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Cervical Spinal Cord Ependymal Tumor

MedGen UID:
1375805
•Concept ID:
C4329651
•
Neoplastic Process

Definition

A finding indicating the presence of an ependymal tumor in the cervical region of spinal cord. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCervical Spinal Cord Ependymal Tumor

Recent clinical studies

Etiology

Giant Myxopapillary Ependymoma with Multi-Site Neural Axis Metastases: A Rare Case with Suboptimal Outcome.
Balodis A, Ņeverčika V, Zavertjajeva M, Mikijanskis R, Kalniņa M, Breikša-Vaivode A, Briede I
Am J Case Rep 2024 Jan 31;25:e942392. doi: 10.12659/AJCR.942392. PMID: 38291726Free PMC Article
MYCN amplification drives an aggressive form of spinal ependymoma.
Ghasemi DR, Sill M, Okonechnikov K, Korshunov A, Yip S, Schutz PW, Scheie D, Kruse A, Harter PN, Kastelan M, Wagner M, Hartmann C, Benzel J, Maass KK, Khasraw M, Sträter R, Thomas C, Paulus W, Kratz CP, Witt H, Kawauchi D, Herold-Mende C, Sahm F, Brandner S, Kool M, Jones DTW, von Deimling A, Pfister SM, Reuss DE, Pajtler KW
Acta Neuropathol 2019 Dec;138(6):1075-1089. Epub 2019 Aug 14 doi: 10.1007/s00401-019-02056-2. PMID: 31414211Free PMC Article
Unilateral multilevel interlaminar fenestration: a minimally invasive approach for cervical intramedullary lesions.
Xie T, Qian J, Lu Y, Jiang Y, Wan Z, Zhang L, Luo C
J Clin Neurosci 2014 Jul;21(7):1196-204. Epub 2014 Jan 2 doi: 10.1016/j.jocn.2013.10.025. PMID: 24674700
Spectrum of nonterminal myelocystoceles.
Rossi A, Piatelli G, Gandolfo C, Pavanello M, Hoffmann C, Van Goethem JW, Cama A, Tortori-Donati P
Neurosurgery 2006 Mar;58(3):509-15; discussion 509-15. doi: 10.1227/01.NEU.0000197122.92954.82. PMID: 16528191
Intradural extramedullary cysts of the spinal canal: clinical presentation, radiographic diagnosis, and surgical management.
Osenbach RK, Godersky JC, Traynelis VC, Schelper RD
Neurosurgery 1992 Jan;30(1):35-42. doi: 10.1227/00006123-199201000-00007. PMID: 1738453

Diagnosis

Disseminated ependymal dysembryoplastic neuroepithelial tumor: a case report and literature review.
Kushel YV, Kutin MA, Ivanov VV, Chernov IV, Adueva DS, Pronin IN, Shishkina LV, Konovalova ES, Kalinin PL
Zh Vopr Neirokhir Im N N Burdenko 2024;88(4):92-99. doi: 10.17116/neiro20248804192. PMID: 39169587
MYCN amplification drives an aggressive form of spinal ependymoma.
Ghasemi DR, Sill M, Okonechnikov K, Korshunov A, Yip S, Schutz PW, Scheie D, Kruse A, Harter PN, Kastelan M, Wagner M, Hartmann C, Benzel J, Maass KK, Khasraw M, Sträter R, Thomas C, Paulus W, Kratz CP, Witt H, Kawauchi D, Herold-Mende C, Sahm F, Brandner S, Kool M, Jones DTW, von Deimling A, Pfister SM, Reuss DE, Pajtler KW
Acta Neuropathol 2019 Dec;138(6):1075-1089. Epub 2019 Aug 14 doi: 10.1007/s00401-019-02056-2. PMID: 31414211Free PMC Article
Hydromyelia associated with spinal lipoma of the conus: case report.
Faggin R, Drigo P, Denaro L, Sartori S, d'Avella D
Spine (Phila Pa 1976) 2010 Sep 15;35(20):E1069-71. doi: 10.1097/BRS.0b013e3181ed0b50. PMID: 20802384
Immunohistochemistry as a diagnostic aid in the evaluation of ovarian tumors.
McCluggage WG, Young RH
Semin Diagn Pathol 2005 Feb;22(1):3-32. doi: 10.1053/j.semdp.2005.11.002. PMID: 16512597
Tanycytic ependymoma of the spinal cord. Case report and review of the literature.
Boccardo M, Telera S, Vitali A
Neurochirurgie 2003 Dec;49(6):605-10. PMID: 14735006

Therapy

Papillary tumor of the spinal cord: report of 2 cases.
Mobley B, Kalani MY, Harsh GR 4th, Edwards MS, Vogel H
Am J Surg Pathol 2009 Aug;33(8):1191-7. doi: 10.1097/PAS.0b013e31819c45ca. PMID: 19417584

Prognosis

MYCN amplification drives an aggressive form of spinal ependymoma.
Ghasemi DR, Sill M, Okonechnikov K, Korshunov A, Yip S, Schutz PW, Scheie D, Kruse A, Harter PN, Kastelan M, Wagner M, Hartmann C, Benzel J, Maass KK, Khasraw M, Sträter R, Thomas C, Paulus W, Kratz CP, Witt H, Kawauchi D, Herold-Mende C, Sahm F, Brandner S, Kool M, Jones DTW, von Deimling A, Pfister SM, Reuss DE, Pajtler KW
Acta Neuropathol 2019 Dec;138(6):1075-1089. Epub 2019 Aug 14 doi: 10.1007/s00401-019-02056-2. PMID: 31414211Free PMC Article
Unilateral multilevel interlaminar fenestration: a minimally invasive approach for cervical intramedullary lesions.
Xie T, Qian J, Lu Y, Jiang Y, Wan Z, Zhang L, Luo C
J Clin Neurosci 2014 Jul;21(7):1196-204. Epub 2014 Jan 2 doi: 10.1016/j.jocn.2013.10.025. PMID: 24674700
Giant cell ependymoma of the cervical spinal cord: case report and review of the literature.
Barbagallo GM, Caltabiano R, Parisi G, Albanese V, Lanzafame S
Eur Spine J 2009 Jul;18 Suppl 2(Suppl 2):186-90. Epub 2008 Sep 27 doi: 10.1007/s00586-008-0789-4. PMID: 18820954Free PMC Article
Spectrum of nonterminal myelocystoceles.
Rossi A, Piatelli G, Gandolfo C, Pavanello M, Hoffmann C, Van Goethem JW, Cama A, Tortori-Donati P
Neurosurgery 2006 Mar;58(3):509-15; discussion 509-15. doi: 10.1227/01.NEU.0000197122.92954.82. PMID: 16528191
Tanycytic ependymoma of the spinal cord. Case report and review of the literature.
Boccardo M, Telera S, Vitali A
Neurochirurgie 2003 Dec;49(6):605-10. PMID: 14735006

Clinical prediction guides

MYCN amplification drives an aggressive form of spinal ependymoma.
Ghasemi DR, Sill M, Okonechnikov K, Korshunov A, Yip S, Schutz PW, Scheie D, Kruse A, Harter PN, Kastelan M, Wagner M, Hartmann C, Benzel J, Maass KK, Khasraw M, Sträter R, Thomas C, Paulus W, Kratz CP, Witt H, Kawauchi D, Herold-Mende C, Sahm F, Brandner S, Kool M, Jones DTW, von Deimling A, Pfister SM, Reuss DE, Pajtler KW
Acta Neuropathol 2019 Dec;138(6):1075-1089. Epub 2019 Aug 14 doi: 10.1007/s00401-019-02056-2. PMID: 31414211Free PMC Article
Intradural Extramedullary Primary Ependymoma of the Craniocervical Junction Combined with C1 Partial Agenesis: Case Report and Review of the Literature.
Morselli C, Ruggeri AG, Pichierri A, Marotta N, Anzidei M, Delfini R
World Neurosurg 2015 Dec;84(6):2076.e1-6. Epub 2015 Jul 23 doi: 10.1016/j.wneu.2015.07.027. PMID: 26210708
Spectrum of nonterminal myelocystoceles.
Rossi A, Piatelli G, Gandolfo C, Pavanello M, Hoffmann C, Van Goethem JW, Cama A, Tortori-Donati P
Neurosurgery 2006 Mar;58(3):509-15; discussion 509-15. doi: 10.1227/01.NEU.0000197122.92954.82. PMID: 16528191
A family with spinal anaplastic ependymoma: evidence of loss of chromosome 22q in tumor.
Yokota T, Tachizawa T, Fukino K, Teramoto A, Kouno J, Matsumoto K, Emi M
J Hum Genet 2003;48(11):598-602. Epub 2003 Oct 18 doi: 10.1007/s10038-003-0078-3. PMID: 14566482
Intramedullary clear cell ependymoma in the cervical spinal cord: case report.
Akutsu H, Shibata Y, Okazaki M, Hyodo A, Matsumura A
Neurosurgery 2000 Dec;47(6):1434-7; discussion 1437-8. PMID: 11126915

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