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Neuroaspergillosis

MedGen UID:
199873
Concept ID:
C0752342
Disease or Syndrome
Synonym: Neuroaspergilloses
 
Monarch Initiative: MONDO:0005873

Definition

Infections of the nervous system caused by fungi of the genus aspergillus, most commonly aspergillus fumigatus. Aspergillus infections may occur in immunocompetent hosts, but are more prevalent in individuals with immunologic deficiency syndromes. The organism may spread to the nervous system from focal infections in the lung, mastoid region, sinuses, inner ear, bones, eyes, gastrointestinal tract, and heart. Sinus infections may be locally invasive and enter the intracranial compartment, producing meningitis, fungal; cranial neuropathies; and abscesses in the frontal lobes of the brain. (From Joynt, Clinical Neurology, 1998, Ch 27, pp62-3) [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeuroaspergillosis

Professional guidelines

PubMed

Meena DS, Kumar D, Bohra GK, Kumar G
Infect Dis Now 2021 Nov;51(8):654-660. Epub 2021 May 5 doi: 10.1016/j.idnow.2021.04.002. PMID: 33964485
Ellenbogen JR, Waqar M, Cooke RP, Javadpour M
Br J Neurosurg 2016 Jun;30(3):280-5. Epub 2016 Feb 6 doi: 10.3109/02688697.2016.1139046. PMID: 26853515

Recent clinical studies

Etiology

Serris A, Rautemaa-Richardson R, Laranjinha JD, Candoni A, Garcia-Vidal C, Alastruey-Izquierdo A, Hammarström H, Seidel D, Styczynski J, Sabino R, Lamoth F, Prattes J, Warris A, Porcher R, Lanternier F; ESCAI Study Group
Clin Infect Dis 2024 Oct 15;79(4):936-943. doi: 10.1093/cid/ciae371. PMID: 39076104
Ray S, Balaini N, Chakravarty K, Pattanayak S, Goel A, Takkar A, Lal V
Postgrad Med J 2019 Jul;95(1125):382-389. Epub 2019 Jun 20 doi: 10.1136/postgradmedj-2018-136095. PMID: 31221685
Anciones C, de Felipe A, de Albóniga-Chindurza A, Acebrón F, Pián H, Masjuán J, Corral I
J Stroke Cerebrovasc Dis 2018 Nov;27(11):3289-3293. Epub 2018 Aug 29 doi: 10.1016/j.jstrokecerebrovasdis.2018.07.031. PMID: 30172679
Gärtner F, Forstenpointner J, Ertl-Wagner B, Hooshmand B, Riedel C, Jansen O
Rofo 2018 Oct;190(10):967-970. Epub 2017 Nov 20 doi: 10.1055/s-0043-120766. PMID: 29156474
Soeffker G, Wichmann D, Loderstaedt U, Sobottka I, Deuse T, Kluge S
Prog Transplant 2013 Mar;23(1):71-4. doi: 10.7182/pit2013386. PMID: 23448824

Diagnosis

Funakoshi S, Nishiyama M, Komori M, Hyodo M, Kawanishi Y, Ueba T, Fujimoto S, Terada Y
Intern Med 2024 Nov 1;63(21):2953-2959. Epub 2024 Mar 11 doi: 10.2169/internalmedicine.3390-23. PMID: 38462513
Ray S, Balaini N, Chakravarty K, Pattanayak S, Goel A, Takkar A, Lal V
Postgrad Med J 2019 Jul;95(1125):382-389. Epub 2019 Jun 20 doi: 10.1136/postgradmedj-2018-136095. PMID: 31221685
Anciones C, de Felipe A, de Albóniga-Chindurza A, Acebrón F, Pián H, Masjuán J, Corral I
J Stroke Cerebrovasc Dis 2018 Nov;27(11):3289-3293. Epub 2018 Aug 29 doi: 10.1016/j.jstrokecerebrovasdis.2018.07.031. PMID: 30172679
Shamim MS, Enam SA, Ali R, Anwar S
J Pak Med Assoc 2010 Jul;60(7):573-9. PMID: 20578611
Ho TV, Zalpour A, D'Amico C, Niangar ML, Gentle B, Mante M, Valdres R, Watson A, Grover T
Clin J Oncol Nurs 2007 Dec;11(6):942-8. doi: 10.1188/CJON.07.942-948. PMID: 18063554

Therapy

McCarthy MW, Walsh TJ
Expert Rev Mol Diagn 2017 Feb;17(2):129-139. Epub 2016 Dec 22 doi: 10.1080/14737159.2017.1271716. PMID: 27936983
Ellenbogen JR, Waqar M, Cooke RP, Javadpour M
Br J Neurosurg 2016 Jun;30(3):280-5. Epub 2016 Feb 6 doi: 10.3109/02688697.2016.1139046. PMID: 26853515
Soeffker G, Wichmann D, Loderstaedt U, Sobottka I, Deuse T, Kluge S
Prog Transplant 2013 Mar;23(1):71-4. doi: 10.7182/pit2013386. PMID: 23448824
Schwartz S, Thiel E
Med Mycol 2009;47 Suppl 1:S387-93. Epub 2009 Feb 28 doi: 10.1080/13693780802537953. PMID: 19255905
Ho TV, Zalpour A, D'Amico C, Niangar ML, Gentle B, Mante M, Valdres R, Watson A, Grover T
Clin J Oncol Nurs 2007 Dec;11(6):942-8. doi: 10.1188/CJON.07.942-948. PMID: 18063554

Prognosis

Ray S, Balaini N, Chakravarty K, Pattanayak S, Goel A, Takkar A, Lal V
Postgrad Med J 2019 Jul;95(1125):382-389. Epub 2019 Jun 20 doi: 10.1136/postgradmedj-2018-136095. PMID: 31221685
Anciones C, de Felipe A, de Albóniga-Chindurza A, Acebrón F, Pián H, Masjuán J, Corral I
J Stroke Cerebrovasc Dis 2018 Nov;27(11):3289-3293. Epub 2018 Aug 29 doi: 10.1016/j.jstrokecerebrovasdis.2018.07.031. PMID: 30172679
Panda PK, Mavidi SK, Wig N, Garg A, Nalwa A, Sharma MC
Mycopathologia 2017 Jun;182(5-6):527-538. Epub 2017 Jan 4 doi: 10.1007/s11046-016-0106-4. PMID: 28054219
Shamim MS, Enam SA, Ali R, Anwar S
J Pak Med Assoc 2010 Jul;60(7):573-9. PMID: 20578611
Schwartz S, Thiel E
Ann Hematol 2004;83 Suppl 1:S42-4. doi: 10.1007/s00277-004-0849-8. PMID: 15124667

Clinical prediction guides

Leroy J, Vuotto F, Le V, Cornu M, François N, Marceau L, Fichet C, Loridant S, Sendid B
J Mycol Med 2020 Sep;30(3):101002. Epub 2020 May 19 doi: 10.1016/j.mycmed.2020.101002. PMID: 32507472
Wilson MR, O'Donovan BD, Gelfand JM, Sample HA, Chow FC, Betjemann JP, Shah MP, Richie MB, Gorman MP, Hajj-Ali RA, Calabrese LH, Zorn KC, Chow ED, Greenlee JE, Blum JH, Green G, Khan LM, Banerji D, Langelier C, Bryson-Cahn C, Harrington W, Lingappa JR, Shanbhag NM, Green AJ, Brew BJ, Soldatos A, Strnad L, Doernberg SB, Jay CA, Douglas V, Josephson SA, DeRisi JL
JAMA Neurol 2018 Aug 1;75(8):947-955. doi: 10.1001/jamaneurol.2018.0463. PMID: 29710329Free PMC Article
Şahintürk F, Demirkaya H, Dere ÜA, Sönmez E, Altınörs N, Moray G, Haberal M
Exp Clin Transplant 2018 Mar;16 Suppl 1(Suppl 1):179-182. doi: 10.6002/ect.TOND-TDTD2017.P56. PMID: 29528023
Saghrouni F, Ben Youssef Y, Gheith S, Bouabid Z, Ben Abdeljelil J, Khammari I, Fathallah A, Khlif A, Ben Saïd M
Med Mal Infect 2011 Dec;41(12):657-62. Epub 2011 Oct 28 doi: 10.1016/j.medmal.2011.09.011. PMID: 22036518
Shamim MS, Enam SA, Ali R, Anwar S
J Pak Med Assoc 2010 Jul;60(7):573-9. PMID: 20578611

Recent systematic reviews

Komorowski AS, Hall CW, Atwal S, Johnstone R, Walker R 3rd, Mertz D, Piessens EA, Yamamura D, Kasper EM
Clin Microbiol Infect 2024 Oct;30(10):1244-1253. Epub 2024 May 27 doi: 10.1016/j.cmi.2024.05.013. PMID: 38810927
Meena DS, Kumar D, Bohra GK, Kumar G
Infect Dis Now 2021 Nov;51(8):654-660. Epub 2021 May 5 doi: 10.1016/j.idnow.2021.04.002. PMID: 33964485
Pajer HB, Asher AM, Gelinne A, Northam W, van Duin D, Quinsey CS
World Neurosurg 2021 May;149:244-248.e13. Epub 2021 Jan 20 doi: 10.1016/j.wneu.2021.01.033. PMID: 33482411
Dotis J, Iosifidis E, Roilides E
Int J Infect Dis 2007 Sep;11(5):381-93. Epub 2007 May 16 doi: 10.1016/j.ijid.2007.01.013. PMID: 17509921

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