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Epidural abscess

MedGen UID:
82848
Concept ID:
C0270629
Disease or Syndrome
Synonyms: Abscess, Epidural; Abscess, Extradural; Epidural Abscess; Extradural Abscess
SNOMED CT: Epidural abscess (61974008); Extradural abscess (61974008)
 
Monarch Initiative: MONDO:0005752

Definition

Circumscribed collections of suppurative material occurring in the spinal or intracranial epidural space. The majority of epidural abscesses occur in the spinal canal and are associated with osteomyelitis of a vertebral body; analgesia, epidural; and other conditions. Clinical manifestations include local and radicular pain, weakness, sensory loss, urinary incontinence, and fecal incontinence. Cranial epidural abscesses are usually associated with osteomyelitis of a cranial bone, sinusitis, or otitis media. (From Adams et al., Principles of Neurology, 6th ed, p710 and pp1240-1; J Neurol Neurosurg Psychiatry 1998 Aug;65(2):209-12) [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEpidural abscess

Professional guidelines

PubMed

Schwab JH, Shah AA
J Am Acad Orthop Surg 2020 Nov 1;28(21):e929-e938. doi: 10.5435/JAAOS-D-19-00685. PMID: 32694325
Lener S, Hartmann S, Barbagallo GMV, Certo F, Thomé C, Tschugg A
Acta Neurochir (Wien) 2018 Mar;160(3):487-496. Epub 2018 Jan 22 doi: 10.1007/s00701-018-3467-2. PMID: 29356895Free PMC Article
David MZ, Daum RS
Curr Top Microbiol Immunol 2017;409:325-383. doi: 10.1007/82_2017_42. PMID: 28900682

Recent clinical studies

Etiology

Galliker G, Scherer DE, Trippolini MA, Rasmussen-Barr E, LoMartire R, Wertli MM
Am J Med 2020 Jan;133(1):60-72.e14. Epub 2019 Jul 3 doi: 10.1016/j.amjmed.2019.06.005. PMID: 31278933
Babic M, Simpfendorfer CS, Berbari EF
Curr Opin Infect Dis 2019 Jun;32(3):265-271. doi: 10.1097/QCO.0000000000000544. PMID: 31021957
Aleman-Ortega H, Lee R, Shambo L, Czinn E
AORN J 2017 Feb;105(2):184-192. doi: 10.1016/j.aorn.2016.12.004. PMID: 28159077
Winters ME, Kluetz P, Zilberstein J
Med Clin North Am 2006 May;90(3):505-23. doi: 10.1016/j.mcna.2005.11.002. PMID: 16473102
Tay BK, Deckey J, Hu SS
J Am Acad Orthop Surg 2002 May-Jun;10(3):188-97. doi: 10.5435/00124635-200205000-00005. PMID: 12041940

Diagnosis

Kleck CCJ, Damioli L, Ou-Yang D
Instr Course Lect 2024;73:675-687. PMID: 38090933
Schwab JH, Shah AA
J Am Acad Orthop Surg 2020 Nov 1;28(21):e929-e938. doi: 10.5435/JAAOS-D-19-00685. PMID: 32694325
Ropper AE, Ropper AH
N Engl J Med 2017 Apr 6;376(14):1358-1369. doi: 10.1056/NEJMra1516539. PMID: 28379788
Mazzie JP, Brooks MK, Gnerre J
Neuroimaging Clin N Am 2014 May;24(2):365-74. doi: 10.1016/j.nic.2014.01.003. PMID: 24792614
Darouiche RO
N Engl J Med 2006 Nov 9;355(19):2012-20. doi: 10.1056/NEJMra055111. PMID: 17093252

Therapy

Tracz J, Judy B, Witham T
World Neurosurg 2022 Oct;166:49-51. Epub 2022 Jul 19 doi: 10.1016/j.wneu.2022.07.024. PMID: 35863647
Schwab JH, Shah AA
J Am Acad Orthop Surg 2020 Nov 1;28(21):e929-e938. doi: 10.5435/JAAOS-D-19-00685. PMID: 32694325
Diehn FE
Radiol Clin North Am 2012 Jul;50(4):777-98. doi: 10.1016/j.rcl.2012.04.001. PMID: 22643395
Darouiche RO
N Engl J Med 2006 Nov 9;355(19):2012-20. doi: 10.1056/NEJMra055111. PMID: 17093252
Sethi A, Sabherwal A, Gulati A, Sareen D
Acta Otolaryngol 2005 Nov;125(11):1236-9. doi: 10.1080/00016480510038158. PMID: 16353409

Prognosis

Wildenthal JA, Atkinson A, Lewis S, Sayood S, Nolan NS, Cabrera NL, Marschall J, Durkin MJ, Marks LR
Clin Infect Dis 2023 Feb 8;76(3):487-496. doi: 10.1093/cid/ciac714. PMID: 36052413Free PMC Article
Babic M, Simpfendorfer CS, Berbari EF
Curr Opin Infect Dis 2019 Jun;32(3):265-271. doi: 10.1097/QCO.0000000000000544. PMID: 31021957
Kolinsky DC, Liang SY
Emerg Med Clin North Am 2018 Nov;36(4):751-766. Epub 2018 Sep 6 doi: 10.1016/j.emc.2018.06.006. PMID: 30297002Free PMC Article
Flanagan EP, Pittock SJ
Handb Clin Neurol 2017;140:319-335. doi: 10.1016/B978-0-444-63600-3.00017-9. PMID: 28187806
Aleman-Ortega H, Lee R, Shambo L, Czinn E
AORN J 2017 Feb;105(2):184-192. doi: 10.1016/j.aorn.2016.12.004. PMID: 28159077

Clinical prediction guides

Pomponio MK, Khan IS, Evans LT, Simmons NE, Ball PA, Ryken TC, Hong J
Spine J 2022 Jun;22(6):921-926. Epub 2022 Jan 10 doi: 10.1016/j.spinee.2022.01.007. PMID: 35017053
Schwab JH, Shah AA
J Am Acad Orthop Surg 2020 Nov 1;28(21):e929-e938. doi: 10.5435/JAAOS-D-19-00685. PMID: 32694325
Flanagan EP, Pittock SJ
Handb Clin Neurol 2017;140:319-335. doi: 10.1016/B978-0-444-63600-3.00017-9. PMID: 28187806
Riddell J 4th, Shuman EK
Neuroimaging Clin N Am 2012 Nov;22(4):543-56. Epub 2012 Aug 11 doi: 10.1016/j.nic.2012.05.003. PMID: 23122256
Bodur H, Erbay A, Colpan A, Akinci E
Rheumatol Int 2004 Jul;24(4):221-6. Epub 2003 Jul 16 doi: 10.1007/s00296-003-0350-z. PMID: 12879273

Recent systematic reviews

Gardner WT, Rehman H, Frost A
Surgeon 2021 Aug;19(4):226-237. Epub 2020 Jul 16 doi: 10.1016/j.surge.2020.06.011. PMID: 32684428
Galliker G, Scherer DE, Trippolini MA, Rasmussen-Barr E, LoMartire R, Wertli MM
Am J Med 2020 Jan;133(1):60-72.e14. Epub 2019 Jul 3 doi: 10.1016/j.amjmed.2019.06.005. PMID: 31278933
Verdú-López F, Vanaclocha-Vanaclocha V, Mayorga-Villa JD
J Neurosurg Sci 2017 Jun;61(3):303-315. Epub 2016 Oct 27 doi: 10.23736/S0390-5616.16.03911-4. PMID: 27787487
Suppiah S, Meng Y, Fehlings MG, Massicotte EM, Yee A, Shamji MF
World Neurosurg 2016 Sep;93:20-8. Epub 2016 Jun 1 doi: 10.1016/j.wneu.2016.05.074. PMID: 27262655
Arko L 4th, Quach E, Nguyen V, Chang D, Sukul V, Kim BS
Neurosurg Focus 2014 Aug;37(2):E4. doi: 10.3171/2014.6.FOCUS14127. PMID: 25081964

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