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Guillain-Barre syndrome

MedGen UID:
5399
•Concept ID:
C0018378
•
Disease or Syndrome
Synonyms: Landry's ascending paralysis; Landry-Guillain-Barre-Strohl syndrome
SNOMED CT: Guillain Barre syndrome (40956001); Landry-Guillain-Barré syndrome (40956001); Guillain-Barré syndrome (40956001); Landry-Guillain-Barre syndrome (40956001); Guillain-Barre syndrome (40956001)
Modes of inheritance:
Non-Mendelian inheritance
MedGen UID:
109109
•Concept ID:
C0600599
•
Genetic Function
Source: Orphanet
A mode of inheritance that depends on genetic determinants in more than one gene.
Non-Mendelian inheritance (Orphanet)
 
Monarch Initiative: MONDO:0016218
Orphanet: ORPHA2103

Definition

A clinically heterogeneous spectrum of rare post-infectious neuropathies that usually occur in otherwise healthy patients and encompasses acute inflammatory demyelinating polyradiculoneuropathy (AIDP), acute motor axonal neuropathy (AMAN) and acute motor-sensory axonal neuropathy (AMSAN), Miller-Fisher syndrome (MFS) and some other regional variants. [from ORDO]

Professional guidelines

PubMed

European Academy of Neurology/Peripheral Nerve Society Guideline on diagnosis and treatment of Guillain-Barré syndrome.
van Doorn PA, Van den Bergh PYK, Hadden RDM, Avau B, Vankrunkelsven P, Attarian S, Blomkwist-Markens PH, Cornblath DR, Goedee HS, Harbo T, Jacobs BC, Kusunoki S, Lehmann HC, Lewis RA, Lunn MP, Nobile-Orazio E, Querol L, Rajabally YA, Umapathi T, Topaloglu HA, Willison HJ
Eur J Neurol 2023 Dec;30(12):3646-3674. Epub 2023 Oct 10 doi: 10.1111/ene.16073. PMID: 37814552
Diagnosis and management of Guillain-Barré syndrome in ten steps.
Leonhard SE, Mandarakas MR, Gondim FAA, Bateman K, Ferreira MLB, Cornblath DR, van Doorn PA, Dourado ME, Hughes RAC, Islam B, Kusunoki S, Pardo CA, Reisin R, Sejvar JJ, Shahrizaila N, Soares C, Umapathi T, Wang Y, Yiu EM, Willison HJ, Jacobs BC
Nat Rev Neurol 2019 Nov;15(11):671-683. Epub 2019 Sep 20 doi: 10.1038/s41582-019-0250-9. PMID: 31541214Free PMC Article
Guillain-Barré syndrome: pathogenesis, diagnosis, treatment and prognosis.
van den Berg B, Walgaard C, Drenthen J, Fokke C, Jacobs BC, van Doorn PA
Nat Rev Neurol 2014 Aug;10(8):469-82. Epub 2014 Jul 15 doi: 10.1038/nrneurol.2014.121. PMID: 25023340

Recent clinical studies

Etiology

Supervised, individualised exercise reduces fatigue and improves strength and quality of life more than unsupervised home exercise in people with chronic Guillain-Barré syndrome: a randomised trial.
Shah N, Shrivastava M, Kumar S, Nagi RS
J Physiother 2022 Apr;68(2):123-129. Epub 2022 Apr 5 doi: 10.1016/j.jphys.2022.03.007. PMID: 35396175
Diagnosis and treatment of Guillain-Barré Syndrome in childhood and adolescence: An evidence- and consensus-based guideline.
Korinthenberg R, Trollmann R, Felderhoff-Müser U, Bernert G, Hackenberg A, Hufnagel M, Pohl M, Hahn G, Mentzel HJ, Sommer C, Lambeck J, Mecher F, Hessenauer M, Winterholler C, Kempf U, Jacobs BC, Rostasy K, Müller-Felber W
Eur J Paediatr Neurol 2020 Mar;25:5-16. Epub 2020 Jan 7 doi: 10.1016/j.ejpn.2020.01.003. PMID: 31941581
Immunotherapy of Guillain-Barré syndrome.
Liu S, Dong C, Ubogu EE
Hum Vaccin Immunother 2018;14(11):2568-2579. Epub 2018 Jul 12 doi: 10.1080/21645515.2018.1493415. PMID: 29953326Free PMC Article
Guillain-Barré syndrome mimics.
Tham SL, Prasad K, Umapathi T
Brain Behav 2018 May;8(5):e00960. Epub 2018 Apr 10 doi: 10.1002/brb3.960. PMID: 29761013Free PMC Article
Guillain-Barré syndrome.
Walling AD, Dickson G
Am Fam Physician 2013 Feb 1;87(3):191-7. PMID: 23418763

Diagnosis

Guillain-Barre Syndrome in Children and Adolescents.
Langille MM
Adv Pediatr 2023 Aug;70(1):91-103. Epub 2023 May 12 doi: 10.1016/j.yapd.2023.04.001. PMID: 37422300
Guillain-Barré syndrome.
Shahrizaila N, Lehmann HC, Kuwabara S
Lancet 2021 Mar 27;397(10280):1214-1228. Epub 2021 Feb 26 doi: 10.1016/S0140-6736(21)00517-1. PMID: 33647239
Guillain-Barre Syndrome.
Malek E, Salameh J
Semin Neurol 2019 Oct;39(5):589-595. Epub 2019 Oct 22 doi: 10.1055/s-0039-1693005. PMID: 31639842
Guillain-Barré syndrome: pathogenesis, diagnosis, treatment and prognosis.
van den Berg B, Walgaard C, Drenthen J, Fokke C, Jacobs BC, van Doorn PA
Nat Rev Neurol 2014 Aug;10(8):469-82. Epub 2014 Jul 15 doi: 10.1038/nrneurol.2014.121. PMID: 25023340
Guillain-Barré syndrome and variants.
Dimachkie MM, Barohn RJ
Neurol Clin 2013 May;31(2):491-510. Epub 2013 Feb 19 doi: 10.1016/j.ncl.2013.01.005. PMID: 23642721Free PMC Article

Therapy

Guillain-Barré syndrome: a comprehensive review.
Bellanti R, Rinaldi S
Eur J Neurol 2024 Aug;31(8):e16365. Epub 2024 May 30 doi: 10.1111/ene.16365. PMID: 38813755Free PMC Article
Guillain-Barré Syndrome.
Habib AA, Waheed W
Continuum (Minneap Minn) 2023 Oct 1;29(5):1327-1356. doi: 10.1212/CON.0000000000001289. PMID: 37851033
Supervised, individualised exercise reduces fatigue and improves strength and quality of life more than unsupervised home exercise in people with chronic Guillain-Barré syndrome: a randomised trial.
Shah N, Shrivastava M, Kumar S, Nagi RS
J Physiother 2022 Apr;68(2):123-129. Epub 2022 Apr 5 doi: 10.1016/j.jphys.2022.03.007. PMID: 35396175
Guillain-Barré syndrome.
Willison HJ, Jacobs BC, van Doorn PA
Lancet 2016 Aug 13;388(10045):717-27. Epub 2016 Mar 2 doi: 10.1016/S0140-6736(16)00339-1. PMID: 26948435
Guillain-Barré syndrome and variants.
Dimachkie MM, Barohn RJ
Neurol Clin 2013 May;31(2):491-510. Epub 2013 Feb 19 doi: 10.1016/j.ncl.2013.01.005. PMID: 23642721Free PMC Article

Prognosis

Guillain-Barré syndrome mimics.
Tham SL, Prasad K, Umapathi T
Brain Behav 2018 May;8(5):e00960. Epub 2018 Apr 10 doi: 10.1002/brb3.960. PMID: 29761013Free PMC Article
Peripheral neuropathies.
Hanewinckel R, Ikram MA, Van Doorn PA
Handb Clin Neurol 2016;138:263-82. doi: 10.1016/B978-0-12-802973-2.00015-X. PMID: 27637963
Guillain-Barré syndrome.
Walling AD, Dickson G
Am Fam Physician 2013 Feb 1;87(3):191-7. PMID: 23418763
Guillain-Barré syndrome.
Yuki N, Hartung HP
N Engl J Med 2012 Jun 14;366(24):2294-304. doi: 10.1056/NEJMra1114525. PMID: 22694000
Guillain-Barré syndrome.
Hughes RA, Cornblath DR
Lancet 2005 Nov 5;366(9497):1653-66. doi: 10.1016/S0140-6736(05)67665-9. PMID: 16271648

Clinical prediction guides

Guillain-Barre Syndrome in Children and Adolescents.
Langille MM
Adv Pediatr 2023 Aug;70(1):91-103. Epub 2023 May 12 doi: 10.1016/j.yapd.2023.04.001. PMID: 37422300
Guillain-Barré Syndrome.
Sheikh KA
Continuum (Minneap Minn) 2020 Oct;26(5):1184-1204. doi: 10.1212/CON.0000000000000929. PMID: 33002998
Guillain-Barré syndrome: causes, immunopathogenic mechanisms and treatment.
Jasti AK, Selmi C, Sarmiento-Monroy JC, Vega DA, Anaya JM, Gershwin ME
Expert Rev Clin Immunol 2016 Nov;12(11):1175-1189. Epub 2016 Jun 21 doi: 10.1080/1744666X.2016.1193006. PMID: 27292311
Guillain-Barré syndrome.
Willison HJ, Jacobs BC, van Doorn PA
Lancet 2016 Aug 13;388(10045):717-27. Epub 2016 Mar 2 doi: 10.1016/S0140-6736(16)00339-1. PMID: 26948435
Guillain-Barré syndrome: pathogenesis, diagnosis, treatment and prognosis.
van den Berg B, Walgaard C, Drenthen J, Fokke C, Jacobs BC, van Doorn PA
Nat Rev Neurol 2014 Aug;10(8):469-82. Epub 2014 Jul 15 doi: 10.1038/nrneurol.2014.121. PMID: 25023340

Recent systematic reviews

Guidelines for Neuroprognostication in Adults with Guillain-Barré Syndrome.
Busl KM, Fried H, Muehlschlegel S, Wartenberg KE, Rajajee V, Alexander SA, Creutzfeldt CJ, Fontaine GV, Hocker SE, Hwang DY, Kim KS, Madzar D, Mahanes D, Mainali S, Meixensberger J, Sakowitz OW, Varelas PN, Westermaier T, Weimar C
Neurocrit Care 2023 Jun;38(3):564-583. Epub 2023 Mar 25 doi: 10.1007/s12028-023-01707-3. PMID: 36964442Free PMC Article
Triggers of Guillain-Barré Syndrome: Campylobacter jejuni Predominates.
Finsterer J
Int J Mol Sci 2022 Nov 17;23(22) doi: 10.3390/ijms232214222. PMID: 36430700Free PMC Article
Plasma exchange for Guillain-Barré syndrome.
Chevret S, Hughes RA, Annane D
Cochrane Database Syst Rev 2017 Feb 27;2(2):CD001798. doi: 10.1002/14651858.CD001798.pub3. PMID: 28241090Free PMC Article
Intravenous immunoglobulin for Guillain-Barré syndrome.
Hughes RA, Swan AV, van Doorn PA
Cochrane Database Syst Rev 2014 Sep 19;2014(9):CD002063. doi: 10.1002/14651858.CD002063.pub6. PMID: 25238327Free PMC Article
Multidisciplinary care for Guillain-Barré syndrome.
Khan F, Ng L, Amatya B, Brand C, Turner-Stokes L
Eur J Phys Rehabil Med 2011 Dec;47(4):607-12. Epub 2011 Sep 13 PMID: 21912364

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