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Lip and oral cavity squamous cell carcinoma

MedGen UID:
124714
•Concept ID:
C0280297
•
Neoplastic Process
Synonyms: lip and oral cavity squamous cell cancer; Lip and Oral Cavity Squamous Cell Carcinoma; lip and oral cavity squamous cell carcinoma; lip/oral cavity squam. cell car.; squamous cell carcinoma of oral cavity and lip; Squamous cell carcinoma of oral cavity and lip
 
Monarch Initiative: MONDO:0044710
Orphanet: ORPHA502369

Definition

A squamous cell carcinoma arising from the lip or the oral cavity. The oral cavity squamous cell carcinoma usually arises from the buccal mucosa, tongue, or gums. It occurs predominantly in adults who use tobacco and alcohol and has a tendency to metastasize early to lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLip and oral cavity squamous cell carcinoma

Professional guidelines

PubMed

Potential Alternative Therapeutic Modalities for Management Head and Neck Squamous Cell Carcinoma: A Review.
Afshari K, Sohal KS
Cancer Control 2023 Jan-Dec;30:10732748231185003. doi: 10.1177/10732748231185003. PMID: 37328298Free PMC Article
Management of high-risk squamous cell carcinoma of the skin.
Samarasinghe V, Madan V, Lear JT
Expert Rev Anticancer Ther 2011 May;11(5):763-9. doi: 10.1586/era.11.36. PMID: 21554051
Recurrent head and neck cancer: the results of treatment.
Williams RG
Br J Surg 1974 Sep;61(9):691-7. doi: 10.1002/bjs.1800610905. PMID: 4415503

Recent clinical studies

Etiology

Lip and Oral Cavity Squamous Cell Carcinoma.
Howard A, Agrawal N, Gooi Z
Hematol Oncol Clin North Am 2021 Oct;35(5):895-911. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.003. PMID: 34274176
Carcinoma cuniculatum of the lip: A case report.
Thibouw F, Anna H, Levasseur J, Mondoloni C, Aubriot-Lorton MH, Zwetyenga N
J Stomatol Oral Maxillofac Surg 2018 Jun;119(3):224-228. Epub 2018 Feb 9 doi: 10.1016/j.jormas.2018.01.006. PMID: 29432817
Management of N0 neck in head and neck cancer: current controversies.
Dünne AA, Budach VG, Wagner W, Werner JA
Onkologie 2004 Aug;27(4):363-7. doi: 10.1159/000079089. PMID: 15347891
Advanced malignancy in the young marijuana smoker.
Donald PJ
Adv Exp Med Biol 1991;288:33-46. doi: 10.1007/978-1-4684-5925-8_4. PMID: 1950738
Reconstruction of the lower lip.
Wilson JS, Walker EP
Head Neck Surg 1981 Sep-Oct;4(1):29-44. doi: 10.1002/hed.2890040108. PMID: 7287447

Diagnosis

Lip and Oral Cavity Squamous Cell Carcinoma.
Howard A, Agrawal N, Gooi Z
Hematol Oncol Clin North Am 2021 Oct;35(5):895-911. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.003. PMID: 34274176
Oral Biopsy Techniques.
Shanti RM, Tanaka T, Stanton DC
Dermatol Clin 2020 Oct;38(4):421-427. Epub 2020 Aug 10 doi: 10.1016/j.det.2020.05.003. PMID: 32892851
Carcinoma cuniculatum of the lip: A case report.
Thibouw F, Anna H, Levasseur J, Mondoloni C, Aubriot-Lorton MH, Zwetyenga N
J Stomatol Oral Maxillofac Surg 2018 Jun;119(3):224-228. Epub 2018 Feb 9 doi: 10.1016/j.jormas.2018.01.006. PMID: 29432817
Two-Piece Extraoral Prosthetic Rehabilitation to a Perineural Invasion Lip Cancer.
Şahan MH, Eskiizmir G, Ateş P
J Prosthodont 2018 Mar;27(3):306-310. Epub 2016 Aug 12 doi: 10.1111/jopr.12493. PMID: 27517479
Congenital epulis.
Merglová V, Mukensnabl P, Andrle P
BMJ Case Rep 2012 Jul 9;2012 doi: 10.1136/bcr.01.2012.5483. PMID: 22778448Free PMC Article

Therapy

The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Tobacco-associated lesions of the oral cavity: Part II. Malignant lesions.
Mirbod SM, Ahing SI
J Can Dent Assoc 2000 Jun;66(6):308-11. PMID: 10927896
Nasolabial flap for the reconstruction of defects of the floor of the mouth.
Ioannides C, Fossion E
Int J Oral Maxillofac Surg 1991 Feb;20(1):40-3. doi: 10.1016/s0901-5027(05)80694-0. PMID: 2019782
Advanced malignancy in the young marijuana smoker.
Donald PJ
Adv Exp Med Biol 1991;288:33-46. doi: 10.1007/978-1-4684-5925-8_4. PMID: 1950738
Selective cytotoxic effect of topical 5-fluorouracil.
Dillaha CJ, Jansen GT, Honeycutt WM, Bradford AC
Arch Dermatol 1983 Sep;119(9):774-83. PMID: 6614965

Prognosis

Donor site morbidity using the buccinator myomucosal island flap.
Ferrari S, Ferri A, Bianchi B, Copelli C, Boni P, Sesenna E
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011 Mar;111(3):306-11. Epub 2010 Sep 1 doi: 10.1016/j.tripleo.2010.05.051. PMID: 20813563
Management of N0 neck in head and neck cancer: current controversies.
Dünne AA, Budach VG, Wagner W, Werner JA
Onkologie 2004 Aug;27(4):363-7. doi: 10.1159/000079089. PMID: 15347891
Applications of brachytherapy in head and neck cancer.
Harrison LB
Semin Surg Oncol 1997 May-Jun;13(3):177-84. doi: 10.1002/(sici)1098-2388(199705/06)13:3<177::aid-ssu4>3.0.co;2-4. PMID: 9143055
Cancer of the perioral region.
Goslen JB, Thomas JR
Dermatol Clin 1989 Oct;7(4):733-49. PMID: 2676286
The dissemination of tumors of the head and neck via the cranial nerves.
Dodd GD, Dolan PA, Ballantyne AJ, Ibanez ML, Chau P
Radiol Clin North Am 1970 Dec;8(3):445-61. PMID: 4923905

Clinical prediction guides

Nodal Metastasis in Surgically Treated Oral Cavity Squamous Cell Carcinoma.
Carey RM, Anagnos VJ, Prasad A, Sangal NR, Rajasekaran K, Shanti RM, Cannady SB, Newman JG, Brant JA, Brody RM
ORL J Otorhinolaryngol Relat Spec 2023;85(6):348-359. Epub 2023 Nov 15 doi: 10.1159/000534491. PMID: 37967536Free PMC Article
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Primary cN0 lip squamous cell carcinoma and elective neck dissection: Systematic review and meta-analysis.
Bhandari K, Wang DC, Li SC, Jiang BH, Guo YX, Koirala U, Du XY
Head Neck 2015 Sep;37(9):1392-400. Epub 2014 Jul 21 doi: 10.1002/hed.23772. PMID: 24839013
The use of maggots in wound debridement.
Reames MK, Christensen C, Luce EA
Ann Plast Surg 1988 Oct;21(4):388-91. doi: 10.1097/00000637-198810000-00017. PMID: 3232928
Selective cytotoxic effect of topical 5-fluorouracil.
Dillaha CJ, Jansen GT, Honeycutt WM, Bradford AC
Arch Dermatol 1983 Sep;119(9):774-83. PMID: 6614965

Recent systematic reviews

Risk of head and neck cancer among opium users.
Mohebbi E, Alimoradi Z, Rozek LS, Mohebbi A, Jafari E
Arch Oral Biol 2024 Jan;157:105846. Epub 2023 Nov 8 doi: 10.1016/j.archoralbio.2023.105846. PMID: 37980840
Hydrochlorothiazide use is associated with the risk of cutaneous and lip squamous cell carcinoma: A systematic review and meta-analysis.
de Macedo Andrade AC, Felix FA, França GM, Ribeiro ILA, Barboza CAG, de Castro RD, de Lisboa Lopes Costa A
Eur J Clin Pharmacol 2022 Jun;78(6):919-930. Epub 2022 Mar 8 doi: 10.1007/s00228-022-03299-x. PMID: 35258665
Primary Intraosseous Squamous Cell Carcinoma Involving the Jaw Bones: A Systematic Review and Update.
de Morais EF, Carlan LM, de Farias Morais HG, Pinheiro JC, Martins HDD, Barboza CAG, de Almeida Freitas R
Head Neck Pathol 2021 Jun;15(2):608-616. Epub 2020 Oct 12 doi: 10.1007/s12105-020-01234-z. PMID: 33044723Free PMC Article
Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions.
Macey R, Walsh T, Brocklehurst P, Kerr AR, Liu JL, Lingen MW, Ogden GR, Warnakulasuriya S, Scully C
Cochrane Database Syst Rev 2015 May 29;2015(5):CD010276. doi: 10.1002/14651858.CD010276.pub2. PMID: 26021841Free PMC Article
Primary cN0 lip squamous cell carcinoma and elective neck dissection: Systematic review and meta-analysis.
Bhandari K, Wang DC, Li SC, Jiang BH, Guo YX, Koirala U, Du XY
Head Neck 2015 Sep;37(9):1392-400. Epub 2014 Jul 21 doi: 10.1002/hed.23772. PMID: 24839013

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