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Tumors Derived from Langerhans Cells

MedGen UID:
1660882
•Concept ID:
C4725926
•
Neoplastic Process

Definition

This category includes two main sub-groups, according to the degree of cytological atypia and clinical aggressiveness: Langerhans cell histiocytosis and Langerhans cell sarcoma. (WHO 2017) [from NCI]

Professional guidelines

PubMed

Trametinib in the treatment of multiple malignancies harboring MEK1 mutations.
Lian T, Li C, Wang H
Cancer Treat Rev 2019 Dec;81:101907. Epub 2019 Oct 14 doi: 10.1016/j.ctrv.2019.101907. PMID: 31715422
Recent progress on normal and malignant pancreatic stem/progenitor cell research: therapeutic implications for the treatment of type 1 or 2 diabetes mellitus and aggressive pancreatic cancer.
Mimeault M, Batra SK
Gut 2008 Oct;57(10):1456-68. doi: 10.1136/gut.2008.150052. PMID: 18791122Free PMC Article
Histiocytoses of lymph nodes: biology and differential diagnosis.
Jaffe ES
Semin Diagn Pathol 1988 Nov;5(4):376-90. PMID: 3064218

Recent clinical studies

Therapy

Dendritic cells: The driver of psoriasis.
Wang A, Bai Y
J Dermatol 2020 Feb;47(2):104-113. Epub 2019 Dec 13 doi: 10.1111/1346-8138.15184. PMID: 31833093
Identification and Targeting of Kinase Alterations in Histiocytic Neoplasms.
Ozkaya N, Dogan A, Abdel-Wahab O
Hematol Oncol Clin North Am 2017 Aug;31(4):705-719. Epub 2017 May 17 doi: 10.1016/j.hoc.2017.04.008. PMID: 28673397Free PMC Article
Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms.
Diamond EL, Durham BH, Haroche J, Yao Z, Ma J, Parikh SA, Wang Z, Choi J, Kim E, Cohen-Aubart F, Lee SC, Gao Y, Micol JB, Campbell P, Walsh MP, Sylvester B, Dolgalev I, Aminova O, Heguy A, Zappile P, Nakitandwe J, Ganzel C, Dalton JD, Ellison DW, Estrada-Veras J, Lacouture M, Gahl WA, Stephens PJ, Miller VA, Ross JS, Ali SM, Briggs SR, Fasan O, Block J, Héritier S, Donadieu J, Solit DB, Hyman DM, Baselga J, Janku F, Taylor BS, Park CY, Amoura Z, Dogan A, Emile JF, Rosen N, Gruber TA, Abdel-Wahab O
Cancer Discov 2016 Feb;6(2):154-65. Epub 2015 Nov 13 doi: 10.1158/2159-8290.CD-15-0913. PMID: 26566875Free PMC Article
Update on islet transplantation.
McCall M, Shapiro AM
Cold Spring Harb Perspect Med 2012 Jul;2(7):a007823. doi: 10.1101/cshperspect.a007823. PMID: 22762022Free PMC Article
Insulin-producing cells derived from stem cells: recent progress and future directions.
Santana A, Enseñat-Waser R, Arribas MI, Reig JA, Roche E
J Cell Mol Med 2006 Oct-Dec;10(4):866-83. doi: 10.1111/j.1582-4934.2006.tb00531.x. PMID: 17125591

Prognosis

Understanding the squamous cell carcinoma immune microenvironment.
Saeidi V, Doudican N, Carucci JA
Front Immunol 2023;14:1084873. Epub 2023 Jan 30 doi: 10.3389/fimmu.2023.1084873. PMID: 36793738Free PMC Article
An IRF1-IRF4 Toggle-Switch Controls Tolerogenic and Immunogenic Transcriptional Programming in Human Langerhans Cells.
Davies J, Vallejo AF, Sirvent S, Porter G, Clayton K, Qumbelo Y, Stumpf P, West J, Gray CM, Chigorimbo-Murefu NTL, MacArthur B, Polak ME
Front Immunol 2021;12:665312. Epub 2021 Jun 15 doi: 10.3389/fimmu.2021.665312. PMID: 34211464Free PMC Article
Immunotherapies in diabetes mellitus type 1.
Gupta S
Med Clin North Am 2012 May;96(3):621-34, xi. Epub 2012 May 24 doi: 10.1016/j.mcna.2012.04.008. PMID: 22703858
Tumor microenvironment is multifaceted.
Sautès-Fridman C, Cherfils-Vicini J, Damotte D, Fisson S, Fridman WH, Cremer I, Dieu-Nosjean MC
Cancer Metastasis Rev 2011 Mar;30(1):13-25. doi: 10.1007/s10555-011-9279-y. PMID: 21271351
Specific cutaneous manifestations of internal malignancy.
Kaplan RP
Adv Dermatol 1986;1:3-42. PMID: 3079247

Clinical prediction guides

Acute myeloid leukaemia-derived Langerhans-like cells enhance Th1 polarization upon TLR2 engagement.
Bock S, Murgueitio MS, Wolber G, Weindl G
Pharmacol Res 2016 Mar;105:44-53. Epub 2016 Jan 18 doi: 10.1016/j.phrs.2016.01.016. PMID: 26794428
Islet Cells Serve as Cells of Origin of Pancreatic Gastrin-Positive Endocrine Tumors.
Bonnavion R, Teinturier R, Jaafar R, Ripoche D, Leteurtre E, Chen YJ, Rehfeld JF, Lepinasse F, Hervieu V, Pattou F, Vantyghem MC, Scoazec JY, Bertolino P, Zhang CX
Mol Cell Biol 2015 Oct;35(19):3274-83. Epub 2015 Jul 13 doi: 10.1128/MCB.00302-15. PMID: 26169832Free PMC Article
Health outcomes of vitamin D. Part II. Role in prevention of diseases.
Wranicz J, Szostak-Węgierek D
Rocz Panstw Zakl Hig 2014;65(4):273-9. PMID: 25526571
The response of human dendritic cells to co-ligation of pattern-recognition receptors.
Dzopalic T, Rajkovic I, Dragicevic A, Colic M
Immunol Res 2012 Apr;52(1-2):20-33. doi: 10.1007/s12026-012-8279-5. PMID: 22392051
Tumor microenvironment is multifaceted.
Sautès-Fridman C, Cherfils-Vicini J, Damotte D, Fisson S, Fridman WH, Cremer I, Dieu-Nosjean MC
Cancer Metastasis Rev 2011 Mar;30(1):13-25. doi: 10.1007/s10555-011-9279-y. PMID: 21271351

Recent systematic reviews

Density of Langerhans Cells in Nonmelanoma Skin Cancers: A Systematic Review.
Pogorzelska-Dyrbuś J, Szepietowski JC
Mediators Inflamm 2020;2020:8745863. Epub 2020 Apr 19 doi: 10.1155/2020/8745863. PMID: 32377167Free PMC Article
Impact of HPV Infection on the Immune System in Oropharyngeal and Non-Oropharyngeal Squamous Cell Carcinoma: A Systematic Review.
Lechien JR, Seminerio I, Descamps G, Mat Q, Mouawad F, Hans S, Julieron M, Dequanter D, Vanderhaegen T, Journe F, Saussez S
Cells 2019 Sep 10;8(9) doi: 10.3390/cells8091061. PMID: 31510065Free PMC Article

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