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Childhood medulloblastoma

MedGen UID:
75829
•Concept ID:
C0278510
•
Neoplastic Process
Synonyms: Childhood Medulloblastoma; Childhood Medulloblastomas; Medulloblastoma, Childhood; Medulloblastomas, Childhood
 
Monarch Initiative: MONDO:0002797

Definition

A medulloblastoma occurring in children. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChildhood medulloblastoma

Professional guidelines

PubMed

Treatment Outcomes of Childhood Medulloblastoma with the SIOP/UKCCSG PNET-3 Protocol.
Kartal İ, Dağdemir A, Dinçer OS, Şimşek HK, Uygun A, Gürsel ŞB
Indian J Pediatr 2023 Nov;90(11):1116-1122. Epub 2023 Jun 19 doi: 10.1007/s12098-023-04675-w. PMID: 37335442Free PMC Article
Treatment options for childhood medulloblastoma.
Nikitović M, Golubicić I
Vojnosanit Pregl 2013 Aug;70(8):773-7. doi: 10.2298/vsp1308773n. PMID: 24069828
Childhood medulloblastoma: the paradigm shift in molecular stratification and treatment profile.
Sadighi Z, Vats T, Khatua S
J Child Neurol 2012 Oct;27(10):1302-7. Epub 2012 Jul 22 doi: 10.1177/0883073812449690. PMID: 22826514

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Pediatric Central Nervous System Cancers, 2024

Recent clinical studies

Etiology

Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma.
Hofman DA, Ruiz-Orera J, Yannuzzi I, Murugesan R, Brown A, Clauser KR, Condurat AL, van Dinter JT, Engels SAG, Goodale A, van der Lugt J, Abid T, Wang L, Zhou KN, Vogelzang J, Ligon KL, Phoenix TN, Roth JA, Root DE, Hubner N, Golub TR, Bandopadhayay P, van Heesch S, Prensner JR
Mol Cell 2024 Jan 18;84(2):261-276.e18. Epub 2024 Jan 3 doi: 10.1016/j.molcel.2023.12.003. PMID: 38176414Free PMC Article
Childhood Medulloblastoma.
Mushtaq N, Resham S, Shamim S, Qureshi BM, Riaz Q, Bouffet E
J Pak Med Assoc 2020 Nov;70(11):2007-2016. doi: 10.5455/JPMA.293142. PMID: 33341849
Childhood Medulloblastoma Revisited.
Cassia GSE, Alves CAPF, Taranath A, López NS, Oztekin O, Gonçalves FG, Patay Z
Top Magn Reson Imaging 2018 Dec;27(6):479-502. doi: 10.1097/RMR.0000000000000184. PMID: 30516696
Childhood medulloblastoma.
Massimino M, Biassoni V, Gandola L, Garrè ML, Gatta G, Giangaspero F, Poggi G, Rutkowski S
Crit Rev Oncol Hematol 2016 Sep;105:35-51. Epub 2016 Jun 15 doi: 10.1016/j.critrevonc.2016.05.012. PMID: 27375228
Risk stratification of childhood medulloblastoma in the molecular era: the current consensus.
Ramaswamy V, Remke M, Bouffet E, Bailey S, Clifford SC, Doz F, Kool M, Dufour C, Vassal G, Milde T, Witt O, von Hoff K, Pietsch T, Northcott PA, Gajjar A, Robinson GW, Padovani L, André N, Massimino M, Pizer B, Packer R, Rutkowski S, Pfister SM, Taylor MD, Pomeroy SL
Acta Neuropathol 2016 Jun;131(6):821-31. Epub 2016 Apr 4 doi: 10.1007/s00401-016-1569-6. PMID: 27040285Free PMC Article

Diagnosis

Childhood Medulloblastoma.
Mushtaq N, Resham S, Shamim S, Qureshi BM, Riaz Q, Bouffet E
J Pak Med Assoc 2020 Nov;70(11):2007-2016. doi: 10.5455/JPMA.293142. PMID: 33341849
Childhood Medulloblastoma Revisited.
Cassia GSE, Alves CAPF, Taranath A, López NS, Oztekin O, Gonçalves FG, Patay Z
Top Magn Reson Imaging 2018 Dec;27(6):479-502. doi: 10.1097/RMR.0000000000000184. PMID: 30516696
Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study.
Schwalbe EC, Lindsey JC, Nakjang S, Crosier S, Smith AJ, Hicks D, Rafiee G, Hill RM, Iliasova A, Stone T, Pizer B, Michalski A, Joshi A, Wharton SB, Jacques TS, Bailey S, Williamson D, Clifford SC
Lancet Oncol 2017 Jul;18(7):958-971. Epub 2017 May 22 doi: 10.1016/S1470-2045(17)30243-7. PMID: 28545823Free PMC Article
Childhood medulloblastoma.
Massimino M, Biassoni V, Gandola L, Garrè ML, Gatta G, Giangaspero F, Poggi G, Rutkowski S
Crit Rev Oncol Hematol 2016 Sep;105:35-51. Epub 2016 Jun 15 doi: 10.1016/j.critrevonc.2016.05.012. PMID: 27375228
Childhood medulloblastoma.
Massimino M, Giangaspero F, Garrè ML, Gandola L, Poggi G, Biassoni V, Gatta G, Rutkowski S
Crit Rev Oncol Hematol 2011 Jul;79(1):65-83. Epub 2010 Dec 3 doi: 10.1016/j.critrevonc.2010.07.010. PMID: 21129995

Therapy

Outcomes of Infants and Young Children With Relapsed Medulloblastoma After Initial Craniospinal Irradiation-Sparing Approaches: An International Cohort Study.
Erker C, Mynarek M, Bailey S, Mazewski CM, Baroni L, Massimino M, Hukin J, Aguilera D, Cappellano AM, Ramaswamy V, Lassaletta A, Perreault S, Kline CN, Rajagopal R, Michaiel G, Zapotocky M, Santa-Maria Lopez V, La Madrid AM, Cacciotti C, Sandler ES, Hoffman LM, Klawinski D, Khan S, Salloum R, Hoppmann AL, Larouche V, Dorris K, Toledano H, Gilheeney SW, Abdelbaki MS, Wilson B, Tsang DS, Knipstein J, Oren MY, Shah S, Murray JC, Ginn KF, Wang ZJ, Fleischhack G, Obrecht D, Tonn S, Harrod VL, Matheson K, Crooks B, Strother DR, Cohen KJ, Hansford JR, Mueller S, Margol A, Gajjar A, Dhall G, Finlay JL, Northcott PA, Rutkowski S, Clifford SC, Robinson G, Bouffet E, Lafay-Cousin L
J Clin Oncol 2023 Apr 1;41(10):1921-1932. Epub 2022 Dec 22 doi: 10.1200/JCO.21.02968. PMID: 36548930
Childhood medulloblastoma-a single institution's historical perspective on survival and functional morbidity.
Phipps K, Kirkman MA, Aquilina K, Gaze M, Michalski A, Wade A, Hayward R
Childs Nerv Syst 2019 Dec;35(12):2327-2338. Epub 2019 Nov 4 doi: 10.1007/s00381-019-04402-x. PMID: 31686139
Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study.
Schwalbe EC, Lindsey JC, Nakjang S, Crosier S, Smith AJ, Hicks D, Rafiee G, Hill RM, Iliasova A, Stone T, Pizer B, Michalski A, Joshi A, Wharton SB, Jacques TS, Bailey S, Williamson D, Clifford SC
Lancet Oncol 2017 Jul;18(7):958-971. Epub 2017 May 22 doi: 10.1016/S1470-2045(17)30243-7. PMID: 28545823Free PMC Article
Childhood medulloblastoma: current status of biology and treatment.
Klesse LJ, Bowers DC
CNS Drugs 2010 Apr;24(4):285-301. doi: 10.2165/11530140-000000000-00000. PMID: 20297854
Medulloblastoma in young children.
Rutkowski S, Cohen B, Finlay J, Luksch R, Ridola V, Valteau-Couanet D, Hara J, Garre ML, Grill J
Pediatr Blood Cancer 2010 Apr;54(4):635-7. doi: 10.1002/pbc.22372. PMID: 20146217

Prognosis

Childhood Medulloblastoma.
Mushtaq N, Resham S, Shamim S, Qureshi BM, Riaz Q, Bouffet E
J Pak Med Assoc 2020 Nov;70(11):2007-2016. doi: 10.5455/JPMA.293142. PMID: 33341849
Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study.
Schwalbe EC, Lindsey JC, Nakjang S, Crosier S, Smith AJ, Hicks D, Rafiee G, Hill RM, Iliasova A, Stone T, Pizer B, Michalski A, Joshi A, Wharton SB, Jacques TS, Bailey S, Williamson D, Clifford SC
Lancet Oncol 2017 Jul;18(7):958-971. Epub 2017 May 22 doi: 10.1016/S1470-2045(17)30243-7. PMID: 28545823Free PMC Article
Childhood medulloblastoma.
Massimino M, Biassoni V, Gandola L, Garrè ML, Gatta G, Giangaspero F, Poggi G, Rutkowski S
Crit Rev Oncol Hematol 2016 Sep;105:35-51. Epub 2016 Jun 15 doi: 10.1016/j.critrevonc.2016.05.012. PMID: 27375228
Risk stratification of childhood medulloblastoma in the molecular era: the current consensus.
Ramaswamy V, Remke M, Bouffet E, Bailey S, Clifford SC, Doz F, Kool M, Dufour C, Vassal G, Milde T, Witt O, von Hoff K, Pietsch T, Northcott PA, Gajjar A, Robinson GW, Padovani L, André N, Massimino M, Pizer B, Packer R, Rutkowski S, Pfister SM, Taylor MD, Pomeroy SL
Acta Neuropathol 2016 Jun;131(6):821-31. Epub 2016 Apr 4 doi: 10.1007/s00401-016-1569-6. PMID: 27040285Free PMC Article
Childhood medulloblastoma.
Massimino M, Giangaspero F, Garrè ML, Gandola L, Poggi G, Biassoni V, Gatta G, Rutkowski S
Crit Rev Oncol Hematol 2011 Jul;79(1):65-83. Epub 2010 Dec 3 doi: 10.1016/j.critrevonc.2010.07.010. PMID: 21129995

Clinical prediction guides

Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma.
Hofman DA, Ruiz-Orera J, Yannuzzi I, Murugesan R, Brown A, Clauser KR, Condurat AL, van Dinter JT, Engels SAG, Goodale A, van der Lugt J, Abid T, Wang L, Zhou KN, Vogelzang J, Ligon KL, Phoenix TN, Roth JA, Root DE, Hubner N, Golub TR, Bandopadhayay P, van Heesch S, Prensner JR
Mol Cell 2024 Jan 18;84(2):261-276.e18. Epub 2024 Jan 3 doi: 10.1016/j.molcel.2023.12.003. PMID: 38176414Free PMC Article
Taste and smell function in long-term survivors after childhood medulloblastoma/CNS-PNET.
Tanem KE, Stensvold E, Wilberg P, Skaare AB, Singh PB, Brandal P, Herlofson BB
Support Care Cancer 2022 Jul;30(7):6155-6162. Epub 2022 Apr 15 doi: 10.1007/s00520-022-07048-9. PMID: 35426047Free PMC Article
Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study.
Schwalbe EC, Lindsey JC, Nakjang S, Crosier S, Smith AJ, Hicks D, Rafiee G, Hill RM, Iliasova A, Stone T, Pizer B, Michalski A, Joshi A, Wharton SB, Jacques TS, Bailey S, Williamson D, Clifford SC
Lancet Oncol 2017 Jul;18(7):958-971. Epub 2017 May 22 doi: 10.1016/S1470-2045(17)30243-7. PMID: 28545823Free PMC Article
Risk stratification of childhood medulloblastoma in the molecular era: the current consensus.
Ramaswamy V, Remke M, Bouffet E, Bailey S, Clifford SC, Doz F, Kool M, Dufour C, Vassal G, Milde T, Witt O, von Hoff K, Pietsch T, Northcott PA, Gajjar A, Robinson GW, Padovani L, André N, Massimino M, Pizer B, Packer R, Rutkowski S, Pfister SM, Taylor MD, Pomeroy SL
Acta Neuropathol 2016 Jun;131(6):821-31. Epub 2016 Apr 4 doi: 10.1007/s00401-016-1569-6. PMID: 27040285Free PMC Article
Childhood medulloblastoma.
Massimino M, Giangaspero F, Garrè ML, Gandola L, Poggi G, Biassoni V, Gatta G, Rutkowski S
Crit Rev Oncol Hematol 2011 Jul;79(1):65-83. Epub 2010 Dec 3 doi: 10.1016/j.critrevonc.2010.07.010. PMID: 21129995

Recent systematic reviews

Neuroimaging Biomarkers and Neurocognitive Outcomes in Pediatric Medulloblastoma Patients: a Systematic Review.
Wauters M, Uyttebroeck A, De Waele L, Sleurs C, Jacobs S
Cerebellum 2021 Jun;20(3):462-480. Epub 2021 Jan 8 doi: 10.1007/s12311-020-01225-4. PMID: 33417160

Supplemental Content

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    Clinical resources

    Practice guidelines

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    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Pediatric Central Nervous System Cancers, 2024

    Reviews

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