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Tetanus neonatorum

MedGen UID:
575516
•Concept ID:
C0343312
•
Disease or Syndrome
Synonyms: Neonatal Tetanus; neonatal tetanus; Tetanus Neonatorum; tetanus neonatorum
SNOMED CT: Tetanus neonatorum (43424001)
 
Monarch Initiative: MONDO:0001737

Definition

A syndrome of generalized rigidity with muscle spasms and seizures in the neonatal period resulting from Clostridium tetani toxin production. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTetanus neonatorum

Professional guidelines

PubMed

Current concepts in the management of Clostridium tetani infection.
Brook I
Expert Rev Anti Infect Ther 2008 Jun;6(3):327-36. doi: 10.1586/14787210.6.3.327. PMID: 18588497
Treatment of tetanus neonatorum with muscle relaxants and intermittent positive-pressure ventilation.
Smythe PM, Bowie MD, Voss TJ
Br Med J 1974 Feb 9;1(5901):223-6. doi: 10.1136/bmj.1.5901.223. PMID: 4131848Free PMC Article
Treatment of tetanus neonatorum.
Smythe PM
Int Anesthesiol Clin 1966 Summer;4(2):435-43. doi: 10.1097/00004311-196622000-00016. PMID: 5335337

Recent clinical studies

Etiology

Bacteria in surface infections of neonates.
Ghosh S, Chatterjee BD, Chakraborty CK, Chakravarty A, Khatua SP
J Indian Med Assoc 1995 Apr;93(4):132-5. PMID: 8699037
Fractures of the acromion in tetanus neonatorum [corrected].
Kalideen JM, Satyapal KS
Clin Radiol 1994 Aug;49(8):563-5. doi: 10.1016/s0009-9260(05)82938-1. PMID: 7955871
Study of tetanus neonatorum in Tanta Fever Hospital, 1988-1989.
el-Sherbini A
J Trop Pediatr 1991 Oct;37(5):262-3. doi: 10.1093/tropej/37.5.262. PMID: 1784062
Trial of pyridoxine therapy for tetanus neonatorum.
Godel JC
J Infect Dis 1982 Apr;145(4):547-9. doi: 10.1093/infdis/145.4.547. PMID: 7069234
Cause of death in tetanus neonatorum: study of 233 cases with 54 necropsies.
Salimpour R
Arch Dis Child 1977 Jul;52(7):587-9. doi: 10.1136/adc.52.7.587. PMID: 879851Free PMC Article

Diagnosis

The influence of pyridoxin in the treatment of tetanus neonatorum.
Dianto, Mustadjab I
Paediatr Indones 1991 May-Jun;31(5-6):165-9. PMID: 1896198
Extent of occurrence of the six vaccine preventable diseases in vaccinated/unvaccinated children.
Singh H, Raizada N, Jain BK, Bhatia RC
Indian Pediatr 1991 Jun;28(6):635-9. PMID: 1748512
Botulism and tetanus: selected epidemiologic and microbiologic aspects.
Dowell VR Jr
Rev Infect Dis 1984 Mar-Apr;6 Suppl 1:S202-7. doi: 10.1093/clinids/6.supplement_1.s202. PMID: 6372030
A new method of grading tetanus neonatorum.
Daud S, Mohammad T, Ahmad A
J Pak Med Assoc 1982 Feb;32(2):41-5. PMID: 6803003
THE TREATMENT OF TETANUS NEONATORUM.
GOMEZ FR, ABELLA P, AMIGO L
J Philipp Med Assoc 1964 Sep;40:709-19. PMID: 14254339

Therapy

Intermittent positive pressure respiration in tetanus neonatorum. 1960.
Sykes MK
Anaesthesia 1995 Apr;50(4):332-7. doi: 10.1111/j.1365-2044.1995.tb04610.x. PMID: 7747851
Tetanus neonatorum (a preliminary report of assessment of different therapeutic regimens).
Daud S, Mohammad T, Ahmad A
J Trop Pediatr 1981 Dec;27(6):308-11. doi: 10.1093/tropej/27.6.308. PMID: 7334565
Therapeutic trial of methocarbamol (Robinax) in tetanus neonatorum.
Lall JC, Gupta HL
Indian Pediatr 1975 Jun;12(6):503-4. PMID: 1184148
The serological assessment of a tetanus toxoid field trial.
Newell KW, Leblanc DR, Edsall G, Levine L, Christensen H, Montouri MH, Ramirez N
Bull World Health Organ 1971;45(6):773-85. PMID: 4947832Free PMC Article
Treatment of tetanus neonatorum.
Smythe PM
Int Anesthesiol Clin 1966 Summer;4(2):435-43. doi: 10.1097/00004311-196622000-00016. PMID: 5335337

Prognosis

A review of 43 cases of tetanus neonatorum.
Yalçin I, Güler N, Kebudi R, Oneş U, Salman N
Turk J Pediatr 1992 Jul-Sep;34(3):121-5. PMID: 1485378
Pyridoxine therapy in tetanus neonatorum.
Hajailay R, Sharan R, Agarwal VK, Srivastava AK
Indian Pediatr 1983 Dec;20(12):935-9. PMID: 6676307
Trial of pyridoxine therapy for tetanus neonatorum.
Godel JC
J Infect Dis 1982 Apr;145(4):547-9. doi: 10.1093/infdis/145.4.547. PMID: 7069234
Tetanus neonatorum--clinical manifestations.
Athavale VB
J Pediatr 1965 Oct;67(4):649-57. doi: 10.1016/s0022-3476(65)80438-3. PMID: 5832559
THE TREATMENT OF TETANUS NEONATORUM.
GOMEZ FR, ABELLA P, AMIGO L
J Philipp Med Assoc 1964 Sep;40:709-19. PMID: 14254339

Clinical prediction guides

P.A. Schleisner: a pioneer in epidemiology.
Olafsson O
J Clin Epidemiol 1999 Oct;52(10):905-7. doi: 10.1016/s0895-4356(99)00096-7. PMID: 10513751
Determinants of neonatal mortality in central Sudan.
Taha TE, Gray RH, Abdelwahab MM
Ann Trop Paediatr 1993;13(4):359-64. doi: 10.1080/02724936.1993.11747671. PMID: 7506883
Pyridoxine in the treatment of tetanus neonatorum.
Caglar MK
Paediatr Indones 1989 Nov-Dec;29(11-12):233-6. PMID: 2488239
Mechanical ventilation in newborn infants.
Kishan J, Valdez ME, Mir NA, Elzouki AY
Afr J Med Med Sci 1988 Jun;17(2):83-8. PMID: 2843022

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