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Cervical and Thoracic Spinal Cord Ependymal Tumor

MedGen UID:
1391795
•Concept ID:
C4329653
•
Neoplastic Process

Definition

A finding indicating the presence of an ependymal tumor in the cervical and thoracic regions of spinal cord. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical and Thoracic Spinal Cord Ependymal Tumor

Recent clinical studies

Etiology

Giant Myxopapillary Ependymoma with Multi-Site Neural Axis Metastases: A Rare Case with Suboptimal Outcome.
Balodis A, Ņeverčika V, Zavertjajeva M, Mikijanskis R, Kalniņa M, Breikša-Vaivode A, Briede I
Am J Case Rep 2024 Jan 31;25:e942392. doi: 10.12659/AJCR.942392. PMID: 38291726Free PMC Article
MYCN amplification drives an aggressive form of spinal ependymoma.
Ghasemi DR, Sill M, Okonechnikov K, Korshunov A, Yip S, Schutz PW, Scheie D, Kruse A, Harter PN, Kastelan M, Wagner M, Hartmann C, Benzel J, Maass KK, Khasraw M, Sträter R, Thomas C, Paulus W, Kratz CP, Witt H, Kawauchi D, Herold-Mende C, Sahm F, Brandner S, Kool M, Jones DTW, von Deimling A, Pfister SM, Reuss DE, Pajtler KW
Acta Neuropathol 2019 Dec;138(6):1075-1089. Epub 2019 Aug 14 doi: 10.1007/s00401-019-02056-2. PMID: 31414211Free PMC Article
Spectrum of nonterminal myelocystoceles.
Rossi A, Piatelli G, Gandolfo C, Pavanello M, Hoffmann C, Van Goethem JW, Cama A, Tortori-Donati P
Neurosurgery 2006 Mar;58(3):509-15; discussion 509-15. doi: 10.1227/01.NEU.0000197122.92954.82. PMID: 16528191
Intradural extramedullary cysts of the spinal canal: clinical presentation, radiographic diagnosis, and surgical management.
Osenbach RK, Godersky JC, Traynelis VC, Schelper RD
Neurosurgery 1992 Jan;30(1):35-42. doi: 10.1227/00006123-199201000-00007. PMID: 1738453

Diagnosis

Giant Myxopapillary Ependymoma with Multi-Site Neural Axis Metastases: A Rare Case with Suboptimal Outcome.
Balodis A, Ņeverčika V, Zavertjajeva M, Mikijanskis R, Kalniņa M, Breikša-Vaivode A, Briede I
Am J Case Rep 2024 Jan 31;25:e942392. doi: 10.12659/AJCR.942392. PMID: 38291726Free PMC Article
MYCN amplification drives an aggressive form of spinal ependymoma.
Ghasemi DR, Sill M, Okonechnikov K, Korshunov A, Yip S, Schutz PW, Scheie D, Kruse A, Harter PN, Kastelan M, Wagner M, Hartmann C, Benzel J, Maass KK, Khasraw M, Sträter R, Thomas C, Paulus W, Kratz CP, Witt H, Kawauchi D, Herold-Mende C, Sahm F, Brandner S, Kool M, Jones DTW, von Deimling A, Pfister SM, Reuss DE, Pajtler KW
Acta Neuropathol 2019 Dec;138(6):1075-1089. Epub 2019 Aug 14 doi: 10.1007/s00401-019-02056-2. PMID: 31414211Free PMC Article
Cervicothoracic nonterminal myelocystocele with mature teratoma.
Gressot LV, Mohila CA, Jea A, Luerssen TG, Bollo RJ
J Neurosurg Pediatr 2014 Feb;13(2):204-8. Epub 2013 Dec 20 doi: 10.3171/2013.12.PEDS13408. PMID: 24359211
Intradural extramedullary cysts of the spinal canal: clinical presentation, radiographic diagnosis, and surgical management.
Osenbach RK, Godersky JC, Traynelis VC, Schelper RD
Neurosurgery 1992 Jan;30(1):35-42. doi: 10.1227/00006123-199201000-00007. PMID: 1738453
Intramedullary cysticercosis. Case report, literature review and comments on pathogenesis.
De Souza Queiroz L, Filho AP, Callegaro D, De Faria LL
J Neurol Sci 1975 Sep;26(1):61-70. doi: 10.1016/0022-510x(75)90114-8. PMID: 1159459

Therapy

Papillary tumor of the spinal cord: report of 2 cases.
Mobley B, Kalani MY, Harsh GR 4th, Edwards MS, Vogel H
Am J Surg Pathol 2009 Aug;33(8):1191-7. doi: 10.1097/PAS.0b013e31819c45ca. PMID: 19417584

Prognosis

MYCN amplification drives an aggressive form of spinal ependymoma.
Ghasemi DR, Sill M, Okonechnikov K, Korshunov A, Yip S, Schutz PW, Scheie D, Kruse A, Harter PN, Kastelan M, Wagner M, Hartmann C, Benzel J, Maass KK, Khasraw M, Sträter R, Thomas C, Paulus W, Kratz CP, Witt H, Kawauchi D, Herold-Mende C, Sahm F, Brandner S, Kool M, Jones DTW, von Deimling A, Pfister SM, Reuss DE, Pajtler KW
Acta Neuropathol 2019 Dec;138(6):1075-1089. Epub 2019 Aug 14 doi: 10.1007/s00401-019-02056-2. PMID: 31414211Free PMC Article
Spectrum of nonterminal myelocystoceles.
Rossi A, Piatelli G, Gandolfo C, Pavanello M, Hoffmann C, Van Goethem JW, Cama A, Tortori-Donati P
Neurosurgery 2006 Mar;58(3):509-15; discussion 509-15. doi: 10.1227/01.NEU.0000197122.92954.82. PMID: 16528191
Tanycytic ependymoma in association with neurofibromatosis type 2.
Kobata H, Kuroiwa T, Isono N, Nagasawa S, Ohta T, Tsutsumi A
Clin Neuropathol 2001 May-Jun;20(3):93-100. PMID: 11430494
Intradural extramedullary cysts of the spinal canal: clinical presentation, radiographic diagnosis, and surgical management.
Osenbach RK, Godersky JC, Traynelis VC, Schelper RD
Neurosurgery 1992 Jan;30(1):35-42. doi: 10.1227/00006123-199201000-00007. PMID: 1738453
Intramedullary cysticercosis. Case report, literature review and comments on pathogenesis.
De Souza Queiroz L, Filho AP, Callegaro D, De Faria LL
J Neurol Sci 1975 Sep;26(1):61-70. doi: 10.1016/0022-510x(75)90114-8. PMID: 1159459

Clinical prediction guides

MYCN amplification drives an aggressive form of spinal ependymoma.
Ghasemi DR, Sill M, Okonechnikov K, Korshunov A, Yip S, Schutz PW, Scheie D, Kruse A, Harter PN, Kastelan M, Wagner M, Hartmann C, Benzel J, Maass KK, Khasraw M, Sträter R, Thomas C, Paulus W, Kratz CP, Witt H, Kawauchi D, Herold-Mende C, Sahm F, Brandner S, Kool M, Jones DTW, von Deimling A, Pfister SM, Reuss DE, Pajtler KW
Acta Neuropathol 2019 Dec;138(6):1075-1089. Epub 2019 Aug 14 doi: 10.1007/s00401-019-02056-2. PMID: 31414211Free PMC Article
Spectrum of nonterminal myelocystoceles.
Rossi A, Piatelli G, Gandolfo C, Pavanello M, Hoffmann C, Van Goethem JW, Cama A, Tortori-Donati P
Neurosurgery 2006 Mar;58(3):509-15; discussion 509-15. doi: 10.1227/01.NEU.0000197122.92954.82. PMID: 16528191

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