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Ganglioglioma

MedGen UID:
60216
Concept ID:
C0206716
Neoplastic Process
Synonym: Mixed cell tumors containing both neural ganglionic cells and neural glial cell components
SNOMED CT: Ganglioglioma (87191000119100); Neuroastrocytoma (1162662003); Glioneuroma (1162662003); Ganglioglioma (1162662003)
 
HPO: HP:0033664
Monarch Initiative: MONDO:0016733
Orphanet: ORPHA251949

Definition

Gangliogliomas are rare tumors of the central nervous system. The are WHO grade I and considered low grade. They are well differentiated neuroepithelial tumors consisting of both dysplastic neuronal and neoplastic glial cells. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Ganglioglioma
Follow this link to review classifications for Ganglioglioma in Orphanet.

Professional guidelines

PubMed

Salge-Arrieta FJ, Carrasco-Moro R, Rodríguez-Berrocal V, Vior-Fernández C, Lee P, Pián H, Martínez-San Millán JS, Ley-Urzáiz L
World Neurosurg 2021 May;149:e651-e663. Epub 2021 Feb 4 doi: 10.1016/j.wneu.2021.01.119. PMID: 33548530
Vecht C, Royer-Perron L, Houillier C, Huberfeld G
Curr Pharm Des 2017;23(42):6464-6487. doi: 10.2174/1381612823666171027130003. PMID: 29076421
Gokden M
Adv Anat Pathol 2017 Nov;24(6):379-391. doi: 10.1097/PAP.0000000000000170. PMID: 28885262

Recent clinical studies

Etiology

Wu PB, Filley AC, Miller ML, Bruce JN
Adv Exp Med Biol 2023;1405:31-71. doi: 10.1007/978-3-031-23705-8_2. PMID: 37452934
Ryall S, Tabori U, Hawkins C
Acta Neuropathol Commun 2020 Mar 12;8(1):30. doi: 10.1186/s40478-020-00902-z. PMID: 32164789Free PMC Article
Kobow K, Blümcke I
Neurosci Lett 2018 Feb 22;667:40-46. Epub 2017 Jan 19 doi: 10.1016/j.neulet.2017.01.012. PMID: 28111355
Blumcke I, Spreafico R, Haaker G, Coras R, Kobow K, Bien CG, Pfäfflin M, Elger C, Widman G, Schramm J, Becker A, Braun KP, Leijten F, Baayen JC, Aronica E, Chassoux F, Hamer H, Stefan H, Rössler K, Thom M, Walker MC, Sisodiya SM, Duncan JS, McEvoy AW, Pieper T, Holthausen H, Kudernatsch M, Meencke HJ, Kahane P, Schulze-Bonhage A, Zentner J, Heiland DH, Urbach H, Steinhoff BJ, Bast T, Tassi L, Lo Russo G, Özkara C, Oz B, Krsek P, Vogelgesang S, Runge U, Lerche H, Weber Y, Honavar M, Pimentel J, Arzimanoglou A, Ulate-Campos A, Noachtar S, Hartl E, Schijns O, Guerrini R, Barba C, Jacques TS, Cross JH, Feucht M, Mühlebner A, Grunwald T, Trinka E, Winkler PA, Gil-Nagel A, Toledano Delgado R, Mayer T, Lutz M, Zountsas B, Garganis K, Rosenow F, Hermsen A, von Oertzen TJ, Diepgen TL, Avanzini G; EEBB Consortium
N Engl J Med 2017 Oct 26;377(17):1648-1656. doi: 10.1056/NEJMoa1703784. PMID: 29069555
Puget S, Alshehri A, Beccaria K, Blauwblomme T, Paternoster G, James S, Dirocco F, Dufour C, Zerah M, Varlet P, Sainte-Rose C
Childs Nerv Syst 2015 Oct;31(10):1707-16. Epub 2015 Sep 9 doi: 10.1007/s00381-015-2860-x. PMID: 26351224

Diagnosis

Vlachos N, Lampros MG, Zigouris A, Voulgaris S, Alexiou GA
Neurosurg Rev 2022 Feb;45(1):295-304. Epub 2021 Jul 27 doi: 10.1007/s10143-021-01612-3. PMID: 34312775
Slegers RJ, Blumcke I
Acta Neuropathol Commun 2020 Mar 9;8(1):27. doi: 10.1186/s40478-020-00904-x. PMID: 32151273Free PMC Article
Kamoun S, Azouz H, Zemmali M, Haouet S, Kchir N
Pan Afr Med J 2019;32:113. Epub 2019 Mar 11 doi: 10.11604/pamj.2019.32.113.12669. PMID: 31223403Free PMC Article
Puget S, Alshehri A, Beccaria K, Blauwblomme T, Paternoster G, James S, Dirocco F, Dufour C, Zerah M, Varlet P, Sainte-Rose C
Childs Nerv Syst 2015 Oct;31(10):1707-16. Epub 2015 Sep 9 doi: 10.1007/s00381-015-2860-x. PMID: 26351224
Fedoul B, Souirti Z
Pan Afr Med J 2012;12:12. Epub 2012 May 22 PMID: 22826736Free PMC Article

Therapy

Audrey C, Lim KS, Ahmad Zaki R, Fong SL, Chan CY, Sathis Kumar T, Narayanan V, Tan CT
Epilepsy Res 2022 Nov;187:107033. Epub 2022 Oct 10 doi: 10.1016/j.eplepsyres.2022.107033. PMID: 36274423
Ryall S, Tabori U, Hawkins C
Acta Neuropathol Commun 2020 Mar 12;8(1):30. doi: 10.1186/s40478-020-00902-z. PMID: 32164789Free PMC Article
Geoerger B, Kang HJ, Yalon-Oren M, Marshall LV, Vezina C, Pappo A, Laetsch TW, Petrilli AS, Ebinger M, Toporski J, Glade-Bender J, Nicholls W, Fox E, DuBois SG, Macy ME, Cohn SL, Pathiraja K, Diede SJ, Ebbinghaus S, Pinto N
Lancet Oncol 2020 Jan;21(1):121-133. Epub 2019 Dec 4 doi: 10.1016/S1470-2045(19)30671-0. PMID: 31812554
Preusser M, Bienkowski M, Birner P
Expert Opin Investig Drugs 2016;25(1):7-14. Epub 2015 Nov 4 doi: 10.1517/13543784.2016.1110143. PMID: 26536389
McLone DG, Stieg PE, Scott RM, Barnett F, Barnes PD, Folkerth R
Neurosurgery 1998 May;42(5):1106-11. doi: 10.1097/00006123-199805000-00093. PMID: 9588556

Prognosis

Auffret L, Ajlil Y, Tauziède-Espariat A, Kergrohen T, Puiseux C, Riffaud L, Blouin P, Bertozzi AI, Leblond P, Blomgren K, Froelich S, Picca A, Touat M, Sanson M, Beccaria K, Blauwblomme T, Dangouloff-Ros V, Boddaert N, Varlet P, Debily MA, Grill J, Castel D
Acta Neuropathol 2023 Dec 8;147(1):2. doi: 10.1007/s00401-023-02651-4. PMID: 38066305Free PMC Article
Wu PB, Filley AC, Miller ML, Bruce JN
Adv Exp Med Biol 2023;1405:31-71. doi: 10.1007/978-3-031-23705-8_2. PMID: 37452934
Rudà R, Capper D, Waldman AD, Pallud J, Minniti G, Kaley TJ, Bouffet E, Tabatabai G, Aronica E, Jakola AS, Pfister SM, Schiff D, Lassman AB, Solomon DA, Soffietti R, Weller M, Preusser M, Idbaih A, Wen PY, van den Bent MJ
Neuro Oncol 2022 Dec 1;24(12):2015-2034. doi: 10.1093/neuonc/noac188. PMID: 35908833Free PMC Article
Kobow K, Blümcke I
Neurosci Lett 2018 Feb 22;667:40-46. Epub 2017 Jan 19 doi: 10.1016/j.neulet.2017.01.012. PMID: 28111355
Soffietti R, Rudà R, Reardon D
Handb Clin Neurol 2016;134:399-415. doi: 10.1016/B978-0-12-802997-8.00024-4. PMID: 26948368

Clinical prediction guides

Rudà R, Capper D, Waldman AD, Pallud J, Minniti G, Kaley TJ, Bouffet E, Tabatabai G, Aronica E, Jakola AS, Pfister SM, Schiff D, Lassman AB, Solomon DA, Soffietti R, Weller M, Preusser M, Idbaih A, Wen PY, van den Bent MJ
Neuro Oncol 2022 Dec 1;24(12):2015-2034. doi: 10.1093/neuonc/noac188. PMID: 35908833Free PMC Article
Petralia F, Tignor N, Reva B, Koptyra M, Chowdhury S, Rykunov D, Krek A, Ma W, Zhu Y, Ji J, Calinawan A, Whiteaker JR, Colaprico A, Stathias V, Omelchenko T, Song X, Raman P, Guo Y, Brown MA, Ivey RG, Szpyt J, Guha Thakurta S, Gritsenko MA, Weitz KK, Lopez G, Kalayci S, Gümüş ZH, Yoo S, da Veiga Leprevost F, Chang HY, Krug K, Katsnelson L, Wang Y, Kennedy JJ, Voytovich UJ, Zhao L, Gaonkar KS, Ennis BM, Zhang B, Baubet V, Tauhid L, Lilly JV, Mason JL, Farrow B, Young N, Leary S, Moon J, Petyuk VA, Nazarian J, Adappa ND, Palmer JN, Lober RM, Rivero-Hinojosa S, Wang LB, Wang JM, Broberg M, Chu RK, Moore RJ, Monroe ME, Zhao R, Smith RD, Zhu J, Robles AI, Mesri M, Boja E, Hiltke T, Rodriguez H, Zhang B, Schadt EE, Mani DR, Ding L, Iavarone A, Wiznerowicz M, Schürer S, Chen XS, Heath AP, Rokita JL, Nesvizhskii AI, Fenyö D, Rodland KD, Liu T, Gygi SP, Paulovich AG, Resnick AC, Storm PB, Rood BR, Wang P; Children’s Brain Tumor Network; Clinical Proteomic Tumor Analysis Consortium
Cell 2020 Dec 23;183(7):1962-1985.e31. Epub 2020 Nov 25 doi: 10.1016/j.cell.2020.10.044. PMID: 33242424Free PMC Article
Kobow K, Blümcke I
Neurosci Lett 2018 Feb 22;667:40-46. Epub 2017 Jan 19 doi: 10.1016/j.neulet.2017.01.012. PMID: 28111355
Gokden M
Adv Anat Pathol 2017 Nov;24(6):379-391. doi: 10.1097/PAP.0000000000000170. PMID: 28885262
Appin CL, Brat DJ
Mol Aspects Med 2015 Nov;45:87-96. Epub 2015 May 21 doi: 10.1016/j.mam.2015.05.002. PMID: 26004297

Recent systematic reviews

Pereira BJA, de Almeida AN, Paiva WS, Tzu WH, Marie SKN
Neurosurg Rev 2024 Feb 26;47(1):93. doi: 10.1007/s10143-024-02327-x. PMID: 38403664
Cai Y, Yang W, Peng X, Yuan L, Ge M
Childs Nerv Syst 2024 May;40(5):1349-1360. Epub 2024 Jan 16 doi: 10.1007/s00381-024-06280-4. PMID: 38227027
Wang S, Sun MZ, Abecassis IJ, Weil AG, Ibrahim GM, Fallah A, Ene C, Leary SES, Cole BL, Lockwood CM, Olson JM, Geyer JR, Ellenbogen RG, Ojemann JG, Wang AC
J Neurooncol 2021 Nov;155(2):155-163. Epub 2021 Oct 6 doi: 10.1007/s11060-021-03860-1. PMID: 34613581Free PMC Article
Sarmiento JM, Venteicher AS, Patil CG
Cochrane Database Syst Rev 2015 Jun 29;6(6):CD009229. doi: 10.1002/14651858.CD009229.pub2. PMID: 26118544Free PMC Article
Englot DJ, Berger MS, Barbaro NM, Chang EF
Epilepsia 2012 Jan;53(1):51-7. Epub 2011 Sep 20 doi: 10.1111/j.1528-1167.2011.03269.x. PMID: 21933181

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