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Adult Subependymoma

MedGen UID:
79277
•Concept ID:
C0281328
•
Neoplastic Process
Synonyms: Adult Subependymal Astrocytoma; Adult Subependymal Astrocytomas; Astrocytoma, Adult Subependymal; Astrocytomas, Adult Subependymal; Subependymal Astrocytoma, Adult; Subependymal Astrocytomas, Adult

Definition

A subependymoma that occurs during adulthood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Subependymoma

Professional guidelines

PubMed

Clinical Characteristics, Management, and Outcomes of Intramedullary Spinal Cord Ependymomas in Adults: A Systematic Review.
Farooqi S, Tebha SS, Qamar MA, Singh S, Alfawares Y, Ramanathan V, Haider AS, Ferini G, Sharma M, Umana GE, Aoun SG, Palmisciano P
World Neurosurg 2023 May;173:237-250.e8. Epub 2023 Feb 28 doi: 10.1016/j.wneu.2023.02.098. PMID: 36858296
Adult intracranial ependymoma-relevance of DNA methylation profiling for diagnosis, prognosis, and treatment.
Träger M, Schweizer L, Pérez E, Schmid S, Hain EG, Dittmayer C, Onken J, Fukuoka K, Ichimura K, Schüller U, Dührsen L, Müther M, Paulus W, Thomas C, Gutt-Will M, Schucht P, Maragkou T, Schittenhelm J, Eckert F, Niyazi M, Fleischmann DF, Dorostkar MM, Feyer P, May SA, Moskopp D, Badakhshi H, Radke C, Walter J, Ehret F, Capper D, Kaul D
Neuro Oncol 2023 Jul 6;25(7):1286-1298. doi: 10.1093/neuonc/noad030. PMID: 36734226Free PMC Article
Biology and management of ependymomas.
Wu J, Armstrong TS, Gilbert MR
Neuro Oncol 2016 Jul;18(7):902-13. Epub 2016 Mar 28 doi: 10.1093/neuonc/now016. PMID: 27022130Free PMC Article

Recent clinical studies

Etiology

Circumscribed astrocytic gliomas: Contribution of molecular analyses to histopathology diagnosis in the WHO CNS5 classification.
Köy Y, Tihan T
Indian J Pathol Microbiol 2022 May;65(Supplement):S33-S41. doi: 10.4103/ijpm.ijpm_1019_21. PMID: 35562132
Neurological malignancies in neurofibromatosis type 1.
Eoli M, Saletti V, Finocchiaro G
Curr Opin Oncol 2019 Nov;31(6):554-561. doi: 10.1097/CCO.0000000000000576. PMID: 31436563
Molecular profiling of gliomas: potential therapeutic implications.
Alentorn A, Duran-Peña A, Pingle SC, Piccioni DE, Idbaih A, Kesari S
Expert Rev Anticancer Ther 2015;15(8):955-62. Epub 2015 Jun 28 doi: 10.1586/14737140.2015.1062368. PMID: 26118895
Epidemiology and pathology of intraventricular tumors.
Waldron JS, Tihan T
Neurosurg Clin N Am 2003 Oct;14(4):469-82. doi: 10.1016/s1042-3680(03)00060-3. PMID: 15024796
Nonmalignant pediatric brain tumors.
Rashidi M, DaSilva VR, Minagar A, Rutka JT
Curr Neurol Neurosci Rep 2003 May;3(3):200-5. doi: 10.1007/s11910-003-0079-9. PMID: 12691624

Diagnosis

Pediatric Gliomas: Molecular Landscape and Emerging Targets.
Peeters SM, Muftuoglu Y, Na B, Daniels DJ, Wang AC
Neurosurg Clin N Am 2021 Apr;32(2):181-190. Epub 2021 Feb 18 doi: 10.1016/j.nec.2020.12.001. PMID: 33781501
MRI of intracranial intraventricular lesions.
Muly S, Liu S, Lee R, Nicolaou S, Rojas R, Khosa F
Clin Imaging 2018 Nov-Dec;52:226-239. Epub 2018 Aug 1 doi: 10.1016/j.clinimag.2018.07.021. PMID: 30138862
Recognizing intraventricular silicone.
Mayl JJ, Flores MA, Stelzer JW, Liu B, Messina SA, Murray JV
Emerg Radiol 2018 Apr;25(2):215-218. Epub 2018 Feb 3 doi: 10.1007/s10140-018-1582-2. PMID: 29397464
Intraocular astrocytoma and its differential diagnosis.
Pusateri A, Margo CE
Arch Pathol Lab Med 2014 Sep;138(9):1250-4. doi: 10.5858/arpa.2013-0448-RS. PMID: 25171711
Ependymomas.
Chamberlain MC
Curr Neurol Neurosci Rep 2003 May;3(3):193-9. doi: 10.1007/s11910-003-0078-x. PMID: 12691623

Therapy

Paediatric strategy forum for medicinal product development of PI3-K, mTOR, AKT and GSK3β inhibitors in children and adolescents with cancer.
Pearson AD, DuBois SG, Macy ME, de Rojas T, Donoghue M, Weiner S, Knoderer H, Bernardi R, Buenger V, Canaud G, Cantley L, Chung J, Fox E, Friend J, Glade-Bender J, Gorbatchevsky I, Gore L, Gupta A, Hawkins DS, Juric D, Lang LA, Leach D, Liaw D, Lesa G, Ligas F, Lindberg G, Lindberg W, Ludwinski D, Marshall L, Mazar A, McDonough J, Nysom K, Ours C, Pappo A, Parsons DW, Rosenfeld A, Scobie N, Smith M, Taylor D, Weigel B, Weinstein A, Karres D, Vassal G
Eur J Cancer 2024 Aug;207:114145. Epub 2024 Jun 8 doi: 10.1016/j.ejca.2024.114145. PMID: 38936103
Distinct DNA Methylation Patterns of Subependymal Giant Cell Astrocytomas in Tuberous Sclerosis Complex.
Bongaarts A, Mijnsbergen C, Anink JJ, Jansen FE, Spliet WGM, den Dunnen WFA, Coras R, Blümcke I, Paulus W, Gruber VE, Scholl T, Hainfellner JA, Feucht M, Kotulska K, Jozwiak S, Grajkowska W, Buccoliero AM, Caporalini C, Giordano F, Genitori L, Söylemezoğlu F, Pimentel J, Jones DTW, Scicluna BP, Schouten-van Meeteren AYN, Mühlebner A, Mills JD, Aronica E
Cell Mol Neurobiol 2022 Nov;42(8):2863-2892. Epub 2021 Oct 28 doi: 10.1007/s10571-021-01157-5. PMID: 34709498Free PMC Article
Cervical Spinal Ependymoma With Hemorrhage in a Renal Transplant Patient.
Şahintürk F, Dere ÜA, Kırnap M, Sönmez E, Altınörs N, Özen Ö, Haberal M
Exp Clin Transplant 2022 Sep;20(9):871-873. Epub 2018 Sep 25 doi: 10.6002/ect.2017.0283. PMID: 30251937
Recognizing intraventricular silicone.
Mayl JJ, Flores MA, Stelzer JW, Liu B, Messina SA, Murray JV
Emerg Radiol 2018 Apr;25(2):215-218. Epub 2018 Feb 3 doi: 10.1007/s10140-018-1582-2. PMID: 29397464
Ependymomas.
Chamberlain MC
Curr Neurol Neurosci Rep 2003 May;3(3):193-9. doi: 10.1007/s11910-003-0078-x. PMID: 12691623

Prognosis

Neurological malignancies in neurofibromatosis type 1.
Eoli M, Saletti V, Finocchiaro G
Curr Opin Oncol 2019 Nov;31(6):554-561. doi: 10.1097/CCO.0000000000000576. PMID: 31436563
Recognizing intraventricular silicone.
Mayl JJ, Flores MA, Stelzer JW, Liu B, Messina SA, Murray JV
Emerg Radiol 2018 Apr;25(2):215-218. Epub 2018 Feb 3 doi: 10.1007/s10140-018-1582-2. PMID: 29397464
Molecular profiling of gliomas: potential therapeutic implications.
Alentorn A, Duran-Peña A, Pingle SC, Piccioni DE, Idbaih A, Kesari S
Expert Rev Anticancer Ther 2015;15(8):955-62. Epub 2015 Jun 28 doi: 10.1586/14737140.2015.1062368. PMID: 26118895
Nonmalignant pediatric brain tumors.
Rashidi M, DaSilva VR, Minagar A, Rutka JT
Curr Neurol Neurosci Rep 2003 May;3(3):200-5. doi: 10.1007/s11910-003-0079-9. PMID: 12691624
Ependymomas.
Chamberlain MC
Curr Neurol Neurosci Rep 2003 May;3(3):193-9. doi: 10.1007/s11910-003-0078-x. PMID: 12691623

Clinical prediction guides

Intramedullary Subependymoma Of Lower Thoracic Cord.
Bashir HH, Aziz HF, Shamim MS
J Pak Med Assoc 2023 Sep;73(9):1919-1920. doi: 10.47391/JPMA.23-66. PMID: 37817716
Neurological malignancies in neurofibromatosis type 1.
Eoli M, Saletti V, Finocchiaro G
Curr Opin Oncol 2019 Nov;31(6):554-561. doi: 10.1097/CCO.0000000000000576. PMID: 31436563
Molecular profiling of gliomas: potential therapeutic implications.
Alentorn A, Duran-Peña A, Pingle SC, Piccioni DE, Idbaih A, Kesari S
Expert Rev Anticancer Ther 2015;15(8):955-62. Epub 2015 Jun 28 doi: 10.1586/14737140.2015.1062368. PMID: 26118895
Thoracolumbar intramedullary subependymoma with multiple cystic formation: a case report and review.
Iwasaki M, Hida K, Aoyama T, Houkin K
Eur Spine J 2013 May;22 Suppl 3(Suppl 3):S317-20. Epub 2012 May 5 doi: 10.1007/s00586-012-2357-1. PMID: 22562689Free PMC Article
Intramedullary subependymoma of the spinal cord.
Jallo GI, Zagzag D, Epstein F
Neurosurgery 1996 Feb;38(2):251-7. doi: 10.1097/00006123-199602000-00004. PMID: 8869051

Recent systematic reviews

The Clinicopathological Features of the Solitary Subependymal Giant Cell Astrocytoma: A Systematic Review.
Piña-Ballantyne SA, Espinosa-Aguilar EJ, Calderón-Garcidueñas AL
Neurol India 2024 Jul 1;72(4):708-717. Epub 2024 Aug 31 doi: 10.4103/neurol-india.Neurol-India-D-23-00343. PMID: 39216021
Clinical Characteristics, Management, and Outcomes of Intramedullary Spinal Cord Ependymomas in Adults: A Systematic Review.
Farooqi S, Tebha SS, Qamar MA, Singh S, Alfawares Y, Ramanathan V, Haider AS, Ferini G, Sharma M, Umana GE, Aoun SG, Palmisciano P
World Neurosurg 2023 May;173:237-250.e8. Epub 2023 Feb 28 doi: 10.1016/j.wneu.2023.02.098. PMID: 36858296
Prevalence of BRAFV600 in glioma and use of BRAF Inhibitors in patients with BRAFV600 mutation-positive glioma: systematic review.
Andrews LJ, Thornton ZA, Saincher SS, Yao IY, Dawson S, McGuinness LA, Jones HE, Jefferies S, Short SC, Cheng HY, McAleenan A, Higgins JPT, Kurian KM
Neuro Oncol 2022 Apr 1;24(4):528-540. doi: 10.1093/neuonc/noab247. PMID: 34718782Free PMC Article
Tumor characteristics and surgical outcomes of intracranial subependymomas: a systematic review and meta-analysis.
Kweh BTS, Rosenfeld JV, Hunn M, Tee JW
J Neurosurg 2022 Mar 1;136(3):736-748. Epub 2021 Aug 20 doi: 10.3171/2021.2.JNS204052. PMID: 34416731
Multi-parametric MR Imaging Biomarkers Associated to Clinical Outcomes in Gliomas: A Systematic Review.
Oltra-Sastre M, Fuster-Garcia E, Juan-Albarracin J, Sáez C, Perez-Girbes A, Sanz-Requena R, Revert-Ventura A, Mocholi A, Urchueguia J, Hervas A, Reynes G, Font-de-Mora J, Muñoz-Langa J, Botella C, Aparici F, Marti-Bonmati L, Garcia-Gomez JM
Curr Med Imaging Rev 2019;15(10):933-947. doi: 10.2174/1573405615666190109100503. PMID: 32008521

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