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Recurrent Ependymal Tumor

MedGen UID:
1389857
•Concept ID:
C4331227
•
Neoplastic Process

Definition

The reemergence of an ependymal tumor after a period of remission. [from NCI]

Professional guidelines

PubMed

Primary intraventricular tumors - Imaging characteristics, post-treatment changes and relapses.
Chong AW, McAdory LE, Low DCY, Lim EJ, Leong NWL, Ho CL
Clin Imaging 2022 Feb;82:38-52. Epub 2021 Oct 29 doi: 10.1016/j.clinimag.2021.10.008. PMID: 34773811
EANO guidelines for the diagnosis and treatment of ependymal tumors.
Rudà R, Reifenberger G, Frappaz D, Pfister SM, Laprie A, Santarius T, Roth P, Tonn JC, Soffietti R, Weller M, Moyal EC
Neuro Oncol 2018 Mar 27;20(4):445-456. doi: 10.1093/neuonc/nox166. PMID: 29194500Free PMC Article
A multicenter study of the prognosis and treatment of adult brain ependymal tumors.
Reni M, Brandes AA, Vavassori V, Cavallo G, Casagrande F, Vastola F, Magli A, Franzin A, Basso U, Villa E
Cancer 2004 Mar 15;100(6):1221-9. doi: 10.1002/cncr.20074. PMID: 15022290

Recent clinical studies

Etiology

Vasari-Based Features Nomogram to Predict the Tumor-Infiltrating CD8+ T Cell Levels in Glioblastoma.
Xue C, Zhou Q, Zhang B, Ke X, Zhang P, Liu X, Li S, Deng J, Zhou J
Acad Radiol 2024 May;31(5):2050-2060. Epub 2023 Nov 18 doi: 10.1016/j.acra.2023.10.049. PMID: 37985291
Pediatric ependymoma: an overview of a complex disease.
Jünger ST, Timmermann B, Pietsch T
Childs Nerv Syst 2021 Aug;37(8):2451-2463. Epub 2021 May 18 doi: 10.1007/s00381-021-05207-7. PMID: 34008056Free PMC Article
cIMPACT-NOW update 7: advancing the molecular classification of ependymal tumors.
Ellison DW, Aldape KD, Capper D, Fouladi M, Gilbert MR, Gilbertson RJ, Hawkins C, Merchant TE, Pajtler K, Venneti S, Louis DN
Brain Pathol 2020 Sep;30(5):863-866. Epub 2020 Jun 23 doi: 10.1111/bpa.12866. PMID: 32502305Free PMC Article
Central nervous system gliomas.
Reni M, Mazza E, Zanon S, Gatta G, Vecht CJ
Crit Rev Oncol Hematol 2017 May;113:213-234. Epub 2017 Mar 22 doi: 10.1016/j.critrevonc.2017.03.021. PMID: 28427510
Ependymal tumors.
Hasselblatt M
Recent Results Cancer Res 2009;171:51-66. doi: 10.1007/978-3-540-31206-2_3. PMID: 19322537

Diagnosis

Comprehensive overview of extracellular vesicle proteomics in meningioma: future strategy.
Rana R, Sharma S, Ganguly NK
Mol Biol Rep 2021 Dec;48(12):8061-8074. Epub 2021 Oct 23 doi: 10.1007/s11033-021-06740-z. PMID: 34687392Free PMC Article
Pediatric ependymoma: an overview of a complex disease.
Jünger ST, Timmermann B, Pietsch T
Childs Nerv Syst 2021 Aug;37(8):2451-2463. Epub 2021 May 18 doi: 10.1007/s00381-021-05207-7. PMID: 34008056Free PMC Article
Drug repurposing towards targeting cancer stem cells in pediatric brain tumors.
Bahmad HF, Elajami MK, El Zarif T, Bou-Gharios J, Abou-Antoun T, Abou-Kheir W
Cancer Metastasis Rev 2020 Mar;39(1):127-148. doi: 10.1007/s10555-019-09840-2. PMID: 31919619
EANO guidelines for the diagnosis and treatment of ependymal tumors.
Rudà R, Reifenberger G, Frappaz D, Pfister SM, Laprie A, Santarius T, Roth P, Tonn JC, Soffietti R, Weller M, Moyal EC
Neuro Oncol 2018 Mar 27;20(4):445-456. doi: 10.1093/neuonc/nox166. PMID: 29194500Free PMC Article
Central nervous system gliomas.
Reni M, Mazza E, Zanon S, Gatta G, Vecht CJ
Crit Rev Oncol Hematol 2017 May;113:213-234. Epub 2017 Mar 22 doi: 10.1016/j.critrevonc.2017.03.021. PMID: 28427510

Therapy

The clinical, radiological, and immunohistochemical characteristics and outcomes of primary intracranial gliosarcoma: a retrospective single-centre study.
Zhang Y, Ma JP, Weng JC, Wang L, Wu Z, Li D, Zhang JT
Neurosurg Rev 2021 Apr;44(2):1003-1015. Epub 2020 Mar 18 doi: 10.1007/s10143-020-01285-4. PMID: 32189095
Baseline multicentric tumors, distant recurrences and leptomeningeal dissemination predict poor survival in patients with recurrent glioblastomas receiving bevacizumab.
Toh CH, Liau CT, Wei KC, Castillo M
J Neurooncol 2019 Mar;142(1):149-159. Epub 2018 Dec 10 doi: 10.1007/s11060-018-03075-x. PMID: 30535596
Subependymomas - Characteristics of a "Leave me Alone" Lesion.
Kammerer S, Mueller-Eschner M, Lauer A, Luger AL, Quick-Weller J, Franz K, Harter P, Berkefeld J, Wagner M
Rofo 2018 Oct;190(10):955-966. Epub 2018 Jun 18 doi: 10.1055/a-0576-1028. PMID: 29913520
Adult ependymal tumors: prognosis and the M. D. Anderson Cancer Center experience.
Armstrong TS, Vera-Bolanos E, Bekele BN, Aldape K, Gilbert MR
Neuro Oncol 2010 Aug;12(8):862-70. Epub 2010 Feb 5 doi: 10.1093/neuonc/noq009. PMID: 20511182Free PMC Article
Ependymal tumors.
Moynihan TJ
Curr Treat Options Oncol 2003 Dec;4(6):517-23. doi: 10.1007/s11864-003-0052-5. PMID: 14585232

Prognosis

Pediatric ependymoma: an overview of a complex disease.
Jünger ST, Timmermann B, Pietsch T
Childs Nerv Syst 2021 Aug;37(8):2451-2463. Epub 2021 May 18 doi: 10.1007/s00381-021-05207-7. PMID: 34008056Free PMC Article
EANO guidelines for the diagnosis and treatment of ependymal tumors.
Rudà R, Reifenberger G, Frappaz D, Pfister SM, Laprie A, Santarius T, Roth P, Tonn JC, Soffietti R, Weller M, Moyal EC
Neuro Oncol 2018 Mar 27;20(4):445-456. doi: 10.1093/neuonc/nox166. PMID: 29194500Free PMC Article
Central nervous system gliomas.
Reni M, Mazza E, Zanon S, Gatta G, Vecht CJ
Crit Rev Oncol Hematol 2017 May;113:213-234. Epub 2017 Mar 22 doi: 10.1016/j.critrevonc.2017.03.021. PMID: 28427510
Ependymal tumors.
Hasselblatt M
Recent Results Cancer Res 2009;171:51-66. doi: 10.1007/978-3-540-31206-2_3. PMID: 19322537
Ependymal tumors.
Moynihan TJ
Curr Treat Options Oncol 2003 Dec;4(6):517-23. doi: 10.1007/s11864-003-0052-5. PMID: 14585232

Clinical prediction guides

Vasari-Based Features Nomogram to Predict the Tumor-Infiltrating CD8+ T Cell Levels in Glioblastoma.
Xue C, Zhou Q, Zhang B, Ke X, Zhang P, Liu X, Li S, Deng J, Zhou J
Acad Radiol 2024 May;31(5):2050-2060. Epub 2023 Nov 18 doi: 10.1016/j.acra.2023.10.049. PMID: 37985291
Primary intraventricular tumors - Imaging characteristics, post-treatment changes and relapses.
Chong AW, McAdory LE, Low DCY, Lim EJ, Leong NWL, Ho CL
Clin Imaging 2022 Feb;82:38-52. Epub 2021 Oct 29 doi: 10.1016/j.clinimag.2021.10.008. PMID: 34773811
The clinical, radiological, and immunohistochemical characteristics and outcomes of primary intracranial gliosarcoma: a retrospective single-centre study.
Zhang Y, Ma JP, Weng JC, Wang L, Wu Z, Li D, Zhang JT
Neurosurg Rev 2021 Apr;44(2):1003-1015. Epub 2020 Mar 18 doi: 10.1007/s10143-020-01285-4. PMID: 32189095
Recurrence rates and functional outcome after resection of intrinsic intramedullary tumors.
Schebesch KM, Mueller S, Wendl C, Brawanski A, Riemenschneider MJ, Proescholdt M
Clin Neurol Neurosurg 2015 Jul;134:60-6. Epub 2015 Apr 24 doi: 10.1016/j.clineuro.2015.04.006. PMID: 25950925
Clinical characteristics and surgical outcomes of spinal intramedullary ependymal cysts.
Yang T, Wu L, Deng X, Yang C, Fang J, Zhao L, Wang G, Yang J, Xu Y
Acta Neurochir (Wien) 2014 Feb;156(2):269-75. Epub 2013 Dec 10 doi: 10.1007/s00701-013-1964-x. PMID: 24322584

Recent systematic reviews

Adjuvant radiotherapy versus observation after gross total resection of WHO grade II ependymoma: a systematic review and individual-participant data meta-analysis.
Zheng Y, Ong SH, Nga VDW, Vellayappan B
Chin Clin Oncol 2024 Apr;13(2):22. Epub 2024 Apr 17 doi: 10.21037/cco-23-136. PMID: 38644544

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