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Meningococcal meningitis

MedGen UID:
6299
Concept ID:
C0025294
Disease or Syndrome
Synonyms: Meningitis, Meningococcal; Meningitis, Meningococcic; Meningitis, Neisseria; Meningococcal Meningitis; Neisseria Meningitides; Neisseria Meningitis
SNOMED CT: Epidemic meningitis (192644005); Meningococcal meningitis (192644005); Meningococcal cerebrospinal fever (192644005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0018059
Orphanet: ORPHA33475

Definition

Meningococcal meningitis is an acute bacterial disease caused by <i>Neisseria meningitides</i> that presents usually, but not always, with a rash (non blanching petechial or purpuric rash), progressively developing signs of meningitis (fever, vomiting, headache, photophobia, and neck stiffness) and later leading to confusion, delirium and drowsiness. Neck stiffness and photophobia are often absent in infants and young children who may manifest nonspecific signs such as irritability, inconsolable crying, poor feeding, and a bulging fontanel. Meningococcal meningitis may also present as part of early or late onset sepsis in neonates. The disease is potentially fatal. Surviving patients may develop neurological sequelae that include sensorineural hearing loss, seizures, spasticity, attention deficits and intellectual disability. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMeningococcal meningitis
Follow this link to review classifications for Meningococcal meningitis in Orphanet.

Professional guidelines

PubMed

Cohen R, Raymond J, Hees L, Pinquier D, Grimprel E, Levy C
Arch Pediatr 2017 Dec;24(12S):S42-S45. doi: 10.1016/S0929-693X(17)30518-3. PMID: 29290234
Agrawal S, Nadel S
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J Antimicrob Chemother 1993 Jul;32 Suppl A:49-59. doi: 10.1093/jac/32.suppl_a.49. PMID: 8407698

Recent clinical studies

Etiology

Gallacher SD, Seaton A
BMJ Case Rep 2020 Aug 25;13(8) doi: 10.1136/bcr-2020-237366. PMID: 32843469Free PMC Article
McAlpine A, Sadarangani M
Curr Opin Infect Dis 2019 Oct;32(5):510-516. doi: 10.1097/QCO.0000000000000580. PMID: 31335439
Aljohani S, Hussein WM, Toth I, Simerska P
Curr Drug Deliv 2019;16(7):609-617. doi: 10.2174/1567201816666190702153612. PMID: 31267872
Lucas MJ, Brouwer MC, van de Beek D
J Infect 2016 Jul;73(1):18-27. Epub 2016 Apr 19 doi: 10.1016/j.jinf.2016.04.009. PMID: 27105658
Bhatt KM, Bhatt SM, Mirza NB
East Afr Med J 1996 Jan;73(1):35-9. PMID: 8625860

Diagnosis

Burnett MW
J Spec Oper Med 2017 Spring;17(1):90-92. doi: 10.55460/URE1-Z992. PMID: 28285486
Mohammed I, Iliyasu G, Habib AG
Pathog Glob Health 2017 Feb;111(1):1-6. Epub 2017 Jan 12 doi: 10.1080/20477724.2016.1274068. PMID: 28081671Free PMC Article
Strelow VL, Vidal JE
Arq Neuropsiquiatr 2013 Sep;71(9B):653-8. doi: 10.1590/0004-282X20130144. PMID: 24141498
Rajapaksa S, Starr M
Aust Fam Physician 2010 May;39(5):276-8. PMID: 20485712
Branco RG, Amoretti CF, Tasker RC
J Pediatr (Rio J) 2007 May;83(2 Suppl):S46-53. Epub 2007 Apr 26 doi: 10.2223/JPED.1612. PMID: 17486194

Therapy

Aljohani S, Hussein WM, Toth I, Simerska P
Curr Drug Deliv 2019;16(7):609-617. doi: 10.2174/1567201816666190702153612. PMID: 31267872
Mann K, Jackson MA
Pediatr Rev 2008 Dec;29(12):417-29; quiz 430. doi: 10.1542/pir.29-12-417. PMID: 19047432
Stephens DS
FEMS Microbiol Rev 2007 Jan;31(1):3-14. doi: 10.1111/j.1574-6976.2006.00051.x. PMID: 17233633
Lancet 1989 Mar 25;1(8639):647-8. PMID: 2564462
J Trop Med Hyg 1978 Dec;81(12):237. PMID: 748568

Prognosis

Brouwer MC, van de Beek D
Curr Opin Infect Dis 2018 Feb;31(1):78-84. doi: 10.1097/QCO.0000000000000417. PMID: 29176349
Lucas MJ, Brouwer MC, van de Beek D
J Infect 2016 Jul;73(1):18-27. Epub 2016 Apr 19 doi: 10.1016/j.jinf.2016.04.009. PMID: 27105658
Bijlsma MW, Brouwer MC, Kasanmoentalib ES, Kloek AT, Lucas MJ, Tanck MW, van der Ende A, van de Beek D
Lancet Infect Dis 2016 Mar;16(3):339-47. Epub 2015 Dec 1 doi: 10.1016/S1473-3099(15)00430-2. PMID: 26652862
Mann K, Jackson MA
Pediatr Rev 2008 Dec;29(12):417-29; quiz 430. doi: 10.1542/pir.29-12-417. PMID: 19047432
Ebrahim GJ
J Trop Pediatr 1997 Jun;43(3):126-7. doi: 10.1093/tropej/43.3.126. PMID: 9231629

Clinical prediction guides

Brouwer MC, van de Beek D
Curr Opin Infect Dis 2018 Feb;31(1):78-84. doi: 10.1097/QCO.0000000000000417. PMID: 29176349
Bijlsma MW, Brouwer MC, Kasanmoentalib ES, Kloek AT, Lucas MJ, Tanck MW, van der Ende A, van de Beek D
Lancet Infect Dis 2016 Mar;16(3):339-47. Epub 2015 Dec 1 doi: 10.1016/S1473-3099(15)00430-2. PMID: 26652862
Mann K, Jackson MA
Pediatr Rev 2008 Dec;29(12):417-29; quiz 430. doi: 10.1542/pir.29-12-417. PMID: 19047432
van de Beek D, de Gans J, Spanjaard L, Weisfelt M, Reitsma JB, Vermeulen M
N Engl J Med 2004 Oct 28;351(18):1849-59. doi: 10.1056/NEJMoa040845. PMID: 15509818
de Gans J, van de Beek D; European Dexamethasone in Adulthood Bacterial Meningitis Study Investigators
N Engl J Med 2002 Nov 14;347(20):1549-56. doi: 10.1056/NEJMoa021334. PMID: 12432041

Recent systematic reviews

Rostamian M, Chegene Lorestani R, Jafari S, Mansouri R, Rezaeian S, Ghadiri K, Akya A
Indian J Med Microbiol 2022 Jul-Sep;40(3):323-329. Epub 2022 May 30 doi: 10.1016/j.ijmmb.2022.05.005. PMID: 35654713
Sudarsanam TD, Rupali P, Tharyan P, Abraham OC, Thomas K
Cochrane Database Syst Rev 2017 Jun 14;6(6):CD005437. doi: 10.1002/14651858.CD005437.pub4. PMID: 28613408Free PMC Article
Bijlsma MW, Brouwer MC, Bossuyt PM, Heymans MW, van der Ende A, Tanck MW, van de Beek D
J Infect 2016 Nov;73(5):393-401. Epub 2016 Aug 9 doi: 10.1016/j.jinf.2016.08.003. PMID: 27519619
Racloz VN, Luiz SJ
BMC Infect Dis 2010 Jun 17;10:175. doi: 10.1186/1471-2334-10-175. PMID: 20565757Free PMC Article
Brouwer MC, de Gans J, Heckenberg SG, Zwinderman AH, van der Poll T, van de Beek D
Lancet Infect Dis 2009 Jan;9(1):31-44. Epub 2008 Nov 25 doi: 10.1016/S1473-3099(08)70261-5. PMID: 19036641

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