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Pseudorabies

MedGen UID:
18730
•Concept ID:
C0033839
•
Disease or Syndrome
Synonyms: Aujeszky Disease; Aujeszky's Disease; Aujeszkys Disease
 
Monarch Initiative: MONDO:0005932

Definition

A highly contagious herpesvirus infection affecting the central nervous system of swine, cattle, dogs, cats, rats, and other animals. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPseudorabies

Professional guidelines

PubMed

Detection of virus or virus specific nucleic acid in foodstuff or bioproducts--hazards and risk assessment.
Büttner M, Oehmig A, Weiland F, Rziha HJ, Pfaff E
Arch Virol Suppl 1997;13:57-66. doi: 10.1007/978-3-7091-6534-8_6. PMID: 9413526
Quantitative risk assessment of the risks associated with the importation of pigs to abattoirs.
Morley RS
Rev Sci Tech 1993 Dec;12(4):1235-63. doi: 10.20506/rst.12.4.747. PMID: 8312623

Recent clinical studies

Etiology

Pseudorabies Virus Infection Activates the TLR-NF-κB Axis and AIM2 Inflammasome To Enhance Inflammatory Responses in Mice.
Zhou Q, Zhang L, Lin Q, Liu H, Ye G, Liu X, Jiao S, Li J, Tang Y, Shi D, Huang L, Weng C
J Virol 2023 Mar 30;97(3):e0000323. Epub 2023 Mar 6 doi: 10.1128/jvi.00003-23. PMID: 36877049Free PMC Article
Will swine veterinarians lead by meeting the next-generation needs of our industry?
Spronk G, Havas K, Patterson G, Dee S
J Am Vet Med Assoc 2022 Dec 22;261(3):424-429. doi: 10.2460/javma.22.10.0480. PMID: 36563066
The Epidemiology and Variation in Pseudorabies Virus: A Continuing Challenge to Pigs and Humans.
Liu Q, Kuang Y, Li Y, Guo H, Zhou C, Guo S, Tan C, Wu B, Chen H, Wang X
Viruses 2022 Jul 1;14(7) doi: 10.3390/v14071463. PMID: 35891443Free PMC Article
A Novel Human Acute Encephalitis Caused by Pseudorabies Virus Variant Strain.
Liu Q, Wang X, Xie C, Ding S, Yang H, Guo S, Li J, Qin L, Ban F, Wang D, Wang C, Feng L, Ma H, Wu B, Zhang L, Dong C, Xing L, Zhang J, Chen H, Yan R, Wang X, Li W
Clin Infect Dis 2021 Dec 6;73(11):e3690-e3700. doi: 10.1093/cid/ciaa987. PMID: 32667972
Exogenous porcine viruses.
Paul PS, Halbur P, Janke B, Joo H, Nawagitgul P, Singh J, Sorden S
Curr Top Microbiol Immunol 2003;278:125-83. doi: 10.1007/978-3-642-55541-1_6. PMID: 12934944

Diagnosis

Pseudorabies Virus: From Pathogenesis to Prevention Strategies.
Zheng HH, Fu PF, Chen HY, Wang ZY
Viruses 2022 Jul 27;14(8) doi: 10.3390/v14081638. PMID: 36016260Free PMC Article
The Epidemiology and Variation in Pseudorabies Virus: A Continuing Challenge to Pigs and Humans.
Liu Q, Kuang Y, Li Y, Guo H, Zhou C, Guo S, Tan C, Wu B, Chen H, Wang X
Viruses 2022 Jul 1;14(7) doi: 10.3390/v14071463. PMID: 35891443Free PMC Article
A Novel Human Acute Encephalitis Caused by Pseudorabies Virus Variant Strain.
Liu Q, Wang X, Xie C, Ding S, Yang H, Guo S, Li J, Qin L, Ban F, Wang D, Wang C, Feng L, Ma H, Wu B, Zhang L, Dong C, Xing L, Zhang J, Chen H, Yan R, Wang X, Li W
Clin Infect Dis 2021 Dec 6;73(11):e3690-e3700. doi: 10.1093/cid/ciaa987. PMID: 32667972
Neural innervation of white adipose tissue and the control of lipolysis.
Bartness TJ, Liu Y, Shrestha YB, Ryu V
Front Neuroendocrinol 2014 Oct;35(4):473-93. Epub 2014 Apr 13 doi: 10.1016/j.yfrne.2014.04.001. PMID: 24736043Free PMC Article
Exogenous porcine viruses.
Paul PS, Halbur P, Janke B, Joo H, Nawagitgul P, Singh J, Sorden S
Curr Top Microbiol Immunol 2003;278:125-83. doi: 10.1007/978-3-642-55541-1_6. PMID: 12934944

Therapy

Membrane fusion, potential threats, and natural antiviral drugs of pseudorabies virus.
Ye N, Feng W, Fu T, Tang D, Zeng Z, Wang B
Vet Res 2023 May 2;54(1):39. doi: 10.1186/s13567-023-01171-z. PMID: 37131259Free PMC Article
The broad spectrum host-directed agent ivermectin as an antiviral for SARS-CoV-2 ?
Jans DA, Wagstaff KM
Biochem Biophys Res Commun 2021 Jan 29;538:163-172. Epub 2020 Oct 21 doi: 10.1016/j.bbrc.2020.10.042. PMID: 33341233Free PMC Article
From heart to brain: the genesis and processing of cardiac pain.
Rosen SD
Can J Cardiol 2012 Mar-Apr;28(2 Suppl):S7-19. doi: 10.1016/j.cjca.2011.09.010. PMID: 22424286
Exogenous porcine viruses.
Paul PS, Halbur P, Janke B, Joo H, Nawagitgul P, Singh J, Sorden S
Curr Top Microbiol Immunol 2003;278:125-83. doi: 10.1007/978-3-642-55541-1_6. PMID: 12934944
Central integration of swallow and airway-protective reflexes.
Broussard DL, Altschuler SM
Am J Med 2000 Mar 6;108 Suppl 4a:62S-67S. doi: 10.1016/s0002-9343(99)00340-x. PMID: 10718454

Prognosis

Acute transcriptomic changes in murine RAW 264.7 cells following pseudorabies virus infection.
Tong C, Fu PF, Ming SL, Zeng L, Zhu HS, Wang J
Arch Virol 2022 Dec;167(12):2623-2631. Epub 2022 Oct 21 doi: 10.1007/s00705-022-05598-1. PMID: 36269412
Human viral encephalitis associated with suid herpesvirus 1.
Zhou Y, Nie C, Wen H, Long Y, Zhou M, Xie Z, Hong D
Neurol Sci 2022 Apr;43(4):2681-2692. Epub 2021 Oct 13 doi: 10.1007/s10072-021-05633-0. PMID: 34647219Free PMC Article
Vitritis and retinal vasculitis caused by pseudorabies virus.
Ying M, Hu X, Wang M, Cheng X, Zhao B, Tao Y
J Int Med Res 2021 Nov;49(11):3000605211058990. doi: 10.1177/03000605211058990. PMID: 34851760Free PMC Article
Generation and characterization of UL41 null pseudorabies virus variant in vitro and in vivo.
Ye C, Chen J, Wang T, Xu J, Zheng H, Wu J, Li G, Yu Z, Tong W, Cheng X, Zhou S, Tong G
Virol J 2018 Aug 2;15(1):119. doi: 10.1186/s12985-018-1025-4. PMID: 30071879Free PMC Article
Identification of rat brainstem multisynaptic connections to the oral motor nuclei using pseudorabies virus. I. Masticatory muscle motor systems.
Fay RA, Norgren R
Brain Res Brain Res Rev 1997 Dec;25(3):255-75. doi: 10.1016/s0165-0173(97)00026-x. PMID: 9495558

Clinical prediction guides

Pseudorabies virus gM and its homologous proteins in herpesviruses induce mitochondria-related apoptosis involved in viral pathogenicity.
Zhou Q, Shi D, Tang YD, Zhang L, Hu B, Zheng C, Huang L, Weng C
PLoS Pathog 2024 Apr;20(4):e1012146. Epub 2024 Apr 26 doi: 10.1371/journal.ppat.1012146. PMID: 38669242Free PMC Article
Pseudorabies virus upregulates low-density lipoprotein receptors to facilitate viral entry.
Ma Y-X, Chai Y-J, Han Y-Q, Zhao S-B, Yang G-Y, Wang J, Ming S-L, Chu B-B
J Virol 2024 Jan 23;98(1):e0166423. Epub 2023 Dec 6 doi: 10.1128/jvi.01664-23. PMID: 38054618Free PMC Article
Establishment of an In Vitro Model of Pseudorabies Virus Latency and Reactivation and Identification of Key Viral Latency-Associated Genes.
Pan L, Li M, Zhang X, Xia Y, Mian AM, Wu H, Sun Y, Qiu HJ
Viruses 2023 Mar 22;15(3) doi: 10.3390/v15030808. PMID: 36992518Free PMC Article
The Epidemiology and Variation in Pseudorabies Virus: A Continuing Challenge to Pigs and Humans.
Liu Q, Kuang Y, Li Y, Guo H, Zhou C, Guo S, Tan C, Wu B, Chen H, Wang X
Viruses 2022 Jul 1;14(7) doi: 10.3390/v14071463. PMID: 35891443Free PMC Article
The broad spectrum host-directed agent ivermectin as an antiviral for SARS-CoV-2 ?
Jans DA, Wagstaff KM
Biochem Biophys Res Commun 2021 Jan 29;538:163-172. Epub 2020 Oct 21 doi: 10.1016/j.bbrc.2020.10.042. PMID: 33341233Free PMC Article

Recent systematic reviews

Human Encephalitis Caused by Pseudorabies Virus in China: A Case Report and Systematic Review.
Hou Y, Wang Y, Zhang Y, Yu H, Zhao Y, Yi A
Vector Borne Zoonotic Dis 2022 Jul;22(7):391-396. Epub 2022 Jun 23 doi: 10.1089/vbz.2022.0002. PMID: 35736787
Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen.
Heidary F, Gharebaghi R
J Antibiot (Tokyo) 2020 Sep;73(9):593-602. Epub 2020 Jun 12 doi: 10.1038/s41429-020-0336-z. PMID: 32533071Free PMC Article

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