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Neurosyphilis

MedGen UID:
14360
Concept ID:
C0027927
Disease or Syndrome
Synonyms: Central Nervous System Syphilis; Syphilis, Central Nervous System; Syphilis, CNS
SNOMED CT: Neurosyphilis (26039008); Syphilis of central nervous system (26039008)
 
Monarch Initiative: MONDO:0004944

Definition

Infection of the brain or spinal cord by Treponema pallidum. It occurs many years following the original infection which remained untreated. Signs and symptoms include abnormal gait, blindness, depression, paralysis, seizures and dementia. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Ren M, Dashwood T, Walmsley S
Curr HIV/AIDS Rep 2021 Aug;18(4):280-288. Epub 2021 Jun 6 doi: 10.1007/s11904-021-00564-z. PMID: 34091858Free PMC Article
Bettuzzi T, Jourdes A, Robineau O, Alcaraz I, Manda V, Molina JM, Mehlen M, Cazanave C, Tattevin P, Mensi S, Terrier B, Régent A, Ghosn J, Charlier C, Martin-Blondel G, Dupin N
Lancet Infect Dis 2021 Oct;21(10):1441-1447. Epub 2021 May 26 doi: 10.1016/S1473-3099(20)30857-4. PMID: 34051142
Clement ME, Okeke NL, Hicks CB
JAMA 2014 Nov 12;312(18):1905-17. doi: 10.1001/jama.2014.13259. PMID: 25387188Free PMC Article

Recent clinical studies

Etiology

Zheng X, Yang J, Hou Y, Shi X, Liu K
Eur J Med Res 2024 Jan 12;29(1):51. doi: 10.1186/s40001-023-01631-4. PMID: 38216970Free PMC Article
Tsan GL, Claiborne RT
Clin Exp Optom 2021 Sep;104(7):756-759. Epub 2021 Apr 8 doi: 10.1080/08164622.2021.1906848. PMID: 33831337
Hook EW 3rd
Lancet 2017 Apr 15;389(10078):1550-1557. Epub 2016 Dec 18 doi: 10.1016/S0140-6736(16)32411-4. PMID: 27993382
Aldave AJ, King JA, Cunningham ET Jr
Curr Opin Ophthalmol 2001 Dec;12(6):433-41. doi: 10.1097/00055735-200112000-00008. PMID: 11734683
Scheck DN, Hook EW 3rd
Infect Dis Clin North Am 1994 Dec;8(4):769-95. PMID: 7890932

Diagnosis

Hamill MM, Ghanem KG, Tuddenham S
Clin Infect Dis 2024 May 15;78(5):e57-e68. doi: 10.1093/cid/ciad437. PMID: 37593890
Chow F
Continuum (Minneap Minn) 2021 Aug 1;27(4):1018-1039. doi: 10.1212/CON.0000000000000982. PMID: 34623102
Ropper AH
N Engl J Med 2019 Oct 3;381(14):1358-1363. doi: 10.1056/NEJMra1906228. PMID: 31577877
Gonzalez H, Koralnik IJ, Marra CM
Semin Neurol 2019 Aug;39(4):448-455. Epub 2019 Sep 18 doi: 10.1055/s-0039-1688942. PMID: 31533185
Tuddenham S, Ghanem KG
Sex Transm Dis 2018 Mar;45(3):147-151. doi: 10.1097/OLQ.0000000000000723. PMID: 29420441Free PMC Article

Therapy

Hamill MM, Ghanem KG, Tuddenham S
Clin Infect Dis 2024 May 15;78(5):e57-e68. doi: 10.1093/cid/ciad437. PMID: 37593890
Ghanem KG, Ram S, Rice PA
N Engl J Med 2020 Feb 27;382(9):845-854. doi: 10.1056/NEJMra1901593. PMID: 32101666
Ropper AH
N Engl J Med 2019 Oct 3;381(14):1358-1363. doi: 10.1056/NEJMra1906228. PMID: 31577877
Gonzalez H, Koralnik IJ, Marra CM
Semin Neurol 2019 Aug;39(4):448-455. Epub 2019 Sep 18 doi: 10.1055/s-0039-1688942. PMID: 31533185
Carod Artal FJ
Expert Rev Neurother 2016;16(2):205-21. Epub 2016 Jan 19 doi: 10.1586/14737175.2015.1134321. PMID: 26689107

Prognosis

Shahan B, Choi EY, Nieves G
Am Fam Physician 2021 Apr 1;103(7):422-428. PMID: 33788511
Gonzalez H, Koralnik IJ, Marra CM
Semin Neurol 2019 Aug;39(4):448-455. Epub 2019 Sep 18 doi: 10.1055/s-0039-1688942. PMID: 31533185
Dutta Majumder P, Chen EJ, Shah J, Ching Wen Ho D, Biswas J, See Yin L, Gupta V, Pavesio C, Agrawal R
Ocul Immunol Inflamm 2019;27(1):117-125. Epub 2017 Oct 11 doi: 10.1080/09273948.2017.1371765. PMID: 29020491
Tuddenham S, Ghanem KG
Sex Transm Dis 2018 Mar;45(3):147-151. doi: 10.1097/OLQ.0000000000000723. PMID: 29420441Free PMC Article
Marra CM
Continuum (Minneap Minn) 2015 Dec;21(6 Neuroinfectious Disease):1714-28. doi: 10.1212/CON.0000000000000250. PMID: 26633785

Clinical prediction guides

Zheng X, Yang J, Hou Y, Shi X, Liu K
Eur J Med Res 2024 Jan 12;29(1):51. doi: 10.1186/s40001-023-01631-4. PMID: 38216970Free PMC Article
Moon S
Curr Med Imaging 2022;18(3):285-291. doi: 10.2174/1573405617666210712130555. PMID: 34931987
Danics K, Forrest SL, Kapas I, Erber I, Schmid S, Törő K, Majtenyi K, Kovacs GG
J Neural Transm (Vienna) 2021 Oct;128(10):1551-1566. Epub 2021 Jul 5 doi: 10.1007/s00702-021-02371-7. PMID: 34223998Free PMC Article
Bettuzzi T, Jourdes A, Robineau O, Alcaraz I, Manda V, Molina JM, Mehlen M, Cazanave C, Tattevin P, Mensi S, Terrier B, Régent A, Ghosn J, Charlier C, Martin-Blondel G, Dupin N
Lancet Infect Dis 2021 Oct;21(10):1441-1447. Epub 2021 May 26 doi: 10.1016/S1473-3099(20)30857-4. PMID: 34051142
Lu Y, Ke W, Yang L, Wang Z, Lv P, Gu J, Hao C, Li J, Cai Y, Gu M, Liu H, Chen W, Zhang X, Wang L, Liu Y, Yang B, Zou H, Zheng H
BMC Infect Dis 2019 Dec 2;19(1):1017. doi: 10.1186/s12879-019-4582-2. PMID: 31791265Free PMC Article

Recent systematic reviews

Tuddenham S, Ghanem KG
Clin Infect Dis 2022 Apr 13;74(Suppl_2):S127-S133. doi: 10.1093/cid/ciac060. PMID: 35416969Free PMC Article
Dersch R, Singh AE
Curr Opin Neurol 2021 Jun 1;34(3):403-409. doi: 10.1097/WCO.0000000000000923. PMID: 33709978
Park IU, Tran A, Pereira L, Fakile Y
Clin Infect Dis 2020 Jun 24;71(Suppl 1):S13-S20. doi: 10.1093/cid/ciaa349. PMID: 32578866Free PMC Article
Marks M, Jarvis JN, Howlett W, Mabey DCW
PLoS Negl Trop Dis 2017 Aug;11(8):e0005880. Epub 2017 Aug 31 doi: 10.1371/journal.pntd.0005880. PMID: 28859081Free PMC Article
Clement ME, Okeke NL, Hicks CB
JAMA 2014 Nov 12;312(18):1905-17. doi: 10.1001/jama.2014.13259. PMID: 25387188Free PMC Article

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