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Infectious disease of the nervous system

MedGen UID:: 108926
•Concept ID:: C0597039
•: Disease or Syndrome

Synonym:	Infectious disorder of the nervous system
SNOMED CT:	Infectious disease of nervous system (128116006); Infection of nervous system (128116006)

Monarch Initiative:	MONDO:0020010
Orphanet:	ORPHA98010

Definition

A infectious disease that involves the nervous system. [from MONDO]

Term Hierarchy

GTR
MeSH
Orphanet

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVInfectious disease of the nervous system

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease Attributes
    - Infectious disease
      - Infectious Disorder by Site
        Infectious disease of the nervous system
        COVID-19-Associated Nervous System Disorder
        COVID-19-Associated Ataxia
        COVID-19-Associated Encephalitis
        COVID-19-Associated Acute Hemorrhagic Necrotizing Encephalitis
        COVID-19-Associated Stroke
        COVID-19-Associated Trigeminal Neuralgia
        HTLV-1-associated myelopathy-tropical spastic paraparesis
        Infection of cranial nerve
        Infectious disease of central nervous system
        Arachnoiditis
        Spinal arachnoiditis
        Bacterial infection of central nervous system
        Bacterial meningitis
        Central nervous system tuberculosis
        Lyme neuroborreliosis
        Neurosyphilis
        Brain abscess
        Cerebral toxoplasmosis
        Cerebral abscess
        Actinomycotic brain abscess
        Cerebritis
        Encephalomyelitis
        Acute disseminated encephalomyelitis
        Encephalomyelitis, Equine
        Infection causing encephalomyelitis
        Myalgic encephalomeyelitis/chronic fatigue syndrome
        Epidural abscess
        Fungal infection of central nervous system
        Fungal meningitis
        Neuroaspergillosis
        Infectious encephalitis
        Bacterial encephalitis
        Viral encephalitis
        Infectious meningitis
        Cryptococcal meningitis
        Viral meningitis
        Infectious Meningoencephalitis
        Leukoencephalopathy
        CNS demyelinating autoimmune disease
        Diffuse leukoencephalopathy
        Diffuse spongiform leukoencephalopathy
        Hereditary Central Nervous System Demyelinating Diseases
        Hereditary diffuse leukoencephalopathy with spheroids
        Human immunodeficiency virus leukoencephalopathy
        Posterior leukoencephalopathy
        Posterior leukoencephalopathy syndrome
        Posterior reversible encephalopathy syndrome
        Progressive leukoencephalopathy
        Progressive multifocal leukoencephalopathy
        Vanishing white matter disease
        Vascular dementia
        Meningoencephalitis
        Central nervous system lupus
        Myelitis
        Acute flaccid myelitis
        Acute transverse myelitis
        Poliomyelitis
        Transverse myelitis
        Parasitic infection of central nervous system
        Central Nervous System Helminthiasis
        Central Nervous System Protozoal Infections
        Perimeningeal Infections
        Subdural empyema
        Prion disease
        Bovine Spongiform Encephalopathy
        Creutzfeldt-Jakob disease
        Fatal familial insomnia
        Gerstmann-Straussler-Scheinker syndrome
        Kuru
        Scrapie
        Variant Creutzfeldt-Jakob disease
        Wasting Disease, Chronic
        Viral infection of central nervous system
        Limbic encephalitis
        Pseudorabies
        Infectious disease with peripheral neuropathy
        Acute infective polyneuritis
        Guillain-Barre syndrome
        Geniculate herpes zoster
        Leprosy
        Multibacillary leprosy
        Paucibacillary leprosy
        Lyme disease
        Early Disseminated Lyme Disease
        Early Localized Lyme Disease
        Erythema migrans
        Late Disseminated Lyme Disease
        Lyme Disease, Chronic
        Post-treatment Lyme disease syndrome
        Meningococcal meningitis
        Waterhouse-Friderichsen Syndrome
        Pneumococcal meningitis
        Rabies
        Tetanus
        Tetanus neonatorum
        Tuberculosis of meninges

Follow this link to review classifications for Infectious disease of the nervous system in Orphanet.

Professional guidelines

PubMed

Autoimmune encephalitis: clinical spectrum and management.

Uy CE, Binks S, Irani SR
Pract Neurol 2021 Oct;21(5):412-423. Epub 2021 Jun 9 doi: 10.1136/practneurol-2020-002567. PMID: 34108243 Free PMC Article

Acute flaccid myelitis: cause, diagnosis, and management.

Murphy OC, Messacar K, Benson L, Bove R, Carpenter JL, Crawford T, Dean J, DeBiasi R, Desai J, Elrick MJ, Farias-Moeller R, Gombolay GY, Greenberg B, Harmelink M, Hong S, Hopkins SE, Oleszek J, Otten C, Sadowsky CL, Schreiner TL, Thakur KT, Van Haren K, Carballo CM, Chong PF, Fall A, Gowda VK, Helfferich J, Kira R, Lim M, Lopez EL, Wells EM, Yeh EA, Pardo CA; AFM working group
Lancet 2021 Jan 23;397(10271):334-346. Epub 2020 Dec 23 doi: 10.1016/S0140-6736(20)32723-9. PMID: 33357469 Free PMC Article

Acute cerebellar ataxia: differential diagnosis and clinical approach.

Pedroso JL, Vale TC, Braga-Neto P, Dutra LA, França MC Jr, Teive HAG, Barsottini OGP
Arq Neuropsiquiatr 2019 Mar;77(3):184-193. doi: 10.1590/0004-282X20190020. PMID: 30970132

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Recent clinical studies

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Herpes simplex virus infection in pregnancy - An update.

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Eur J Obstet Gynecol Reprod Biol 2021 Apr;259:38-45. Epub 2021 Feb 4 doi: 10.1016/j.ejogrb.2021.01.055. PMID: 33581405

The diagnostic value of metagenomic next⁃generation sequencing in infectious diseases.

Duan H, Li X, Mei A, Li P, Liu Y, Li X, Li W, Wang C, Xie S
BMC Infect Dis 2021 Jan 13;21(1):62. doi: 10.1186/s12879-020-05746-5. PMID: 33435894 Free PMC Article

Exercise-induced immune system response: Anti-inflammatory status on peripheral and central organs.

Scheffer DDL, Latini A
Biochim Biophys Acta Mol Basis Dis 2020 Oct 1;1866(10):165823. Epub 2020 Apr 29 doi: 10.1016/j.bbadis.2020.165823. PMID: 32360589 Free PMC Article

Diagnostic and therapeutic approach to infectious diseases in solid organ transplant recipients.

Timsit JF, Sonneville R, Kalil AC, Bassetti M, Ferrer R, Jaber S, Lanternier F, Luyt CE, Machado F, Mikulska M, Papazian L, Pène F, Poulakou G, Viscoli C, Wolff M, Zafrani L, Van Delden C
Intensive Care Med 2019 May;45(5):573-591. Epub 2019 Mar 25 doi: 10.1007/s00134-019-05597-y. PMID: 30911807 Free PMC Article

A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2018 Update by the Infectious Diseases Society of America and the American Society for Microbiology.

Miller JM, Binnicker MJ, Campbell S, Carroll KC, Chapin KC, Gilligan PH, Gonzalez MD, Jerris RC, Kehl SC, Patel R, Pritt BS, Richter SS, Robinson-Dunn B, Schwartzman JD, Snyder JW, Telford S 3rd, Theel ES, Thomson RB Jr, Weinstein MP, Yao JD
Clin Infect Dis 2018 Aug 31;67(6):e1-e94. doi: 10.1093/cid/ciy381. PMID: 29955859 Free PMC Article

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Diagnosis

Infectious Neuropathies.

Boegle AK, Narayanaswami P
Continuum (Minneap Minn) 2023 Oct 1;29(5):1418-1443. doi: 10.1212/CON.0000000000001334. PMID: 37851037

Herpes simplex virus infection in pregnancy - An update.

Hammad WAB, Konje JC
Eur J Obstet Gynecol Reprod Biol 2021 Apr;259:38-45. Epub 2021 Feb 4 doi: 10.1016/j.ejogrb.2021.01.055. PMID: 33581405

Exercise-induced immune system response: Anti-inflammatory status on peripheral and central organs.

Scheffer DDL, Latini A
Biochim Biophys Acta Mol Basis Dis 2020 Oct 1;1866(10):165823. Epub 2020 Apr 29 doi: 10.1016/j.bbadis.2020.165823. PMID: 32360589 Free PMC Article

Pathophysiology and Mechanisms of Zika Virus Infection in the Nervous System.

Christian KM, Song H, Ming GL
Annu Rev Neurosci 2019 Jul 8;42:249-269. doi: 10.1146/annurev-neuro-080317-062231. PMID: 31283901 Free PMC Article

A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2018 Update by the Infectious Diseases Society of America and the American Society for Microbiology.

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Therapy

Review of microbiota gut brain axis and innate immunity in inflammatory and infective diseases.

Yuan C, He Y, Xie K, Feng L, Gao S, Cai L
Front Cell Infect Microbiol 2023;13:1282431. Epub 2023 Oct 4 doi: 10.3389/fcimb.2023.1282431. PMID: 37868345 Free PMC Article

Herpes simplex virus infection in pregnancy - An update.

Hammad WAB, Konje JC
Eur J Obstet Gynecol Reprod Biol 2021 Apr;259:38-45. Epub 2021 Feb 4 doi: 10.1016/j.ejogrb.2021.01.055. PMID: 33581405

Infectious Myelitis.

Asundi A, Cervantes-Arslanian AM, Lin NH, Barbosa F
Semin Neurol 2019 Aug;39(4):472-481. Epub 2019 Sep 18 doi: 10.1055/s-0039-1688923. PMID: 31533188

Vidal JE
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Prognosis

Approach to Neurologic Infections.

Berkowitz AL
Continuum (Minneap Minn) 2021 Aug 1;27(4):818-835. doi: 10.1212/CON.0000000000000984. PMID: 34623094

The diagnostic value of metagenomic next⁃generation sequencing in infectious diseases.

Duan H, Li X, Mei A, Li P, Liu Y, Li X, Li W, Wang C, Xie S
BMC Infect Dis 2021 Jan 13;21(1):62. doi: 10.1186/s12879-020-05746-5. PMID: 33435894 Free PMC Article

Infectious Etiologies of Stroke.

Shulman JG, Cervantes-Arslanian AM
Semin Neurol 2019 Aug;39(4):482-494. Epub 2019 Sep 18 doi: 10.1055/s-0039-1687915. PMID: 31533189

Diagnostic and therapeutic approach to infectious diseases in solid organ transplant recipients.

Neurosyphilis.

Marra CM
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Clinical prediction guides

Diagnostic Performance and Clinical Impact of Metagenomic Next-Generation Sequencing for Pediatric Infectious Diseases.

Zhu Y, Gan M, Ge M, Dong X, Yan G, Zhou Q, Yu H, Wang X, Cao Y, Lu G, Wu B, Zhou W
J Clin Microbiol 2023 Jun 20;61(6):e0011523. Epub 2023 Jun 1 doi: 10.1128/jcm.00115-23. PMID: 37260394 Free PMC Article

Effects of Antiretroviral Therapy in the Central Nervous System: Beyond Viral Suppression.

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J Neuroimmune Pharmacol 2021 Mar;16(1):71-73. Epub 2021 Mar 2 doi: 10.1007/s11481-021-09987-2. PMID: 33649998 Free PMC Article

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The Role of the Immune System Beyond the Fight Against Infection.

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Adv Exp Med Biol 2017;1003:3-14. doi: 10.1007/978-3-319-57613-8_1. PMID: 28667551

Menière's disease.

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Recent systematic reviews

Ultra-processed food consumption and cancer risk: A systematic review and meta-analysis.

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Roles of neuropathology-associated reactive astrocytes: a systematic review.

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Acta Neuropathol Commun 2023 Mar 13;11(1):42. doi: 10.1186/s40478-023-01526-9. PMID: 36915214 Free PMC Article

Analysis the Link between Periodontal Diseases and Alzheimer's Disease: A Systematic Review.

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How do I manage nocardiosis?

Margalit I, Lebeaux D, Tishler O, Goldberg E, Bishara J, Yahav D, Coussement J
Clin Microbiol Infect 2021 Apr;27(4):550-558. Epub 2021 Jan 5 doi: 10.1016/j.cmi.2020.12.019. PMID: 33418019

Whole grain consumption and risk of cardiovascular disease, cancer, and all cause and cause specific mortality: systematic review and dose-response meta-analysis of prospective studies.

Aune D, Keum N, Giovannucci E, Fadnes LT, Boffetta P, Greenwood DC, Tonstad S, Vatten LJ, Riboli E, Norat T
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MedGen

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Infectious disease of the nervous system

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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