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Bleeding requiring red cell transfusion

MedGen UID:
868739
Concept ID:
C4023144
Finding; Pathologic Function
HPO: HP:0011888

Definition

Bleeding sufficiently severe as to require red cell transfusion (WHO Grade 3 or 4). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBleeding requiring red cell transfusion

Conditions with this feature

Cholestasis, progressive familial intrahepatic, 6
MedGen UID:
1794175
Concept ID:
C5561965
Disease or Syndrome
Progressive familial intrahepatic cholestasis-6 (PFIC6) is an autosomal recessive disorder characterized by elevated liver transaminases, cholestasis, and congenital diarrhea (Gao et al., 2020). For a general phenotypic description and a discussion of genetic heterogeneity of PFIC, see PFIC1 (211600).

Professional guidelines

PubMed

Sengupta N, Feuerstein JD, Jairath V, Shergill AK, Strate LL, Wong RJ, Wan D
Am J Gastroenterol 2023 Feb 1;118(2):208-231. Epub 2022 Sep 21 doi: 10.14309/ajg.0000000000002130. PMID: 36735555
Mo YD, Delaney M
Clin Lab Med 2021 Mar;41(1):1-14. doi: 10.1016/j.cll.2020.10.001. PMID: 33494878
Gralnek IM, Dumonceau JM, Kuipers EJ, Lanas A, Sanders DS, Kurien M, Rotondano G, Hucl T, Dinis-Ribeiro M, Marmo R, Racz I, Arezzo A, Hoffmann RT, Lesur G, de Franchis R, Aabakken L, Veitch A, Radaelli F, Salgueiro P, Cardoso R, Maia L, Zullo A, Cipolletta L, Hassan C
Endoscopy 2015 Oct;47(10):a1-46. Epub 2015 Sep 29 doi: 10.1055/s-0034-1393172. PMID: 26417980

Recent clinical studies

Etiology

Lewis SR, Pritchard MW, Estcourt LJ, Stanworth SJ, Griffin XL
Cochrane Database Syst Rev 2023 Jun 8;6(6):CD013737. doi: 10.1002/14651858.CD013737.pub2. PMID: 37294864Free PMC Article
Beverly A, Ong G, Kimber C, Sandercock J, Dorée C, Welton NJ, Wicks P, Estcourt LJ
Cochrane Database Syst Rev 2023 Feb 17;2(2):CD013649. doi: 10.1002/14651858.CD013649.pub2. PMID: 36800489Free PMC Article
Mo YD, Delaney M
Clin Lab Med 2021 Mar;41(1):1-14. doi: 10.1016/j.cll.2020.10.001. PMID: 33494878
Stanley AJ, Laine L
BMJ 2019 Mar 25;364:l536. doi: 10.1136/bmj.l536. PMID: 30910853
Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, del Junco DJ, Brasel KJ, Bulger EM, Callcut RA, Cohen MJ, Cotton BA, Fabian TC, Inaba K, Kerby JD, Muskat P, O'Keeffe T, Rizoli S, Robinson BR, Scalea TM, Schreiber MA, Stein DM, Weinberg JA, Callum JL, Hess JR, Matijevic N, Miller CN, Pittet JF, Hoyt DB, Pearson GD, Leroux B, van Belle G; PROPPR Study Group
JAMA 2015 Feb 3;313(5):471-82. doi: 10.1001/jama.2015.12. PMID: 25647203Free PMC Article

Diagnosis

Sengupta N, Feuerstein JD, Jairath V, Shergill AK, Strate LL, Wong RJ, Wan D
Am J Gastroenterol 2023 Feb 1;118(2):208-231. Epub 2022 Sep 21 doi: 10.14309/ajg.0000000000002130. PMID: 36735555
D'Amore K, Swaminathan A
Emerg Med Clin North Am 2020 Nov;38(4):871-889. Epub 2020 Jul 30 doi: 10.1016/j.emc.2020.06.008. PMID: 32981623
Stanley AJ, Laine L
BMJ 2019 Mar 25;364:l536. doi: 10.1136/bmj.l536. PMID: 30910853
Gralnek IM, Dumonceau JM, Kuipers EJ, Lanas A, Sanders DS, Kurien M, Rotondano G, Hucl T, Dinis-Ribeiro M, Marmo R, Racz I, Arezzo A, Hoffmann RT, Lesur G, de Franchis R, Aabakken L, Veitch A, Radaelli F, Salgueiro P, Cardoso R, Maia L, Zullo A, Cipolletta L, Hassan C
Endoscopy 2015 Oct;47(10):a1-46. Epub 2015 Sep 29 doi: 10.1055/s-0034-1393172. PMID: 26417980
Whiting P, Al M, Westwood M, Ramos IC, Ryder S, Armstrong N, Misso K, Ross J, Severens J, Kleijnen J
Health Technol Assess 2015 Jul;19(58):1-228, v-vi. doi: 10.3310/hta19580. PMID: 26215747Free PMC Article

Therapy

Smith MM, Schroeder DR, Nelson JA, Mauermann WJ, Welsby IJ, Pochettino A, Montonye BL, Assawakawintip C, Nuttall GA
JAMA Surg 2022 Sep 1;157(9):757-764. doi: 10.1001/jamasurg.2022.2235. PMID: 35767271Free PMC Article
D'Amore K, Swaminathan A
Emerg Med Clin North Am 2020 Nov;38(4):871-889. Epub 2020 Jul 30 doi: 10.1016/j.emc.2020.06.008. PMID: 32981623
Stanley AJ, Laine L
BMJ 2019 Mar 25;364:l536. doi: 10.1136/bmj.l536. PMID: 30910853
McQuilten ZK, Crighton G, Brunskill S, Morison JK, Richter TH, Waters N, Murphy MF, Wood EM
Transfus Med Rev 2018 Jan;32(1):6-15. Epub 2017 Jul 6 doi: 10.1016/j.tmrv.2017.06.003. PMID: 28803752
Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, del Junco DJ, Brasel KJ, Bulger EM, Callcut RA, Cohen MJ, Cotton BA, Fabian TC, Inaba K, Kerby JD, Muskat P, O'Keeffe T, Rizoli S, Robinson BR, Scalea TM, Schreiber MA, Stein DM, Weinberg JA, Callum JL, Hess JR, Matijevic N, Miller CN, Pittet JF, Hoyt DB, Pearson GD, Leroux B, van Belle G; PROPPR Study Group
JAMA 2015 Feb 3;313(5):471-82. doi: 10.1001/jama.2015.12. PMID: 25647203Free PMC Article

Prognosis

Goltstein LCMJ, Grooteman KV, Rocco A, Holleran G, Frago S, Salgueiro PS, Aparicio T, Scaglione G, Chetcuti Zammit S, Prados-Manzano R, Benamouzig R, Nardone G, McNamara D, Benallaoua M, Michopoulos S, Sidhu R, Kievit W, Drenth JPH, van Geenen EJM
Lancet Gastroenterol Hepatol 2021 Nov;6(11):922-932. Epub 2021 Sep 9 doi: 10.1016/S2468-1253(21)00262-4. PMID: 34508668
Long B, Koyfman A
J Emerg Med 2016 Aug;51(2):120-30. Epub 2016 Jun 1 doi: 10.1016/j.jemermed.2016.04.010. PMID: 27262735
Gonzalez E, Moore EE, Moore HB, Chapman MP, Chin TL, Ghasabyan A, Wohlauer MV, Barnett CC, Bensard DD, Biffl WL, Burlew CC, Johnson JL, Pieracci FM, Jurkovich GJ, Banerjee A, Silliman CC, Sauaia A
Ann Surg 2016 Jun;263(6):1051-9. doi: 10.1097/SLA.0000000000001608. PMID: 26720428Free PMC Article
Whiting P, Al M, Westwood M, Ramos IC, Ryder S, Armstrong N, Misso K, Ross J, Severens J, Kleijnen J
Health Technol Assess 2015 Jul;19(58):1-228, v-vi. doi: 10.3310/hta19580. PMID: 26215747Free PMC Article
Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, del Junco DJ, Brasel KJ, Bulger EM, Callcut RA, Cohen MJ, Cotton BA, Fabian TC, Inaba K, Kerby JD, Muskat P, O'Keeffe T, Rizoli S, Robinson BR, Scalea TM, Schreiber MA, Stein DM, Weinberg JA, Callum JL, Hess JR, Matijevic N, Miller CN, Pittet JF, Hoyt DB, Pearson GD, Leroux B, van Belle G; PROPPR Study Group
JAMA 2015 Feb 3;313(5):471-82. doi: 10.1001/jama.2015.12. PMID: 25647203Free PMC Article

Clinical prediction guides

Goltstein LCMJ, Grooteman KV, Rocco A, Holleran G, Frago S, Salgueiro PS, Aparicio T, Scaglione G, Chetcuti Zammit S, Prados-Manzano R, Benamouzig R, Nardone G, McNamara D, Benallaoua M, Michopoulos S, Sidhu R, Kievit W, Drenth JPH, van Geenen EJM
Lancet Gastroenterol Hepatol 2021 Nov;6(11):922-932. Epub 2021 Sep 9 doi: 10.1016/S2468-1253(21)00262-4. PMID: 34508668
Gralnek IM, Dumonceau JM, Kuipers EJ, Lanas A, Sanders DS, Kurien M, Rotondano G, Hucl T, Dinis-Ribeiro M, Marmo R, Racz I, Arezzo A, Hoffmann RT, Lesur G, de Franchis R, Aabakken L, Veitch A, Radaelli F, Salgueiro P, Cardoso R, Maia L, Zullo A, Cipolletta L, Hassan C
Endoscopy 2015 Oct;47(10):a1-46. Epub 2015 Sep 29 doi: 10.1055/s-0034-1393172. PMID: 26417980
Holcomb JB, Tilley BC, Baraniuk S, Fox EE, Wade CE, Podbielski JM, del Junco DJ, Brasel KJ, Bulger EM, Callcut RA, Cohen MJ, Cotton BA, Fabian TC, Inaba K, Kerby JD, Muskat P, O'Keeffe T, Rizoli S, Robinson BR, Scalea TM, Schreiber MA, Stein DM, Weinberg JA, Callum JL, Hess JR, Matijevic N, Miller CN, Pittet JF, Hoyt DB, Pearson GD, Leroux B, van Belle G; PROPPR Study Group
JAMA 2015 Feb 3;313(5):471-82. doi: 10.1001/jama.2015.12. PMID: 25647203Free PMC Article
Shah A, Stanworth SJ, McKechnie S
Anaesthesia 2015 Jan;70 Suppl 1:10-9, e3-5. doi: 10.1111/anae.12893. PMID: 25440390
Gruenbaum SE, Ruskin KJ
Curr Opin Anaesthesiol 2014 Oct;27(5):470-3. doi: 10.1097/ACO.0000000000000109. PMID: 25051263Free PMC Article

Recent systematic reviews

Lewis SR, Pritchard MW, Estcourt LJ, Stanworth SJ, Griffin XL
Cochrane Database Syst Rev 2023 Jun 8;6(6):CD013737. doi: 10.1002/14651858.CD013737.pub2. PMID: 37294864Free PMC Article
Goltstein LCMJ, Grooteman KV, Rocco A, Holleran G, Frago S, Salgueiro PS, Aparicio T, Scaglione G, Chetcuti Zammit S, Prados-Manzano R, Benamouzig R, Nardone G, McNamara D, Benallaoua M, Michopoulos S, Sidhu R, Kievit W, Drenth JPH, van Geenen EJM
Lancet Gastroenterol Hepatol 2021 Nov;6(11):922-932. Epub 2021 Sep 9 doi: 10.1016/S2468-1253(21)00262-4. PMID: 34508668
Stanley AJ, Laine L
BMJ 2019 Mar 25;364:l536. doi: 10.1136/bmj.l536. PMID: 30910853
McQuilten ZK, Crighton G, Brunskill S, Morison JK, Richter TH, Waters N, Murphy MF, Wood EM
Transfus Med Rev 2018 Jan;32(1):6-15. Epub 2017 Jul 6 doi: 10.1016/j.tmrv.2017.06.003. PMID: 28803752
Whiting P, Al M, Westwood M, Ramos IC, Ryder S, Armstrong N, Misso K, Ross J, Severens J, Kleijnen J
Health Technol Assess 2015 Jul;19(58):1-228, v-vi. doi: 10.3310/hta19580. PMID: 26215747Free PMC Article

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