U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pancytopenia caused by medication

MedGen UID:
1613695
•Concept ID:
C3251580
•
Disease or Syndrome
Synonyms: Drug induced pancytopenia; Drug Induced Pancytopenia; Drug-Induced Pancytopenia
SNOMED CT: Pancytopenia caused by medication (736024007); Drug induced pancytopenia (736024007)

Definition

Pancytopenia caused by exposure to certain drugs. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancytopenia caused by medication

Professional guidelines

PubMed

Deficiency of Adenosine Deaminase 2: Clinical Manifestations, Diagnosis, and Treatment.
Grim A, Veiga KR, Saad N
Rheum Dis Clin North Am 2023 Nov;49(4):773-787. Epub 2023 Aug 1 doi: 10.1016/j.rdc.2023.06.004. PMID: 37821195
Herbal approach in the treatment of pancytopenia.
Bagwe SM, Kale PP, Bhatt LK, Prabhavalkar KS
J Complement Integr Med 2017 Mar 1;14(1) doi: 10.1515/jcim-2016-0053. PMID: 28195548
Management of immune cytopenias in patients with systemic lupus erythematosus - Old and new.
Newman K, Owlia MB, El-Hemaidi I, Akhtari M
Autoimmun Rev 2013 May;12(7):784-91. Epub 2013 Feb 24 doi: 10.1016/j.autrev.2013.02.001. PMID: 23462431

Recent clinical studies

Etiology

Methotrexate-Induced Pancytopenia and Mucositis Caused by Medication Error.
Amissah-Arthur MB, Baah W
Ghana Med J 2020 Mar;54(1):68-71. doi: 10.4314/gmj.v54i1.10. PMID: 32863415Free PMC Article
Low-dose methotrexate toxicity.
Pivovarov K, Zipursky JS
CMAJ 2019 Apr 15;191(15):E423. doi: 10.1503/cmaj.181054. PMID: 30988043Free PMC Article
Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.
Yoshizato T, Dumitriu B, Hosokawa K, Makishima H, Yoshida K, Townsley D, Sato-Otsubo A, Sato Y, Liu D, Suzuki H, Wu CO, Shiraishi Y, Clemente MJ, Kataoka K, Shiozawa Y, Okuno Y, Chiba K, Tanaka H, Nagata Y, Katagiri T, Kon A, Sanada M, Scheinberg P, Miyano S, Maciejewski JP, Nakao S, Young NS, Ogawa S
N Engl J Med 2015 Jul 2;373(1):35-47. doi: 10.1056/NEJMoa1414799. PMID: 26132940Free PMC Article
Disseminated intravascular coagulation.
Naz H, Fawad A, Islam A, Shahid H, Abbasi AU
J Ayub Med Coll Abbottabad 2011 Oct-Dec;23(4):111-3. PMID: 23472430
Adalimumab: a review of side effects.
Scheinfeld N
Expert Opin Drug Saf 2005 Jul;4(4):637-41. doi: 10.1517/14740338.4.4.637. PMID: 16011443

Diagnosis

Case of leptospirosis causing pancytopenia.
Haryono IS, Tinson AJ, Abasszade JH, O'Donnobhain R
BMJ Case Rep 2023 Jan 5;16(1) doi: 10.1136/bcr-2022-251506. PMID: 36604107Free PMC Article
HAEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS IN PREGNANT AND POSTPARTUM WOMEN.
Obuchowska A, Kamiński M, Kimber-Trojnar Ż, Grzesik P, Standyło A, Turżańska K, Leszczyńka-Gorzelak B
Wiad Lek 2020;73(9 cz. 1):1844-1847. PMID: 33099527
Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.
Yoshizato T, Dumitriu B, Hosokawa K, Makishima H, Yoshida K, Townsley D, Sato-Otsubo A, Sato Y, Liu D, Suzuki H, Wu CO, Shiraishi Y, Clemente MJ, Kataoka K, Shiozawa Y, Okuno Y, Chiba K, Tanaka H, Nagata Y, Katagiri T, Kon A, Sanada M, Scheinberg P, Miyano S, Maciejewski JP, Nakao S, Young NS, Ogawa S
N Engl J Med 2015 Jul 2;373(1):35-47. doi: 10.1056/NEJMoa1414799. PMID: 26132940Free PMC Article
Adult acute leukemia.
Cornell RF, Palmer J
Dis Mon 2012 Apr;58(4):219-38. doi: 10.1016/j.disamonth.2012.01.011. PMID: 22449370
Disseminated intravascular coagulation.
Naz H, Fawad A, Islam A, Shahid H, Abbasi AU
J Ayub Med Coll Abbottabad 2011 Oct-Dec;23(4):111-3. PMID: 23472430

Therapy

Low-dose methotrexate toxicity.
Pivovarov K, Zipursky JS
CMAJ 2019 Apr 15;191(15):E423. doi: 10.1503/cmaj.181054. PMID: 30988043Free PMC Article
Herbal approach in the treatment of pancytopenia.
Bagwe SM, Kale PP, Bhatt LK, Prabhavalkar KS
J Complement Integr Med 2017 Mar 1;14(1) doi: 10.1515/jcim-2016-0053. PMID: 28195548
Splenic irradiation for splenomegaly: A systematic review.
Zaorsky NG, Williams GR, Barta SK, Esnaola NF, Kropf PL, Hayes SB, Meyer JE
Cancer Treat Rev 2017 Feb;53:47-52. Epub 2016 Dec 22 doi: 10.1016/j.ctrv.2016.11.016. PMID: 28063304Free PMC Article
Idiopathic aplastic anemia: diagnosis and classification.
Dolberg OJ, Levy Y
Autoimmun Rev 2014 Apr-May;13(4-5):569-73. Epub 2014 Jan 12 doi: 10.1016/j.autrev.2014.01.014. PMID: 24424170
Adalimumab: a review of side effects.
Scheinfeld N
Expert Opin Drug Saf 2005 Jul;4(4):637-41. doi: 10.1517/14740338.4.4.637. PMID: 16011443

Prognosis

Splenic irradiation for splenomegaly: A systematic review.
Zaorsky NG, Williams GR, Barta SK, Esnaola NF, Kropf PL, Hayes SB, Meyer JE
Cancer Treat Rev 2017 Feb;53:47-52. Epub 2016 Dec 22 doi: 10.1016/j.ctrv.2016.11.016. PMID: 28063304Free PMC Article
Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.
Yoshizato T, Dumitriu B, Hosokawa K, Makishima H, Yoshida K, Townsley D, Sato-Otsubo A, Sato Y, Liu D, Suzuki H, Wu CO, Shiraishi Y, Clemente MJ, Kataoka K, Shiozawa Y, Okuno Y, Chiba K, Tanaka H, Nagata Y, Katagiri T, Kon A, Sanada M, Scheinberg P, Miyano S, Maciejewski JP, Nakao S, Young NS, Ogawa S
N Engl J Med 2015 Jul 2;373(1):35-47. doi: 10.1056/NEJMoa1414799. PMID: 26132940Free PMC Article
Disseminated intravascular coagulation.
Naz H, Fawad A, Islam A, Shahid H, Abbasi AU
J Ayub Med Coll Abbottabad 2011 Oct-Dec;23(4):111-3. PMID: 23472430
Orthopaedic management of the patient with osteopetrosis.
Landa J, Margolis N, Di Cesare P
J Am Acad Orthop Surg 2007 Nov;15(11):654-62. doi: 10.5435/00124635-200711000-00004. PMID: 17989416
Low-dose methotrexate-induced pancytopenia.
Preet Singh Y, Aggarwal A, Misra R, Agarwal V
Clin Rheumatol 2007 Jan;26(1):84-7. Epub 2006 Apr 25 doi: 10.1007/s10067-006-0301-7. PMID: 16636937

Clinical prediction guides

HAEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS IN PREGNANT AND POSTPARTUM WOMEN.
Obuchowska A, Kamiński M, Kimber-Trojnar Ż, Grzesik P, Standyło A, Turżańska K, Leszczyńka-Gorzelak B
Wiad Lek 2020;73(9 cz. 1):1844-1847. PMID: 33099527
Clinical features of idiopathic portal hypertension in China: A retrospective study of 338 patients and literature review.
Sun Y, Lan X, Shao C, Wang T, Yang Z
J Gastroenterol Hepatol 2019 Aug;34(8):1417-1423. Epub 2018 Dec 16 doi: 10.1111/jgh.14552. PMID: 30462857
Herbal approach in the treatment of pancytopenia.
Bagwe SM, Kale PP, Bhatt LK, Prabhavalkar KS
J Complement Integr Med 2017 Mar 1;14(1) doi: 10.1515/jcim-2016-0053. PMID: 28195548
Ataxia-Pancytopenia Syndrome Is Caused by Missense Mutations in SAMD9L.
Chen DH, Below JE, Shimamura A, Keel SB, Matsushita M, Wolff J, Sul Y, Bonkowski E, Castella M, Taniguchi T, Nickerson D, Papayannopoulou T, Bird TD, Raskind WH
Am J Hum Genet 2016 Jun 2;98(6):1146-1158. doi: 10.1016/j.ajhg.2016.04.009. PMID: 27259050Free PMC Article
Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.
Yoshizato T, Dumitriu B, Hosokawa K, Makishima H, Yoshida K, Townsley D, Sato-Otsubo A, Sato Y, Liu D, Suzuki H, Wu CO, Shiraishi Y, Clemente MJ, Kataoka K, Shiozawa Y, Okuno Y, Chiba K, Tanaka H, Nagata Y, Katagiri T, Kon A, Sanada M, Scheinberg P, Miyano S, Maciejewski JP, Nakao S, Young NS, Ogawa S
N Engl J Med 2015 Jul 2;373(1):35-47. doi: 10.1056/NEJMoa1414799. PMID: 26132940Free PMC Article

Recent systematic reviews

Graft-versus-host disease following liver transplantation: A systematic review of literature.
Kneifel F, Vogel T, Bormann E, Becker F, Houben P, Flammang I, Slepecka P, Eichelmann AK, Brockmann JG, Pascher A
Hepatol Commun 2023 Oct 1;7(10) Epub 2023 Sep 27 doi: 10.1097/HC9.0000000000000260. PMID: 37755878Free PMC Article
Splenic irradiation for splenomegaly: A systematic review.
Zaorsky NG, Williams GR, Barta SK, Esnaola NF, Kropf PL, Hayes SB, Meyer JE
Cancer Treat Rev 2017 Feb;53:47-52. Epub 2016 Dec 22 doi: 10.1016/j.ctrv.2016.11.016. PMID: 28063304Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...