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Paucibacillary leprosy

MedGen UID:
288331
•Concept ID:
C1562908
•
Disease or Syndrome
Synonyms: Borderline Tuberculoid; Borderline Tuberculoids; Indeterminate Tuberculoid; Indeterminate Tuberculoids; Leprosies, Paucibacillary; Leprosy, Paucibacillary; Paucibacillary Leprosies; Paucibacillary Leprosy; Tuberculoid, Borderline; Tuberculoid, Indeterminate; Tuberculoids, Borderline; Tuberculoids, Indeterminate
SNOMED CT: Paucibacillary leprosy (416483009); PB leprosy (416483009)
 
Monarch Initiative: MONDO:0041752

Definition

A tuberculoid form of leprosy that is characterized by a small number of hypopigmented, well-bordered, anesthetic skin lesions with a low bacillary load, early peripheral nerve impairment, and a T-helper 1 (Th1)–mediated immune response. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPaucibacillary leprosy

Professional guidelines

PubMed

Update on the epidemiology, diagnosis, and treatment of leprosy.
Reibel F, Cambau E, Aubry A
Med Mal Infect 2015 Sep;45(9):383-93. Epub 2015 Oct 1 doi: 10.1016/j.medmal.2015.09.002. PMID: 26428602
Hansen's disease (Leprosy): current and future pharmacotherapy and treatment of disease-related immunologic reactions.
Legendre DP, Muzny CA, Swiatlo E
Pharmacotherapy 2012 Jan;32(1):27-37. doi: 10.1002/PHAR.1009. PMID: 22392826
Advances in the diagnosis and treatment of leprosy.
Katoch VM
Expert Rev Mol Med 2002 Jul 22;4(15):1-14. doi: 10.1017/S1462399402004763. PMID: 14585155

Recent clinical studies

Etiology

Viral co-infections in leprosy: a scoping review.
Fróes LAR Jr, Toma TS, Poderoso RE, Trindade MÂB
Int J Dermatol 2023 Apr;62(4):547-557. Epub 2023 Feb 3 doi: 10.1111/ijd.16613. PMID: 36738114
Serum lipocalin-2 levels are decreased in patients with leprosy.
Bazid HAS, Shoeib MA, Shoeib MM, Sharaf REA, Mosatafa MI, Abd El Gayed EM
Indian J Dermatol Venereol Leprol 2023 [SEASON];90(1):59-63. doi: 10.25259/IJDVL_116_2022. PMID: 36688893
Clinical and histopathological features of paucibacillary leprosy before and after multidrug therapy: a prospective study.
Jain S, Ramesh V, Singh A, Yadav A, Ramam M, Khandpur S
Trans R Soc Trop Med Hyg 2016 Jun;110(6):350-8. Epub 2016 Jun 17 doi: 10.1093/trstmh/trw039. PMID: 27317754
Update on the epidemiology, diagnosis, and treatment of leprosy.
Reibel F, Cambau E, Aubry A
Med Mal Infect 2015 Sep;45(9):383-93. Epub 2015 Oct 1 doi: 10.1016/j.medmal.2015.09.002. PMID: 26428602
Epidemiological situation of leprosy in Salvador from 2001 to 2009.
Moreira SC, Batos CJ, Tawil L
An Bras Dermatol 2014 Jan-Feb;89(1):107-17. doi: 10.1590/abd1806-4841.20142175. PMID: 24626655Free PMC Article

Diagnosis

Dermoscopy and clinicopathology features in diagnosing paucibacillary leprosy: Case series.
Rusmawardiana R, Nursyarifah N, Argentina F, Pamudji R
Int J Mycobacteriol 2022 Jul-Sep;11(3):332-336. doi: 10.4103/ijmy.ijmy_113_22. PMID: 36260456
Acquired disorders with hypopigmentation: A clinical approach to diagnosis and treatment.
Saleem MD, Oussedik E, Picardo M, Schoch JJ
J Am Acad Dermatol 2019 May;80(5):1233-1250.e10. Epub 2018 Sep 17 doi: 10.1016/j.jaad.2018.07.070. PMID: 30236514
Understanding "patient discharge in leprosy": a concept analysis.
Pinheiro MGC, Miranda FAN, Simpson CA, Carvalho FPB, Ataide CAV, Lira ALBC
Rev Gaucha Enferm 2018 Jun 7;38(4):e63290. doi: 10.1590/1983-1447.2017.04.63290. PMID: 29933418
Update on the epidemiology, diagnosis, and treatment of leprosy.
Reibel F, Cambau E, Aubry A
Med Mal Infect 2015 Sep;45(9):383-93. Epub 2015 Oct 1 doi: 10.1016/j.medmal.2015.09.002. PMID: 26428602
Advances in the diagnosis and treatment of leprosy.
Katoch VM
Expert Rev Mol Med 2002 Jul 22;4(15):1-14. doi: 10.1017/S1462399402004763. PMID: 14585155

Therapy

Understanding "patient discharge in leprosy": a concept analysis.
Pinheiro MGC, Miranda FAN, Simpson CA, Carvalho FPB, Ataide CAV, Lira ALBC
Rev Gaucha Enferm 2018 Jun 7;38(4):e63290. doi: 10.1590/1983-1447.2017.04.63290. PMID: 29933418
Update on the epidemiology, diagnosis, and treatment of leprosy.
Reibel F, Cambau E, Aubry A
Med Mal Infect 2015 Sep;45(9):383-93. Epub 2015 Oct 1 doi: 10.1016/j.medmal.2015.09.002. PMID: 26428602
Leprosy.
Smith WC, Saunderson P
BMJ Clin Evid 2010 Jun 28;2010 PMID: 21418690Free PMC Article
Leprosy.
Lockwood DNj
BMJ Clin Evid 2007 Apr 1;2007 PMID: 19454067Free PMC Article
Advances in the diagnosis and treatment of leprosy.
Katoch VM
Expert Rev Mol Med 2002 Jul 22;4(15):1-14. doi: 10.1017/S1462399402004763. PMID: 14585155

Prognosis

Serum lipocalin-2 levels are decreased in patients with leprosy.
Bazid HAS, Shoeib MA, Shoeib MM, Sharaf REA, Mosatafa MI, Abd El Gayed EM
Indian J Dermatol Venereol Leprol 2023 [SEASON];90(1):59-63. doi: 10.25259/IJDVL_116_2022. PMID: 36688893
Monitoring and detection of leprosy patients in Southwest China: A retrospective study, 2010-2014.
Le W, Haiqin J, Danfeng H, Ying S, Wenyue Z, Jun Y, Li X, Tiejun S, Limei S, Jie L, De W, Yong N, Yangying L, Hao W, Yanfei K, Bin L, Maeda Y, Duthie M, Meiwen Y, Hongsheng W, Liangbin Y, Guocheng Z, Baoxi W, Heng G
Sci Rep 2018 Jul 30;8(1):11407. doi: 10.1038/s41598-018-29753-4. PMID: 30061618Free PMC Article
Leprosy and HIV coinfection: a critical approach.
Massone C, Talhari C, Ribeiro-Rodrigues R, Sindeaux RH, Mira MT, Talhari S, Naafs B
Expert Rev Anti Infect Ther 2011 Jun;9(6):701-10. doi: 10.1586/eri.11.44. PMID: 21692674
HLA and leprosy in the pre and postgenomic eras.
Geluk A, Ottenhoff TH
Hum Immunol 2006 Jun;67(6):439-45. Epub 2006 Apr 3 doi: 10.1016/j.humimm.2006.03.009. PMID: 16728267
Duration of multidrug therapy in paucibacillary leprosy patients; experience in the leprosy control program of the All Africa Leprosy and Rehabilitation Training Center (ALERT) in Ethiopia.
Becx-Bleumink M
Int J Lepr Other Mycobact Dis 1992 Sep;60(3):436-44. PMID: 1474282

Clinical prediction guides

Allele-dependent interaction of LRRK2 and NOD2 in leprosy.
Dallmann-Sauer M, Xu YZ, da Costa ALF, Tao S, Gomes TA, Prata RBDS, Correa-Macedo W, Manry J, Alcaïs A, Abel L, Cobat A, Fava VM, Pinheiro RO, Lara FA, Probst CM, Mira MT, Schurr E
PLoS Pathog 2023 Mar;19(3):e1011260. Epub 2023 Mar 27 doi: 10.1371/journal.ppat.1011260. PMID: 36972292Free PMC Article
Leprosy and HIV coinfection: a critical approach.
Massone C, Talhari C, Ribeiro-Rodrigues R, Sindeaux RH, Mira MT, Talhari S, Naafs B
Expert Rev Anti Infect Ther 2011 Jun;9(6):701-10. doi: 10.1586/eri.11.44. PMID: 21692674
Leprosy.
Smith WC, Saunderson P
BMJ Clin Evid 2010 Jun 28;2010 PMID: 21418690Free PMC Article
Leprosy.
Lockwood DNj
BMJ Clin Evid 2007 Apr 1;2007 PMID: 19454067Free PMC Article
Advances in the diagnosis and treatment of leprosy.
Katoch VM
Expert Rev Mol Med 2002 Jul 22;4(15):1-14. doi: 10.1017/S1462399402004763. PMID: 14585155

Recent systematic reviews

Establishing a standard method for analysing case detection delay in leprosy using a Bayesian modelling approach.
Hambridge T, Coffeng LE, de Vlas SJ, Richardus JH
Infect Dis Poverty 2023 Feb 20;12(1):12. doi: 10.1186/s40249-023-01065-4. PMID: 36800979Free PMC Article
World Health Organization (WHO) antibiotic regimen against other regimens for the treatment of leprosy: a systematic review and meta-analysis.
Lazo-Porras M, Prutsky GJ, Barrionuevo P, Tapia JC, Ugarte-Gil C, Ponce OJ, Acuña-Villaorduña A, Domecq JP, De la Cruz-Luque C, Prokop LJ, Málaga G
BMC Infect Dis 2020 Jan 20;20(1):62. doi: 10.1186/s12879-019-4665-0. PMID: 31959113Free PMC Article
Is there a role for rifampicin, ofloxacin and minocycline (ROM) therapy in the treatment of leprosy? Systematic review and meta-analysis.
Setia MS, Shinde SS, Jerajani HR, Boivin JF
Trop Med Int Health 2011 Dec;16(12):1541-51. Epub 2011 Sep 13 doi: 10.1111/j.1365-3156.2011.02873.x. PMID: 21914093
Leprosy.
Smith WC, Saunderson P
BMJ Clin Evid 2010 Jun 28;2010 PMID: 21418690Free PMC Article
Leprosy.
Lockwood DNj
BMJ Clin Evid 2007 Apr 1;2007 PMID: 19454067Free PMC Article

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