinal canal and spine. A review of 185 consecutive cases with more detailed close-up on some chosen pathologies.
Kwinta B, Adamek D, Moskała M, Stachura K
Pol J Pathol 2011;62(1):50-9. PMID: 21574106
Treatment of meningeal gliomatosis.
Pradat PF, Hoang-Xuan K, Cornu P, Mokhtari K, Martin-Duverneuil N, Poisson M, Delattre JY
J Neurooncol 1999 Sep;44(2):163-8. doi: 10.1023/a:1006399804896. PMID: 10619500
Survival of patients with high grade glioma treated with intrathecal thiotriethylenephosphoramide for ependymal or leptomeningeal gliomatosis.
Witham TF, Fukui MB, Meltzer CC, Burns R, Kondziolka D, Bozik ME
Cancer 1999 Oct 1;86(7):1347-53. doi: 10.1002/(sici)1097-0142(19991001)86:7<1347::aid-cncr34>3.0.co;2-m. PMID: 10506724
Intrathecal chemotherapy with 1,3-bis(2-chloroethyl)-1-nitrosourea encapsulated into hybrid liposomes for meningeal gliomatosis: an experimental study.
Kitamura I, Kochi M, Matsumoto Y, Ueoka R, Kuratsu J, Ushio Y
Cancer Res 1996 Sep 1;56(17):3986-92. PMID: 8752168

Diagnosis

Primary and secondary leptomeningeal gliomatosis in dogs.
Rissi DR, Reyes VAA, Donovan TA, Church ME, Howerth EW, Klang A, Woolard KD, Miller AD
Vet Pathol 2024 Mar;61(2):171-178. Epub 2023 Aug 14 doi: 10.1177/03009858231193104. PMID: 37577961
Survival of patients with high grade glioma treated with intrathecal thiotriethylenephosphoramide for ependymal or leptomeningeal gliomatosis.
Witham TF, Fukui MB, Meltzer CC, Burns R, Kondziolka D, Bozik ME
Cancer 1999 Oct 1;86(7):1347-53. doi: 10.1002/(sici)1097-0142(19991001)86:7<1347::aid-cncr34>3.0.co;2-m. PMID: 10506724
Primary diffuse leptomeningeal gliomatosis.
Bailey P, Robitaille Y
Can J Neurol Sci 1985 Aug;12(3):278-81. doi: 10.1017/s031716710004717x. PMID: 4052890
Brainstem glioma: clinical manifestations of meningeal gliomatosis.
Packer RJ, Allen J, Nielsen S, Petito C, Deck M, Jereb B
Ann Neurol 1983 Aug;14(2):177-82. doi: 10.1002/ana.410140204. PMID: 6625534
Meningeal gliomatosis: a review of 12 cases.
Yung WA, Horten BC, Shapiro WR
Ann Neurol 1980 Dec;8(6):605-8. doi: 10.1002/ana.410080610. PMID: 6260012

Therapy

Treatment of meningeal gliomatosis.
Pradat PF, Hoang-Xuan K, Cornu P, Mokhtari K, Martin-Duverneuil N, Poisson M, Delattre JY
J Neurooncol 1999 Sep;44(2):163-8. doi: 10.1023/a:1006399804896. PMID: 10619500
Survival of patients with high grade glioma treated with intrathecal thiotriethylenephosphoramide for ependymal or leptomeningeal gliomatosis.
Witham TF, Fukui MB, Meltzer CC, Burns R, Kondziolka D, Bozik ME
Cancer 1999 Oct 1;86(7):1347-53. doi: 10.1002/(sici)1097-0142(19991001)86:7<1347::aid-cncr34>3.0.co;2-m. PMID: 10506724
Intrathecal 5-fluoro-2'-deoxyuridine (FdUrd) for the treatment of solid tumor neoplastic meningitis: an in vivo study.
Nakagawa H, Yamada M, Fukushima M, Ikenaka K
Cancer Chemother Pharmacol 1999;43(3):247-56. doi: 10.1007/s002800050891. PMID: 9923556
Adoptive immunotherapy of human meningeal gliomatosis and carcinomatosis with LAK cells and recombinant interleukin-2.
Shimizu K, Okamoto Y, Miyao Y, Yamada M, Ushio Y, Hayakawa T, Ikeda H, Mogami H
J Neurosurg 1987 Apr;66(4):519-21. doi: 10.3171/jns.1987.66.4.0519. PMID: 3494108
Brainstem glioma: clinical manifestations of meningeal gliomatosis.
Packer RJ, Allen J, Nielsen S, Petito C, Deck M, Jereb B
Ann Neurol 1983 Aug;14(2):177-82. doi: 10.1002/ana.410140204. PMID: 6625534

Prognosis

Primary and secondary leptomeningeal gliomatosis in dogs.
Rissi DR, Reyes VAA, Donovan TA, Church ME, Howerth EW, Klang A, Woolard KD, Miller AD
Vet Pathol 2024 Mar;61(2):171-178. Epub 2023 Aug 14 doi: 10.1177/03009858231193104. PMID: 37577961
Survival of patients with high grade glioma treated with intrathecal thiotriethylenephosphoramide for ependymal or leptomeningeal gliomatosis.
Witham TF, Fukui MB, Meltzer CC, Burns R, Kondziolka D, Bozik ME
Cancer 1999 Oct 1;86(7):1347-53. doi: 10.1002/(sici)1097-0142(19991001)86:7<1347::aid-cncr34>3.0.co;2-m. PMID: 10506724
Fatal pleomorphic xanthoastrocytoma with meningeal gliomatosis.
Leonard N, Alcutt DA, Farrell MA
Histopathology 1998 Apr;32(4):375-8. doi: 10.1046/j.1365-2559.1998.00407.x. PMID: 9602336
Meningeal gliomatosis presenting as multiple cerebral infarcts: a case report.
Moonis M, Smith TW
Neurology 1996 Jun;46(6):1760-2. doi: 10.1212/wnl.46.6.1760. PMID: 8649589
Measurements of CSF biochemical tumor markers in patients with meningeal carcinomatosis and brain tumors.
Nakagawa H, Kubo S, Murasawa A, Nakajima S, Nakajima Y, Izumoto S, Hayakawa T
J Neurooncol 1992 Feb;12(2):111-20. doi: 10.1007/BF00172659. PMID: 1560255

Clinical prediction guides

Primary and secondary leptomeningeal gliomatosis in dogs.
Rissi DR, Reyes VAA, Donovan TA, Church ME, Howerth EW, Klang A, Woolard KD, Miller AD
Vet Pathol 2024 Mar;61(2):171-178. Epub 2023 Aug 14 doi: 10.1177/03009858231193104. PMID: 37577961
Survival of patients with high grade glioma treated with intrathecal thiotriethylenephosphoramide for ependymal or leptomeningeal gliomatosis.
Witham TF, Fukui MB, Meltzer CC, Burns R, Kondziolka D, Bozik ME
Cancer 1999 Oct 1;86(7):1347-53. doi: 10.1002/(sici)1097-0142(19991001)86:7<1347::aid-cncr34>3.0.co;2-m. PMID: 10506724
Fatal pleomorphic xanthoastrocytoma with meningeal gliomatosis.
Leonard N, Alcutt DA, Farrell MA
Histopathology 1998 Apr;32(4):375-8. doi: 10.1046/j.1365-2559.1998.00407.x. PMID: 9602336
Measurements of CSF biochemical tumor markers in patients with meningeal carcinomatosis and brain tumors.
Nakagawa H, Kubo S, Murasawa A, Nakajima S, Nakajima Y, Izumoto S, Hayakawa T
J Neurooncol 1992 Feb;12(2):111-20. doi: 10.1007/BF00172659. PMID: 1560255

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