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Childhood ganglioglioma

MedGen UID:
234128
•Concept ID:
C1332969
•
Neoplastic Process
Synonym: Childhood Ganglioglioma

Definition

A ganglioglioma that arises from the central nervous system and occurs during childhood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Childhood ganglioglioma

Recent clinical studies

Etiology

Cerebellopontine angle tumors in infants and children.
Tomita T, Grahovac G
Childs Nerv Syst 2015 Oct;31(10):1739-50. Epub 2015 Sep 9 doi: 10.1007/s00381-015-2747-x. PMID: 26351227Free PMC Article
Molecular pathways in gliomagenesis and their relevance to neuropathologic diagnosis.
Appin CL, Brat DJ
Adv Anat Pathol 2015 Jan;22(1):50-8. doi: 10.1097/PAP.0000000000000048. PMID: 25461780
Childhood ganglioglioma and medically intractable epilepsy. A clinicopathological study of 15 patients and a review of the literature.
Khajavi K, Comair YG, Prayson RA, Wyllie E, Palmer J, Estes ML, Hahn JF
Pediatr Neurosurg 1995;22(4):181-8. doi: 10.1159/000120899. PMID: 7619718
The new WHO classification of brain tumours.
Kleihues P, Burger PC, Scheithauer BW
Brain Pathol 1993 Jul;3(3):255-68. doi: 10.1111/j.1750-3639.1993.tb00752.x. PMID: 8293185
Gangliogliomas in childhood.
Smith NM, Carli MM, Hanieh A, Clark B, Bourne AJ, Byard RW
Childs Nerv Syst 1992 Aug;8(5):258-62. doi: 10.1007/BF00300792. PMID: 1394264

Diagnosis

Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer.
Petralia F, Tignor N, Reva B, Koptyra M, Chowdhury S, Rykunov D, Krek A, Ma W, Zhu Y, Ji J, Calinawan A, Whiteaker JR, Colaprico A, Stathias V, Omelchenko T, Song X, Raman P, Guo Y, Brown MA, Ivey RG, Szpyt J, Guha Thakurta S, Gritsenko MA, Weitz KK, Lopez G, Kalayci S, Gümüş ZH, Yoo S, da Veiga Leprevost F, Chang HY, Krug K, Katsnelson L, Wang Y, Kennedy JJ, Voytovich UJ, Zhao L, Gaonkar KS, Ennis BM, Zhang B, Baubet V, Tauhid L, Lilly JV, Mason JL, Farrow B, Young N, Leary S, Moon J, Petyuk VA, Nazarian J, Adappa ND, Palmer JN, Lober RM, Rivero-Hinojosa S, Wang LB, Wang JM, Broberg M, Chu RK, Moore RJ, Monroe ME, Zhao R, Smith RD, Zhu J, Robles AI, Mesri M, Boja E, Hiltke T, Rodriguez H, Zhang B, Schadt EE, Mani DR, Ding L, Iavarone A, Wiznerowicz M, Schürer S, Chen XS, Heath AP, Rokita JL, Nesvizhskii AI, Fenyö D, Rodland KD, Liu T, Gygi SP, Paulovich AG, Resnick AC, Storm PB, Rood BR, Wang P; Children’s Brain Tumor Network; Clinical Proteomic Tumor Analysis Consortium
Cell 2020 Dec 23;183(7):1962-1985.e31. Epub 2020 Nov 25 doi: 10.1016/j.cell.2020.10.044. PMID: 33242424Free PMC Article
Molecular pathways in gliomagenesis and their relevance to neuropathologic diagnosis.
Appin CL, Brat DJ
Adv Anat Pathol 2015 Jan;22(1):50-8. doi: 10.1097/PAP.0000000000000048. PMID: 25461780
Childhood ganglioglioma and medically intractable epilepsy. A clinicopathological study of 15 patients and a review of the literature.
Khajavi K, Comair YG, Prayson RA, Wyllie E, Palmer J, Estes ML, Hahn JF
Pediatr Neurosurg 1995;22(4):181-8. doi: 10.1159/000120899. PMID: 7619718
The new WHO classification of brain tumours.
Kleihues P, Burger PC, Scheithauer BW
Brain Pathol 1993 Jul;3(3):255-68. doi: 10.1111/j.1750-3639.1993.tb00752.x. PMID: 8293185
Gangliogliomas in childhood.
Smith NM, Carli MM, Hanieh A, Clark B, Bourne AJ, Byard RW
Childs Nerv Syst 1992 Aug;8(5):258-62. doi: 10.1007/BF00300792. PMID: 1394264

Therapy

Efficacy of Dabrafenib for three children with brainstem BRAF(V600E) positive ganglioglioma.
Philippe L, Maria K, Tariq A, Sofia M, Christine SM, Jean-Pierre F, Dudley RW, Sébastien P, Nada J, Valérie L
J Neurooncol 2019 Oct;145(1):135-141. Epub 2019 Sep 9 doi: 10.1007/s11060-019-03280-2. PMID: 31502039
Epilepsy-associated tumours: what epileptologists should know about neuropathology, terminology, and classification systems.
Holthausen H, Blümcke I
Epileptic Disord 2016 Sep 1;18(3):240-51. doi: 10.1684/epd.2016.0851. PMID: 27506282
A lower-dose, lower-toxicity cisplatin-etoposide regimen for childhood progressive low-grade glioma.
Massimino M, Spreafico F, Riva D, Biassoni V, Poggi G, Solero C, Gandola L, Genitori L, Modena P, Simonetti F, Potepan P, Casanova M, Meazza C, Clerici CA, Catania S, Sardi I, Giangaspero F
J Neurooncol 2010 Oct;100(1):65-71. Epub 2010 Feb 12 doi: 10.1007/s11060-010-0136-6. PMID: 20151174
Diffuse and focal brain stem tumors in childhood: prognostic factors and surgical outcome. Experience in a single institution.
Sandri A, Sardi N, Genitori L, Giordano F, Peretta P, Basso ME, Bertin D, Mastrodicasa L, Todisco L, Mussa F, Forni M, Ricardi U, Cordero di Montezemolo L, Madon E
Childs Nerv Syst 2006 Sep;22(9):1127-35. Epub 2006 Mar 28 doi: 10.1007/s00381-006-0083-x. PMID: 16568342
Pineal region tumors of childhood.
Packer RJ, Sutton LN, Rosenstock JG, Rorke LB, Bilaniuk LT, Zimmerman RA, Littman PA, Bruce DA, Schut L
Pediatrics 1984 Jul;74(1):97-102. PMID: 6739222

Prognosis

High-grade desmoplastic infantile astrocytoma in a 1-year-old child with Down's syndrome: a case report.
Habib MH, Alavi MZ, Goraya A, Zaman S, Ahmed A
J Med Case Rep 2022 Nov 4;16(1):427. doi: 10.1186/s13256-022-03615-0. PMID: 36333774Free PMC Article
Molecular pathways in gliomagenesis and their relevance to neuropathologic diagnosis.
Appin CL, Brat DJ
Adv Anat Pathol 2015 Jan;22(1):50-8. doi: 10.1097/PAP.0000000000000048. PMID: 25461780
Epilepsy surgery for glioneuronal tumors in childhood: avoid loss of time.
Ramantani G, Kadish NE, Anastasopoulos C, Brandt A, Wagner K, Strobl K, Mayer H, Schubert-Bast S, Stathi A, Korinthenberg R, Feuerstein TJ, Mader I, van Velthoven V, Zentner J, Schulze-Bonhage A, Bast T
Neurosurgery 2014 Jun;74(6):648-57; discussion 657. doi: 10.1227/NEU.0000000000000327. PMID: 24584135
Childhood ganglioglioma and medically intractable epilepsy. A clinicopathological study of 15 patients and a review of the literature.
Khajavi K, Comair YG, Prayson RA, Wyllie E, Palmer J, Estes ML, Hahn JF
Pediatr Neurosurg 1995;22(4):181-8. doi: 10.1159/000120899. PMID: 7619718
Gangliogliomas in childhood.
Smith NM, Carli MM, Hanieh A, Clark B, Bourne AJ, Byard RW
Childs Nerv Syst 1992 Aug;8(5):258-62. doi: 10.1007/BF00300792. PMID: 1394264

Clinical prediction guides

Clinical and histopathological profile of dysembryoplastic neuroepithelial tumor: An experience from a tertiary care center.
Gupta P, Siraj F, Malik A, Shankar KB
J Cancer Res Ther 2021 Jul-Sep;17(4):912-916. doi: 10.4103/jcrt.JCRT_632_19. PMID: 34528541
Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer.
Petralia F, Tignor N, Reva B, Koptyra M, Chowdhury S, Rykunov D, Krek A, Ma W, Zhu Y, Ji J, Calinawan A, Whiteaker JR, Colaprico A, Stathias V, Omelchenko T, Song X, Raman P, Guo Y, Brown MA, Ivey RG, Szpyt J, Guha Thakurta S, Gritsenko MA, Weitz KK, Lopez G, Kalayci S, Gümüş ZH, Yoo S, da Veiga Leprevost F, Chang HY, Krug K, Katsnelson L, Wang Y, Kennedy JJ, Voytovich UJ, Zhao L, Gaonkar KS, Ennis BM, Zhang B, Baubet V, Tauhid L, Lilly JV, Mason JL, Farrow B, Young N, Leary S, Moon J, Petyuk VA, Nazarian J, Adappa ND, Palmer JN, Lober RM, Rivero-Hinojosa S, Wang LB, Wang JM, Broberg M, Chu RK, Moore RJ, Monroe ME, Zhao R, Smith RD, Zhu J, Robles AI, Mesri M, Boja E, Hiltke T, Rodriguez H, Zhang B, Schadt EE, Mani DR, Ding L, Iavarone A, Wiznerowicz M, Schürer S, Chen XS, Heath AP, Rokita JL, Nesvizhskii AI, Fenyö D, Rodland KD, Liu T, Gygi SP, Paulovich AG, Resnick AC, Storm PB, Rood BR, Wang P; Children’s Brain Tumor Network; Clinical Proteomic Tumor Analysis Consortium
Cell 2020 Dec 23;183(7):1962-1985.e31. Epub 2020 Nov 25 doi: 10.1016/j.cell.2020.10.044. PMID: 33242424Free PMC Article
Molecular pathways in gliomagenesis and their relevance to neuropathologic diagnosis.
Appin CL, Brat DJ
Adv Anat Pathol 2015 Jan;22(1):50-8. doi: 10.1097/PAP.0000000000000048. PMID: 25461780
Epilepsy surgery for glioneuronal tumors in childhood: avoid loss of time.
Ramantani G, Kadish NE, Anastasopoulos C, Brandt A, Wagner K, Strobl K, Mayer H, Schubert-Bast S, Stathi A, Korinthenberg R, Feuerstein TJ, Mader I, van Velthoven V, Zentner J, Schulze-Bonhage A, Bast T
Neurosurgery 2014 Jun;74(6):648-57; discussion 657. doi: 10.1227/NEU.0000000000000327. PMID: 24584135
CT and MRI aspects of supratentorial hemispheric tumors of childhood and adolescence.
Finizio FS
Childs Nerv Syst 1995 Oct;11(10):559-67. doi: 10.1007/BF00300993. PMID: 8556721

Supplemental Content

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      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Pediatric Central Nervous System Cancers, 2024

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