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Adult Ependymal Tumor

MedGen UID:
323813
•Concept ID:
C1541566
•
Neoplastic Process

Definition

An ependymal tumor of the central nervous system occurring in adults. [from NCI]

Professional guidelines

PubMed

Adult intracranial ependymoma-relevance of DNA methylation profiling for diagnosis, prognosis, and treatment.
Träger M, Schweizer L, Pérez E, Schmid S, Hain EG, Dittmayer C, Onken J, Fukuoka K, Ichimura K, Schüller U, Dührsen L, Müther M, Paulus W, Thomas C, Gutt-Will M, Schucht P, Maragkou T, Schittenhelm J, Eckert F, Niyazi M, Fleischmann DF, Dorostkar MM, Feyer P, May SA, Moskopp D, Badakhshi H, Radke C, Walter J, Ehret F, Capper D, Kaul D
Neuro Oncol 2023 Jul 6;25(7):1286-1298. doi: 10.1093/neuonc/noad030. PMID: 36734226Free PMC Article
EANO guidelines for the diagnosis and treatment of ependymal tumors.
Rudà R, Reifenberger G, Frappaz D, Pfister SM, Laprie A, Santarius T, Roth P, Tonn JC, Soffietti R, Weller M, Moyal EC
Neuro Oncol 2018 Mar 27;20(4):445-456. doi: 10.1093/neuonc/nox166. PMID: 29194500Free PMC Article
Recent Advances in the Classification and Treatment of Ependymomas.
Leeper H, Felicella MM, Walbert T
Curr Treat Options Oncol 2017 Aug 10;18(9):55. doi: 10.1007/s11864-017-0496-7. PMID: 28795287

Recent clinical studies

Etiology

Glioma.
Weller M, Wick W, Aldape K, Brada M, Berger M, Pfister SM, Nishikawa R, Rosenthal M, Wen PY, Stupp R, Reifenberger G
Nat Rev Dis Primers 2015 Jul 16;1:15017. doi: 10.1038/nrdp.2015.17. PMID: 27188790
Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups.
Pajtler KW, Witt H, Sill M, Jones DT, Hovestadt V, Kratochwil F, Wani K, Tatevossian R, Punchihewa C, Johann P, Reimand J, Warnatz HJ, Ryzhova M, Mack S, Ramaswamy V, Capper D, Schweizer L, Sieber L, Wittmann A, Huang Z, van Sluis P, Volckmann R, Koster J, Versteeg R, Fults D, Toledano H, Avigad S, Hoffman LM, Donson AM, Foreman N, Hewer E, Zitterbart K, Gilbert M, Armstrong TS, Gupta N, Allen JC, Karajannis MA, Zagzag D, Hasselblatt M, Kulozik AE, Witt O, Collins VP, von Hoff K, Rutkowski S, Pietsch T, Bader G, Yaspo ML, von Deimling A, Lichter P, Taylor MD, Gilbertson R, Ellison DW, Aldape K, Korshunov A, Kool M, Pfister SM
Cancer Cell 2015 May 11;27(5):728-43. doi: 10.1016/j.ccell.2015.04.002. PMID: 25965575Free PMC Article
Ependyma-lined cysts.
Williams Z, Herrick MK, Tse V
Clin Neuropathol 2000 May-Jun;19(3):138-41. PMID: 14606587
Ependymomas of the third ventricle.
Oppenheim JS, Strauss RC, Mormino J, Sachdev VP, Rothman AS
Neurosurgery 1994 Feb;34(2):350-2; discussion 352-3. doi: 10.1227/00006123-199402000-00020. PMID: 8177398
Leptomeningeal metastasis: MR imaging.
Davis PC, Friedman NC, Fry SM, Malko JA, Hoffmann JC Jr, Braun IF
Radiology 1987 May;163(2):449-54. doi: 10.1148/radiology.163.2.3562825. PMID: 3562825

Diagnosis

Glioma.
Weller M, Wen PY, Chang SM, Dirven L, Lim M, Monje M, Reifenberger G
Nat Rev Dis Primers 2024 May 9;10(1):33. doi: 10.1038/s41572-024-00516-y. PMID: 38724526
Ependymomas in Children and Adults.
Lampros M, Vlachos N, Alexiou GA
Adv Exp Med Biol 2023;1405:99-116. doi: 10.1007/978-3-031-23705-8_4. PMID: 37452936
Clinical implications of the 2021 edition of the WHO classification of central nervous system tumours.
Horbinski C, Berger T, Packer RJ, Wen PY
Nat Rev Neurol 2022 Sep;18(9):515-529. Epub 2022 Jun 21 doi: 10.1038/s41582-022-00679-w. PMID: 35729337
Differential Diagnosis of Central Neurocytoma: Two Cases.
Steinsiepe VK, Frick H, Jochum W, Fournier JY
J Neurol Surg A Cent Eur Neurosurg 2021 Nov;82(6):599-603. Epub 2020 Dec 22 doi: 10.1055/s-0040-1718693. PMID: 33352608
EANO guidelines for the diagnosis and treatment of ependymal tumors.
Rudà R, Reifenberger G, Frappaz D, Pfister SM, Laprie A, Santarius T, Roth P, Tonn JC, Soffietti R, Weller M, Moyal EC
Neuro Oncol 2018 Mar 27;20(4):445-456. doi: 10.1093/neuonc/nox166. PMID: 29194500Free PMC Article

Therapy

Clinical implications of the 2021 edition of the WHO classification of central nervous system tumours.
Horbinski C, Berger T, Packer RJ, Wen PY
Nat Rev Neurol 2022 Sep;18(9):515-529. Epub 2022 Jun 21 doi: 10.1038/s41582-022-00679-w. PMID: 35729337
The cystic dilation of ventriculus terminalis with neurological symptoms: Three case reports and a literature review.
Lotfinia I, Mahdkhah A
J Spinal Cord Med 2018 Nov;41(6):741-747. Epub 2018 May 23 doi: 10.1080/10790268.2018.1474680. PMID: 29791269Free PMC Article
Central nervous system lymphoma: a morphological MRI study.
Koubska E, Weichet J, Malikova H
Neuro Endocrinol Lett 2016 Sep;37(4):318-324. PMID: 27857050
Prolonged response of meningeal carcinomatosis from non-small cell lung cancer to salvage intrathecal etoposide subsequent to failure of first-line methotrexate: a case report and literature review.
Park MJ
Am J Case Rep 2015 Apr 16;16:224-7. doi: 10.12659/AJCR.894061. PMID: 25879815Free PMC Article
Brainstem cavernomas: long-term results of microsurgical resection in 52 patients.
Ferroli P, Sinisi M, Franzini A, Giombini S, Solero CL, Broggi G
Neurosurgery 2005 Jun;56(6):1203-12; discussion 1212-4. doi: 10.1227/01.neu.0000159644.04757.45. PMID: 15918936

Prognosis

Glioma.
Weller M, Wen PY, Chang SM, Dirven L, Lim M, Monje M, Reifenberger G
Nat Rev Dis Primers 2024 May 9;10(1):33. doi: 10.1038/s41572-024-00516-y. PMID: 38724526
EANO guidelines for the diagnosis and treatment of ependymal tumors.
Rudà R, Reifenberger G, Frappaz D, Pfister SM, Laprie A, Santarius T, Roth P, Tonn JC, Soffietti R, Weller M, Moyal EC
Neuro Oncol 2018 Mar 27;20(4):445-456. doi: 10.1093/neuonc/nox166. PMID: 29194500Free PMC Article
Glioma.
Weller M, Wick W, Aldape K, Brada M, Berger M, Pfister SM, Nishikawa R, Rosenthal M, Wen PY, Stupp R, Reifenberger G
Nat Rev Dis Primers 2015 Jul 16;1:15017. doi: 10.1038/nrdp.2015.17. PMID: 27188790
Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups.
Pajtler KW, Witt H, Sill M, Jones DT, Hovestadt V, Kratochwil F, Wani K, Tatevossian R, Punchihewa C, Johann P, Reimand J, Warnatz HJ, Ryzhova M, Mack S, Ramaswamy V, Capper D, Schweizer L, Sieber L, Wittmann A, Huang Z, van Sluis P, Volckmann R, Koster J, Versteeg R, Fults D, Toledano H, Avigad S, Hoffman LM, Donson AM, Foreman N, Hewer E, Zitterbart K, Gilbert M, Armstrong TS, Gupta N, Allen JC, Karajannis MA, Zagzag D, Hasselblatt M, Kulozik AE, Witt O, Collins VP, von Hoff K, Rutkowski S, Pietsch T, Bader G, Yaspo ML, von Deimling A, Lichter P, Taylor MD, Gilbertson R, Ellison DW, Aldape K, Korshunov A, Kool M, Pfister SM
Cancer Cell 2015 May 11;27(5):728-43. doi: 10.1016/j.ccell.2015.04.002. PMID: 25965575Free PMC Article
Ependymomas of the third ventricle.
Oppenheim JS, Strauss RC, Mormino J, Sachdev VP, Rothman AS
Neurosurgery 1994 Feb;34(2):350-2; discussion 352-3. doi: 10.1227/00006123-199402000-00020. PMID: 8177398

Clinical prediction guides

Adult Primary Brain Neoplasm, Including 2016 World Health Organization Classification.
Wang KY, Chen MM, Malayil Lincoln CM
Neuroimaging Clin N Am 2021 Feb;31(1):121-138. doi: 10.1016/j.nic.2020.09.011. PMID: 33220825
Adult Primary Brain Neoplasm, Including 2016 World Health Organization Classification.
Wang KY, Chen MM, Malayil Lincoln CM
Radiol Clin North Am 2019 Nov;57(6):1147-1162. Epub 2019 Aug 16 doi: 10.1016/j.rcl.2019.07.004. PMID: 31582041
Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups.
Pajtler KW, Witt H, Sill M, Jones DT, Hovestadt V, Kratochwil F, Wani K, Tatevossian R, Punchihewa C, Johann P, Reimand J, Warnatz HJ, Ryzhova M, Mack S, Ramaswamy V, Capper D, Schweizer L, Sieber L, Wittmann A, Huang Z, van Sluis P, Volckmann R, Koster J, Versteeg R, Fults D, Toledano H, Avigad S, Hoffman LM, Donson AM, Foreman N, Hewer E, Zitterbart K, Gilbert M, Armstrong TS, Gupta N, Allen JC, Karajannis MA, Zagzag D, Hasselblatt M, Kulozik AE, Witt O, Collins VP, von Hoff K, Rutkowski S, Pietsch T, Bader G, Yaspo ML, von Deimling A, Lichter P, Taylor MD, Gilbertson R, Ellison DW, Aldape K, Korshunov A, Kool M, Pfister SM
Cancer Cell 2015 May 11;27(5):728-43. doi: 10.1016/j.ccell.2015.04.002. PMID: 25965575Free PMC Article
Molecular alterations in ependymomas.
Biernat W, Zawrocki A
Folia Neuropathol 2007;45(4):155-63. PMID: 18176888
Ovarian ependymoma.
Erdoğan G, Ozel E, Peştereli HE, Salar Z, Tirak B, Karaveli S
APMIS 2005 Apr;113(4):301-3. doi: 10.1111/j.1600-0463.2005.apm_10.x. PMID: 15865613

Recent systematic reviews

Intracranial glioependymal (neuroglial) cysts: a systematic review.
Robles LA, Paez JM, Ayala D, Boleaga-Duran B
Acta Neurochir (Wien) 2018 Jul;160(7):1439-1449. Epub 2018 May 25 doi: 10.1007/s00701-018-3566-0. PMID: 29802560

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