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Oligodendroglial tumor

MedGen UID:
233266
•Concept ID:
C1335110
•
Neoplastic Process
Synonyms: Oligodendroglial Neoplasm; oligodendroglial neoplasm; Oligodendroglial Tumor; oligodendroglial tumor
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
•Concept ID:
C0600599
•
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Non-Mendelian inheritance (Orphanet)
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0018744
Orphanet: ORPHA46484

Definition

Oligodendrogliomas are cerebral tumors that are differentiated from other gliomas on the basis of their unique genetic characteristics and better response to chemotherapy. These tumors are classified according to their grade (low grade oligodendrogliomas: grade II of the WHO classification and anaplastic oligodendrogliomas: grade III of the WHO classification) and according to their pure or mixed histology (oligoastrocytomas). [from ORDO]

Professional guidelines

PubMed

Input of molecular analysis in medical management of primary brain tumor patients.
Idbaih A, Duran-Peña A, Bonnet C, Ducray F
Rev Neurol (Paris) 2015 Jun-Jul;171(6-7):457-65. Epub 2015 May 27 doi: 10.1016/j.neurol.2015.04.002. PMID: 26026669
Classification of oligodendroglial tumors based on histopathology criteria is a significant predictor of survival--clinical, radiological and pathologic long-term follow-up analysis.
Sepulveda Sanchez JM, Martinez Montero JC, Diez-Lobato R, Hernandez-Lain A, Cabello A, Ramos A, Gonzalez Leon P, Ricoy Campo JR
Clin Neuropathol 2009 Jan-Feb;28(1):11-20. doi: 10.5414/npp28011. PMID: 19216215
Molecular genetics of oligodendrogliomas: a model for improved clinical management in the field of neurooncology.
Nutt CL
Neurosurg Focus 2005 Nov 15;19(5):E2. doi: 10.3171/foc.2005.19.5.3. PMID: 16398466

Recent clinical studies

Etiology

Cognitive and brain structural changes in long-term oligodendroglial tumor survivors.
Cayuela N, Jaramillo-Jiménez E, Càmara E, Majós C, Vidal N, Lucas A, Gil-Gil M, Graus F, Bruna J, Simó M
Neuro Oncol 2019 Nov 4;21(11):1470-1479. doi: 10.1093/neuonc/noz130. PMID: 31549152Free PMC Article
Not all 1p/19q non-codeleted oligodendroglial tumors are astrocytic.
Li YX, Shi Z, Aibaidula A, Chen H, Tang Q, Li KK, Chung NY, Chan DT, Poon WS, Mao Y, Wu J, Zhou L, Chan AK, Ng HK
Oncotarget 2016 Oct 4;7(40):64615-64630. doi: 10.18632/oncotarget.11378. PMID: 27556304Free PMC Article
Input of molecular analysis in medical management of primary brain tumor patients.
Idbaih A, Duran-Peña A, Bonnet C, Ducray F
Rev Neurol (Paris) 2015 Jun-Jul;171(6-7):457-65. Epub 2015 May 27 doi: 10.1016/j.neurol.2015.04.002. PMID: 26026669
Oligodendroglial tumors.
Jaeckle KA
Semin Oncol 2014 Aug;41(4):468-477. Epub 2014 Jun 30 doi: 10.1053/j.seminoncol.2014.06.009. PMID: 25173140
Prediction of oligodendroglial tumor subtype and grade using perfusion weighted magnetic resonance imaging.
Whitmore RG, Krejza J, Kapoor GS, Huse J, Woo JH, Bloom S, Lopinto J, Wolf RL, Judy K, Rosenfeld MR, Biegel JA, Melhem ER, O'Rourke DM
J Neurosurg 2007 Sep;107(3):600-9. doi: 10.3171/JNS-07/09/0600. PMID: 17886561

Diagnosis

Not all 1p/19q non-codeleted oligodendroglial tumors are astrocytic.
Li YX, Shi Z, Aibaidula A, Chen H, Tang Q, Li KK, Chung NY, Chan DT, Poon WS, Mao Y, Wu J, Zhou L, Chan AK, Ng HK
Oncotarget 2016 Oct 4;7(40):64615-64630. doi: 10.18632/oncotarget.11378. PMID: 27556304Free PMC Article
Input of molecular analysis in medical management of primary brain tumor patients.
Idbaih A, Duran-Peña A, Bonnet C, Ducray F
Rev Neurol (Paris) 2015 Jun-Jul;171(6-7):457-65. Epub 2015 May 27 doi: 10.1016/j.neurol.2015.04.002. PMID: 26026669
Oligodendroglial tumors.
Jaeckle KA
Semin Oncol 2014 Aug;41(4):468-477. Epub 2014 Jun 30 doi: 10.1053/j.seminoncol.2014.06.009. PMID: 25173140
Prediction of oligodendroglial tumor subtype and grade using perfusion weighted magnetic resonance imaging.
Whitmore RG, Krejza J, Kapoor GS, Huse J, Woo JH, Bloom S, Lopinto J, Wolf RL, Judy K, Rosenfeld MR, Biegel JA, Melhem ER, O'Rourke DM
J Neurosurg 2007 Sep;107(3):600-9. doi: 10.3171/JNS-07/09/0600. PMID: 17886561
Oligodendroglioma: pathology and molecular biology.
Engelhard HH, Stelea A, Cochran EJ
Surg Neurol 2002 Aug;58(2):111-7; discussion 117. doi: 10.1016/s0090-3019(02)00751-6. PMID: 12453646

Therapy

Cognitive and brain structural changes in long-term oligodendroglial tumor survivors.
Cayuela N, Jaramillo-Jiménez E, Càmara E, Majós C, Vidal N, Lucas A, Gil-Gil M, Graus F, Bruna J, Simó M
Neuro Oncol 2019 Nov 4;21(11):1470-1479. doi: 10.1093/neuonc/noz130. PMID: 31549152Free PMC Article
Oligodendroglial tumors.
Jaeckle KA
Semin Oncol 2014 Aug;41(4):468-477. Epub 2014 Jun 30 doi: 10.1053/j.seminoncol.2014.06.009. PMID: 25173140
Novel MSH6 mutations in treatment-naïve glioblastoma and anaplastic oligodendroglioma contribute to temozolomide resistance independently of MGMT promoter methylation.
Nguyen SA, Stechishin OD, Luchman HA, Lun XQ, Senger DL, Robbins SM, Cairncross JG, Weiss S
Clin Cancer Res 2014 Sep 15;20(18):4894-903. Epub 2014 Jul 30 doi: 10.1158/1078-0432.CCR-13-1856. PMID: 25078279
Multimodal MR imaging (diffusion, perfusion, and spectroscopy): is it possible to distinguish oligodendroglial tumor grade and 1p/19q codeletion in the pretherapeutic diagnosis?
Fellah S, Caudal D, De Paula AM, Dory-Lautrec P, Figarella-Branger D, Chinot O, Metellus P, Cozzone PJ, Confort-Gouny S, Ghattas B, Callot V, Girard N
AJNR Am J Neuroradiol 2013 Jul;34(7):1326-33. Epub 2012 Dec 6 doi: 10.3174/ajnr.A3352. PMID: 23221948Free PMC Article
Prognostic variables in oligodendroglial tumors: a single-institution study of 95 cases.
Scheie D, Meling TR, Cvancarova M, Skullerud K, Mørk S, Lote K, Eide TJ, Helseth E, Beiske K
Neuro Oncol 2011 Nov;13(11):1225-33. Epub 2011 Aug 19 doi: 10.1093/neuonc/nor114. PMID: 21856683Free PMC Article

Prognosis

Cognitive and brain structural changes in long-term oligodendroglial tumor survivors.
Cayuela N, Jaramillo-Jiménez E, Càmara E, Majós C, Vidal N, Lucas A, Gil-Gil M, Graus F, Bruna J, Simó M
Neuro Oncol 2019 Nov 4;21(11):1470-1479. doi: 10.1093/neuonc/noz130. PMID: 31549152Free PMC Article
Not all 1p/19q non-codeleted oligodendroglial tumors are astrocytic.
Li YX, Shi Z, Aibaidula A, Chen H, Tang Q, Li KK, Chung NY, Chan DT, Poon WS, Mao Y, Wu J, Zhou L, Chan AK, Ng HK
Oncotarget 2016 Oct 4;7(40):64615-64630. doi: 10.18632/oncotarget.11378. PMID: 27556304Free PMC Article
Oligodendroglial tumors.
Jaeckle KA
Semin Oncol 2014 Aug;41(4):468-477. Epub 2014 Jun 30 doi: 10.1053/j.seminoncol.2014.06.009. PMID: 25173140
Prognosis of oligodendroglial tumor with ring enhancement showing central necrotic portion.
Choi KY, Jung TY, Jung S, Kim YH, Moon KS, Kim IY, Kang SS, Lee KH
J Neurooncol 2011 May;103(1):103-10. Epub 2010 Aug 25 doi: 10.1007/s11060-010-0353-z. PMID: 20737192
Oligodendroglioma: pathology and molecular biology.
Engelhard HH, Stelea A, Cochran EJ
Surg Neurol 2002 Aug;58(2):111-7; discussion 117. doi: 10.1016/s0090-3019(02)00751-6. PMID: 12453646

Clinical prediction guides

Carbonic anhydrase related protein expression in astrocytomas and oligodendroglial tumors.
Karjalainen SL, Haapasalo HK, Aspatwar A, Barker H, Parkkila S, Haapasalo JA
BMC Cancer 2018 May 23;18(1):584. doi: 10.1186/s12885-018-4493-4. PMID: 29792187Free PMC Article
Survival trends of oligodendroglial tumor patients and associated clinical practice patterns: a SEER-based analysis.
Brandel MG, Alattar AA, Hirshman BR, Dong X, Carroll KT, Ali MA, Carter BS, Chen CC
J Neurooncol 2017 May;133(1):173-181. Epub 2017 Apr 24 doi: 10.1007/s11060-017-2430-z. PMID: 28439777
Coexpression of cyclin D1 and alpha-internexin in oligodendroglial tumors.
Matsumura N, Nobusawa S, Ikota H, Hirato J, Hirose T, Yokoo H, Nakazato Y
Brain Tumor Pathol 2015 Oct;32(4):261-7. Epub 2015 Aug 2 doi: 10.1007/s10014-015-0228-2. PMID: 26233522
Input of molecular analysis in medical management of primary brain tumor patients.
Idbaih A, Duran-Peña A, Bonnet C, Ducray F
Rev Neurol (Paris) 2015 Jun-Jul;171(6-7):457-65. Epub 2015 May 27 doi: 10.1016/j.neurol.2015.04.002. PMID: 26026669
Prediction of oligodendroglial tumor subtype and grade using perfusion weighted magnetic resonance imaging.
Whitmore RG, Krejza J, Kapoor GS, Huse J, Woo JH, Bloom S, Lopinto J, Wolf RL, Judy K, Rosenfeld MR, Biegel JA, Melhem ER, O'Rourke DM
J Neurosurg 2007 Sep;107(3):600-9. doi: 10.3171/JNS-07/09/0600. PMID: 17886561

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